Games

Social for Facebook is a collection of social management tools that is ideal for people who use multiple social network accounts. It is the only Mac-native multi social network client, and it saves you time by following statuses on Facebook.

No more jumping from site to site to monitor, update and engage your social services at the speed of real time. No need to open it up in a web browser, or have it clutter your workspace.

With the advanced instant notification and chat features, Social is the most comprehensive solution on the market.

Main Features:

Instant messaging on different client like Facebook Chat and GTalk.
The Social icon at menu bar shows you at-a-glance if you have unread messages, notifications or friend requests.
Preview of incoming chat messages

Version 2.0.0:

Facebook support
Multiple accounts login
Desktop and Mobile View
Notification for new tweets
Sound notification
Ability to disable notification for each services
Resizable windows

Mac OS X 10.6 or later

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Capster 2.0 - Shows when the caps lock is on.. (Commercial)

Posted: 22 Dec 2011 03:29 AM PST

Capster is an easy to use application that will tell you when you pressed the Caps Lock, either on its own or through Growl.

When you press the Caps Lock key, Capster's menu bar icon will change as well. For touch typists this is a great way to keep your focus on the screen.

If you accidentally press the Caps Lock key all the time, Capster is exactly what you need.

Version 2.0:

no longer requires Growl to notify you of changes (but can still use Growl)

Mac OS X 10.6 or later
64-bit processor

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SimpleKeys 2.4.1 - Assign functions to your keyboard F-keys.. (Shareware)

Posted: 22 Dec 2011 03:24 AM PST

SimpleKeys is a complete rewrite of the popular f-key shortcut program. Now in addition to programing your function keys, SimpleKeys allows you to:

Execute an action with any key combination
Now types as fast as the recieving application can accept keystrokes
Create Macros by combining multiple actions under a single KeyStroke
Import and Export Settings
Supports drag and drop of shortcuts to and from the items list. This allows you to email a shortcut to a friend, or save it for later.
Execute AppleScripts on the files selected in the finder or using the text on the clipboard.
Supports all special accented characters.
Type text, including the date, the text on the clipboard, and any KeyCombo (ie. Apple-S to save a file)
Paste text, including the date.
Pause to wait for events to complete.
Launch a file with the default application, or with a specific application.
Open a URL in your default browser. PPC version also available from pidog.com

Version 2.4.1:

Added the option to run without a dock icon.
Fixed some bugs with international keyboards

Mac OS X 10.4 or later

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Christmas is saved! Nintendo releasing 'Mario Monopoly' early (note: it's actually called Boom Street)

Posted: 22 Dec 2011 03:22 AM PST

Thought you were going to have bugger all new Wii games to play this Christmas? Well think again - Nintendo is releasing Boom Street early! It really might be a Merry Christmas!

Battlefield 3 headshot: Amazing or lucky? We can't even see the guy...

Posted: 22 Dec 2011 02:59 AM PST

IJMS, Vol. 13, Pages 71-83: Is Remusatia (Araceae) Monophyletic? Evidence from Three Plastid Regions

Posted: 22 Dec 2011 12:00 AM PST

The genus Remusatia (Araceae) includes four species distributed in the tropical and subtropical Old World. The phylogeny of Remusatia was constructed using parsimony and Bayesian analyses of sequence data from three plastid regions (the rbcL gene, the trnL-trnF intergenic spacer, and the rps16 intron). Phylogenetic analyses of the concatenated plastid data suggested that the monophyly of Remusatia was not supported because R. hookeriana did not form a clade with the other three species R. vivipara, R. yunnanensis, and R. pumila. Nevertheless, the topology of the analysis constraining Remusatia to monophyly was congruent with the topology of the unconstrained analysis. The results confirmed the inclusion of the previously separate genus Gonatanthus within Remusatia and disagreed with the current infrageneric classification of the genus.

IJMS, Vol. 13, Pages 56-70: The Bone-Protective Effect of Genistein in the Animal Model of Bilateral Ovariectomy: Roles of Phytoestrogens and PTH/PTHR1 Against Post-Menopausal Osteoporosis

Posted: 22 Dec 2011 12:00 AM PST

Genistein, a major phytoestrogen of soy, is considered a potential drug for the prevention and treatment of post-menopausal osteoporosis. Mounting evidence suggested a positive correlation between genistein consumption and bone health both in vivo and in vitro. Earlier studies have revealed that genistein acted as a natural estrogen analogue which activated estrogen receptor and exerted anti-osteoporotic effect. However, it remains unclear whether PTH, the most crucial hormone that regulates mineral homeostasis, participates in the process of genistein-mediated bone protection. In the present study, we compared the therapeutic effects between genistein and nilestriol and investigated whether PTH and its specific receptor PTHR1 altered in response to genistein-containing diet in the animal model of ovariectomy. Our results showed that genistein administration significantly improved femoral mechanical properties and alleviates femoral turnover. Genistein at all doses (4.5 mg/kg, 9.0 mg/kg and 18.0 mg/kg per day, respectively) exerted improved bending strength and b-ALP limiting effects than nilestriol in the present study. However, genistein administration did not exert superior effects on bone protection than nilestriol. We also observed circulating PTH restoration in ovariectomized rats receiving genistein at the dose of 18 mg/kg per day. Meanwhile, PTHR1 abnormalities were attenuated in the presence of genistein as confirmed by RT-PCR, Western blot and immunohistochemistry. These findings strongly support the idea that besides serving as an estrogen, genistein could interact with PTH/PTHR1, causing a superior mineral restoring effect than nilestriol on certain circumstance. In conclusion, our study reported for the first time that the anti-osteoporotic effect of genistein is partly PTH/PTHR1-dependent. Genistein might be a potential option in the prevention and treatment of post-menopausal osteoporosis with good tolerance, more clinical benefits and few undesirable side effects.

