Games |
- Toau 1.2 - Convert plain text into audio.. (Free)
- Super Flexible File Synchronizer 5.60a - Back-up and synchronize Macs, servers and more.. (Shareware)
- TextExpander 3.4 - On-the-fly typing accelerator.. (Demo)
- Cryptext 1.0.0 - Helps you secure your writings and notes.. (Commercial)
- Marine Drugs, Vol. 9, Pages 2537-2552: Inhibition of Virulence Gene Expression in Staphylococcus aureus by Novel Depsipeptides from a Marine Photobacterium
- Molecules, Vol. 16, Pages 10187-10201: Synthesis and Analgesic Activity of Some New Pyrazoles and Triazoles Bearing a 6,8-Dibromo-2-methylquinazoline Moiety
- IJERPH, Vol. 8, Pages 4563-4581: Local Heat Stroke Prevention Plans in Japan: Characteristics and Elements for Public Health Adaptation to Climate Change
- IJERPH, Vol. 8, Pages 4550-4562: Controlling Access to Suicide Means
- Petition to get a pardon for Turing's "gross indecency" conviction
- Nevada court upholds Harrah's ban of Vegas gambler
- IJERPH, Vol. 8, Pages 4521-4549: Mass Casualties and Health Care Following the Release of Toxic Chemicals or Radioactive Material—Contribution of Modern Biotechnology
- 3 Doors
- IJMS, Vol. 12, Pages 9057-9082: Molecular Motor Proteins and Amyotrophic Lateral Sclerosis
- IJMS, Vol. 12, Pages 9031-9056: Enhanced Immunomodulatory Activity of Gelatin-Encapsulated Rubus coreanus Miquel Nanoparticles
- IJMS, Vol. 12, Pages 9009-9030: Mechanobiology of Platelets: Techniques to Study the Role of Fluid Flow and Platelet Retraction Forces at the Micro- and Nano-Scale
- IJMS, Vol. 12, Pages 8993-9008: New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves
- Viruses, Vol. 3, Pages 2412-2424: The Use of Fluorescence Microscopy to Study the Association Between Herpesviruses and Intrinsic Resistance Factors
- Dropbox 1.2.49 - Online synchronization tool with Finder integration; free 2 GB account.. (Free)
- A Better Finder Rename 8.93 - File, photo, and MP3 batch renamer.. (Shareware)
- Hear 1.1.1 - Improves audio quality and adds audio options system-wide.. (Demo)
| Toau 1.2 - Convert plain text into audio.. (Free) Posted: 07 Dec 2011 02:54 AM PST  Toau helps you convert plain text into audio file. To let it speak a different language other than the default English, go to "Preferences - System Voice - Customize..", then choose the new voice you want to download. After the download is finished, set the "System Voice" to the new voice you just downloaded.
Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 07 Dec 2011 03:17 AM PST  Super Flexible File Synchronizer is used to back-up your data and synchronize Macs, servers, notebooks, and online storage space. You can set up as many different jobs as you need and run them manually or using the scheduler. The software comes with support for FTP, WebDAV, Amazon S3, and AES file encryption, as well as SSH and ZIP compression. There are powerful synchronization modes, including Standard Copying, Exact Mirror, and SmartTracking. Numerous improvements to make an extremely versatile synchronizing and back-up tool. The wealth of features fulfills all requirements that users typically have, while still being easy to use. Version 5.60a: You can now synchronize with Microsoft Azure Storage and Google Docs! Azure Storage is quite straightforward and even retains the files' original timestamps. Google Docs has limitations and peculiarities, described here You can now use RUN PROFILE in Job->Execute before/after to chain profiles. Additional enhancements are documented on the Execute before/after dialog. The timezones of FTP and other Internet servers can now be auto-detected, fixing some common timestamp-related problems. A new setting "Verify Copied Files" is now available. Where possible, it uses server-generated MD5 checksums. The ExtremeSync Remote Service can now generate such checksums, as well as some FTP servers and Amazon S3. See the settings on the tab sheet "Files" as well as "Comparison->More". Binary Comparison is now supported for all protocols and also uses MD5 where possible. You can now combine Partial File Updating with Versioning, Zipping and Encryption and use it with any backup storage location, including FTP and other Internet Protocols. Mac OS X 10.5.8 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| TextExpander 3.4 - On-the-fly typing accelerator.. (Demo) Posted: 07 Dec 2011 03:05 AM PST  TextExpander (formerly Textpander) is a customizable typing shortcut tool that saves time and keystrokes. With TextExpander, you can define abbreviations for frequently-used text strings and images, also known as snippets. When an abbreviation is typed, it expands automatically to the full snippet. Here are a few examples for what you can do with TextExpander:
TextExpander is controlled from its own preference pane inside your System Preferences. Designed for easy handling, TextExpander blends in perfectly with your operating system. Version 3.4:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Cryptext 1.0.0 - Helps you secure your writings and notes.. (Commercial) Posted: 07 Dec 2011 02:57 AM PST  Cryptext is a small encryption application that can help you secure your writings and notes easily. Initial Release Mac OS X 10.6.6 or later Download Now |
