Games

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• gbrainy 2.1 (updated)
• Marine Drugs, Vol. 10, Pages 329-339: Toxicity of Cultured Bullseye Puffer Fish Sphoeroides annulatus
• Marine Drugs, Vol. 10, Pages 319-328: Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis
• Cubosphere Beta 0.2 (updated)
• Molecules, Vol. 17, Pages 1425-1436: Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives
• Molecules, Vol. 17, Pages 1419-1424: A New Iridoid Glycoside from the Roots of Dipsacus asper
• Slovenia's ambassador apologizes to her children and her nation for signing ACTA, calls for mass demonstrations in Ljubljana tomorrow
• ChatChat
• Molecules, Vol. 17, Pages 1408-1418: Supramolecular Photodimerization of Coumarins
• Zombie Grinder pre-alpha (new)
• The Darkness II Interview With Seth Olshfski
• Shooters, MMOs linked to problem game playing - study
• Beginners Guide - Twisted Metal: Multiplayer Demo
• Doodle Boat - Screenshots
• Tribes: Ascend - Screenshots
• IJMS, Vol. 13, Pages 1658-1669: Preparation of TiO2 Nanocrystallite Powders Coated with 9 mol% ZnO for Cosmetic Applications in Sunscreens
• Pharmaceuticals, Vol. 5, Pages 155-168: Concerns Regarding the Use of Dabigatran for Stroke Prevention in Atrial Fibrillation
• Molecules, Vol. 17, Pages 1388-1407: Synthesis, Docking Studies and Biological Evaluation of Benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one Derivatives on 5-HT1A Serotonin Receptors
• Insects, Vol. 3, Pages 131-132: Correction: Lim and Forschler, Reticulitermes nelsonae, a New Species of Subterranean Termite (Rhinotermitidae) from the Southeastern United States. Insects 2012, 3, 62-90.
• Administrative Sciences, Vol. 2, Pages 63-81: Leadership and Knowledge Management in an E-Government Environment

gbrainy 2.1 (updated) Posted: 03 Feb 2012 03:21 AM PST gbrainy is a brain teaser game More about gbrainy

Marine Drugs, Vol. 10, Pages 329-339: Toxicity of Cultured Bullseye Puffer Fish Sphoeroides annulatus Posted: 03 Feb 2012 12:00 AM PST The toxin content in various life cycle stages of tank-cultivated bullseye puffer (Sphoeroides annulatus) were analyzed by mouse bioassay and ESI-MS spectrometry analysis. The presence of toxin content was determined in extracts of sperm, eggs, embryo, larvae, post-larvae, juvenile, pre-adult, and adult fish, as well as in food items used during the cultivation of the species. Our findings show that only the muscle of juveniles, the viscera of pre-adults, and muscle, liver, and gonad of adult specimens were slightly toxic ( < 1 mouse unit). Thus, cultivated S. annulatus, as occurs with other cultivated puffer fish species, does not represent a food safety risk to consumers. This is the first report of toxin analysis covering the complete life stages of a puffer fish under controlled conditions.

Marine Drugs, Vol. 10, Pages 319-328: Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis Posted: 03 Feb 2012 12:00 AM PST Four novel amicoumacins, namely lipoamicoumacins A–D (1–4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.

Cubosphere Beta 0.2 (updated) Posted: 03 Feb 2012 02:29 AM PST 3d Puzzle similar to Kula World / Roll Away More about Cubosphere

Molecules, Vol. 17, Pages 1425-1436: Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives Posted: 03 Feb 2012 12:00 AM PST The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.

Molecules, Vol. 17, Pages 1419-1424: A New Iridoid Glycoside from the Roots of Dipsacus asper Posted: 03 Feb 2012 12:00 AM PST A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4′,4′′-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ25–35 induced cell death in PC12 cells.

