среда, 22 февраля 2012 г.

Games

Games

Ambush

Posted: 22 Feb 2012 01:51 AM PST

A fun army tower-defense game! Place your soldiers in the fighting map and try stopping enemy troops.

Quantum

Posted: 22 Feb 2012 01:44 AM PST

Leap through platforms, avoid deadly traps and shoot magical portals that will help you reaching impossible places.

IJMS, Vol. 13, Pages 2387-2404: Pyrrolo[3,2-d]pyrimidine Derivatives as Type II Kinase Insert Domain Receptor (KDR) Inhibitors: CoMFA and CoMSIA Studies

Posted: 22 Feb 2012 12:00 AM PST

Kinase insert domain receptor (KDR) inhibitors have been proved to be very effective anticancer agents. Molecular docking, 3D-QSAR methods, CoMFA and CoMSIA were performed on pyrrolo[3,2-d]pyrimidine derivatives as non-ATP competitive KDR inhibitors (type II). The bioactive conformation was explored by docking one potent compound 20 into the active site of KDR in its DFG-out inactive conformation. The constructed CoMFA and CoMSIA models produced statistically significant results with the cross-validated correlation coefficients q2 of 0.542 and 0.552, non-cross-validated correlation coefficients r2 of 0.912 and 0.955, and predicted correction coefficients r2pred of 0.913 and 0.897, respectively. These results ensure the CoMFA and CoMSIA models as a tool to guide the design of a series of new potent KDR inhibitors.

IJMS, Vol. 13, Pages 2368-2386: Impaired Iron Status in Aging Research

Posted: 22 Feb 2012 12:00 AM PST

Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.

Cancers, Vol. 4, Pages 218-243: Tumor Microenvironment in the Brain

Posted: 22 Feb 2012 12:00 AM PST

In addition to malignant cancer cells, tumors contain a variety of different stromal cells that constitute the tumor microenvironment. Some of these cell types provide crucial support for tumor growth, while others have been suggested to actually inhibit tumor progression. The composition of tumor microenvironment varies depending on the tumor site. The brain in particular consists of numerous specialized cell types such as microglia, astrocytes, and brain endothelial cells. In addition to these brain-resident cells, primary and metastatic brain tumors have also been shown to be infiltrated by different populations of bone marrow-derived cells. The role of different cell types that constitute tumor microenvironment in the progression of brain malignancies is only poorly understood. Tumor microenvironment has been shown to be a promising therapeutic target and diagnostic marker in extracranial malignancies. A better understanding of tumor microenvironment in the brain would therefore be expected to contribute to the development of improved therapies for brain tumors that are urgently required due to a poor availability of treatments for these malignancies. This review summarizes some of the known interactions between brain tumors and different stromal cells, and also discusses potential therapeutic approaches within this context.

Cancers, Vol. 4, Pages 193-217: Tumor-Associated Antigens for Specific Immunotherapy of Prostate Cancer

Posted: 22 Feb 2012 12:00 AM PST

Prostate cancer (PCa) is the most common noncutaneous cancer diagnosis and the second leading cause of cancer-related deaths among men in the United States. Effective treatment modalities for advanced metastatic PCa are limited. Immunotherapeutic strategies based on T cells and antibodies represent interesting approaches to prevent progression from localized to advanced PCa and to improve survival outcomes for patients with advanced disease. CD8+ cytotoxic T lymphocytes (CTLs) efficiently recognize and destroy tumor cells. CD4+ T cells augment the antigen-presenting capacity of dendritic cells and promote the expansion of tumor-reactive CTLs. Antibodies mediate their antitumor effects via antibody-dependent cellular cytotoxicity, activation of the complement system, improving the uptake of coated tumor cells by phagocytes, and the functional interference of biological pathways essential for tumor growth. Consequently, several tumor-associated antigens (TAAs) have been identified that represent promising targets for T cell- or antibody-based immunotherapy. These TAAs comprise proteins preferentially expressed in normal and malignant prostate tissues and molecules which are not predominantly restricted to the prostate, but are overexpressed in various tumor entities including PCa. Clinical trials provide evidence that specific immunotherapeutic strategies using such TAAs represent safe and feasible concepts for the induction of immunological and clinical responses in PCa patients. However, further improvement of the current approaches is required which may be achieved by combining T cell- and/or antibody-based strategies with radio-, hormone-, chemo- or antiangiogenic therapy.

