Games |
- jalada Chain Reaction 1.3.4 - Remake of popular chain arcade puzzle game.. (Shareware)
- jalada Ultimate Racing 1.7.0 - Prepare for a racing experience immersive and real.. (Demo)
- Water, Vol. 3, Pages 1149-1173: The 2011 Brisbane Floods: Causes, Impacts and Implications
- Pharmaceutics, Vol. 3, Pages 932-953: Ionic Channels as Targets for Drug Design: A Review on Computational Methods
- Sensors, Vol. 11, Pages 11544-11559: Heterogeneous Collaborative Sensor Network for Electrical Management of an Automated House with PV Energy
- Bots flood Twitter with noise to drown out anti-Kremlin tweets
- Sensors, Vol. 11, Pages 11516-11543: An Integrated Testbed for Cooperative Perception with Heterogeneous Mobile and Static Sensors
- Molecules, Vol. 16, Pages 10269-10291: Preparation, Spectrochemical, and Computational Analysis of L-Carnosine (2-[(3-Aminopropanoyl)amino]-3-(1H-imidazol-5-yl)propanoic Acid) and Its Ruthenium (II) Coordination Complexes in Aqueous Solution
- Catalysts, Vol. 1, Pages 175-190: Pre-Reduction of Au/Iron Oxide Catalyst for Low-Temperature Water-Gas Shift Reaction Below 150 °C
- Catalysts, Vol. 1, Pages 155-174: Nano-Scale Au Supported on Carbon Materials for the Low Temperature Water Gas Shift (WGS) Reaction
- IJMS, Vol. 12, Pages 9226-9235: The Effect of the Acetone Extract of Arctotis arctotoides (Asteraceae) on the Growth and Ultrastructure of Some Opportunistic Fungi Associated with HIV/AIDS
- Gather the Gems - Screenshots
- Action Puzzle - Screenshots
- Red Stone - Screenshots
- MacGuffin's Curse - Screenshots
- IJMS, Vol. 12, Pages 9216-9225: Hormonal Influence on Coenzyme Q10 Levels in Blood Plasma
- Aussie emulation mashup Dec 9
- GameSpot Plays Chrono Trigger
- Crosshairs-- Game Swinging, Kingdoms of Amalur, WWE '12
- IJMS, Vol. 12, Pages 9203-9215: Differential Motor Neuron Impairment and Axonal Regeneration in Sporadic and Familiar Amyotrophic Lateral Sclerosis with SOD-1 Mutations: Lessons from Neurophysiology
| jalada Chain Reaction 1.3.4 - Remake of popular chain arcade puzzle game.. (Shareware) Posted: 09 Dec 2011 03:09 AM PST  jalada Chain Reaction is an entertaining remake of a popular chain arcade puzzle game. Everything is made to envelop you in a relaxing, but also mind challenging universe. Be prepared to enter the exciting world of Chain Reaction and let yourself be mesmerized by this unique arcade puzzle game. Collect the color bubbles on the field by combining them into chains to enter the next level, and create the longest chain ever to get the highest score. Besides a subtle strategy, various rewards will help you to solve a level in a faster way. The mixture of easy control, quick to learn plus 100 unique levels makes jalada Chain Reaction a nearly never ending game experience for the whole family.
Download Now This posting includes an audio/video/photo media file: Download Now |
| jalada Ultimate Racing 1.7.0 - Prepare for a racing experience immersive and real.. (Demo) Posted: 09 Dec 2011 03:05 AM PST  jalada Ultimate Racing takes you to a racing experience so immersive and real that it just might make players better or at least much faster drivers in real life. The adrenaline rush of driving at ultimate speeds, the pressure of fierce competition, the fear of losing control and the intense concentration needed to harness the power of speeding chrome and steel. In jalada Ultimate Racing, players enter a world of high-definition, high-speed races and take control of the wheel in a variety of racing modes. Take your Mac for a real test drive with a racing game that shows you what a Mac can really do! jalada Ultimate Racing brings you more speed, excitement and gameplay variety than ever before in the world of high-definition, high-speed races. With graphics optimized for modern graphic cards, jalada Ultimate Racing features more than 40 amazing fine tuned cars, more than 30 exciting tracks, 50 opponents to race against, and with jalada Ultimate Racing you can choose between different types of races from simple practice sessions up to complete championships. Through the combination of accurate, accessible physics-based model, cockpit view, damage model, lighting, smoke, skid marks, aerodynamics and glowing brake disks you'll be thrust into the driver's seat. Start your engine and immerse yourself with "jalada Ultimate Racing" into a new great driving experience.
