понедельник, 20 февраля 2012 г.

Games

Games

Copyright forever

Posted: 20 Feb 2012 02:54 AM PST

Games creator Adrian Hon has a parodical modest proposal in the Telegraph: eternal copyright.

Go fish

Posted: 20 Feb 2012 02:38 AM PST

The Kendall Young Library was packed to the rafters Friday night as scores of area families attended the fourth annual Family Game Night.

This posting includes an audio/video/photo media file: Download Now

Shane Warne's Ad Appears on Porn Site [VIDEO]

Posted: 20 Feb 2012 02:38 AM PST

Australia's famous former cricketer is now involved in another controversy as the advertisement for his 888 online poker business appeared on a hardcore porn website.

This posting includes an audio/video/photo media file: Download Now

Temple Guns - Screenshots

Posted: 20 Feb 2012 02:21 AM PST

Temple Gun is the most exciting and addictive typing game ever on the app store. It is also one of the best agility game available.

Features:
- Progressive difficulty
- Increasingly difficult levels.
- Compete and compare scores against players around the world via Game Center.
- Global Leaderboards

Tips:
- Try not to make mistakes to avoid paratroopers falling faster
- Shoot perfectly to maximize your score
- Kill'em'all before the destroy you!

Pizza Vs. Skeletons - Screenshots

Posted: 20 Feb 2012 02:31 AM PST

FEATURES:
- 100 fantastically ridiculous levels with more to come
- 3 distinct challenges in each level
- Dozens of enemies
- Huge bosses
- Customize the perfect hero--add peppers, a powdered wig, be a peanut butter and jelly sandwich... design over A QUARTER MILLION PIZZAS!
- Facebook and Twitter: post pictures of your tricked-out hero and brag about your hi-scores
- Universal App: buy it once, play on iPhone, iPad, and iPod Touch
- Game Center: online leaderboards and challenging achievements
- High-definition "Retina" graphics for iPhone 4/4S

Grand Theft Auto: Chinatown Wars - Screenshots

Posted: 20 Feb 2012 02:19 AM PST

Grand Theft Auto: Chinatown Wars Lite is an introduction to your criminal career in the most dangerous city in America brought to Your iPhone or iPod Touch.

League of Evil 2 - Screenshots

Posted: 20 Feb 2012 02:39 AM PST

FEATURES:
- Over 100 levels across 5 environments
- Boss Battles
- Sick acrobatics: Jump, flip, wall jump, wall hug, double jump
- Decapitations and gibs
- Ridiculously smooth animations.
- User selectable costumes.
- Hand illustrated graphics and comic book style cutscenes

Running Fred - Screenshots

Posted: 20 Feb 2012 02:11 AM PST

Main Features:
- Lots of acrobatic maneuvers
- Dozens of perilous traps
- Multiple game modes: Adventure, Challenge and our favourite Endless Survival!
- Tons of special skills and perks
- Lot of characters to choose from!
- Pimp up your character with special outfits
- Keep your progress across all your devices
- Share your score with your friends via Game Center

Mobile Monday

Posted: 19 Feb 2012 04:23 PM PST

[Platform: Mobile (Android)] Word games everywhere! Word games galore! Except, there's just one word game, but it's really fun, so let's pretend! There's also crazy RPG running game and a game with cherries and a guy with really long legs. And if you thought "hey, I know what long legs are!", you're probably wrong, because this guy's legs are really long.

IJMS, Vol. 13, Pages 2263-2275: Comprehensive and Facile Synthesis of Some Functionalized Bis-Heterocyclic Compounds Containing a Thieno[2,3-b]thiophene Motif

Posted: 20 Feb 2012 12:00 AM PST

A comprehensive and facile method for the synthesis of new functionalized bis-heterocyclic compounds containing a thieno[2,3-b]thiophene motif is described. The hitherto unknown bis-pyrazolothieno[2,3-b]thiophene derivatives 2a–c, bis-pyridazin othieno[2,3-b]thiophene derivatives 4, bis-pyridinothieno[2,3-b]thiophene derivatives 6a,b, and to an analogous bis-pyridinothieno[2,3-b]thiophene nitrile derivatives 7 are obtained. Additionally, the novel bis-pyradazinonothieno[2,3-b]thiophene derivatives 9, and nicotinic acid derivatives 10, 11 are obtained via bis-dienamide 8. The structures of all newly synthesized compounds have been elucidated by 1H, 13C NMR, GCMS, and IR spectrometry. These compounds represent a new class of sulfur and Nitrogen containing heterocycles that should also be of interest as new materials.