| Posted: 07 Dec 2011 12:00 AM PST During a global research expedition, more than five hundred marine bacterial strains capable of inhibiting the growth of pathogenic bacteria were collected. The purpose of the present study was to determine if these marine bacteria are also a source of compounds that interfere with the agr quorum sensing system that controls virulence gene expression in Staphylococcus aureus. Using a gene reporter fusion bioassay, we recorded agr interference as enhanced expression of spa, encoding Protein A, concomitantly with reduced expression of hla, encoding α-hemolysin, and rnaIII encoding RNAIII, the effector molecule of agr. A marine Photobacterium produced compounds interfering with agr in S. aureus strain 8325-4, and bioassay-guided fractionation of crude extracts led to the isolation of two novel cyclodepsipeptides, designated solonamide A and B. Northern blot analysis confirmed the agr interfering activity of pure solonamides in both S. aureus strain 8325-4 and the highly virulent, community-acquired strain USA300 (CA-MRSA). To our knowledge, this is the first report of inhibitors of the agr system by a marine bacterium. |
| Posted: 07 Dec 2011 12:00 AM PST 2-(6,8-Dibromo-2-methylquinazolin-4-yloxy)-acetohydrazide (4) was prepared by the reaction of 6,8-dibromo-2-methylbenzo-[d][1,3]oxazin-4-one with formamide to afford quinazolinone 2, followed by alkylation with ethyl chloroacetate to give the ester 3. Treatment of ester 3 with hydrazine hydrate and benzaldehyde afforded 4 and styryl quinazoline 5. The hydrazide was reacted with triethyl orthoformate, acetylacetone and ethyl acetoacetate and benzaldehyde derivatives to afford the corresponding pyrazoles 6, 7, 9 and hydrazone derivatives 10a-c. Cyclization of hydrazones 10a-c with thioglycolic acid afforded the thiazole derivatives 11a-c. Reaction of the hydrazide with isothiocyanate derivatives afforded hydrazinecarbothioamide derivatives 12a-c, which cyclized to triazole-3-thiols and thiadiazoles 13a-c and 14a-c, respectively. Fusion of the hydrazide with phthalimide afforded the annelated compound 1,2,4-triazolo[3,4-a]isoindol-5-one (15). The newly synthesized compounds were characterized by their spectral (IR, 1H-, 13C-NMR) data. Selected compounds were screened for analgesic activity. |
| Posted: 07 Dec 2011 12:00 AM PST The adverse health effects from hot weather and heat waves represent significant public health risks in vulnerable areas worldwide. Rising temperatures due to climate change are aggravating these risks in a context of fast urbanization, population growth and societal ageing. However, environmental heat-related health effects are largely preventable through adequate preparedness and responses. Public health adaptation to climate change will often require the implementation of heat wave warning systems and targeted preventive activities at different levels. While several national governments have established such systems at the country level, municipalities do not generally play a major role in the prevention of heat disorders. This paper analyzes selected examples of locally operated heat-health prevention plans in Japan. The analysis of these plans highlights their strengths, but also the need of local institutions for assistance to make the transition towards an effective public health management of high temperatures and heat waves. It can also provide useful elements for municipal governments in vulnerable areas, both in planning their climate change and health adaptation activities or to better protect their communities against current health effects from heat. |
| IJERPH, Vol. 8, Pages 4550-4562: Controlling Access to Suicide Means Posted: 07 Dec 2011 12:00 AM PST Background: Restricting access to common means of suicide, such as firearms, toxic gas, pesticides and other, has been shown to be effective in reducing rates of death in suicide. In the present review we aimed to summarize the empirical and clinical literature on controlling the access to means of suicide. Methods: This review made use of both MEDLINE, ISI Web of Science and the Cochrane library databases, identifying all English articles with the keywords "suicide means", "suicide method", "suicide prediction" or "suicide prevention" and other relevant keywords. Results: A number of factors may influence an individual's decision regarding method in a suicide act, but there is substantial support that easy access influences the choice of method. In many countries, restrictions of access to common means of suicide has lead to lower overall suicide rates, particularly regarding suicide by firearms in USA, detoxification of domestic and motor vehicle gas in England and other countries, toxic pesticides in rural areas, barriers at jumping sites and hanging, by introducing "safe rooms" in prisons and hospitals. Moreover, decline in prescription of barbiturates and tricyclic antidepressants (TCAs), as well as limitation of drugs pack size for paracetamol and salicylate has reduced suicides by overdose, while increased prescription of SSRIs seems to have lowered suicidal rates. Conclusions: Restriction to means of suicide may be particularly effective in contexts where the method is popular, highly lethal, widely available, and/or not easily substituted by other similar methods. However, since there is some risk of means substitution, restriction of access should be implemented in conjunction with other suicide prevention strategies. |
