Games |
- MuteMyMic 1.3 - Control selected input volume from your status bar.. (Commercial)
- Board Games That Make You Feel Like A Kid Again
- IJMS, Vol. 13, Pages 187-207: Multi-Parametric Profiling Network Based on Gene Expression and Phenotype Data: A Novel Approach to Developmental Neurotoxicity Testing
- Sensors, Vol. 12, Pages 162-174: Tongue Tumor Detection in Medical Hyperspectral Images
- Materials, Vol. 5, Pages 12-26: Statistical and Graphical Assessment of Circumferential and Radial Hardness Variation of AISI 4140, AISI 1020 and AA 6082 Aluminum Alloy
- IJMS, Vol. 13, Pages 180-186: The Effect of Hydrogen Content on Ballistic Transport Behaviors in the Ni-Nb-Zr-H Glassy Alloys
- IJMS, Vol. 13, Pages 173-179: Significance of Dietary Antioxidants for Health
- 300 Miles to Pigsland
- IJMS, Vol. 13, Pages 142-172: Protein Kinases and Transcription Factors Activation in Response to UV-Radiation of Skin: Implications for Carcinogenesis
- IJMS, Vol. 13, Pages 133-141: Effect of Byrsonima crassa and Phenolic Constituents on Helicobacter pylori-Induced Neutrophils Oxidative Burst
- IJMS, Vol. 13, Pages 115-132: New PCR Assays for the Identification of Fusarium verticillioides, Fusarium subglutinans, and Other Species of the Gibberella fujikuroi Complex
- IJMS, Vol. 13, Pages 97-114: Bioinformatics Tools and Novel Challenges in Long Non-Coding RNAs (lncRNAs) Functional Analysis
- Molecules, Vol. 17, Pages 145-150: The Biological Response of Spermidine Induced by Ionization Radiation
- Molecules, Vol. 17, Pages 98-144: Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics
- X-Plane 10.03b5 - Ultra-realistic flight simulator.. (Updater)
- OnyX 2.4.3b2 - Mac OS X maintenance and optimisation tool (beta available).. (Free)
- Artlantis Studio 4.0.15.1 - 3D rendering of interior and exterior homes and buildings.. (Demo)
- Parallels Desktop 7.0.15052 - Run Windows, Linux, and more without rebooting; trial now available.. (Demo)
- Yasu 2.7.6 - System maintenance app performs many tasks.. (Shareware)
- aTV Flash (black) 1.1.1 - Supercharge your 2nd generation Apple TV. (Commercial)
| MuteMyMic 1.3 - Control selected input volume from your status bar.. (Commercial) Posted: 23 Dec 2011 03:13 AM PST  MuteMyMic is a simple, yet useful application It allows you to control the volume of currently selected input. MuteMyMic shows its presence by adding a new icon into the menu bar. This icon allows you to adjust the volume of the input exactly the same way as output volume adjustment works. In addition to that, MuteMyMic provides keyboard shortcuts to decrease (F5) and increase volume (F6). You can also use fast-mute (option+F5) and fast-max-volume (option+F6). One great benefit of the application is that it works in background and allows you to control the input's volume with a single key or mouse click while at the same time you can enjoy your favorite applications that require your mic. So, now you can adjust volume of your Internet phone calls right from the keyboard shortcuts. You can always quit the application by performing secondary click on the menu icon (Right-Click/Ctrl+Click). Version 1.1 introduces ability to show/hide application with Dock. You can set this settings via Preferences menu. If you prefer PayPal or would like to check the application before you buy it, it is still available via product page: http://mutemymic.com Version 1.3:
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| Board Games That Make You Feel Like A Kid Again Posted: 23 Dec 2011 02:50 AM PST If you're playing a game these days, you likely need a battery charger, a wi-fi connection and some expensive technological device. |
| Posted: 23 Dec 2011 12:00 AM PST The establishment of more efficient approaches for developmental neurotoxicity testing (DNT) has been an emerging issue for children's environmental health. Here we describe a systematic approach for DNT using the neuronal differentiation of mouse embryonic stem cells (mESCs) as a model of fetal programming. During embryoid body (EB) formation, mESCs were exposed to 12 chemicals for 24 h and then global gene expression profiling was performed using whole genome microarray analysis. Gene expression signatures for seven kinds of gene sets related to neuronal development and neuronal diseases were selected for further analysis. At the later stages of neuronal cell differentiation from EBs, neuronal phenotypic parameters were determined using a high-content image analyzer. Bayesian network analysis was then performed based on global gene expression and neuronal phenotypic data to generate comprehensive networks with a linkage between early events and later effects. Furthermore, the probability distribution values for the strength of the linkage between parameters in each network was calculated and then used in principal component analysis. The characterization of chemicals according to their neurotoxic potential reveals that the multi-parametric analysis based on phenotype and gene expression profiling during neuronal differentiation of mESCs can provide a useful tool to monitor fetal programming and to predict developmentally neurotoxic compounds. |