Download Now This posting includes an audio/video/photo media file: Download Now |
| Water, Vol. 3, Pages 1149-1173: The 2011 Brisbane Floods: Causes, Impacts and Implications Posted: 09 Dec 2011 12:00 AM PST On 13th January 2011 major flooding occurred throughout most of the Brisbane River catchment, most severely in Toowoomba and the Lockyer Creek catchment (where 23 people drowned), the Bremer River catchment and in Brisbane, the state capital of Queensland. Some 56,200 claims have been received by insurers with payouts totalling $2.55 billion. This paper backgrounds weather and climatic factors implicated in the flooding and the historical flood experience of Brisbane. We examine the time history of water releases from the Wivenhoe dam, which have been accused of aggravating damage downstream. The dam was built in response to even worse flooding in 1974 and now serves as Brisbane's main water supply. In our analysis, the dam operators made sub-optimal decisions by neglecting forecasts of further rainfall and assuming a 'no rainfall' scenario. Questions have also been raised about the availability of insurance cover for riverine flood, and the Queensland government's decision not to insure its infrastructure. These and other questions have led to Federal and State government inquiries. We argue that insurance is a form of risk transfer for the residual risk following risk management efforts and cannot in itself be a solution for poor land-use planning. With this in mind, we discuss the need for risk-related insurance premiums to encourage flood risk mitigating behaviours by all actors, and for transparency in the availability of flood maps. Examples of good flood risk management to arise from this flood are described. |
| Posted: 09 Dec 2011 12:00 AM PST Ion channels are involved in a broad range of physiological and pathological processes. The implications of ion channels in a variety of diseases, including diabetes, epilepsy, hypertension, cancer and even chronic pain, have signaled them as pivotal drug targets. Thus far, drugs targeting ion channels were developed without detailed knowledge of the molecular interactions between the lead compounds and the target channels. In recent years, however, the emergence of high-resolution structures for a plethora of ion channels paves the way for computer-assisted drug design. Currently, available functional and structural data provide an attractive platform to generate models that combine substrate-based and protein-based approaches. In silico approaches include homology modeling, quantitative structure-activity relationships, virtual ligand screening, similarity and pharmacophore searching, data mining, and data analysis tools. These strategies have been frequently used in the discovery and optimization of novel molecules with enhanced affinity and specificity for the selected therapeutic targets. In this review we summarize recent applications of in silico methods that are being used for the development of ion channel drugs. |
| Posted: 09 Dec 2011 12:00 AM PST In this paper we present a heterogeneous collaborative sensor network for electrical management in the residential sector. Improving demand-side management is very important in distributed energy generation applications. Sensing and control are the foundations of the "Smart Grid" which is the future of large-scale energy management. The system presented in this paper has been developed on a self-sufficient solar house called "MagicBox" equipped with grid connection, PV generation, lead-acid batteries, controllable appliances and smart metering. Therefore, there is a large number of energy variables to be monitored that allow us to precisely manage the energy performance of the house by means of collaborative sensors. The experimental results, performed on a real house, demonstrate the feasibility of the proposed collaborative system to reduce the consumption of electrical power and to increase energy efficiency. |
| Bots flood Twitter with noise to drown out anti-Kremlin tweets Posted: 09 Dec 2011 02:31 AM PST Russia's contested election have roused the ire of the Russian people, who have risked brutal crackdowns to take to the streets and protest irregularities like ballot-stuffing, which returned Putin to power. Some of that anger is being vented on the Web. Russia's power-brokers may be thugs, but they aren't technologically naive or unsophisticated. A network of Twitterbots have taken to Twitter to flood the service with junk messages that pollute anti-Kremlin hashtags. Meanwhile, someone (perhaps Russian President Dmitry Medvedev) used Medvedev's official Twitter account to tweet, "It has become clear that if a person writes the expression 'party of swindlers and thieves' in their blog then they are a stupid sheep getting f****d in the mouth :)." The smiley face is a nice touch.
