среда, 28 декабря 2011 г.

Games

Games

Rawker 2.3.4 - Single or batch process RAW converter.. (Free)

Posted: 28 Dec 2011 03:19 AM PST



Rawker is a freeware converter program for RAW files produced by digital photo cameras. It's philosophy is the good old Apple motto: "Keep it simple". It allows you to convert a single RAW file or batch process a folder of RAW files. It is also possible to specify a hot folder that Rawker scans every few seconds. When new files show up in the hot folder, Rawker automatically converts them.

Before processing any files you can modify settings that may optimize the appearance of your image(s). These settings can be saved in a file and re-loaded later.

During batch processing Rawker shows the image it is currently working on. Rawker produces TIFF image files with 16 bits color depth (which is 48 bits per RGB pixel) or PNG (16 bits) or JPEG (8 bits) files.

Metadata present in the RAW files will be preserved when exporting as TIFF and JPEG output files.

Rawker converts RAW files using one of two modes: It can convert RAW files using Apple's Core Graphics (Quartz) technology, or it can use Dave Coffin's DCRaw tool. You choose which mode Rawker will use for RAW file conversion. DCRaw doesn't need to be installed separately, it's embedded into Rawker.



Version 2.3.4:
  • Code cleanup in batch and hot folder mode.


Mac OS X 10.4 or later

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Social for Gmail 2.0 - Manage multiple Gmail accounts.. (Shareware)

Posted: 28 Dec 2011 03:28 AM PST

Social for Gmail is the best solution for you if you have multiple Gmail accounts and you're looking to manage all your email accounts at one single application - !

Main Features:

  • Instant messaging on GTalk.
  • The Social icon at menu bar shows you at-a-glance if you have unread messages, notifications or friend requests.
  • Preview of incoming chat messages



Version 2.0:
  • Multiple accounts login
  • Desktop and Mobile View
  • Notification for new tweets
  • Sound notification
  • Ability to disable notification for each services
  • Resizable windows


Mac OS X 10.5 or later

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MacDropAny 1.8 - Sync any folder through Dropbox.. (Free)

Posted: 28 Dec 2011 03:21 AM PST



MacDropAny is a simple app that painlessly allows Mac users to sync any folder on their computer through Dropbox. It provides similar functionality to DropboxFolderSync, which is an application for Windows. It should be compatible with Mac OS X 10.4 and above, however I am only able to test it on 10.7, so I don't really know.

Version 1.8:
  • Now includes a right-click button for Finder that allows you to right click on any folder in Finder, and have it open directly in MacDropAny ready for syncing with Dropbox.
  • Improved auto-updating.


    • Mac OS X 10.6 or later
    • Dropbox account.


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Magican 0.9.67 - Optimize your Mac.. (Free)

Posted: 28 Dec 2011 03:11 AM PST



Magican is an integrated system utility for optimizing Mac OS X, featuring:
  • Magican can scan out all useless items on Mac and clear them by only "One-Click". It can display the total amount of deleted junks for users to clearly catch the sum of junks that Magican helps clean up.
  • Cleaner helps clean up all useless files including duplicated files, unneeded languages packages, useless binaries, system logs, caches, web browser caches and former app's leftover.
  • Stat shows the system information in pictorial symbols. It also displays all running process and enables users to kill unwanted process by one-click. Still historical file operations are showed in list to help users catch what have been done in their files.
  • Software displays all the installed applications on Mac, and then users can get basic information for each application. What's more, users can uninstall any software by a "Remove" button.
  • Document arranges all documents in categories. Users can easily find out any desired files and do further operations directly.
  • Hardware displays hardware information for Mac. It helps users get familiar with their Mac; still the hardware information can be exported out as documents and images.
  • Floating window displays the monthly network traffic to help users clearly catch the traffic they brought monthly. The "Purge RAM" button on floating window helps expands your Mac memory by keeping data in order. And users can end a process freely in floating window directly. What's more, users could catch the next 3 days weather reports in floating window.
  • Different types of skins can be freely selected to dress up Magican on your preference.