| Petition to get a pardon for Turing's "gross indecency" conviction Posted: 07 Dec 2011 02:02 AM PST The UK government has officially apologised to computing giant and war hero Alan Turing for forcing him to take hormone injections as "therapy" for being gay (driving him to suicide), but now a petition has been mounted to get an official pardon Turing's 1952 for "gross indecency."
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| Nevada court upholds Harrah's ban of Vegas gambler Posted: 07 Dec 2011 01:44 AM PST A Las Vegas gambler who was banned from Harrah's casinos because of alleged card counting lost an appeal to the Nevada Supreme Court on Tuesday. |
| Posted: 07 Dec 2011 12:00 AM PST Catastrophic chemical or radiological events can cause thousands of casualties. Such disasters require triage procedures to identify the development of health consequences requiring medical intervention. Our objective is to analyze recent advancements in biotechnology for triage in mass emergency situations. In addition to identifying persons "at risk" of developing health problems, these technologies can aid in securing the unaffected or "worried well". We also highlight the need for public/private partnerships to engage in some of the underpinning sciences, such as patho-physiological mechanisms of chemical and radiological hazards, and for the necessary investment in the development of rapid assessment tools through identification of biochemical, molecular, and genetic biomarkers to predict health effects. For chemical agents, biomarkers of neurotoxicity, lung damage, and clinical and epidemiological databases are needed to assess acute and chronic effects of exposures. For radiological exposures, development of rapid, sensitive biomarkers using advanced biotechnologies are needed to sort exposed persons at risk of life-threatening effects from persons with long-term risk or no risk. The final implementation of rapid and portable diagnostics tools suitable for emergency care providers to guide triage and medical countermeasures use will need public support, since commercial incentives are lacking. |
| Posted: 06 Dec 2011 09:24 PM PST [Platform: Flash] 3 Doors is a standard point-and-click escape game that involves a basic room with three mysterious doors and a lot of fun and tricky puzzles, mostly visual. You're faced with the usual dilemma, getting out of a locked room, and the standard "pick up everything that's not nailed down" in order to get out scenario. This is definitely an escape skewed towards those who take careful note of their surroundings and can spot the hidden patterns. |
| IJMS, Vol. 12, Pages 9057-9082: Molecular Motor Proteins and Amyotrophic Lateral Sclerosis Posted: 07 Dec 2011 12:00 AM PST Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons in the brain, brainstem and spinal cord, which is characterized by motor dysfunction, muscle dystrophy and progressive paralysis. Both inherited and sporadic forms of ALS share common pathological features, however, the initial trigger of neurodegeneration remains unknown. Motor neurons are uniquely targeted by ubiquitously expressed proteins in ALS but the reason for this selectively vulnerability is unclear. However motor neurons have unique characteristics such as very long axons, large cell bodies and high energetic metabolism, therefore placing high demands on cellular transport processes. Defects in cellular trafficking are now widely reported in ALS, including dysfunction to the molecular motors dynein and kinesin. Abnormalities to dynein in particular are linked to ALS, and defects in dynein-mediated axonal transport processes have been reported as one of the earliest pathologies in transgenic SOD1 mice. Furthermore, dynein is very highly expressed in neurons and neurons are particularly sensitive to dynein dysfunction. Hence, unravelling cellular transport processes mediated by molecular motor proteins may help shed light on motor neuron loss in ALS. |