Future Internet, Vol. 4, Pages 179-215: A Flexible Object-of-Interest Annotation Framework for Online Video Portals

Posted: 22 Feb 2012 12:00 AM PST

In this work, we address the use of object recognition techniques to annotate what is shown where in online video collections. These annotations are suitable to retrieve specific video scenes for object related text queries which is not possible with the manually generated metadata that is used by current portals. We are not the first to present object annotations that are generated with content-based analysis methods. However, the proposed framework possesses some outstanding features that offer good prospects for its application in real video portals. Firstly, it can be easily used as background module in any video environment. Secondly, it is not based on a fixed analysis chain but on an extensive recognition infrastructure that can be used with all kinds of visual features, matching and machine learning techniques. New recognition approaches can be integrated into this infrastructure with low development costs and a configuration of the used recognition approaches can be performed even on a running system. Thus, this framework might also benefit from future advances in computer vision. Thirdly, we present an automatic selection approach to support the use of different recognition strategies for different objects. Last but not least, visual analysis can be performed efficiently on distributed, multi-processor environments and a database schema is presented to store the resulting video annotations as well as the off-line generated low-level features in a compact form. We achieve promising results in an annotation case study and the instance search task of the TRECVID 2011 challenge.

Energies, Vol. 5, Pages 459-465: Thermodynamic Stability of Structure H Hydrates Based on the Molecular Properties of Large Guest Molecules

Posted: 22 Feb 2012 12:00 AM PST

This paper report analyses of thermodynamic stability of structure-H clathrate hydrates formed with methane and large guest molecules in terms of their gas phase molecular sizes and molar masses for the selection of a large guest molecule providing better hydrate stability. We investigated the correlation among the gas phase molecular sizes, the molar masses of large molecule guest substances, and the equilibrium pressures. The results suggest that there exists a molecular-size value for the best stability. Also, at a given molecule size, better stability may be available when the large molecule guest substance has a larger molar mass.

Xia-Xia - Screenshots

Posted: 22 Feb 2012 02:13 AM PST

Set out on dozens of missions and along the way meet kooky friends and unlock loads of secret rewards in five unique worlds across 25 levels!  Keep your eyes open, you must discover the hidden starfish in each world to move on to other adventures.  With more than 30 collectible shells to uncover and over 60 missing friends to seek out, Xia-Xia the game provides hours of fun for all ages!

Persona 4 Arena - Screenshots

Posted: 22 Feb 2012 02:24 AM PST

Persona 4 Arena uses gorgeous, hand-drawn, high definition 2D anime-style fighters and colorful, over-the-top special effects to bring to life characters from the acclaimed, highly popular Persona 3 and Persona 4.  Backed up by an original, hardcore fighting engine from one of the most respected 2D fighting game developers in the industry, Persona 4 Arena represents the biggest, most noteworthy expansion of the esteemed series to date.

Energies, Vol. 5, Pages 438-458: Numerical Simulation of Methane Production from Hydrates Induced by Different Depressurizing Approaches

Posted: 22 Feb 2012 12:00 AM PST

Several studies have demonstrated that methane production from hydrate-bearing porous media by means of depressurization-induced dissociation can be a promising technique. In this study, a 2D axisymmetric model for simulating the gas production from hydrates by depressurization is developed to investigate the gas production behavior with different depressurizing approaches. The simulation results showed that the depressurization process with depressurizing range has significant influence on the final gas production. On the contrary, the depressurizing rate only affects the production lifetime. More amount of cumulative gas can be produced with a larger depressurization range or lowering the depressurizing rate for a certain depressurizing range. Through the comparison of the combined depressurization modes, the Class 2 (all the hydrate dissociation simulations are performed by reducing the initial system pressure with the same depressurizing range initially, then to continue the depressurization process conducted by different depressurizing rates and complete when the system pressure decreases to the atmospheric pressure) is much superior to the Class 1 (different depressurizing ranges are adopted in the initial period of the gas production process, when the pressure is reduced to the corresponding value of depressurization process at the different depressurizing range, the simulations are conducted at a certain depressurizing rate until the pressure reaches the atmospheric pressure) for a long and stable gas production process. The parameter analysis indicated that the gas production performance decreases and the period of stable production increases with the initial pressure for the case of depressurizing range. Additionally, for the case of depressurizing range, the better gas production performance is associated with higher ambient temperature for production process, and the effect of thermal conductivity on gas production performance can be negligible. However, for the case of depressurizing rate, the ambient temperature or thermal conductivity is dominant in different period of gas production process.

