Games |
- Output Factory 1.0b20 - Automates printing and exporting from Adobe InDesign.. (Demo)
- AFPStatus 1.5 - Menu item displays the status of File Sharing.. (Free)
- OnyX 2.4.3b3 - Mac OS X maintenance and optimisation tool (beta available).. (Free)
- Company Proposes Election Options Market
- Buildings, Vol. 1, Pages 4-15: Retrofitting of Energy Habitability in Social Housing: A Case Study in A Mediterranean Climate
- Genes, Vol. 3, Pages 62-80: Implication of an Aldehyde Dehydrogenase Gene and a Phosphinothricin N-Acetyltransferase Gene in the Diversity of Pseudomonas cichorii Virulence
- Molecules, Vol. 17, Pages 207-226: Molecular Properties of Water-Unextractable Proteoglycans from Hypsizygus marmoreus and Their in Vitro Immunomodulatory Activities
- Sudoku of the day for December 27
- Membranes, Vol. 2, Pages 1-15: Physical Characterization of Mouse Deep Vein Thrombosis Derived Microparticles by Differential Filtration with Nanopore Filters
- Sensors, Vol. 12, Pages 226-232: Self-Calibrated Humidity Sensor in CMOS without Post-Processing
- Brain Sciences, Vol. 2, Pages 1-21: Why the Brain Knows More than We Do: Non-Conscious Representations and Their Role in the Construction of Conscious Experience
- Sensors, Vol. 12, Pages 215-225: Online Assessment of Human-Robot Interaction for Hybrid Control of Walking
- Crystals, Vol. 2, Pages 1-21: Differential Scanning Calorimetry (DSC) and Synchrotron X-ray Diffraction Study of Unmilled and Milled LiBH4: A Partial Release of Hydrogen at Moderate Temperatures
- Sensors, Vol. 12, Pages 189-214: Hierarchical Leak Detection and Localization Method in Natural Gas Pipeline Monitoring Sensor Networks
- Sensors, Vol. 12, Pages 175-188: Development of a Hybrid Atomic Force Microscopic Measurement System Combined with White Light Scanning Interferometry
- Metals, Vol. 2, Pages 10-21: Metal Foaming Investigated by X-ray Radioscopy
- Molecules, Vol. 17, Pages 191-206: Chromone and Flavonoid Alkaloids: Occurrence and Bioactivity
- Molecules, Vol. 17, Pages 179-190: Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition
- Molecules, Vol. 17, Pages 163-178: Template Directed Reversible Photochemical Ligation of Oligodeoxynucleotides
- Entropy, Vol. 14, Pages 1-23: Entropy Generation Analysis of Open Parallel Microchannels Embedded Within a Permeable Continuous Moving Surface: Application to Magnetohydrodynamics (MHD)
| Output Factory 1.0b20 - Automates printing and exporting from Adobe InDesign.. (Demo) Posted: 27 Dec 2011 03:31 AM PST  Output Factory automates printing and exporting from Adobe InDesign. Export as single pages with variable file names, update modified links on the fly, preflight InDesign files before output, preflight final PDF and send output files to FTP site with email notifications. Just select the documents, adjust settings and Output Factory will do the rest for you. Keep working with other programs while Output Factory processes InDesign files in the background. Or let Output Factory work while you're on a lunch break. Or leave it working overnight to output hundreds of documents, and the job will be done when you return in the morning. Key features:
Qualified beta testers will receive 50% discount (see read me files for details). Version 1.0b20:
Download Now This posting includes an audio/video/photo media file: Download Now |
| AFPStatus 1.5 - Menu item displays the status of File Sharing.. (Free) Posted: 27 Dec 2011 03:28 AM PST  AFPStatus gives you a simple icon inside your menu bar that will show you the current status of your file sharing with one look. It will show you if file sharing is enabeled or not and it will list the IP-Addresses of other users currently connected to your Mac. And with a klick on the address it will be copied to your clipboard.
