четверг, 1 декабря 2011 г.

Games

Games

The Testament of Sherlock Holmes - Videos and Trailers

Posted: 01 Dec 2011 03:14 AM PST

The Testament of Sherlock Holmes teaser trailer.

Traffic Panic 3D - Videos and Trailers

Posted: 01 Dec 2011 01:29 AM PST

Traffic Panic 3D trailer.

Ion Assault - Videos and Trailers

Posted: 01 Dec 2011 02:50 AM PST

Ion Assault PS3 trailer.

Norton AntiVirus Definitions 11/30/2011 - Virus definitions for Symantec/Norton AntiVirus.. (Updater)

Posted: 01 Dec 2011 03:41 AM PST



Norton AntiVirus Definitions are the latest anti-virus detection files. The installer will automatically update Norton AntiVirus 11 virus definitions and engine files to detect and repair the most recently discovered Macintosh viruses. This file is a self-extracting archive which contains the Norton AntiVirus Virus Definitions Installer. Once downloaded and expanded on your hard drive, simply double-click on the Installer and the appropriate files will be installed on your computer.

Version 11/30/2011:
  • Includes the latest virus definitions


  • Mac OS X 10.4 or later
  • Norton AntiVirus 11.x, or Norton AntiVirus 10.2


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Fun gifts for the gamer geek

Posted: 01 Dec 2011 03:06 AM PST

The gamer in your life has probably already given you an extensive list of the many video games he or she would love to find wrapped up in a gift box this holiday season.

This posting includes an audio/video/photo media file: Download Now

Gourmania 3 1.0 - Find the ingredients for those spicy fajitas and help Victoria.. (Demo)

Posted: 01 Dec 2011 03:03 AM PST



Gourmania 3 sees you helping Victoria patch things up with her estranged father by launching a chain of exotic restaurants. Find the ingredients for spicy fajitas at Tres Amigos, or prepare a mouthwatering Greek Salad at Aesop's Tables! From pouring hot java at Bean Me Up to serving ice-cold treats at Beaches and Cream, there's never a dull moment as you work quickly to please your customers and increase your profits! Between levels, build a zoo featuring the five animals on Victoria's family crest. Try the free trial version or download the full version of Gourmania 3: Zoo Zoom today.

Features:

  • More than 80 levels
  • Over 15 restaurants
  • More than 500 recipes
  • Casual and Expert modes
  • Five mini-quests



Version 1.0: Initial release.

Mac OS X 10.5 or later

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Infinity Blade II Screens

Posted: 01 Dec 2011 02:36 AM PST

25 new shots posted.

     

Get the full article at GameSpot

"Infinity Blade II Screens" was posted on Thu, 01 Dec 2011 02:36:00 -0800

PlugSpy 1.2.1 - Protect your Mac from unauthorised access.. (Shareware)

Posted: 01 Dec 2011 02:46 AM PST



PlugSpy provides basic Protection for your MacBook.

Plug-Spy is an instant warning system for your MacBook in case that someone try to take it away or is entering a wrong password in the standard OS X login panel. It's easy to setup and integrates seamlessly with Mac OS X and the "Find my Mac" Apple offers with iCloud.

There is no additional password or shortcut you have to remember. Plug Spy auto activates when your screen is locked and start an annoying high volume alert sound and send a Growl notification when your MacBook gets unplugged from the MagSafe power adapter.

With access protection enabled, you will also get notified when someone enter a wrong password in the login panel, try to access your MacBook with a different user account, or restart your Mac in Safari Guest mode.

With Boxcar or Prowl on your iPhone you can receive the notification right on your phone to initiate further steps.



Version 1.2:
  • New: Boxcar support.
  • Other Bug fixes and improvements.


  • Mac OS X 10.7 or later.
  • MacBook Pro or MacBook Air


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McCready is pregnant

Posted: 01 Dec 2011 02:01 AM PST

Singer Mindy McCready of the Queens of Heart poker team participates in the Ladies No-Limit Hold 'em poker tournament at the World Series of Poker at the Rio Hotel & Casino June 8, 2008 in Las Vegas, Nevada.