IJMS, Vol. 13, Pages 2249-2262: Seasonal Variations of the Antioxidant Composition in Ground Bamboo Sasa argenteastriatus Leaves

Posted: 20 Feb 2012 12:00 AM PST

Sasa argenteastriatus, with abundant active compounds and high antioxidant activity in leaves, is a new leafy bamboo grove suitable for exploitation. To utilize it more effectively and scientifically, we investigate the seasonal variations of antioxidant composition in its leaves and antioxidant activity. The leaves of Sasa argenteastriatus were collected on the 5th day of each month in three same-sized sample plots from May 2009 to May 2011. The total flavonoids (TF): phenolics (TP) and triterpenoid (TT) of bamboo leaves were extracted and the contents analyzed by UV-spectrophotometer. Our data showed that all exhibited variations with the changing seasons, with the highest levels appearing in November to March. Antioxidant activity was measured using DPPH and FRAP methods. The highest antioxidant activity appeared in December with the lowest in May. Correlation analyses demonstrated that TP and TF exhibited high correlation with bamboo antioxidant activity. Eight bamboo characteristic compounds (orientin, isoorientin, vitexin, homovitexin and p-coumaric acid, chlorogenic acid, caffeic acid, ferulic acid) were determined by RP-HPLC synchronously. We found that chlorogenic acid, isoorientin and vitexin are the main compounds in Sasa argenteastriatus leaves and the content of isovitexin and chlorogenic acid showed a similar seasonal variation with the TF, TP and TT. Our results suggested that the optimum season for harvesting Sasa argenteastriatus leaves is between autumn and winter.

Cancers, Vol. 4, Pages 156-164: Does Secondary Inflammatory Breast Cancer Represent Post-Surgical Metastatic Disease?

Posted: 20 Feb 2012 12:00 AM PST

The phenomenon of accelerated tumor growth following surgery has been observed repeatedly and merits further study. Inflammatory breast carcinoma (IBC) is widely recognized as an extremely aggressive malignancy characterized by micrometastasis at the time of diagnosis, with one interesting subgroup defined as secondary IBC where pathologically identifiable IBC appears after surgical treatment of a primary non-inflammatory breast cancer. One possible mechanism can be related to the stimulation of dormant micrometastasis through local angiogenesis occurring as part of posttraumatic healing. In this report, we review cases of secondary IBC and others where localized trauma was followed by the appearance of IBC at the traumatized site that have been identified by our IBC Registry (IBCR) and hypothesize that angiogenesis appearing as part of the healing process could act as an accelerant to an otherwise latent breast malignancy. It is therefore possible that secondary IBC can be used as a model to support local angiogenesis as an important contributor to the development of an aggressive cancer.

Molecules, Vol. 17, Pages 2073-2081: The Role of Water in Lanthanide-Catalyzed Carbon–Carbon Bond Formation

Posted: 20 Feb 2012 12:00 AM PST

Luminescence-decay measurements in combination with high-performance liquid chromatography analyses were used to study the relationship between rates of catalysis and water-coordination numbers of europium-based precatalysts in the aqueous Mukaiyama aldol reaction. A correlation between reactivity and water-coordination number was observed and is reported here.

Nutrients, Vol. 4, Pages 112-131: Assessment of the Effect of High or Low Protein Diet on the Human Urine Metabolome as Measured by NMR

Posted: 20 Feb 2012 12:00 AM PST

The objective of this study was to identify urinary metabolite profiles that discriminate between high and low intake of dietary protein during a dietary intervention. Seventy-seven overweight, non-diabetic subjects followed an 8-week low-calorie diet (LCD) and were then randomly assigned to a high (HP) or low (LP) protein diet for 6 months. Twenty-four hours urine samples were collected at baseline (prior to the 8-week LCD) and after dietary intervention; at months 1, 3 and 6, respectively. Metabolite profiling was performed by 1H NMR and chemometrics. Using partial least squares regression (PLS), it was possible to develop excellent prediction models for urinary nitrogen (root mean square error of cross validation (RMSECV) = 1.63 mmol/L; r = 0.89) and urinary creatinine (RMSECV = 0.66 mmol/L; r = 0.98). The obtained high correlations firmly establish the validity of the metabolomic approach since urinary nitrogen is a well established biomarker for daily protein consumption. The models showed that trimethylamine-N-oxide (TMAO) is correlated to urinary nitrogen. Furthermore, urinary creatine was found to be increased by the HP diet whereas citric acid was increased by the LP diet. Despite large variations in individual dietary intake, differentiated metabolite profiles were observed at the dietary group-level.

Symmetry, Vol. 4, Pages 143-207: Intrinsic Symmetry Groups of Links with 8 and Fewer Crossings

Posted: 20 Feb 2012 12:00 AM PST

We present an elementary derivation of the "intrinsic" symmetry groups for links of 8 or fewer crossings. We show that standard invariants are enough to rule out all potential symmetries outside the symmetry group of the group of the link for all but one of these links and present explicit isotopies generating the symmetry group for every link.

Marine Drugs, Vol. 10, Pages 497-508: A Sterol and Spiroditerpenoids from a Penicillium sp. Isolated from a Deep Sea Sediment Sample

Posted: 20 Feb 2012 12:00 AM PST

A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I–K (2–4), and the known breviones (5–8), were isolated from the crude extract of a Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of 1–4 were elucidated primarily by NMR experiments, and 1 was further confirmed by X-ray crystallography. The absolute configurations of 2 and 3 were deduced by comparison of their CD spectra with those of the model compounds. Compounds 2 and 5 showed significant cytotoxicity against MCF-7 cells, which is comparable to the positive control cisplatin.