IJMS, Vol. 13, Pages 44-55: Relation Between the Adsorbed Quantity and the Immersion Enthalpy in Catechol Aqueous Solutions on Activated Carbons

Posted: 22 Dec 2011 12:00 AM PST

An activated carbon, CarbochemTM—PS230, was modified by chemical and thermal treatment in flow of H2, in order to evaluate the influence of the activated carbon chemical characteristics in the adsorption of the catechol. The catechol adsorption in aqueous solution was studied along with the effect of the pH solution in the adsorption process of modified activated carbons and the variation of immersion enthalpy of activated carbons in the aqueous solutions of catechol. The interaction solid-solution is characterized by adsorption isotherms analysis, at 298 K and pH 7, 9 and 11 in order to evaluate the adsorption value above and below that of the catechol pKa. The adsorption capacity of carbons increases when the solution pH decreases. The retained amount increases slightly in the reduced carbon to maximum adsorption pH and diminishes in the oxidized carbon. Similar conclusions are obtained from the immersion enthalpies, whose values increase with the solute quantity retained. In granular activated carbon (CAG), the immersion enthalpies obtained are between 21.5 and 45.7 J·g−1 for catechol aqueous solutions in a range of 20 at 1500 mg·L−1.

IJMS, Vol. 13, Pages 18-43: Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery

Posted: 22 Dec 2011 12:00 AM PST

Recent pharmaceutical research has focused on controlled drug delivery having an advantage over conventional methods. Adequate controlled plasma drug levels, reduced side effects as well as improved patient compliance are some of the benefits that these systems may offer. Controlled delivery systems that can provide zero-order drug delivery have the potential for maximizing efficacy while minimizing dose frequency and toxicity. Thus, zero-order drug release is ideal in a large area of drug delivery which has therefore led to the development of various technologies with such drug release patterns. Systems such as multilayered tablets and other geometrically altered devices have been created to perform this function. One of the principles of multilayered tablets involves creating a constant surface area for release. Polymeric materials play an important role in the functioning of these systems. Technologies developed to date include among others: Geomatrix® multilayered tablets, which utilizes specific polymers that may act as barriers to control drug release; Procise®, which has a core with an aperture that can be modified to achieve various types of drug release; core-in-cup tablets, where the core matrix is coated on one surface while the circumference forms a cup around it; donut-shaped devices, which possess a centrally-placed aperture hole and Dome Matrix® as well as "release modules assemblage", which can offer alternating drug release patterns. This review discusses the novel altered geometric system technologies that have been developed to provide controlled drug release, also focusing on polymers that have been employed in such developments.

IJMS, Vol. 13, Pages 1-17: Genetic Variability and Phylogeny of High Risk HPV Type 16, 18, 31, 33 and 45 L1 Gene in Greek Women

Posted: 22 Dec 2011 12:00 AM PST

The present study explores nucleotide variability, phylogeny and association with cervical neoplasia in high risk HPV types 16, 18, 31, 33 and 45 collected from Greek women. Of the 1894 women undergoing routine cervical cytology examination, 160 samples test positive for single infections of HPV type 16 (n = 104), HPV 31 (n = 40), HPV 33 (n = 7), HPV 18 (n = 5), and HPV 45 (n = 4) were typed by microarrays method, amplified by PCR then sequenced and phylogenetically analyzed. For HPV 16, 9 variants with nucleotide variations were included into the study. For HPV 31, 33, 18 and 45, nucleotide variations were identified in 6, 4, 2 and 3 variants, respectively. The Bayesian inference and Maximum Parsimony methods were used in order to construct the phylogenetic trees. When types were analyzed independently HPV 16 (European and non-European) and HPV 18 (African and non-African) formed distinct clades. The genomic characterization of HPV variants will be important for illuminating the geographical relatedness and biological differences and for the determination of their risk.

2 businesses raided, gaming gear seized

Posted: 22 Dec 2011 01:58 AM PST

The store's large window still advertised 'Simulated Vegas Style Games' and '$Cash Prizes$,' along with crude drawings of gambling chips and slot machine cherries, but inside, agents from the Indiana Gaming Commission left next to nothing.

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Colliding Fronts

Posted: 21 Dec 2011 10:00 PM PST

The German troops are trying to break through weak front lines. Prepare your units and stop the German invasion!

Sensors, Vol. 12, Pages 55-91: Security Issues in Healthcare Applications Using Wireless Medical Sensor Networks: A Survey

Posted: 22 Dec 2011 12:00 AM PST

Healthcare applications are considered as promising fields for wireless sensor networks, where patients can be monitored using wireless medical sensor networks (WMSNs). Current WMSN healthcare research trends focus on patient reliable communication, patient mobility, and energy-efficient routing, as a few examples. However, deploying new technologies in healthcare applications without considering security makes patient privacy vulnerable. Moreover, the physiological data of an individual are highly sensitive. Therefore, security is a paramount requirement of healthcare applications, especially in the case of patient privacy, if the patient has an embarrassing disease. This paper discusses the security and privacy issues in healthcare application using WMSNs. We highlight some popular healthcare projects using wireless medical sensor networks, and discuss their security. Our aim is to instigate discussion on these critical issues since the success of healthcare application depends directly on patient security and privacy, for ethic as well as legal reasons. In addition, we discuss the issues with existing security mechanisms, and sketch out the important security requirements for such applications. In addition, the paper reviews existing schemes that have been recently proposed to provide security solutions in wireless healthcare scenarios. Finally, the paper ends up with a summary of open security research issues that need to be explored for future healthcare applications using WMSNs.

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четверг, 22 декабря 2011 г.

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четверг, 22 декабря 2011 г.

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четверг, 22 декабря 2011 г.