Version 1.5
Mac OS X 10.4 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| OnyX 2.4.3b3 - Mac OS X maintenance and optimisation tool (beta available).. (Free) Posted: 27 Dec 2011 03:20 AM PST  OnyX is a multifunctional utility for Mac OS X. It allows you to verify the Startup Disk and the structure of its System files, to run miscellaneous tasks of system maintenance, to configure the hidden parameters of the Finder, Dock and of some of Apple's own applications, to delete caches, to remove a certain number of files and folders that may become cumbersome and more. Version 2.4.3b3:
Mac OS X 10.7 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Company Proposes Election Options Market Posted: 27 Dec 2011 01:51 AM PST As soon as next week, a new market may open, where anyone can place bets on the outcome of upcoming political contests. This posting includes an audio/video/photo media file: Download Now |
| Posted: 27 Dec 2011 12:00 AM PST Much of the residential sector in Spain is obsolete, with inadequate conditions of comfort and high energy consumption. For this reason most of the potential for improving energy efficiency lies in the existing residential sector, which requires upgrading to meet the quantitative and qualitative changes required at present. This study of specific cases aimed at establishing general criteria for action has been prompted by the difficulty in proposing general intervention strategies. This paper presents a case study for the energy retrofit of 68 social housing units in Cordoba (Spain) evaluating their energy consumption, with a view to improving the building's energy balance and indoor thermal comfort, on which user comfort depends. |
| Posted: 27 Dec 2011 12:00 AM PST Pseudomonas cichorii harbors the hrp genes. hrp-mutants lose their virulence on eggplant but not on lettuce. A phosphinothricin N-acetyltransferase gene (pat) is located between hrpL and an aldehyde dehydrogenase gene (aldH) in the genome of P. cichorii. Comparison of nucleotide sequences and composition of the genes among pseudomonads suggests a common ancestor of hrp and pat between P. cichorii strains and P. viridiflava strains harboring the single hrp pathogenicity island. In contrast, phylogenetic diversification of aldH corresponded to species diversification amongst pseudomonads. In this study, the involvement of aldH and pat in P. cichorii virulence was analyzed. An aldH-deleted mutant (ΔaldH) and a pat-deleted mutant (Δpat) lost their virulence on eggplant but not on lettuce. P. cichorii expressed both genes in eggplant leaves, independent of HrpL, the transcriptional activator for the hrp. Inoculation into Asteraceae species susceptible to P. cichorii showed that the involvement of hrp, pat and aldH in P. cichorii virulence is independent of each other and has no relationship with the phylogeny of Asteraceae species based on the nucleotide sequences of ndhF and rbcL. It is thus thought that not only the hrp genes but also pat and aldH are implicated in the diversity of P. cichorii virulence on susceptible host plant species. |
| Posted: 27 Dec 2011 12:00 AM PST Four proteoglycans were sequentially extracted from Hypsizygus marmoreus using 0.1 M NaOH (alkali-soluble proteoglycans [F1] and alkali-insoluble proteoglycans [F3]) and 0.1 M HCl (acid-soluble proteoglycans [F2] and acid-insoluble proteoglycans [F4]), and their structures and immunomodulatory activities were investigated. The proteoglycans were found to contain carbohydrates (19.8–82.4%) with various amounts of proteins (7.7–67.3%), and glucose was the major monosaccharide unit present, along with trace amounts of galactose. The molecular weights (Mw) and the radius of gyration (Rg) of these proteoglycans showed ranges of 16 × 104–19,545 × 104 g/mol and 35–148 nm, respectively, showing significant variations in their molecular conformations. The backbones of F1 and F2 were mainly connected through a-(1→3), (1→4) and b-(1→6)-glycosidic linkages with some branches. The F1 and F2 proteoglycans significantly stimulated Raw264.7 cells to release nitric oxide (NO), prostaglandin E2 (PGE2) and various cytokines, such as IL-1β, TNF-α and IL-6 by inducing their mRNA expressions. |
| Sudoku of the day for December 27 Posted: 27 Dec 2011 12:46 AM PST How to Play Fill in each square with a number so that each row , column and block contains 1 to 9. Each row, column, and 3 x 3 block must contain only one instance of each number. |
| Posted: 27 Dec 2011 12:00 AM PST With the objective of making advancements in the area of pro-thrombotic microparticle characterization in cardiovascular biology, we present a novel method to separate blood circulating microparticles using a membrane-based, nanopore filtration system. In this qualitative study, electron microscopy observations of these pro-thrombotic mouse microparticles, as well as mouse platelets and leukocytes obtained using a mouse inferior vena cava ligation model of deep-vein thrombosis are presented. In particular, we present mouse microparticle morphology and microstructure using SEM and TEM indicating that they appear to be mostly spherical with diameters in the 100 to 350 nm range. The nanopore filtration technique presented is focused on the development of novel methodologies to isolate and characterize blood circulating microparticles that can be used in conjunction with other methodologies. We believe that determination of microparticle size and structure is a critical step for the development of reliable assays with clinical or research application in thrombosis and it will contribute to the field of nanomedicine in thrombosis. |