Version 0.9.67:
  • To easily catch memory info, interface of memory release is redesigned
  • Fix bugs in clean item, like app compatible problem
  • Fix weather broadcasting UI bug under Mac OS X 10.6
  • Stop producing useless logs during Magican running


  • Mac OS X 10.6 or later
  • 64-bit processor


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Cancers, Vol. 4, Pages 1-10: Tertiary Intratumor Lymphoid Tissue in Colo-Rectal Cancer

Posted: 28 Dec 2011 12:00 AM PST

Ectopic (or tertiary) lymphoid tissue develops at sites of inflammation or infection in non lymphoid organs and is associated with chronic inflammation. In colon mucosa, small lymphoid aggregates are already present in homeostatic conditions, as part of the gut-associated lymphoid tissue and play an essential role in the immune response to perturbations of the mucosal microenvironment. Despite the recognized role of inflammation in tumor progression, the presence and biological function of lymphoid tissue in cancer has been poorly investigated. We identified aggregates of lymphocytes resembling tertiary lymphoid tissue in human colorectal cancer specimens; intratumor accumulations of lymphocytes display a high degree of compartmentalization, with B and T cells, mature dendritic cells and a network of CD21+ follicular dendritic cells (FDC). We analyzed the adaptation of colon lymphoid tissue in a murine model of colitis-associated cancer (AOM/DSS). B cell follicle formation increases in the context of the chronic inflammation associated to intestinal neoplasia, in this model. A network of lymphatic and haematic vessels surrounding B cell follicles is present and includes high endothelial venules (HEV). Future task is to determine whether lymphoid tissue contributes to the persistence of the tumor-associated inflammatory reaction, rather than represent a functional immune compartment, potentially participating to the anti tumor response.

Materials, Vol. 5, Pages 47-84: Buckling of Carbon Nanotubes: A State of the Art Review

Posted: 28 Dec 2011 12:00 AM PST

The nonlinear mechanical response of carbon nanotubes, referred to as their "buckling" behavior, is a major topic in the nanotube research community. Buckling means a deformation process in which a large strain beyond a threshold causes an abrupt change in the strain energy vs. deformation profile. Thus far, much effort has been devoted to analysis of the buckling of nanotubes under various loading conditions: compression, bending, torsion, and their certain combinations. Such extensive studies have been motivated by (i) the structural resilience of nanotubes against buckling, and (ii) the substantial influence of buckling on their physical properties. In this contribution, I review the dramatic progress in nanotube buckling research during the past few years.

Forests, Vol. 3, Pages 22-32: Effects of Mechanical Site Preparation on Growth of Oaks Planted on Former Agricultural Fields

Posted: 28 Dec 2011 12:00 AM PST

Mechanical site preparation is frequently proposed to alleviate problematic soil conditions when afforesting retired agricultural fields. Without management of soil problems, any seedlings planted in these areas may exhibit poor growth and survival. While mechanical site preparation methods currently employed in hardwood afforestation are proven, there is a substantial void in research comparing subsoiling, bedding, and combination plowing treatments. A total of 4,320 bare-root Nuttall oak (Quercus texana Buckley), Shumard oak (Quercus shumardii Buckley), and swamp chestnut oak (Quercus michauxii Nutt.) seedlings were planted in February 2008 on three Mississippi sites. All sites were of comparable soils and received above average precipitation throughout the three-year duration of the study. Four site preparation treatments were replicated at each site, with 480 seedlings planted in each of nine replications, and a total of 1,440 seedlings per species planted across all sites. Mechanical treatments were installed using 3.1 m row centers, with treatments as follows: control, subsoiling, bedding, and combination plowing. Treatment effects on seedling height, groundline diameter (GLD), and survival were analyzed. Seedlings exhibited greater height in bedded and combination plowed areas (79.7 cm to 102.7 cm and 82.6 cm to 100.1 cm, respectively) compared to subsoiled or control areas (70.4 cm to 84.6 cm and 71.4 cm to 86.9 cm, respectively). Greater GLD was observed in bedded and combination plowed areas (11.9 mm to 18.4 mm and 12.2 mm to 18.3 mm, respectively) compared to subsoiled or control areas (10.2 mm to 14.6 mm and 10.5 mm to 15.6 mm, respectively). Survival was high for this study (94.%), and no differences were detected among treatments.