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| Posted: 09 Dec 2011 12:00 AM PST Cooperation among devices with different sensing, computing and communication capabilities provides interesting possibilities in a growing number of problems and applications including domotics (domestic robotics), environmental monitoring or intelligent cities, among others. Despite the increasing interest in academic and industrial communities, experimental tools for evaluation and comparison of cooperative algorithms for such heterogeneous technologies are still very scarce. This paper presents a remote testbed with mobile robots and Wireless Sensor Networks (WSN) equipped with a set of low-cost off-the-shelf sensors, commonly used in cooperative perception research and applications, that present high degree of heterogeneity in their technology, sensed magnitudes, features, output bandwidth, interfaces and power consumption, among others. Its open and modular architecture allows tight integration and interoperability between mobile robots and WSN through a bidirectional protocol that enables full interaction. Moreover, the integration of standard tools and interfaces increases usability, allowing an easy extension to new hardware and software components and the reuse of code. Different levels of decentralization are considered, supporting from totally distributed to centralized approaches. Developed for the EU-funded Cooperating Objects Network of Excellence (CONET) and currently available at the School of Engineering of Seville (Spain), the testbed provides full remote control through the Internet. Numerous experiments have been performed, some of which are described in the paper. |
| Posted: 09 Dec 2011 12:00 AM PST This study reports the synthesis and characterization of novel ruthenium (II) complexes with the polydentate dipeptide, L-carnosine (2-[(3-aminopropanoyl)amino]-3-(1H-imidazol-5-yl)propanoic acid). Mixed-ligand complexes with the general composition [MLp(Cl)q(H2O)r]·xH2O (M = Ru(II); L = L-carnosine; p = 3 − q; r = 0–1; and x = 1–3) were prepared by refluxing aqueous solutions of the ligand with equimolar amounts of ruthenium chloride (black-alpha form) at 60 °C for 36 h. Physical properties of the complexes were characterized by elemental analysis, DSC/TGA, and cyclic voltammetry. The molecular structures of the complexes were elucidated using UV-Vis, ATR-IR, and heteronuclear NMR spectroscopy, then confirmed by density function theory (DFT) calculations at the B3LYP/LANL2DZ level. Two-dimensional NMR experiments (1H COSY, 13C gHMBC, and 15N gHMBC) were also conducted for the assignment of chemical shifts and calculation of relative coordination-induced shifts (RCIS) by the complex formed. According to our results, the most probable coordination geometries of ruthenium in these compounds involve nitrogen (N1) from the imidazole ring and an oxygen atom from the carboxylic acid group of the ligand as donor atoms. Additional thermogravimetric and electrochemical data suggest that while the tetrahedral-monomer or octahedral-dimer are both possible structures of the formed complexes, the metal in either structure occurs in the (2+) oxidation state. Resulting RCIS values indicate that the amide-carbonyl, and the amino-terminus of the dipeptide are not involved in chelation and these observations correlate well with theoretical shift predictions by DFT. |
| Posted: 09 Dec 2011 12:00 AM PST Low-temperature water-gas shift reaction (WGS) using gold catalyst is expected to be an attractive technique to realize an efficient on-site hydrogen production process. In this paper, Au/Fe3O4 catalysts for promoting the WGS below 150 °C were developed by a preliminary reduction of Au/iron oxide (Fe3+) catalyst utilizing high reactivity of Au nano-particles. The reduction was conducted under a CO, H2, or CO/H2O stream at either 140 or 200 °C, and the effect of reduction conditions on the characteristics of the Au/Fe3O4 catalyst and on the catalytic activity in WGS at 80 °C was investigated. The reaction progress during the pre-reduction treatment was qualitatively analyzed, and it was found that the iron oxide in Au/Fe2O3 calcined at 200 °C was easily reduced to Fe3O4 phase in all reduction conditions. The reduction conditions affected the characteristics of both Au and iron oxide, but all of the reduced catalysts had small Fe3O4 particles of less than 20 nm with Au particles on the surface. The surface area and content of cationic Au were high in the order of CO, H2, CO/H2O, and 140, 200 °C. In the WGS test at 80 °C using the developed catalysts, the activities of the catalysts pre-reduced by CO at 140 or 200 °C and by H2 at 140 °C were very high with 100% CO conversion even at such a low temperature. These results indicated that factors such as higher surface area, crystallized Fe3O4, and cationic Au content contributed to the catalytic activity. |