| Sensors, Vol. 12, Pages 226-232: Self-Calibrated Humidity Sensor in CMOS without Post-Processing Posted: 27 Dec 2011 12:00 AM PST A 1.1 µW power dissipation, voltage-output humidity sensor with 10% relative humidity accuracy was developed in the LFoundry 0.15 µm CMOS technology without post-processing. The sensor consists of a woven lateral array of electrodes implemented in CMOS top metal, a humidity-sensitive layer of Intervia Photodielectric 8023D-10, a CMOS capacitance to voltage converter, and the self-calibration circuitry. |
| Posted: 27 Dec 2011 12:00 AM PST Scientific studies have shown that non-conscious stimuli and representations influence information processing during conscious experience. In the light of such evidence, questions about potential functional links between non-conscious brain representations and conscious experience arise. This article discusses neural model capable of explaining how statistical learning mechanisms in dedicated resonant circuits could generate specific temporal activity traces of non-conscious representations in the brain. How reentrant signaling, top-down matching, and statistical coincidence of such activity traces may lead to the progressive consolidation of temporal patterns that constitute the neural signatures of conscious experience in networks extending across large distances beyond functionally specialized brain regions is then explained. |
| Posted: 27 Dec 2011 12:00 AM PST Restoration of walking ability of Spinal Cord Injury subjects can be achieved by different approaches, as the use of robotic exoskeletons or electrical stimulation of the user's muscles. The combined (hybrid) approach has the potential to provide a solution to the drawback of each approach. Specific challenges must be addressed with specific sensory systems and control strategies. In this paper we present a system and a procedure to estimate muscle fatigue from online physical interaction assessment to provide hybrid control of walking, regarding the performances of the muscles under stimulation. |
| Posted: 27 Dec 2011 12:00 AM PST A systematic investigation of phase transitions in unmilled and milled LiBH4 has been performed by Pressurized Differential Scanning Calorimetry (PDSC). It was found that a large exotherm is present below the low temperature (LT) → high temperature (HT) phase transition. This exotherm is not caused by air contamination but seems to originate from hydrogen release from a solid solution in the matrix of LiBH4 low temperature phase. The exotherm activation energy has been measured to be 100 kJ mol–1. Calorimetric measurements under argon and hydrogen have shown that for the milled sample, the endothermic peak of the LT → HT transition is split in two when the PDSC scan is performed under hydrogen atmosphere. Synchrotron X-ray powder diffraction on the milled LiBH4 sample revealed only a single-step transition from the LT to HT phase, both under vacuum and under 2 and 40 bar of hydrogen pressure. The axial ratios for the LT LiBH4 below 300 K are significantly altered by milling; they are also considerably different under 40 bar of hydrogen, indicating an interaction between the hydrogen gas and the LT LiBH4 solid phase. |
| Posted: 27 Dec 2011 12:00 AM PST In light of the problems of low recognition efficiency, high false rates and poor localization accuracy in traditional pipeline security detection technology, this paper proposes a type of hierarchical leak detection and localization method for use in natural gas pipeline monitoring sensor networks. In the signal preprocessing phase, original monitoring signals are dealt with by wavelet transform technology to extract the single mode signals as well as characteristic parameters. In the initial recognition phase, a multi-classifier model based on SVM is constructed and characteristic parameters are sent as input vectors to the multi-classifier for initial recognition. In the final decision phase, an improved evidence combination rule is designed to integrate initial recognition results for final decisions. Furthermore, a weighted average localization algorithm based on time difference of arrival is introduced for determining the leak point's position. Experimental results illustrate that this hierarchical pipeline leak detection and localization method could effectively improve the accuracy of the leak point localization and reduce the undetected rate as well as false alarm rate. |