Pharmaceuticals, Vol. 5, Pages 49-60: Anti-HCV RNA Aptamers Targeting the Genomic cis-Acting Replication Element

Posted: 28 Dec 2011 12:00 AM PST

Hepatitis C virus (HCV) replication is dependent on the existence of several highly conserved functional genomic RNA domains. The cis-acting replication element (CRE), located within the 3' end of the NS5B coding region of the HCV genome, has been shown essential for efficient viral replication. Its sequence and structural features determine its involvement in functional interactions with viral RNA-dependent RNA polymerase and distant RNA domains of the viral genome. This work reports the use of an in vitro selection strategy to select aptamer RNA molecules against the complete HCV-CRE. After six selection cycles, five potential target sites were identified within this domain. Inhibition assays using a sample of representative aptamers showed that the selected RNAs significantly inhibit the replication (>80%) of a subgenomic HCV replicon in Huh-7 cell cultures. These results highlight the potential of aptamer RNA molecules as therapeutic antiviral agents.

Tudor games at the Mary Rose Museum

Posted: 28 Dec 2011 01:48 AM PST

Tudor game are availble to play daily at the museum. Contact Becky Ashton 02392 812931 Picture:Steve Reid It is one of a wealth of games visitors can try out at the Mary Rose Museum in Portsmouth Historic Dockyard as part of hands-on activities for all the family on offer at the Tudor Games and Pastimes event.

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Symmetry, Vol. 4, Pages 1-14: Convex-Faced Combinatorially Regular Polyhedra of Small Genus

Posted: 28 Dec 2011 12:00 AM PST

Combinatorially regular polyhedra are polyhedral realizations (embeddings) in Euclidean 3-space E3 of regular maps on (orientable) closed compact surfaces. They are close analogues of the Platonic solids. A surface of genus g ≥ 2 admits only finitely many regular maps, and generally only a small number of them can be realized as polyhedra with convex faces. When the genus g is small, meaning that g is in the historically motivated range 2 ≤ g ≤ 6, only eight regular maps of genus g are known to have polyhedral realizations, two discovered quite recently. These include spectacular convex-faced polyhedra realizing famous maps of Klein, Fricke, Dyck, and Coxeter. We provide supporting evidence that this list is complete; in other words, we strongly conjecture that in addition to those eight there are no other regular maps of genus g, with 2 ≤ g ≤ 6, admitting realizations as convex-faced polyhedra in E3. For all admissible maps in this range, save Gordan's map of genus 4, and its dual, we rule out realizability by a polyhedron in E3.

IJMS, Vol. 13, Pages 369-382: Potentiation of Anticancer Drugs: Effects of Pentoxifylline on Neoplastic Cells

Posted: 28 Dec 2011 12:00 AM PST

The drug efflux activity of P-glycoprotein (P-gp, a product of the mdr1 gene, ABCB1 member of ABC transporter family) represents a mechanism by which tumor cells escape death induced by chemotherapeutics. In this study, we investigated the mechanisms involved in the effects of pentoxifylline (PTX) on P-gp-mediated multidrug resistance (MDR) in mouse leukemia L1210/VCR cells. Parental sensitive mouse leukemia cells L1210, and multidrug-resistant cells, L1210/VCR, which are characterized by the overexpression of P-gp, were used as experimental models. The cells were exposed to 100 μmol/L PTX in the presence or absence of 1.2 μmol/L vincristine (VCR). Western blot analysis indicated a downregulation of P-gp protein expression when multidrug-resistant L1210/VCR cells were exposed to PTX. The effects of PTX on the sensitization of L1210/VCR cells to VCR correlate with the stimulation of apoptosis detected by Annexin V/propidium iodide apoptosis necrosis kit and proteolytic activation of both caspase-3 and caspase-9 monitored by Western blot analysis. Higher release of matrix metalloproteinases (MMPs), especially MMP-2, which could be attenuated by PTX, was found in L1210/VCR than in L1210 cells by gelatin zymography in electrophoretic gel. Exposure of resistant cells to PTX increased the content of phosphorylated Akt kinase. In contrast, the presence of VCR eliminated the effects of PTX on Akt kinase phosphorylation. Taken together, we conclude that PTX induces the sensitization of multidrug-resistant cells to VCR via downregulation of P-gp, stimulation of apoptosis and reduction of MMPs released from drug-resistant L1210/VCR cells. These facts bring new insights into the mechanisms of PTX action on cancer cells.