| Sensors, Vol. 12, Pages 162-174: Tongue Tumor Detection in Medical Hyperspectral Images Posted: 23 Dec 2011 12:00 AM PST A hyperspectral imaging system to measure and analyze the reflectance spectra of the human tongue with high spatial resolution is proposed for tongue tumor detection. To achieve fast and accurate performance for detecting tongue tumors, reflectance data were collected using spectral acousto-optic tunable filters and a spectral adapter, and sparse representation was used for the data analysis algorithm. Based on the tumor image database, a recognition rate of 96.5% was achieved. The experimental results show that hyperspectral imaging for tongue tumor diagnosis, together with the spectroscopic classification method provide a new approach for the noninvasive computer-aided diagnosis of tongue tumors. |
| Posted: 23 Dec 2011 12:00 AM PST Hardness homogeneity of the commonly used structural ferrous and nonferrous engineering materials is of vital importance in the design stage, therefore, reliable information regarding material properties homogeneity should be validated and any deviation should be addressed. In the current study the hardness variation, over wide spectrum radial locations of some ferrous and nonferrous structural engineering materials, was investigated. Measurements were performed over both faces (cross-section) of each stock bar according to a pre-specified stratified design, ensuring the coverage of the entire area both in radial and circumferential directions. Additionally the credibility of the apparatus and measuring procedures were examined through a statistically based calibration process of the hardness reference block. Statistical and response surface graphical analysis are used to examine the nature, adequacy and significance of the measured hardness values. Calibration of the apparatus reference block proved the reliability of the measuring system, where no strong evidence was found against the stochastic nature of hardness measures over the various stratified locations. Also, outlier elimination procedures were proved to be beneficial only at fewer measured points. Hardness measurements showed a dispersion domain that is within the acceptable confidence interval. For AISI 4140 and AISI 1020 steels, hardness is found to have a slight decrease trend as the diameter is reduced, while an opposite behavior is observed for AA 6082 aluminum alloy. However, no definite significant behavior was noticed regarding the effect of the sector sequence (circumferential direction). |
| Posted: 23 Dec 2011 12:00 AM PST The electronic transport behaviors of (Ni0.39Nb0.25Zr0.35)100−xHx (0 ≤ x < 23.5) glassy alloys with subnanostructural icosahedral Zr5Nb5Ni3 clusters have been studied as a function of hydrogen content. These alloys show semiconducting, electric current-induced voltage (Coulomb) oscillation and ballistic transport behaviors. Coulomb oscillation and ballistic transport occur at hydrogen contents between 6.7 and 13.5 at% and between 13.5 and 21.2 at%, respectively. These results suggest that the localization effect of hydrogen in the clusters plays an important role in various electron transport phenomena. |
| IJMS, Vol. 13, Pages 173-179: Significance of Dietary Antioxidants for Health Posted: 23 Dec 2011 12:00 AM PST Since evidence became available that free radicals were involved in mechanisms for the development of major diseases, including cardiovascular disease and cancer, there has been considerable research into the properties of natural dietary antioxidants. However, it has become clear that dietary antioxidants can only have beneficial effects in vivo by radical scavenging or effects on redox potential if they are present in tissues or bodily fluids at sufficient concentrations. For many dietary components, absorption is limited or metabolism into derivatives reduces the antioxidant capacity. For many dietary phytochemicals, direct antioxidant effects may be less important for health than other effects including effects on cell signalling or gene expression in vivo. |
| Posted: 22 Dec 2011 06:19 PM PST [Platform: Flash] Farmer Vlad has built a paradise for piggies. He sends a letter to the closest litter, inviting them to vacation in his literal hog heaven. Unfortunately, all sorts of danger lies in their path: bears, wolves, birds, UFOs... A reflex platformer by VladG, 300 Miles to Pigsland takes the non-stop gameplay of Canabalt, sends it through the cute-ifier machine and adds a sprinkling of upgrades, making for a fun, if repetitive, time. |
| Posted: 23 Dec 2011 12:00 AM PST Solar ultraviolet (UV) radiation is an important environmental factor that leads to immune suppression, inflammation, photoaging, and skin carcinogenesis. Here, we reviewed the specific signal transduction pathways and transcription factors involved in the cellular response to UV-irradiation. Increasing experimental data supporting a role for p38, MAPK, JNK, ERK1/2, and ATM kinases in the response network to UV exposure is discussed. We also reviewed the participation of NF-κB, AP-1, and NRF2 transcription factors in the control of gene expression after UV-irradiation. In addition, we discussed the promising chemotherapeutic intervention of transcription factors signaling by natural compounds. Finally, we focused on the review of data emerging from the use of DNA microarray technology to determine changes in global gene expression in keratinocytes and melanocytes in response to UV treatment. Efforts to obtain a comprehensive portrait of the transcriptional events regulating photodamage of intact human epidermis after UV exposure reveals the existence of novel factors participating in UV-induced cell death. Progress in understanding the multitude of mechanisms induced by UV-irradiation could lead to the potential use of protein kinases and novel proteins as specific targets for the prevention and control of skin cancer. |