| Posted: 27 Dec 2011 12:00 AM PST A hybrid atomic force microscopic (AFM) measurement system combined with white light scanning interferometry for micro/nanometer dimensional measurement is developed. The system is based on a high precision large-range positioning platform with nanometer accuracy on which a white light scanning interferometric module and an AFM head are built. A compact AFM head is developed using a self-sensing tuning fork probe. The head need no external optical sensors to detect the deflection of the cantilever, which saves room on the head, and it can be directly fixed under an optical microscopic interferometric system. To enhance the system's dynamic response, the frequency modulation (FM) mode is adopted for the AFM head. The measuring data can be traceable through three laser interferometers in the system. The lateral scanning range can reach 25 mm × 25 mm by using a large-range positioning platform. A hybrid method combining AFM and white light scanning interferometry is proposed to improve the AFM measurement efficiency. In this method, the sample is measured firstly by white light scanning interferometry to get an overall coarse morphology, and then, further measured with higher resolution by AFM. Several measuring experiments on standard samples demonstrate the system's good measurement performance and feasibility of the hybrid measurement method. |
| Metals, Vol. 2, Pages 10-21: Metal Foaming Investigated by X-ray Radioscopy Posted: 27 Dec 2011 12:00 AM PST The use of X-ray radioscopy for in-situ studies of metal foam formation and evolution is reviewed. Selected results demonstrate the power of X-ray radioscopy as diagnostic tool for metal foaming. Qualitative analyses of foam nucleation and evolution, drainage development, issues of thermal contact, mold filling, cell wall rupture and more are given. Additionally, quantitative analyses based on series of images of foam expansion yielding coalescence rates, density distributions, etc., are performed by dedicated software. These techniques help us to understand the foaming behavior of metals and to improve both foaming methods and foam quality. |
| Molecules, Vol. 17, Pages 191-206: Chromone and Flavonoid Alkaloids: Occurrence and Bioactivity Posted: 27 Dec 2011 12:00 AM PST The chromone and flavonoid alkaloids represent an unusual group of structurally diverse secondary metabolites, derived from the convergence of multiple biosynthetic pathways that are widely distributed through the plant and animal kingdoms. Many of them have been discovered through bioassay-guided chemical investigations of traditional medicines, suggesting potential therapeutic significance. Their unique structures and varied pharmacological activities may provide important new leads for the discovery of drugs with novel mechanisms of action. Potential therapeutic indications are as diverse as cancer and viral infections, inflammation and immunomodulation, neurological and psychiatric conditions, and diabetes. |
| Posted: 27 Dec 2011 12:00 AM PST A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the azido-pseudo-sugar 4-azidobutylacetate under solvent-free microwave conditions, followed by treatment with K2CO3/MeOH, or NH3/MeOH. All compounds studied in this work were screened for their antiviral activities [against human rhinovirus (HRV) and hepatitis C virus (HCV)] and antibacterial activities against a series of Gram positive and negative bacteria. |
| Posted: 27 Dec 2011 12:00 AM PST We demonstrated that 5-vinyldeoxyuridine (VU) and 5-carboxyvinyldeoxyuridine (CVU) can be used to photoligate a longer oligonucleotide (ODN) from smaller ODNs on a template. By performing irradiation at 366 nm, these artificial nucleotides make photoligated ODNs with high efficiency without any side reactions. Moreover, by performing irradiation at 312 nm, these photoligated ODNs were reversed to the original ODN. VU needs to be irradiated 366 nm for 6 h, but CVU needs to be irradiated at 366 nm for 15 min. Finally, we made a self-assembled structure with an ODN containing CVU and observed the photoligated ODN by photoirradiation. |
| Posted: 27 Dec 2011 12:00 AM PST This paper presents a new design of open parallel microchannels embedded within a permeable continuous moving surface due to reduction of exergy losses in magnetohydrodynamic (MHD) flow at a prescribed surface temperature (PST). The entropy generation number is formulated by an integral of the local rate of entropy generation along the width of the surface based on an equal number of microchannels and no-slip gaps interspersed between those microchannels. The velocity, the temperature, the velocity gradient and the temperature gradient adjacent to the wall are substituted into this equation resulting from the momentum and energy equations obtained numerically by an explicit Runge-Kutta (4, 5) formula, the Dormand-Prince pair and shooting method. The entropy generation number, as well as the Bejan number, for various values of the involved parameters of the problem are also presented and discussed in detail. |
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