IJMS, Vol. 13, Pages 358-368: Expression, Immobilization and Enzymatic Properties of Glutamate Decarboxylase Fused to a Cellulose-Binding Domain

Posted: 28 Dec 2011 12:00 AM PST

Escherichia coli-derived glutamate decarboxylase (GAD), an enzyme that catalyzes the conversion of glutamic acid to gamma-aminobutyric acid (GABA), was fused to the cellulose-binding domain (CBD) and a linker of Trichoderma harzianum endoglucanase II. To prevent proteolysis of the fusion protein, the native linker was replaced with a S3N10 peptide known to be completely resistant to E. coli endopeptidase. The CBD-GAD expressed in E. coli was successfully immobilized on Avicel, a crystalline cellulose, with binding capacity of 33 ± 2 nmolCBD-GAD/gAvicel and the immobilized enzymes retained 60% of their initial activities after 10 uses. The results of this report provide a feasible alternative to produce GABA using immobilized GAD through fusion to CBD.

IJMS, Vol. 13, Pages 348-357: Acidic Pretreatment of Wheat Straw in Decanol for the Production of Surfactant, Lignin and Glucose

Posted: 28 Dec 2011 12:00 AM PST

Wheat straw is an abundant residue of agriculture which is increasingly being considered as feedstock for the production of fuels, energy and chemicals. The acidic decanol-based pre-treatment of wheat straw has been investigated in this work. Wheat straw hemicellulose has been efficiently converted during a single step operation into decyl pentoside surfactants and the remaining material has been preserved keeping all its promises as potential feedstock for fuels or value added platform chemicals such as hydroxymethylfurfural (HMF). The enzymatic digestibility of the cellulose contained in the straw residue has been evaluated and the lignin prepared from the material characterized. Wheat-based surfactants thus obtained have exhibited superior surface properties compared to fossil-based polyethoxylates decyl alcohol or alkyl oligoglucosides, some of which are largely used surfactants. In view of the growing importance of renewable resource-based molecules in the chemical industry, this approach may open a new avenue for the conversion of wheat straw into various chemicals.

IJMS, Vol. 13, Pages 336-347: Wound Healing Activity of Elaeis guineensis Leaf Extract Ointment

Posted: 28 Dec 2011 12:00 AM PST

Elaeis guineensis of the Arecaceae family is widely used in the traditional medicine of societies in West Africa for treating various ailments. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied. The results showed that E. guineensis leaf extract had potent wound healing capacity as evident from the better wound closure (P < 0.05), improved tissue regeneration at the wound site, and supporting histopathological parameters pertaining to wound healing. Matrix metalloproteinases expression correlated well with the results thus confirming efficacy of E. guineensis in the treatment of the wound. E. guineensis accelerated wound healing in rats, thus supporting its traditional use. The result of this study suggested that, used efficiently, oil palm leaf extract is a renewable resource with wound healing properties.

Gamesys: Online Slots Player Scoops A 40k win at Jackpotjoy

Posted: 28 Dec 2011 12:48 AM PST

Online slots company Jackpotjoy has awarded Mrs. Sue H, who took home a staggering A 40,144 after trying her luck on the Wonderland Slots game.

Sensors, Vol. 12, Pages 233-259: A Theoretical Model to Predict Both Horizontal Displacement and Vertical Displacement for Electromagnetic Induction-Based Deep Displacement Sensors

Posted: 28 Dec 2011 12:00 AM PST

Deep displacement observation is one basic means of landslide dynamic study and early warning monitoring and a key part of engineering geological investigation. In our previous work, we proposed a novel electromagnetic induction-based deep displacement sensor (I-type) to predict deep horizontal displacement and a theoretical model called equation-based equivalent loop approach (EELA) to describe its sensing characters. However in many landslide and related geological engineering cases, both horizontal displacement and vertical displacement vary apparently and dynamically so both may require monitoring. In this study, a II-type deep displacement sensor is designed by revising our I-type sensor to simultaneously monitor the deep horizontal displacement and vertical displacement variations at different depths within a sliding mass. Meanwhile, a new theoretical modeling called the numerical integration-based equivalent loop approach (NIELA) has been proposed to quantitatively depict II-type sensors' mutual inductance properties with respect to predicted horizontal displacements and vertical displacements. After detailed examinations and comparative studies between measured mutual inductance voltage, NIELA-based mutual inductance and EELA-based mutual inductance, NIELA has verified to be an effective and quite accurate analytic model for characterization of II-type sensors. The NIELA model is widely applicable for II-type sensors' monitoring on all kinds of landslides and other related geohazards with satisfactory estimation accuracy and calculation efficiency.