| Posted: 07 Dec 2011 12:00 AM PST The aim of this work was to investigate the immunomodulatory activities of Rubus coreanus Miquel extract-loaded gelatin nanoparticles. The mean size of the produced nanoparticles was 143 ± 18 nm with a bandwidth of 76 nm in the size distribution and a maximum size of ~200 nm, which allows effective nanoparticle uptake by cells. Confocal imaging confirmed this, since the nanoparticles were internalized within 30 min and heterogeneously distributed throughout the cell. Zeta-potential measurements showed that from pH = 5 onwards, the nanoparticles were highly negatively charged, which prevents agglomeration to clusters by electrostatic repulsion. This was confirmed by TEM imaging, which showed a well dispersed colloidal solution. The encapsulation efficiency was nearly 60%, which is higher than for other components encapsulated in gelatin nanoparticles. Measurements of immune modulation in immune cells showed a significant effect by the crude extract, which was only topped by the nanoparticles containing the extract. Proliferation of B-, T- and NK cells was notably enhanced by Rubus coreanus-gelatin nanoparticles and in general ~2–3 times higher than control and on average ~2 times higher than ferulic acid. R. coreanus-gelatin nanoparticles induced cytokine secretion (IL-6 and TNF-α) from B- and T-cells on average at a ~2–3 times higher rate compared with the extract and ferulic acid. In vivo immunomodulatory activity in mice fed with R. coreanus-gelatin nanoparticles at 1 mL/g body weight showed a ~5 times higher antibody production compared to control, a ~1.3 times higher production compared to the extract only, and a ~1.6 times higher production compared to ferulic acid. Overall, our results suggest that gelatin nanoparticles represent an excellent transport vehicle for Rubus coreanus extract and extracts from other plants generally used in traditional Asian medicine. Such nanoparticles ensure a high local concentration that results in enhancement of immune cell activities, including proliferation, cytokine secretion, and antibody production. |
| Posted: 07 Dec 2011 12:00 AM PST Coagulation involves a complex set of events that are important in maintaining hemostasis. Biochemical interactions are classically known to regulate the hemostatic process, but recent evidence has revealed that mechanical interactions between platelets and their surroundings can also play a substantial role. Investigations into platelet mechanobiology have been challenging however, due to the small dimensions of platelets and their glycoprotein receptors. Platelet researchers have recently turned to microfabricated devices to control these physical, nanometer-scale interactions with a higher degree of precision. These approaches have enabled exciting, new insights into the molecular and biomechanical factors that affect platelets in clot formation. In this review, we highlight the new tools used to understand platelet mechanobiology and the roles of adhesion, shear flow, and retraction forces in clot formation. |
| Posted: 07 Dec 2011 12:00 AM PST The present study was aimed at evaluating the antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves in animal models, in order to afford a better understanding of these properties. The extract reduced the number of abdominal contortions at doses of 100 (51.00 ± 3.00), 200 (42.00 ± 2.98) and 400 mg/kg (39.00 ± 4.00). In formalin tests, a significant reduction in the licking time (p < 0.01) was observed in the first phase by 25.14 (200 mg/kg = 51.50 ± 4.44) and 31.15% (400 mg/kg = 48.00 ± 4.37). The doses of 100 (43.37 ± 5.15), 200 (34.62 ± 4.16) and 400 mg/kg (28.37 ± 3.98) inhibited (p < 0.001) the second phase. After 60 and 90 min of treatment, a dose of 400 mg/kg (10.13 ± 0.39 and 11.14 ± 1.33, respectively) increased the latency time. Doses of 200 and 400 mg/kg potentiated the sleeping time induced by diazepam, pentobarbital and meprobamate. The extracts (100, 200 and 400 mg/kg) showed anti-inflammatory effects by a decrease in paw edema. The extracts also reduced the exudate volume at the doses of 200 and 400 mg/kg. The leukocyte migration had significant effect (p < 0.001) at doses of 100, 200 and 400 mg/kg. The completion of additional experiments in the investigation of the antinociceptive and anti-inflammatory activities of V. condensata allowed a better understanding of the central and peripheral mechanisms involved. |
| Posted: 07 Dec 2011 12:00 AM PST Intrinsic antiviral resistance is a branch of antiviral defence that involves constitutively expressed cellular proteins that act within individual infected cells. In recent years it has been discovered that components of cellular nuclear structures known as ND10 or PML nuclear bodies contribute to intrinsic resistance against a variety of viruses, notably of the herpesvirus family. Several ND10 components are rapidly recruited to sites that are closely associated with herpes simplex virus type 1 (HSV-1) genomes during the earliest stages of infection, and this property correlates with the efficiency of ND10 mediated restriction of HSV-1 replication. Similar but distinct recruitment of certain DNA damage response proteins also occurs during infection. These recruitment events are inhibited in a normal wild type HSV-1 infection by the viral regulatory protein ICP0. HSV‑1 mutants that do not express ICP0 are highly susceptible to repression through intrinsic resistance factors, but they replicate more efficiently in cells depleted of certain ND10 proteins or in which ND10 component recruitment is inefficient. This article presents the background to this recruitment phenomenon and summaries how it is conveniently studied by fluorescence microscopy. |