Slovenia's ambassador apologizes to her children and her nation for signing ACTA, calls for mass demonstrations in Ljubljana tomorrow Posted: 03 Feb 2012 01:47 AM PST After Helena Drnovsek Zorko, Slovenia's ambassador to Japan, signed the Anti-Counterfeiting Trade Agreement, she was deluged with emails from Slovenians criticizing her for signing onto the agreement, which encourages widespread network censorship and creates criminal penalties for copyright infringement. The ambassador read the agreement more closely and decided she agreed with the critics, and wrote an open letter of apology to her country for signing them up to the treaty. The ambassador calls on Slovenians to converge on Ljubljana tomorrow, Saturday, Feb 4, to protest ACTA. I signed ACTA out of civic carelessness, because I did not pay enough attention. Quite simply, I did not clearly connect the agreement I had been instructed to sign with the agreement that, according to my own civic conviction, limits and withholds the freedom of engagement on the largest and most significant network in human history, and thus limits particularly the future of our children. I allowed myself a period of civic complacency, for a short time I unplugged myself from media reports from Slovenia, I took a break from Avaaz and its inflation of petitions, quite simply I allowed myself a rest. In my defence, I want to add that I very much needed this rest and that I am still having trouble gaining enough energy for the upcoming dragon year. At the same time, I am tackling a workload that increased, not lessened, with the advent of the current year. All in line with a motto that has become familiar to us all, likely not only diplomats: less for more. Less money and fewer people for more work. And then you overlook the significance of what you are signing. And you wake up the following morning with the weight of the unbearable lightness of some signature. First I apologised to my children. Then I tried to reply to those acquaintances and strangers who expressed their surprise and horror. Because there are more and more of them, I am responding to them publicly. I want to apologise because I carried out my official duty, but not my civic duty. I don't know how many options I had with regard to not signing, but I could have tried. I did not. I missed an opportunity to fight for the right of conscientious objection on the part of us bureaucrats. Full Text Of Slovenian Ambassador's Apology For Signing ACTA

ChatChat Posted: 02 Feb 2012 02:13 PM PST [Platform: Flash] ChatChat is an online multiplayer game by Terry Cavanagh, creator of VVVVVV. It's a highly intricate simulation involving deep-level behavioral algorithms and calculus-based — wait, no it isn't! It's about being a kitty! The wildest dream of every internet human has come true in this simple little game, giving you full permission to nap, purr, meow, and catch mice to your furry heart's content.

Molecules, Vol. 17, Pages 1408-1418: Supramolecular Photodimerization of Coumarins Posted: 03 Feb 2012 12:00 AM PST Stereoselective photodimerization of coumarin and its derivatives in supra-molecular systems is reviewed. The enantioselective photodimerization of coumarin and thiocoumarin in inclusion crystals with optically active host compounds is also described.

Zombie Grinder pre-alpha (new) Posted: 03 Feb 2012 01:26 AM PST Arcade-style multiplayer zombie shooter More about Zombie Grinder

The Darkness II Interview With Seth Olshfski Posted: 02 Feb 2012 10:18 PM PST Randolph Ramsay speaks to producer Seth Olshfski about the marriage of art style and gore in The Darkness II, as well as taking risks, changing studios, and the colour of demon piss!   Read and Post Comments | Get the full article at GameSpot "The Darkness II Interview With Seth Olshfski" was posted by edmondt on Thu, 02 Feb 2012 22:18:11 -0800