| Posted: 23 Dec 2011 12:00 AM PST Byrsonima crassa Niedenzu (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In a previous study, our group described the gastric protective effect of the methanolic extract from the leaves of B. crassa. The present study was carried out to investigate the effects of methanolic extract and its phenolic compounds on the respiratory burst of neutrophils stimulated by H. pylori using a luminol-based chemiluminescence assay as well as their anti-H. pylori activity. The suppressive activity on oxidative burst of H. pylori-stimulated neutrophils was in the order of methyl gallate > (+)-catechin > methanol extract > quercetin 3-O-α-l-arabinopyranoside > quercetin 3-O-β-d-galactopyranoside > amentoflavone. Methyl gallate, compound that induced the highest suppressive activity with IC50 value of 3.4 µg/mL, did not show anti-H. pylori activity. B. crassa could be considered as a potential source of natural antioxidant in gastric ulcers by attenuating the effects on the damage to gastric mucosa caused by neutrophil generated reactive oxygen species, even when H. pylori displays its evasion mechanisms. |
| Posted: 23 Dec 2011 12:00 AM PST Fusarium verticillioides and Fusarium subglutinans are important fungal pathogens of maize and other cereals worldwide. In this study, we developed PCR-based protocols for the identification of these pathogens targeting the gaoB gene, which codes for galactose oxidase. The designed primers recognized isolates of F. verticillioides and F. subglutinans that were obtained from maize seeds from several producing regions of Brazil but did not recognize other Fusarium spp. or other fungal genera that were either obtained from fungal collections or isolated from maize seeds. A multiplex PCR protocol was established to simultaneously detect the genomic DNA from F. verticillioides and F. subglutinans. This protocol could detect the DNA from these fungi growing in artificially or naturally infected maize seeds. Another multiplex reaction with a pair of primers developed in this work combined with a pre-existing pair of primers has allowed identifying F. subglutinans, F. konzum, and F. thapsinum. In addition, the identification of F. nygamai was also possible using a combination of two PCR reactions described in this work, and another described in the literature. |
| Posted: 23 Dec 2011 12:00 AM PST The advent of next generation sequencing revealed that a fraction of transcribed RNAs (short and long RNAs) is non-coding. Long non-coding RNAs (lncRNAs) have a crucial role in regulating gene expression and in epigenetics (chromatin and histones remodeling). LncRNAs may have different roles: gene activators (signaling), repressors (decoy), cis and trans gene expression regulators (guides) and chromatin modificators (scaffolds) without the need to be mutually exclusive. LncRNAs are also implicated in a number of diseases. The huge amount of inhomogeneous data produced so far poses several bioinformatics challenges spanning from the simple annotation to the more complex functional annotation. In this review, we report and discuss several bioinformatics resources freely available and dealing with the study of lncRNAs. To our knowledge, this is the first review summarizing all the available bioinformatics resources on lncRNAs appeared in the literature after the completion of the human genome project. Therefore, the aim of this review is to provide a little guide for biologists and bioinformaticians looking for dedicated resources, public repositories and other tools for lncRNAs functional analysis. |
| Posted: 23 Dec 2011 12:00 AM PST Globally, there are concerns over the risks associated with radiation exposure, so it is important to understand the biological effects of radiation exposure. Driven by the need to detect the presence of radiation exposure, biomarkers to monitor potential exposure after radiological accidents can be developed and would be extremely valuable for biological response. In this study, the behavior of spermidine as a biomarker was investigated in a C57BL/6 mouse model exposed to an acute whole-body sublethal dose of 6 Gy. The spermidine content values in serum increased for up to two days after 6 Gy irradiation. However, the enhanced spermidine content observed on day +3 in irradiated mice returned to normal levels on the subsequent five days. The result indicates that spermidine can be used as a biomarker of biological response to radiation exposure. |