5 Sex Games

Posted: 01 Dec 2011 02:01 AM PST

Spin the Bottle, Two Minutes in the Closet, Strip Poker, Naked Twister -- in college, flirty games are a rite of passage, but once you settle into your 20s and 30s, and into a real relationship , it's easy to let all the grown-up stuff push playtime to the back of the line.

This posting includes an audio/video/photo media file: Download Now

Nazi games for boys and girls

Posted: 01 Dec 2011 02:01 AM PST

The world's oldest Holocaust museum has moved to a new home in London's Russell Square.

This posting includes an audio/video/photo media file: Download Now

Nottingham hackspace growing

Posted: 01 Dec 2011 02:00 AM PST

David from Nottinghack -- the hackspace in Nottingham, England -- writes, "It's been six months since we moved into a 4500 square foot hackspace, in large part thanks to Boing Boing featuring our cause in May. We'd like to extend our heartfelt thanks to you, and to all of the people who generously donated to keep the hackspace going. For those who requested it, we've painted your names on our wall, and made a time lapse video of the final coat going up. There's also now a hackspace manual showing a lot of the projects done and facilities now available at the space. Membership has been growing steadily ever since we moved in, and as a result, among many things we've been able to put in place laser cutters, CNC machines, a metal lathe, PCB etching equipment and bicycle repair facilities. All things we had no room for at the old space!"

Time Lapse: Nottinghack Wall of Friends

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Molecules, Vol. 16, Pages 9957-9971: Structural and Molecular Characterization of meso-Substituted Zinc Porphyrins: A DFT Supported Study

Posted: 01 Dec 2011 12:00 AM PST

Structural parameters of a range of over 100 meso-substituted zinc porphyrins were reviewed and compared to show how far the nature of the functional group may affect the interatomic distances and bond angles within the porphyrin core. It was proved that even despite evident deformations of the molecular structure, involving twisting of the porphyrin's central plane, the coupled π-bonding system remains flexible and stable. DFT calculations were applied to a number of selected porphyrins representative for the reviewed compounds to emphasize the relevance of theoretical methods in structural investigations of complex macrocyclic molecular systems. Experimental and DFT-simulated IR spectral data were reported and analyzed in context of the individual molecular features introduced by the meso substituents into the porphyrin moiety base. Raw experimental spectral data, including 1H- and 13C-NMR, UV-Vis, FTIR, XRD, and other relevant physicochemical details have been provided for a specially chosen reference zinc porphyrin functionalized by tert-butylphenyl groups.

Molecules, Vol. 16, Pages 9939-9956: The Triterpenes 3β-Lup-20(29)-en-3-ol and 3β-Lup-20(29)-en-3-yl Acetate and the Carbohydrate 1,2,3,4,5,6-Hexa-O-acetyl-dulcitol as Photosynthesis Light Reactions Inhibitors

Posted: 01 Dec 2011 12:00 AM PST

Three compounds were isolated from Maytenus acanthophylla Reissek (Celastraceae): the pentacyclic triterpenes lup-20(29)-en-3β-ol (lupeol, 1) and 3β-lup-20(29)-en-3-yl acetate (2) and the carbohydrate 1,2,3,4,5,6-hexa-O-acetyldulcitol (3); lupeol was also isolated from Xylosma flexuosa. The compounds' structures were elucidated by spectroscopic and spectrometric analysis. Compound 1 acts as an energy transfer inhibitor, interacting with isolated CF1 bound to thylakoid membrane, and dulcitol hexaacetate 3 behaves as a Hill reaction inhibitor and as an uncoupler, as determined by polarography. Chlorophyll a (Chl a) fluorescence induction kinetics from the minimum yield F0 to the maximum yield FM provides information of the filling up from electrons coming from water to plastoquinone pool with reducing equivalents. In this paper we have examined the effects of compounds 1 and 3 on spinach leaf discs. Compound 1 induces the appearance of a K-band, which indicates that it inhibits the water splitting enzyme. In vivo assays measuring the fluorescence of chl a in P. ixocarpa leaves sprayed with compound 1, showed the appearance of the K-band and the PSII reaction centers was transformed to "heat sinks" or silent reaction centers unable to reduce QA. However, 3 also induced the appearance of a K band and a new band I appears in P. ixocarpa plants, therefore it inhibits at the water splitting enzyme complex and at the PQH2 site on b6f complex. Compounds 1 and 3 did not affect chlorophyll a fluorescence of L. perenne plants.