Shooters, MMOs linked to problem game playing - study Posted: 02 Feb 2012 08:37 PM PST A new study conducted by the Institute for Special Populations Research in New York reveals that some game genres are more prone to problem game-playing habits.   Video-game addiction has become a widely debated public health issue both in the US and overseas in the last five years, despite the lack of a formal diagnosis. While the American Psychiatric Association (APA) recently rejected a proposal to include video-game addiction in the next Diagnostic and Statistical Manual of Mental Disorders (DSM-V)--to be published in May 2013--researchers around the world continue to investigate methods of determining, treating, and preventing what has now become a recognised mental-health issue. A recent study conducted by the National Development and Research Institutes' Special Populations Research branch in New York has discovered a link between problem game playing and particular types of game genres. First-person shooters have been linked to problem game-playing habits. Luther Elliott, Andrew Golub, Eloise Dunlap, and Geoffrey Ream (the latter from the School of Social Work at Adelphi University in New York) surveyed 3380 adult participants over the age of 18 who said they played video games for an hour or more during the last week. The survey paid particular attention to characteristics of video-game use, including time played, titles played in the past year, and problems associated with playing. The research team then used Gamefaqs.com to sort the 2652 valid titles into 15 mutually exclusive genres: MMORPG, other role-playing, action-adventure, first-person shooter, other shooter, sports general, sports other, rhythm, driving, platformer, real-time strategy, other strategy, puzzle, board and card games, gambling, and other. The results of the survey showed that only 5 percent of respondents reported moderate to extreme problem game playing; of that 5 percent, the most problems showed up among those who reported playing either first-person shooters, action-adventure, role-playing, and gambling games during the past year. The most common titles reported by participants in the problem categories were: Call of Duty (first-person shooter category); Grand Theft Auto (action-adventure category); World of Warcraft (MMORPG category); and poker (gambling games category). This led the team to conclude that there is evidence to suggest that problem game playing is linked to particular kinds of game genres, but that future research into this area is needed, particularly research that pays attention to the game-design elements specific to the problem genres. "Recent sales figures for blockbuster series such as Call of Duty and Halo indicate a huge audience for the FPS genre in America; our findings suggest that a considerable sub-population is experiencing at least moderate degrees of problem video-game playing," the study says. "Perhaps the immersion potential of a first-person perspective, commonly combined with online competition, largely accounts for the higher rates of problem game playing. For action-adventure games, a trend towards nonlinear 'open-world' style environments in which extensive, time-consuming exploration is encouraged may create a context for more pervasive experiences of problem game playing." "These interpretations are speculative at this point, but suggest important avenues of exploration for future research." Read and Post Comments | Get the full article at GameSpot "Shooters, MMOs linked to problem game playing - study" was posted by Laura Parker on Thu, 02 Feb 2012 20:37:42 -0800

Beginners Guide - Twisted Metal: Multiplayer Demo Posted: 02 Feb 2012 08:04 PM PST We walk beginners through their first moments of slaughter in Twisted Metal.   Read and Post Comments | Get the full article at GameSpot "Beginners Guide - Twisted Metal: Multiplayer Demo" was posted by sampsona on Thu, 02 Feb 2012 20:04:07 -0800

Doodle Boat - Screenshots Posted: 03 Feb 2012 12:41 AM PST Steer your boat with absolutely precise tilt controls. Enjoy relaxing, but dexterity-challenging gameplay, and colorful graphics recreating the feel of summer vacation. Just don't forget to collect fuel tanks across the way, without them your ride will end sooner than you expect! Features: - colorful, doodle graphics - endless, always different game levels - relaxing, yet challenging gameplay - precise tilt controls - various obstacles such as buoyas, small islands, piers, other boats and many more! - sunbathing chicks!

Tribes: Ascend - Screenshots Posted: 03 Feb 2012 12:26 AM PST Loadouts Tribes: Ascend will feature a freemium payment system where they will pay for loadouts, such as Light, Medium and Heavy. Each loadout specifies what type of armor you have, along with what weapons and items you can carry. Loadouts will only support three weapons; two in-hand weapons and one melee object. Players select which loadouts to bring with them into each match, and can change them when either respawning or at an inventory station. H Game modes and Maps Hi-Rez Studios have stated that they are currently testing Capture the Flag, Team Deathmatch and Rabbit game modes. While some maps will retain the classic nature of the Tribes franchise with large open areas and base structures, others will have a more urban feel to them, featuring buildings and streets. Katabatic is one confirmed map for Tribes: Ascend, which originally appeared in Tribes 2. Mods and Servers The game will not be launched with any sort of mod or map making features.