| Molecules, Vol. 17, Pages 98-144: Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics Posted: 23 Dec 2011 12:00 AM PST The purpose of this review is to compile preclinical and clinical results on phthalocyanines (Pcs) as photosensitizers (PS) for Photodynamic Therapy (PDT) and contrast agents for fluorescence imaging. Indeed, Pcs are excellent candidates in these fields due to their strong absorbance in the NIR region and high chemical and photo-stability. In particular, this is mostly relevant for their in vivo activation in deeper tissular regions. However, most Pcs present two major limitations, i.e., a strong tendency to aggregate and a low water-solubility. In order to overcome these issues, both chemical tuning and pharmaceutical formulation combined with tumor targeting strategies were applied. These aspects will be developed in this review for the most extensively studied Pcs during the last 25 years, i.e., aluminium-, zinc- and silicon-based Pcs. |
| X-Plane 10.03b5 - Ultra-realistic flight simulator.. (Updater) Posted: 22 Dec 2011 08:59 PM PST  X-Plane is the world's most comprehensive, powerful flight simulator, and has the most realistic flight model available for personal computers. Welcome to the world of props, jets, single- and multi-engine airplanes, as well as gliders, helicopters and VTOLs such as the V-22 Osprey and AV8-B Harrier. X-Plane comes with subsonic and supersonic flight dynamics, sporting aircraft from the Bell 206 Jet-Ranger helicopter and Cessna 172 light plane to the supersonic SR-71 and Space Shuttle. X-Plane comes with 35 aircraft spanning the aviation industry (and history), and several thousand more are freely downloadable from the internet. (See www.X-Plane.org as a good place to start). X-Plane scenery is world-wide, with scenery for the entire planet Earth between 74 degrees north to 60 degrees south latitude. We also have MARS scenery! (thanks to the Mars Orbiting Laser Altimeter, which mapped that planet's elevation). On Earth, you can land at any of over 33,000 airports, as well as test your mettle on aircraft carriers, helipads on building tops, frigates that pitch and roll in the waves, and oil rigs. Weather is variable from clear skies and high visibility to thunderstorms with controllable wind, wind shear, turbulence, and microbursts! Rain, snow and clouds are available for an instrument flying challenge, and thermals are available for the gliders! Real weather conditions can be downloaded from the internet, allowing you to fly in the actual weather that currently exists at the location of flight! X-Plane also has detailed failure-modeling, with multitudes of systems that can be failed manually or randomly, when you least expect it! You can fail instruments, engines, flight controls, landing gear, or dozens of other systems at any moment. While X-Plane is the world's most COMPREHENSIVE flight sim, your purchase also comes with Plane-Maker (to create your own airplanes) Airfoil-Maker (allowing users to create airfoil performance profiles), and Weather Briefer (to get a weather briefing before the flight if you use real weather conditions downloaded from the internet). X-Plane is also extremely customizable, allowing you to easily create textures, sounds, and instrument panels for your own airplanes that you design or the planes that come with the sim. X-Plane's accuracy (in flight model), scope (in aircraft and terrain coverage), versatility (in aircraft type and weather conditions), add-on programs (in aircraft and scenery editors), customizability, downloadable aircraft, and downloadable scenery makes it the ULTIMATE flight simulation experience for Macintosh, Windows, and Linux platforms. BE SURE TO TURN ON THE >BETA< option in the installer before you run it to get the beta! The demo contains a limited scenery area to keep the download size reasonable. It will run for 10 minutes before it begins to ignore the user's input, at which point the simulator must be restarted to fly more. Version 10.03b5: Rendering:
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| OnyX 2.4.3b2 - Mac OS X maintenance and optimisation tool (beta available).. (Free) Posted: 22 Dec 2011 08:59 PM PST  OnyX is a multifunctional utility for Mac OS X. It allows you to verify the Startup Disk and the structure of its System files, to run miscellaneous tasks of system maintenance, to configure the hidden parameters of the Finder, Dock and of some of Apple's own applications, to delete caches, to remove a certain number of files and folders that may become cumbersome and more. Version 2.4.3b2:
Mac OS X 10.7 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Artlantis Studio 4.0.15.1 - 3D rendering of interior and exterior homes and buildings.. (Demo) Posted: 22 Dec 2011 08:59 PM PST  Artlantis Studio is a unique and ideal tool for performing very high resolution rendering easily and in real time. The new FastRadiosity engine now lets you compute images in radiosity-even in preview. Another innovative feature of Artlantis is that 3D objects and vegetation can be used directly in the preview window by simply dragging and dropping them. This enables users to work on different scenarios quickly and to simulate true virtual scenes in a real environment. Version 4.0.15.1: Release notes were unavailable when this listing was updated.