| Posted: 09 Dec 2011 12:00 AM PST Au-based catalysts supported on carbon materials with different structures such as graphite (G) and fishbone type carbon nanofibers (CNF-F) were prepared using two different methods (impregnation and gold-sol) to be tested in the water gas shift (WGS) reaction. Atomic absorption spectrometry, transmission electron microscopy (TEM), temperature-programmed oxidation (TPO), X-ray diffraction (XRD), Raman spectroscopy, elemental analyses (CNH), N2 adsorption-desorption analysis, temperature-programmed reduction (TPR) and temperature-programmed decomposition were employed to characterize both the supports and catalysts. Both the crystalline nature of the carbon supports and the method of gold incorporation had a strong influence on the way in which Au particles were deposited on the carbon surface. The higher crystallinity and the smaller and well dispersed Au particle size were, the higher activity of the catalysts in the WGS reaction was noted. Finally, catalytic activity showed an important dependence on the reaction temperature and steam-to-CO molar ratio. |
| Posted: 09 Dec 2011 12:00 AM PST In this study, the effect of the acetone extract of Arctotis arctotoides (L.f.) O. Hoffm. (Asteraceae) on the growth and ultrastructure of some opportunistic fungi associated with HIV/AIDS was analyzed by means of scanning electron microscope (SEM). Remarkable morphological alterations in the fungal mycelia which were attributed to the loss of cell wall strength ranged from loss of turgidity and uniformity, collapse of entire hyphae to evident destruction of the hyphae. The elements responsible for giving the fungi their characteristic virulence were detected and quantified by energy dispersive X-ray microanalysis techniques. X-ray microanalysis showed the specific spectra of sodium, potassium and sulfur as the principal intersection of the four pathogenic fungi studied. Since these ions have the potential of fostering fungal invasion by altering the permeability of hosts' membranes, their presence was considered inherent to the pathogenicity of the opportunistic fungi. Hence, these findings indicate the potential of the crude extract of A. arctotoides in preventing fungal invasion and subsequent infection of host's membranes. |
| Posted: 09 Dec 2011 01:34 AM PST The gameplay is simple: shoot the golden ball to collect all gems. All you need is dexterity and luck! Players will be charmed by the natural look of the game and the carefully selected music scores. "Gather the Gems!" is a game that people of both sex can love! But enough said: let the screenshots and the game trailer speak for themselves! Features: - A new type ball game - 60 levels in various sizes and complexity - Easy to learn, hard to master - Very simple control - Carefully selected music scores - Detailed, full 3d graphics - Fast app switching - Pick up and Play |
| Posted: 09 Dec 2011 01:39 AM PST Action Puzzle has 3 epic modes of play: Classic, Squares and Challenge, and features a built-in audio player supporting multitasking, enabling players to listen to metal tracks as the game runs in the background. The game also supports the headset's remote control functions. Additionally, Action Puzzle has a built-in video player making it possible to watch any and all video-clips at convenience, and with intuitive controls, a slick interface, not to mention stunning visuals; this game has plenty to offer. And last but not least, Action Puzzle has 8 unique puzzle shapes, 5 levels of difficulty, and an astonishing 24 awesome and stunning wallpapers to collect (with codes gathered online). |
| Posted: 09 Dec 2011 01:48 AM PST K2 NETWORK RELEASES NEW DETAILS FOR UPCOMING FANTASY MMORPG RED STONE UNIQUE QUEST AND TRANSFORMATION SYSTEMS SET THE EPIC MMORPG APART IRVINE, Calif. September 10, 2007-- K2 Network, Inc. (www.k2network.net), an online game publisher, in partnership with Samsung Electronics Co., Ltd. and developer L & K Logic Korea Co. Ltd., is pleased to announce more in-depth details about its 2D Fantasy MMORPG, Red Stone. One of the many innovative and unique components within the soon-to-be-released Red Stone is its unique quest system, branching out over three distinct types of quests; Main, Title, and General. Main Quest The Main Quest starts when you begin the game and continues as you advance through the game on your search for fragments of the Red Stone. The Red Stone Main Quest line guides you on an adventure across the continent of Prandel, following rumors and cryptic hints about the location of this mysterious object, which is said to grant power and wealth to whoever possesses it. Title Quests Various NPCs in the game will send the player on Title Quests, and upon quest completion, will bestow certain Titles on the player. Titles come with benefits – for example, one could earn the title of Banker, which enabling bank access, or Master Monster Distinguisher (say that three times fast!), which allows you to see the types and levels of monsters your are fighting. The Red Stone Title Quests will teach your character useful abilities and beneficial skills. General Quests Consisting of standard NPCs asking for basic assistance, General Quests encourage you to explore the world of Prandel and gain experience completing tasks. Completing the Red Stone General Quests will not only provide your character with rewards such as items, experience and gold, but ... |