Energies, Vol. 5, Pages 420-437: The Driving Forces of Guest Substitution in Gas Hydrates—A Laser Raman Study on CH4-CO2 Exchange in the Presence of Impurities

Posted: 22 Feb 2012 12:00 AM PST

The recovery of CH4 gas from natural hydrate formations by injection of industrially emitted CO2 is considered to be a promising solution to simultaneously access an unconventional fossil fuel reserve and counteract atmospheric CO2 increase. CO2 obtained from industrial processes may contain traces of impurities such as SO2 or NOx and natural gas hydrates may contain higher hydrocarbons such as C2H6 and C3H8. These additions have an influence on the properties of the resulting hydrate phase and the conversion process of CH4-rich hydrates to CO2-rich hydrates. Here we show results of a microscopic and laser Raman in situ study investigating the effects of SO2-polluted CO2 and mixed CH4-C2H6 hydrate on the exchange process. Our study shows that the key driving force of the exchange processes is the establishment of the chemical equilibrium between hydrate phase and the surrounding phases. The exchange rate is also influenced by the guest-to-cavity ratio as well as the thermodynamic stability in terms of p-T conditions of the original and resulting hydrate phase. The most effective molecule exchange is related to structural changes (sI-sII) which indicates that hydrate decomposition and reformation processes are the occurring processes.

Energies, Vol. 5, Pages 399-419: A Review on Research on Replacement of CH4 in Natural Gas Hydrates by Use of CO2

Posted: 22 Feb 2012 12:00 AM PST

This paper introduces the research advances on replacement of CH4 in Natural Gas Hydrates (NGHs) by use of CO2 and discusses the advantages and disadvantages of the method on the natural gas production from such hydrates. Firstly, the feasibility of replacement is proven from the points of view of kinetics and thermodynamics, and confirmed by experiments. Then, the latest progress in CH4 replacement experiments with gaseous CO2, liquid CO2 and CO2 emulsion are presented Moreover, the superiority of CO2 emulsion for replacement of CH4 is emphasized. The latest experiment progress on preparation of CO2 emulsions are introduced. Finally, the advancements in simulation research on replacement is introduced, and the deficiencies of the simulations are pointed. The factors influencing on the replacement with different forms of CO2 are analyzed and the optimum conditions for the replacement of CH4 in hydrated with different forms of CO2 is suggested.

Das Liquid Democracy and the German Pirate Pary

Posted: 22 Feb 2012 01:59 AM PST

Amelia_G sez, "The German Pirate Party is working out its platform online, transparently. One key concept is 'das Liquid Democracy,' intended to be a flowing interface between direct and indirect democracy. You can delegate your vote to someone who will represent you, but you can withdraw your vote from that person at any time without waiting for new elections."

Bill to expand gambling to get Senate hearing

Posted: 22 Feb 2012 01:19 AM PST

The Senate Budget and Taxation Committee is scheduled to discuss the bill that would pave the way for table games like blackjack.

Etrian Odyssey IV slated for July in Japan

Posted: 22 Feb 2012 01:05 AM PST

Sequel to DS RPG now on its way to 3DS; features option to change difficulty.

The Etrian Odyssey series is known for its hardcore RPG gameplay tailor-made for the dual screens of the DS. Japanese magazine Famitsu (via Andriasang) recently announced a fourth game in the works by Atlus that will be released for the 3DS on July 5.

The sequel 's full title is Etrian Odyssey IV: Densetsu no Kyojin (Myth of the Giant) and introduces seven classes like the sniper, dancer and medic. New to the series is the option to set the game's difficulty to cater towards newcomers interested in the genre. The difficulty can be adjusted at any point during the game.

There is currently no word on a North American or European release at this point in time. The most recent entry in the franchise is Etrian Odyssey III: The Drowned City, which was released on the DS in 2010. The game was praised for its challenge level and sea voyages that complement the dungeon-crawling segments, but was criticized for its steep learning curve and bare-bones plot.