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| Posted: 22 Dec 2011 08:59 PM PST  Save $10 with this exclusive MacUpdate discount! Parallels Desktop is simply the world's bestselling, top-rated, and most trusted solution for running Windows applications on your Mac. With Parallels Desktop for Mac, you can seamlessly run both Windows and Mac OS X applications side-by-side without rebooting. Drag-and-drop files between Windows and Mac applications, launch Windows applications from your Mac dock, and do much more with speed, control and confidence. Seamless Simplicity Use Run Windows programs like they were native to your Mac. Setting up Parallels Desktop for Mac is simple and quick. Enjoy the best of both worlds - Windows and Mac OS X - on one seamless desktop. Performance and Personalization Experience as much or as little Windows as you want. Multiple view modes make it possible for you to customize the level of integration between Mac and Windows without compromising performance. Version 7.0.15052.710728:
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| Yasu 2.7.6 - System maintenance app performs many tasks.. (Shareware) Posted: 22 Dec 2011 08:59 PM PST  Yasu was originally created with System Administrators who service large groups of workstations in mind, Yasu (Yet Another System Utility) was made to do a specific group of maintenance tasks quickly within a few clicks, rather than needing to endlessly type shell script commands in the Terminal application. Yasu allows system administrators, as well as the average user, to conveniently run various system level Unix shell scripts in order to perform maintenance routines and clear the many cache files used by OS X. Yasu was designed to be a simple, first line of attack for a workstation that has started "acting up." More often than not, a thorough purge of the cache files of a Mac will bring its behavior back into line. Version 2.7.6:
Mac OS X 10.4 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
| aTV Flash (black) 1.1.1 - Supercharge your 2nd generation Apple TV. (Commercial) Posted: 22 Dec 2011 08:59 PM PST  We are also offering aTV Flash 4.4 for the first generation Apple TV for 15% off! Installing aTV Flash (black) requires that you first jailbreak your 2nd Gen. Apple TV which can be done easily, and for free with Seas0nPass. Learn more about jailbreaking your Apple TV and installing aTV Flash (black) here. aTV Flash (black) supercharges your 2nd generation Apple TV, empowering it to do things you never thought possible! All new features are installed alongside the normal Apple TV features, so things like movie rentals, Netflix, and AirPlay will remain unchanged. Featured in aTV Flash (black) are tons of exciting new features, including an all-new Media Player, WebKit based browser, Last.fm radio, Weather, RSS feeds and more! Expanded media support with all the extras The new Media Player included in aTV Flash (black) empowers you to go beyond iTunes and play most popular media formats. This includes formats such as: AVI, FLAC, ISO, M2TS, MKV, MP3, MP4, MPEG, MPG, VOB, WMV and many others. Form and function remain in perfect balance, and you can enjoy all your media through natively styled menus that include simple access to extras such as AC3/DTS sound, subtitles, DVD menus, playlists, and many others. Automatic metadata and cover art Cover art and metadata are downloaded automatically and added to your files with an end result of amazing! If you've already taken the time to add your own metadata you can you can use that too. Native web browser Surf the web with a native web browser that provides a rich web experience on the Apple TV. Included is support for things like HTML5 music and video streaming as well as easy to use bookmarks and history. Navigating the web is easily done with the included Apple TV remote or the free Remote app for the iPhone and iPad. More than just music Go beyond just listening to music and start truly experiencing it by utilizing the full power of Last.fm. While streaming Last.fm radio (or playing your own music) you'll have access to artist bios, and a seemingly endless amount of artist photos. Weather and RSS feeds Get quick access to weather and RSS news feeds. Your current weather location will be detected automatically, and other locations can be easily added as well.
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