| Dropbox 1.2.49 - Online synchronization tool with Finder integration; free 2 GB account.. (Free) Posted: 06 Dec 2011 08:59 PM PST  Dropbox is an application that creates a special Finder folder that automatically syncs online and between your computers. It allows you to both backup files and keep them up-to-date between systems. Note: You must first sign up to use Dropbox. For a free 2GB account with 250MB bonus, click here. The Dropbox application is available for Mac OS X, Windows, and Linux. A video on the site explains more. Version 1.2.49:
Mac OS X 10.4 or later Download Now |
| A Better Finder Rename 8.93 - File, photo, and MP3 batch renamer.. (Shareware) Posted: 06 Dec 2011 08:59 PM PST  A Better Finder Rename is the most complete renaming solution available on the market today. That's why, since 1996, thousands of hobbyists, professionals and businesses depend on A Better Finder Rename to organize and maintain files. A Better Finder Rename's user interface supports complex renaming tasks without sacrificing ease and speed of use. Simply drag the files you want to rename straight from the Finder into the large preview table or the application icon.. or use our Finder context menu and hot key. The Instant Preview feature eliminates guesswork and costly errors and helps you find the right settings quickly and accurately by providing as-you-type feedback. A Better Finder Rename offers a complete set of renaming options that are organized into 7 categories covering all the text, character, position, conversion and truncation features that you would expect from a file renamer, but it does not stop there. Photographers use the advanced sequence number and date & time features to clean up their portfolios or prepare photos for delivery to their client. A Better Finder Rename knows how to extract EXIF shooting date and time information from digital camera images and exploit them in creating sequence numbers or adding time and date information to the file name. Support for all major RAW formats (including JPEG, CRW, CR2, THM, NEF, TIFF, RAJ, ORF , MRW, DNG, PEF, SRF, etc.) extends this to professional photographers. Version 8 now also deals gracefully with multiple shots captured in the same second. System administrators, web masters and other power users will appreciate the presence of advanced features, such as regular expression support, conversion to Windows NTFS/SMB compatible names, the ability to import file names from a database, a spreadsheet or any other source that can produce plain or tab-delimited text files. Last but not least, the ability to save a record of the current and new file names greatly facilitates tracking your files. Music lovers can use the built-in MP3/AAC support to exploit the id3 meta-data tags embedded in your most music files to create their own naming schemes for their music collection. Meta-data information from mp3, aac and iTunes music store files are supported. The multi-step renaming feature allows multiple renaming steps to be combined to deal with complex renaming jobs in a single operation. Unlike other tools, A Better Finder Rename allows any number of renaming actions to be combined, re-ordered, copied and deleted.
Mac OS X 10.6 or later Download Now |
| Hear 1.1.1 - Improves audio quality and adds audio options system-wide.. (Demo) Posted: 06 Dec 2011 08:59 PM PST  Hear greatly improves audio quality in movies and music throughout all of your Mac OS X applications. With Hear, music is richer, movie sound and dialog is clearer and games will blow you out of your chair!
Hear more with Hear. Version 1.1.1:
Mac OS X 10.5 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
We ask the HM Government to grant a pardon to Alan Turing for the conviction of 'gross indecency'. In 1952, he was convicted of 'gross indecency' with another man and was forced to undergo so-called 'organo-therapy' - chemical castration. Two years later, he killed himself with cyanide, aged just 41. Alan Turing was driven to a terrible despair and early death by the nation he'd done so much to save. This remains a shame on the UK government and UK history. A pardon can go to some way to healing this damage. It may act as an apology to many of the other gay men, not as well known as Alan Turing, who were subjected to these laws. | You are subscribed to email updates from Games To stop receiving these emails, you may unsubscribe now. | Email delivery powered by Google |
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