Read and Post Comments | Get the full article at GameSpot

"Etrian Odyssey IV slated for July in Japan" was posted by Jonathan Leo Toyad on Wed, 22 Feb 2012 01:05:40 -0800

Persona 4 The Golden shining on June 14 in Japan

Posted: 21 Feb 2012 09:59 PM PST

PS Vita remake of acclaimed RPG to also come in special bundle.

 

The last update regarding a Vita version of PS2 darling Persona 4 was back in 2011. Fans of the RPG who wished for a portable version will not have to wait too long, as Japanese magazine Famitsu has now revealed the date for the port: June 14.

In addition, Famitsu publisher Enterbrain is teaming up with Atlus to release a Famitsu DX Pack exclusively in Japan via the company's e-commerce site. The bundle contains 10 post cards, a customized pouch, and six A3-sized posters featuring Persona 4 artwork from Shigenori Soejima, Shuji Sogabe, Mad House, Studio Hibari and Hiroyuki Maeda. This set will cost gamers 10,290 yen.

In related news, Arc System Works is also developing a 2D fighting game called Persona 4: Ultimate in Mayonaka Arena which is coming out for the US market this Summer. The arcade version of the title is hitting Japan this March.

Read and Post Comments | Get the full article at GameSpot

"Persona 4 The Golden shining on June 14 in Japan" was posted by Jonathan Leo Toyad on Tue, 21 Feb 2012 21:59:19 -0800

D.I.C.E. 2012 PlayStation Vita Thoughts Video Feature

Posted: 21 Feb 2012 09:24 PM PST

Leaders of the industry chime in on their thoughts of the Sony PlayStation Vita and the future of Mobile gaming at D.I.C.E 2012

 

Read and Post Comments | Get the full article at GameSpot

"D.I.C.E. 2012 PlayStation Vita Thoughts Video Feature" was posted by Wern on Tue, 21 Feb 2012 21:24:12 -0800

Kojima hiring for next Metal Gear Solid

Posted: 21 Feb 2012 09:01 PM PST

Hideo Kojima unveils GDC job site for upcoming Metal Gear title; site displays Big Boss; Californian development studio on the horizon.

 

Metal Gear Solid creator Hideo Kojima today revealed the search is on to find new development talent for the next title in the popular franchise.

Kojima used Twitter to unveil a GDC job portal site with the title: "Big Boss Wants You; The 'Next' MGS".

The site advertises for programming, art, game design, sound, and production roles, highlighting the next Metal Gear Solid is "targeted for high-end consoles and PC" and will use the FOX Engine.

The site advertises for positions in two locations: Japan, and California, US. Kojima Productions producer Ken-ichiro Imaizumi tweeted that the company is planning to open a studio in California, "if we can find the right people".

Another part of the site links to an image of Big Boss, but reveals no further information.

Kojima has alluded to the next series in the franchise in the past, and rumours pinned Kojima's next project as powered by the FOX Engine, which was publicly shown for the first time during Konami's Electronic Entertainment Expo press conference last year.

Read and Post Comments | Get the full article at GameSpot

"Kojima hiring for next Metal Gear Solid" was posted by Laura Parker on Tue, 21 Feb 2012 21:01:30 -0800

Simplz: Zoo - Screenshots

Posted: 22 Feb 2012 01:30 AM PST

While half of  Simplz: Zoo is spent improving the zoo itself, the other half is spent playing a match-3 puzzle game to gather the resources needed to keep the zoo running and expanding. Each exhibit purchased comes with a new power-up or token that will be added to the match-3 game. As the zoo expands and changes so does the match-3 game, fueled by the choices made in purchasing exhibits.  Simplz: Zoo  puts the game play in the hands of the player allowing players to customize it to whatever suits them best.

This unique blend of gameplay  isn't the only thing unique to  Simplz: Zoo as the puzzle half of the game features a variety of different types of match-3 puzzles including the clearing of tiles and chains, getting boxes to the bottom of the board, and our unique Animal Trail levels where players will need to make matches in front of an animal in order for it to reach its goal! Players will also discover the joy of diagonal movement and we promise that after trying it they'll never look at a match-3 board in quite the same way again!
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