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- Molecules, Vol. 17, Pages 1686-1697: Phytochemical and Antioxidant-Related Investigations on Bark of Abies spectabilis (D. Don) Spach. from Nepal
- Molecules, Vol. 17, Pages 1675-1685: Multicomponent Synthesis of 3,6-Dihydro-2H-1,3-thiazine-2-thiones
- Molecules, Vol. 17, Pages 1665-1674: Chiral Flavanones from Amygdalus lycioides Spach: Structural Elucidation and Identification of TNFalpha Inhibitors by Bioactivity-guided Fractionation
- Minerals, Vol. 2, Pages 1-10: Management of Sulfide-Bearing Waste, a Challenge for the Mining Industry
- Religions, Vol. 3, Pages 37-49: Inscribing Authority: Female Title Bearers in Jewish Inscriptions
- Toss the Barrel - Screenshots
- Hip-Hop Chess Tourney Comes to Silicon Valley
- English plainclothes police officer follows himself for 20 minutes
- Membranes, Vol. 2, Pages 40-69: Thin Hydrogel Films for Optical Biosensor Applications
- Micromachines, Vol. 3, Pages 55-61: Surface Plasmon Excitation and Localization by Metal-Coated Axicon Prism
- IJMS, Vol. 13, Pages 1790-1803: Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium
- IJMS, Vol. 13, Pages 1778-1789: Cinnamic Acid and Its Derivatives Inhibit Fructose-Mediated Protein Glycation
- IJMS, Vol. 13, Pages 1762-1777: 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell Proliferation and Migration Enhancer
- Cancers, Vol. 4, Pages 113-129: Medical Treatment of Gastroenteropancreatic Neuroendocrine Tumors
- Cancers, Vol. 4, Pages 100-112: PET-Guided Surgery — High Correlation between Positron Emission Tomography with 11C-5-Hydroxytryptophane (5-HTP) and Surgical Findings in Abdominal Neuroendocrine Tumours
- Energies, Vol. 5, Pages 270-290: Experimental Investigation on NOx Reduction by Primary Measures in Biomass Combustion: Straw, Peat, Sewage Sludge, Forest Residues and Wood Pellets
- QuickBooks Pro 2012 13.0.7 R8 - Financial management and accounting for small businesses.. (Demo)
- Apple iMac EFI Firmware Update 1.8 - For mid 2010 iMacs.. (Updater)
- ForkLift 2.5 Alpha 8 - Powerful file manager: FTP, WebDAV, S3, Bluetooth, more.. (Shareware)
- MacBook Pro EFI Firmware Update 2.6 - For early 2010 MacBook Pros.. (Updater)
| Posted: 08 Feb 2012 12:00 AM PST The bark of several coniferous species, a waste product of the timber industry, contains significant amounts of natural antioxidants. In our ongoing studies of Nepalese medicinal plants, we examined the bark from Abies spectabilis as the starting material for extracting antioxidant compounds. In vitro antioxidant activity evaluated by means of three antioxidant methods, namely 2,2-diphenyl-1-picrylhydrazyl (DPPH), Briggs-Rauscher oscillating reaction (BR) and Trolox Equivalent Antioxidant Capacity (TEAC) and total phenol contents with the Folin-Ciocalteau reagent; the ferrous iron chelating capacity was also assessed. The methanol extract of A. spectabilis showed significant antioxidant activity and polyphenol contents (IC50 4.13 µg/mL, 0.20 μg/mL eq. resorcinol, 4.22 mM eq. Trolox, 3.9 µg/g eq. gallic Acid in the DPPH, BR, TEAC and Folin-Ciocalteau tests, respectively) and weak Fe2+ chelating capacity. Phytochemical studies were also carried out with 1D- and 2D NMR experiments and DI-ESI-MS, HPLC-DAD and LC-MSn measurements. Oligomeric C-type proanthocyanidins, mainly trimeric gallocatechin derivatives, were the most abundant compounds (16% of extract expressed as procyanindin B1). Gallocatechin oligomers (up to six units) and prodelphynidin-gallocatechin polymers were also identified in the extract. Prodelphynidin B4, cyclograndisolide and trans-docosanil ferulate were also isolated and characterized by NMR and MS spectroscopy. |
| Posted: 08 Feb 2012 12:00 AM PST Non-fused 3,6-dihydro-2H-1,3-thiazine-2-thiones constitute a so far rather unexplored class of compounds, with the latest report dating back more than two decades. Thiazine-2-thiones contain an endocyclic dithiocarbamate group, which is often found in pesticides, in substrates for radical chemistry and in synthetic intermediates towards thioureas and amidines. We now report the multicomponent reaction (MCR) of in situ-generated 1-azadienes with carbon disulfide. With this reaction, a one-step protocol towards the potentially interesting 3,6-dihydro-2H-1,3-thiazine-2-thiones was established and a small library was synthesized. |
| Posted: 08 Feb 2012 12:00 AM PST Phytochemical investigation on the Amygdalus lycioides Spach branchelets resulted in the isolation of four chiral flavanones: (2R,3R)-Taxifolin, (2R,3R)-aromadendrin, (S)-5,7,3',5'-tetrahydroxyflavanone and (S)-naringenin. The flavanones were isolated by semi-preparative HPLC, their structures elucidated based on spectroscopic data and their absolute configuration assigned. As a part of our ethnobotanical-directed search for novel TNFα inhibitors, the bioassay-guided fractionation of the n-hexane-acetone (n-Hex-Ac, 1:1 v/v) Amygdalus lycioides Spach branchelets extract was performed. In this way, (S)-naringenin was identified as the constituent responsible for the TNFα blocking effect, being effective in vitro and in vivo after oral administration. This is the first investigation on bioactive secondary metabolites of Amygdalus lycioides Spach branchelets. |