Molecules, Vol. 16, Pages 9925-9938: Antimicrobial Activity of Piper gaudichaudianum Kuntze and Its Synergism with Different Antibiotics

Posted: 01 Dec 2011 12:00 AM PST

One of the oldest forms of medical practice is the use of plants for the treatment and prevention of diseases that affect humans. We have studied the antimicrobial activity and synergism of Piper gaudichaudianum Kuntze with different antibiotics. The crude extract from the leaves of P. gaudichaudianum was submitted to chromatographic separation, resulting in five fractions. Fraction F3 contained a chromone (2,2-dimethyl-6-carboxycroman-4-one), and fraction F2 contained isomers that are prenylated derivatives of benzoic acid [4-hydroxy-(3',7'-dimethyl-1'-oxo-octa-E-2'-6'-dienyl)benzoic acid and 4-hydroxy-(3',7'-dimethyl-1'-oxo-octa-2'-Z-6'-dienyl) benzoic acid]. The chemical structures of both compounds were determined by analysis of 1H-NMR, 13C-NMR, COZY, DEPT, HMQC, and HMBC spectral data, and by comparison with data in the literature. The crude extract, fraction F2, and fraction F3 showed good activity against Staphylococcus aureus, Bacillus subtilis, and Candida tropicalis. The two benzoic acid derivatives only showed activity against S. aureus and B. subtilis. The bioauthographic analysis showed an inhibition zone only in fraction F2. Fractions F2 and F3 showed synergism in combination with ceftriaxone, tetracycline, and vancomycin. Morphological changes in form and structure were found by scanning electron microscopy in S. aureus treated with the combination of fraction F2 with vancomycin.

Molecules, Vol. 16, Pages 9912-9924: Protective Effect of Salidroside from Rhodiolae Radix on Diabetes-Induced Oxidative Stress in Mice

Posted: 01 Dec 2011 12:00 AM PST

It has been confirmed that diabetes mellitus (DM) carries increased oxidative stress. This study evaluated the effects of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. After induction of diabetes, diabetic mice were administered daily doses of 50, 100 and 200 mg/kg salidroside for 28 days. Body weights, fasting blood glucose (FBG), serum insulin, TC (total cholesterol), TG (triglyceride), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured. Results showed that salidroside possessed hypoglycemic activity and protective effects against diabetes-induced oxidative stress, which could significantly reduce FBG, TC, TG and MDA levels, and at same time increase serum insulin levels, SOD, GPx and CAT activities. Therefore, salidroside should be considered as a candidate for future studies on diabetes.

IJMS, Vol. 12, Pages 8713-8739: Combined Pharmacophore Modeling, Docking, and 3D-QSAR Studies of PLK1 Inhibitors

Posted: 01 Dec 2011 12:00 AM PST

Polo-like kinase 1, an important enzyme with diverse biological actions in cell mitosis, is a promising target for developing novel anticancer drugs. A combined molecular docking, structure-based pharmacophore modeling and three-dimensional quantitative structure-activity relationship (3D-QSAR) study was performed on a set of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as PLK1 inhibitors. The common substructure, molecular docking and pharmacophore-based alignment were used to develop different 3D-QSAR models. The comparative molecular field analysis (CoMFA) and comparative molecule similarity indices analysis (CoMSIA) models gave statistically significant results. These models showed good q2 and r2pred values and revealed a good response to test set validation. All of the structural insights obtained from the 3D-QSAR contour maps are consistent with the available crystal structure of PLK1. The contour maps obtained from the 3D-QSAR models in combination with the structure based pharmacophore model help to better interpret the structure-activity relationship. These satisfactory results may aid the design of novel PLK1 inhibitors. This is the first report on 3D-QSAR study of PLK1 inhibitors.