IJMS, Vol. 13, Pages 1658-1669: Preparation of TiO2 Nanocrystallite Powders Coated with 9 mol% ZnO for Cosmetic Applications in Sunscreens Posted: 03 Feb 2012 12:00 AM PST The preparation of TiO2 nanocrystallite powders coated with and without 9 mol% ZnO has been studied for cosmetic applications in sunscreens by a co-precipitation process using TiCl4 and Zn(NO3)2·6H2O as starting materials. XRD results show that the phases of anatase TiO2 and rutile TiO2 coexist for precursor powders without added ZnO (T-0Z) and calcined at 523 to 973 K for 2 h. When the T-0Z precursor powders are calcined at 1273 K for 2 h, only the rutile TiO2 appears. In addition, when the TiO2 precursor powders contain 9 mol% ZnO (T-9Z) are calcined at 873 to 973 K for 2 h, the crystallized samples are composed of the major phase of rutile TiO2 and the minor phases of anatase TiO2 and Zn2Ti3O8. The analyses of UV/VIS/NIR spectra reveal that the absorption of the T-9Z precursor powders after being calcined has a red-shift effect in the UV range with increasing calcination temperature. Therefore, the TiO2 nanocrystallite powders coated with 9 mol% ZnO can be used as the attenuate agent in the UV-A region for cosmetic applications in sunscreens.

Pharmaceuticals, Vol. 5, Pages 155-168: Concerns Regarding the Use of Dabigatran for Stroke Prevention in Atrial Fibrillation Posted: 03 Feb 2012 12:00 AM PST Dabigatran is an oral thrombin inhibitor which has been approved in several countries as an alternative to vitamin-K-antagonists for the prevention of stroke or embolism in atrial fibrillation patients. Dabigatran is introduced into clinical practice, although many issues regarding this drug are still unclear, like laboratory monitoring, use in elderly patients, drug- and food-interactions and use in patients with renal insufficiency. Additionally, there is no antidote for dabigatran. Thus, aim of the present review is to give an overview of concerns and unresolved issues concerning dabigatran.

Molecules, Vol. 17, Pages 1388-1407: Synthesis, Docking Studies and Biological Evaluation of Benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one Derivatives on 5-HT1A Serotonin Receptors Posted: 03 Feb 2012 12:00 AM PST A series of novel benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and evaluated for their affinity towards 5-HT1A receptors. The influence of arylpiperazine moiety and benzo[b]thiophene ring substitutions on binding affinity was studied. The most promising analogue, 1-(benzo[b]thiophen-2-yl)-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-1-one (7e) displayed micromolar affinity (Ki = 2.30 μM) toward 5-HT1A sites. Docking studies shed light on the relevant electrostatic interactions which could explain the observed affinity for this compound.

Insects, Vol. 3, Pages 131-132: Correction: Lim and Forschler, Reticulitermes nelsonae, a New Species of Subterranean Termite (Rhinotermitidae) from the Southeastern United States. Insects 2012, 3, 62-90. Posted: 03 Feb 2012 12:00 AM PST Following publication of our article [1], we found errors in Table 4b. These errors do not make any difference to the main findings and conclusions reported in our paper. The numbers in the column for the range of mean ± 1 standard deviation for hind wings were incorrect. We wish to apologize for the mistake made and inconveniences caused. [...]

Administrative Sciences, Vol. 2, Pages 63-81: Leadership and Knowledge Management in an E-Government Environment Posted: 03 Feb 2012 12:00 AM PST The Malcolm Baldrige National Quality Award (MBNQA) is well known to assess quality and business processes in a variety of sectors, including government. In this study, we investigate the relationship between aspects of the MBNQA's leadership triad and knowledge management in an e-government context. Specifically, we survey 1,100 employees of a medium-sized city government in the United States to investigate the relationship between leadership triad components, leadership strategic planning, and customer/market focus, with knowledge management. Our results show that these components are significantly related to knowledge management and are important in the delivery of e-government applications to the citizenry.

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