| MacGuffin's Curse - Screenshots Posted: 09 Dec 2011 01:28 AM PST Features: - Switch between wolf and human forms, each with unique skills! - Sneak and smash your way through a high-tech city in lockdown! - Hilarious conversations with a huge cast of characters, with nearly 100 sidequests in the tradition of classic PC adventure games! - Cohesive, fully integrated hint and task tracking system! - A huge character-driven story that will have you hooked! |
| IJMS, Vol. 12, Pages 9216-9225: Hormonal Influence on Coenzyme Q10 Levels in Blood Plasma Posted: 09 Dec 2011 12:00 AM PST Coenzyme Q10 (CoQ10), also known as ubiquinone for its presence in all body cells, is an essential part of the cell energy-producing system. However, it is also a powerful lipophilic antioxidant protecting lipoproteins and cell membranes. Due to these two actions, CoQ10 is commonly used in clinical practice in chronic heart failure, male infertility, and neurodegenerative disease. However, it is also taken as an anti-aging substance by healthy people aiming for long-term neuroprotection and by sportsmen to improve endurance. Many hormones are known to be involved in body energy regulation, in terms of production, consumption and dissipation, and their influence on CoQ10 body content or blood values may represent an important pathophysiological mechanism. We summarize the main findings of the literature about the link between hormonal systems and circulating CoQ10 levels. In particular the role of thyroid hormones, directly involved in the regulation of energy homeostasis, is discussed. There is also a link with gonadal and adrenal hormones, partially due to the common biosynthetic pathway with CoQ10, but also to the increased oxidative stress found in hypogonadism and hypoadrenalism. |
| Posted: 08 Dec 2011 10:11 PM PST The Mortal Kombat Arcade Kollection finds its way onto the PlayStation Network Store.
Get the full article at GameSpot "Aussie emulation mashup Dec 9" was posted by James Kozanecki on Thu, 08 Dec 2011 22:11:29 -0800 |
| Posted: 08 Dec 2011 10:10 PM PST Randolph Ramsay takes Chrono Trigger on iOS for a quick spin to take a look at all the interface changes this classic JRPG has received. Read and Post Comments | Get the full article at GameSpot "GameSpot Plays Chrono Trigger" was posted by edmondt on Thu, 08 Dec 2011 22:10:53 -0800 |
| Crosshairs-- Game Swinging, Kingdoms of Amalur, WWE '12 Posted: 08 Dec 2011 09:18 PM PST This week on Crosshairs we see what retailer GAME's "Game Swinging" event is all about, sit down with the devs behind Kingdoms of Amalur: Reckoning and chat to you, the community at our WWE '12 launch event at The Mana Bar in Melbourne! Read and Post Comments | Get the full article at GameSpot "Crosshairs-- Game Swinging, Kingdoms of Amalur, WWE '12" was posted by edmondt on Thu, 08 Dec 2011 21:18:44 -0800 |
| Posted: 09 Dec 2011 12:00 AM PST Amyotrophic Lateral Sclerosis (ALS) is a degenerative disorder of the motor system. About 10% of cases are familial and 20% of these families have point mutations in the Cu/Zn superoxide dismutase 1 (SOD-1) gene. SOD-1 catalyses the superoxide radical (O−2) into hydrogen peroxide and molecular oxygen. The clinical neurophysiology in ALS plays a fundamental role in differential diagnosis between the familial and sporadic forms and in the assessment of its severity and progression. Sixty ALS patients (34 males; 26 females) were enrolled in the study and examined basally (T0) and every 4 months (T1, T2, and T3). Fifteen of these patients are SOD-1 symptomatic mutation carriers (nine males, six females). We used Macro-EMG and Motor Unit Number Estimation (MUNE) in order to evaluate the neuronal loss and the re-innervation process at the onset of disease and during follow-up period. Results and Discussion: SOD-1 mutation carriers have a higher number of motor units at the moment of diagnosis when compared with the sporadic form, despite a more dramatic drop in later stages. Moreover, in familiar SOD-1 ALS there is not a specific time interval in which the axonal regeneration can balance the neuronal damage. Taken together, these results strengthen the idea of a different pathogenetic mechanism at the base of sALS and fALS. |
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