Sensors, Vol. 12, Pages 2309-2323: Design and Implementation of an Omni-Directional Underwater Acoustic Micro-Modem Based on a Low-Power Micro-Controller Unit

Posted: 20 Feb 2012 12:00 AM PST

For decades, underwater acoustic communication has been restricted to the point-to-point long distance applications such as deep sea probes and offshore oil fields. For this reason, previous acoustic modems were typically characterized by high data rates and long working ranges at the expense of large size and high power consumption. Recently, as the need for underwater wireless sensor networks (UWSNs) has increased, the research and development of compact and low-power consuming communication devices has become the focus. From the consideration that the requisites of acoustic modems for UWSNs are low power consumption, omni-directional beam pattern, low cost and so on, in this paper, we design and implement an omni-directional underwater acoustic micro-modem satisfying these requirements. In order to execute fast digital domain signal processing and support flexible interfaces with other peripherals, an ARM Cortex-M3 is embedded in the micro-modem. Also, for the realization of small and omni-directional properties, a spherical transducer having a resonant frequency of 70 kHz and a diameter of 34 mm is utilized for the implementation. Physical layer frame format and symbol structure for efficient packet-based underwater communication systems are also investigated. The developed acoustic micro-modem is verified analytically and experimentally in indoor and outdoor environments in terms of functionality and performance. Since the modem satisfies the requirements for use in UWSNs, it could be deployed in a wide range of applications requiring underwater acoustic communication.

Molecules, Vol. 17, Pages 2058-2072: Volatile Organic Compounds from Centaurium erythraea Rafn (Croatia) and the Antimicrobial Potential of Its Essential Oil

Posted: 20 Feb 2012 12:00 AM PST

GC and MS were used for the analysis of Croatian Centaurium erythraea Rafn essential oil (obtained by hydrodistillation) and headspace (applying headspace solid-phase microextraction). The headspace contained numerous monoterpene hydrocarbons (the major ones were terpinene-4-ol, methone, p-cymene, γ-terpinene and limonene). Oxygenated monoterpenes were present in the headspace and oil, while 1,8-cineole, bornyl acetate and verbenone were present only in the headspace. High headspace percentages of toluene and naphthalene were found, followed by hemimellitene. Lot of similarities were observed with Serbian C. erythraea oil [neophytadiene (1.4%), thymol (2.6%), carvacrol (6.1%) and hexadecanoic acid (5.7%)], but different features were also noted such as the presence of menthol, menthone and phytone. The oil fractionation enabled identification of other minor compounds not found in total oil such as norisoprenoides, alk-1-enes or chromolaenin. The essential oil showed antimicrobial potential on Escherichia coli, Salmonella enteritidis, Staphylococcus aureus and Bacillus cereus. On the other hand, no antibacterial activity of the oil was observed on Pseudomonas fluorescens and Lysteria monocytogenes.

Molecules, Vol. 17, Pages 2049-2057: Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides

Posted: 20 Feb 2012 12:00 AM PST

In the present work we describe the structure and anti-inflammatory activity of a new compound, kramecyne, isolated from a methanol extract of Krameria cytisoides (Krameriaceae). The structure of kramecyne was determined by IR, NMR, MS, and elemental analysis, which indicated that the structure corresponded to a hexamer of cyclic peroxide monomers. This compound exhibited good anti-inflammatory activity in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema (51.8 ± 6.9% inhibition) and carrageenan-induced rat paw edema models at doses of 50 mg/kg. The compound significantly reduced edema to 63.1% after 1.0 h, and the effect was unchanged for 5 h. Kramecyne did not present acute toxicity, even at doses of 5,000 mg/kg.

Molecules, Vol. 17, Pages 2030-2048: Astaxanthin in Cardiovascular Health and Disease

Posted: 20 Feb 2012 12:00 AM PST

Oxidative stress and inflammation are established processes contributing to cardiovascular disease caused by atherosclerosis. However, antioxidant therapies tested in cardiovascular disease such as vitamin E, C and β-carotene have proved unsuccessful at reducing cardiovascular events and mortality. Although these outcomes may reflect limitations in trial design, new, more potent antioxidant therapies are being pursued. Astaxanthin, a carotenoid found in microalgae, fungi, complex plants, seafood, flamingos and quail is one such agent. It has antioxidant and anti-inflammatory effects. Limited, short duration and small sample size studies have assessed the effects of astaxanthin on oxidative stress and inflammation biomarkers and have investigated bioavailability and safety. So far no significant adverse events have been observed and biomarkers of oxidative stress and inflammation are attenuated with astaxanthin supplementation. Experimental investigations in a range of species using a cardiac ischaemia-reperfusion model demonstrated cardiac muscle preservation when astaxanthin is administered either orally or intravenously prior to the induction of ischaemia. Human clinical cardiovascular studies using astaxanthin therapy have not yet been reported. On the basis of the promising results of experimental cardiovascular studies and the physicochemical and antioxidant properties and safety profile of astaxanthin, clinical trials should be undertaken.
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