Molecules, Vol. 17, Pages 275-294: Estimation of Dermatological Application of Creams with St. John’s Wort Oil Extracts

Posted: 28 Dec 2011 12:00 AM PST

Oleum Hyperici, the oil extract of St. John's Wort (SJW), is one of the oldest folk remedies, traditionally used in the topical treatment of wounds, bruises, ulcers, cuts, burns, hemorrhoids and also as an antiseptic. Considering the advantageous characteristics of emulsion applications, in the present study we have formulated three O/W creams containing 15% (w/v) of SJW oil extract as an active ingredient. The aim was to estimate dermatological application of the prepared creams for the abovementioned indications. The extracts were prepared according to the prescriptions from traditional medicine, however with different vegetable oils used as an extractant, namely: Olive, palm and sunflower oil. The investigated O/W creams demonstrated significant antiinflammatory effects in an in vivo double-blind randomized study, using a sodium lauryl sulphate test. Both skin parameters assessed in the study (electrical capacitance and erythema index), were restored to the baseline value after a seven-day treatment with the tested creams. Almost all investigated SJW oil extracts and corresponding creams displayed the same antimicrobial activity against the most of the investigated microorganisms with obtained minimal inhibitory concentrations values of 1,280 µg/mL, 2,560 µg/mL or >2,560 µg/mL.

Molecules, Vol. 17, Pages 267-274: Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae)

Posted: 28 Dec 2011 12:00 AM PST

A new indole alkaloid; neonaucline (1), along with six known compounds–Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A–were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, 13C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1–3 after injection of each sample at 1 × 10−5 M.

Molecules, Vol. 17, Pages 248-266: Oligosaccharides Might Contribute to the Antidiabetic Effect of Honey: A Review of the Literature

Posted: 28 Dec 2011 12:00 AM PST

Evidence shows that honey improves glycemic control in diabetes mellitus. Besides its hypoglycemic effect, studies indicate that honey ameliorates lipid abnormalities in rats and humans with diabetes. The majority of these studies do not examine the mechanisms by which honey ameliorates glycemic and/or lipid derangements. The gut microbiota is now recognized for its ability to increase energy harvest from the diet and alter lipid metabolism of the host. Recently available data implicate a causal role of these gut microbes in the pathophysiology of obesity, insulin resistance, and diabetes mellitus. In this review, we present some of the latest findings linking gut microbiota to pathogenesis of obesity, insulin resistance, and diabetes mellitus. The review also underlines data that demonstrate the beneficial effects of oligosaccharides on various abnormalities commonly associated with these disorders. Based on the similarities of some of these findings with those of honey, together with the evidence that honey contains oligosaccharides, we hypothesize that oligosaccharides present in honey might contribute to the antidiabetic and other health-related beneficial effects of honey. We anticipate that the possibility of oligosaccharides in honey contributing to the antidiabetic and other health-related effects of honey will stimulate a renewed research interest in this field.

OnyX 2.4.3b3 - Mac OS X maintenance and optimisation tool.. (Free)

Posted: 27 Dec 2011 08:59 PM PST



OnyX is a multifunctional utility for Mac OS X. It allows you to verify the Startup Disk and the structure of its System files, to run miscellaneous tasks of system maintenance, to configure the hidden parameters of the Finder, Dock and of some of Apple's own applications, to delete caches, to remove a certain number of files and folders that may become cumbersome and more.

Version 2.4.3b3:
  • OnyX doesn't relaunch anymore after restart or shut down
  • Deleting the Logs improved
  • Enable/disable Text Selection in Quick Look
  • Enable/disable iTunes notifications
  • Choose search option by default in Safari
  • Path Bar displayed from the Home folder or root
  • Show/hide the path of background image on the Desktop
  • Enable/disable Time Machine Local Backups
  • Translations improved
  • New version integrated 3.7.9 of sqlite3
  • Bug corrected while rebuilding the Mail Envelope Index
  • Bug corrected while emptying the trash


Mac OS X 10.7 or later

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