IJMS, Vol. 12, Pages 8695-8712: Genetic Association and Altered Gene Expression of Mir-155 in Multiple Sclerosis Patients

Posted: 01 Dec 2011 12:00 AM PST

Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system characterized by chronic inflammation, demyelination, and axonal damage. As microRNA (miRNA)-dependent alterations in gene expression in hematopoietic cells are critical for mounting an appropriate immune response, miRNA deregulation may result in defects in immune tolerance. In this frame, we sought to explore the possible involvement of miRNAs in MS pathogenesis by monitoring the differential expression of 22 immunity-related miRNAs in peripheral blood mononuclear cells of MS patients and healthy controls, by using a microbead-based technology. Three miRNAs resulted >2 folds up-regulated in MS vs controls, whereas none resulted down-regulated. Interestingly, the most up-regulated miRNA (mir-155; fold change = 3.30; P = 0.013) was previously reported to be up-regulated also in MS brain lesions. Mir-155 up-regulation was confirmed by qPCR experiments. The role of mir-155 in MS susceptibility was also investigated by genotyping four single nucleotide polymorphisms (SNPs) mapping in the mir-155 genomic region. A haplotype of three SNPs, corresponding to a 12-kb region encompassing the last exon of BIC (the B-cell Integration Cluster non-coding RNA, from which mir-155 is processed), resulted associated with the disease status (P = 0.035; OR = 1.36, 95% CI = 1.05–1.77), suggesting that this locus strongly deserves further investigations.

Alfred 1.0 - Quick launcher for apps and more.. (Free)

Posted: 30 Nov 2011 08:59 PM PST



Alfred is a quicklaunch application for Mac OS X, which aims to save you time in searching your local computer and the web. Whether it's maps, Amazon, eBay, Wikipedia, you can feed your web addiction quicker than ever before.
  • Increase your productivity by launching apps with shortcuts
  • Quicker access to web searches, bookmarks & more
  • Be the first to identify "that guy" in a movie with speedy IMDB search
  • Ward off RSI - skip using the mouse with easy shortcuts
  • Best of all, it's FREE!


Version 1.0:

Global Hotkeys

  • Significant improvements to Powerpack Global Hotkeys:
  • Assign hotkey to Application and optionally toggle show/hide with assigned hotkey
  • Assign hotkeys to your extensions and optionally pass a parameter
  • Assign hotkeys to Alfred's built in system commands such as Sleep, Empty Trash etc
  • Assign hotkeys to Alfred's iTunes functions such as Random Album, next, previous, iTunes volume
  • Assign hotkeys to groups of URLs to show all your favourite sites in a single keypress
  • Assign a hotkey to a folder to browse in Finder or directly within Alfred's filesystem navigation
  • Global Hotkey Syncing between your macs
  • Relative ~ paths for hotkeys linked to files for better syncing
Features
  • New Payment process: We now accept CC payments & PayPal directly: alfredapp.com/purchase
  • Remember recently typed URLs for subsequent recall / use. New preferences section to configure this
  • cmd+c now copies information for the current result in Alfred's default results (e.g. file path or URL)
  • Improvements to snippets preferences allowing for searching and sorting for editing:
Improvements
  • Improved preferences, consistency and performance
  • Snippets can now be used when the Clipboard History is disabled
  • Show the clipboard history source icon next to the clipboard history icon for better context
  • Show a nice generic icon to represent web links rather than the Safari document icon
  • More available custom fallback searches (6 instead of 3)
  • Allow wildcarding in iTunes search and also improve search accuracy
  • Flatten diacritics in iTunes search for more predictable matching
  • Better distinction between Album and Artist icons in iTunes mini player
  • Tickbox to enable/disable individual extensions
  • Improved / less imposing look to the "Alfred should have found something" fallback result:
  • Better URL handling and recognition (can now accept things like messages://)
  • Nicknames now accepted in Alfred's 'Email to' action
  • Drop folders directly into Alfred's search scope list
  • Increase the total storage time for clipboard history to 3 months
  • Allow for + for space encodings in custom searches to support more site searches
  • Improve accuracy when using double tap hotkeys, ensuring that shift doesn't interfere
  • If {query} is used in a custom search's title, no longer automatically appending {query}
  • Alfred can now eject all items in /Volumes (set this in the preferences)
  • Improve the 'play' keyword to also look at file name as well as track name
  • Allow extension parameters to be marked as 'optional' as well as 'required' for more flexiblility
  • Global [advanced] option to mark AppleScripts as 'run' instead of 'open' (can still open using cmd+o)
  • Update to newer Growl framework
  • Remove and update deprecated code to make Alfred more future proof
  • Make the delete/backspace key work for deleting extensions for consistency
Bug Fixes
  • Improve defence against odd unicode character entry into Alfred search box
  • Run "empty trash" command in the background to prevent blocking Alfred with very many trash items
  • Fix subtext for iCloud synced contacts for correctly showing in Alfred
  • Ensure that ~ correctly resolves to the home folder in the actions views
  • Make the numpad "enter" key work the same as the "return" key
  • Better handling of symbolic linked folders and files in Alfred's file system navigation
  • iTunes keywords now removed from the default results when disabled in prefs
  • Remove trailing slash from Applications when using the Finder Selection hotkey
  • Remove defunct § key from launching the iTunes mini player (legacy)
  • When importing a new extension, correctly scroll to the new extension in the list
  • Correctly launch contact web addresses when they are missing the http://
  • Work around Lion bug where isCaseInsensitiveLike was failing for certain strings causing a hang
  • No longer miss off the first letter of an email address if setting the email keyword to @
  • Stop custom search icon from being lost when adding a second custom search with identical URL
  • Fix help text on reindexing shell script, changing 'any key' to 'enter' for continue


Mac OS X 10.6 or later

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Sparrow 1.5 - Minimalist e-mail for IMAP accounts.. (Demo)

Posted: 30 Nov 2011 08:59 PM PST



Sparrow is a minimalist mail application for Mac. It was designed to keep things simple and efficient. No fancy stuff here... just your mail and nothing else.

Threads - Quickly flick through threaded conversations on your Mac like never before.

Not so minimal - See your mails the way you want. Quickly glance at the preview. Read it in a new window or open the right pane to enjoy Sparrow's full potential.

Notifications - Growl is integrated for notifications addicts.

Multiple Accounts - Seamlessly switch between your mail accounts.

What's next? - Sparrow will soon support several IMAP email providers and integrate labels for Gmail users.



Version 1.5:

New features:

  • Dropbox integration: drag, drop, send (& sync). Attaching files has never been easier.
  • Search has been dramatically improved. Search suggestions lets you find the message you're looking for in a matter of seconds.
  • Block remote images: keep control of the images displayed in your mail. Turn it on in Sparrow's Preferences.
Bug fixes:
  • Font always go back in Helvetica 13
  • Encoding problems in Chinese, Korean, Russian & Thai
  • Crash when opening emails from a certain sender
  • Crash when opening a protected PDF
  • CPU usage is too high
  • iCloud messages deleted on iPhone still appear on Sparrow
  • Unread counter does not always reflect the number of unread messages
  • and many more…


Mac OS X 10.6 or later

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