| Posted: 08 Feb 2012 12:00 AM PST Oxidation of iron sulfides in waste rock dumps and tailings deposits may result in formation of acid rock drainage (ARD), which often is a challenging problem at mine sites. Therefore, integrating an ARD management plan into the actual mine operations in the early phases of exploration, continuing through the mine life until final closure might be successful and decrease the environmental impact. A thorough characterization of ore and waste should be performed at an early stage. A detailed knowledge of mineralogical composition, chemical composition and physical properties such as grain size, porosity and hydraulic conductivity of the different waste types is necessary for reliable predictions of ARD formation and efficiency of mitigation measures. Different approaches to prevent and mitigate ARD are discussed. Another key element of successfully planning to prevent ARD and to close a mining operation sustainably is to engage the mine stakeholders (regulators, community and government leaders, non-governmental organization (NGOs) and lenders) in helping develop and implement the ARD management plan. |
| Religions, Vol. 3, Pages 37-49: Inscribing Authority: Female Title Bearers in Jewish Inscriptions Posted: 08 Feb 2012 12:00 AM PST This paper investigates representations of gender in the material culture of the ancient synagogue. The pertinent data are numerous dedicatory and funerary inscriptions linking individual Jews, men and women, with titles seemingly associated with leadership in Late Antique synagogues (ca. 200–600 CE). Bernadette Brooten's influential 1982 monograph argued against the prevailing tendency to characterize these titles as indications of power, authority, and responsibility when associated with men but as meaningless flattery when applied to women. She suggests that synagogue titles denote power, authority and responsibility on all title bearers equally, both men and women. I question the continued utility of proffering female title-holders as enumerable examples of powerful women rescued from their forgotten place in history. Using theoretical insights developed by historians Elizabeth Clark and Gabrielle Spiegel, this paper will engage a comparative analysis with the work of Riet van Bremen and Saba Mahmood to develop new methods of conceptualizing women's authority in early Jewish communities. I propose that viewing women's synagogue titles as culturally constructed representations allows for a fruitful inquiry into how women's titles were used by male-dominated synagogue communities in their self-articulation and public presentation of Judaism. |
| Posted: 08 Feb 2012 03:04 AM PST You have to toss a specific amount of barrels on every level to proceed to the next one. Each level will present you with different obstacles sets , those together with a very limited amount of time and weapon will make each level more and more challenging to pass. Game Includes: - Realistic 3D Graphics - Real Physics Engine - Unique Levels with increasing difficulty - TOP Scores Board - Different Environments - Different Weapons to Choose From |
| Hip-Hop Chess Tourney Comes to Silicon Valley Posted: 08 Feb 2012 02:22 AM PST We're talking about a chess board. Come Saturday, February 11th, in San Jose, the boards will be hot, and so will the turntables. This posting includes an audio/video/photo media file: Download Now |
| English plainclothes police officer follows himself for 20 minutes Posted: 08 Feb 2012 02:21 AM PST An undercover police officer in Sussex, England, shadowed a suspicious character through the streets a small market town for 20 minutes, following directions passed to him by a CCTV operator who guided him towards the suspect. After 20 minutes, the CCTV operator realized that the "suspicious character" was the police officer himself.
CCTV police officer 'chased himself' after being mistaken for burglar (via Neatorama) |
| Membranes, Vol. 2, Pages 40-69: Thin Hydrogel Films for Optical Biosensor Applications Posted: 08 Feb 2012 12:00 AM PST Hydrogel materials consisting of water-swollen polymer networks exhibit a large number of specific properties highly attractive for a variety of optical biosensor applications. This properties profile embraces the aqueous swelling medium as the basis of biocompatibility, non-fouling behavior, and being not cell toxic, while providing high optical quality and transparency. The present review focuses on some of the most interesting aspects of surface-attached hydrogel films as active binding matrices in optical biosensors based on surface plasmon resonance and optical waveguide mode spectroscopy. In particular, the chemical nature, specific properties, and applications of such hydrogel surface architectures for highly sensitive affinity biosensors based on evanescent wave optics are discussed. The specific class of responsive hydrogel systems, which can change their physical state in response to externally applied stimuli, have found large interest as sophisticated materials that provide a complex behavior to hydrogel-based sensing devices. |
| Posted: 08 Feb 2012 12:00 AM PST Collimated Gaussian beams are efficiently localized at the apex of a metal-coated axicon prism by surface plasmon excitations. We observed the light scattered at the apex and the light reflected by the prism. Intense scattered light was observed with the radial polarization incidence. Further, each incidence of the radial, azimuthal, and linear polarizations provided field distributions of bright and dark intensities in the reflected images according to the surface plasmon excitation. We have demonstrated that surface plasmon waves are excited at the sides of the prism in the Kretschmann configuration and that they converge to its apex. |
| Posted: 08 Feb 2012 12:00 AM PST Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of several cancers, but with several side effects such as nephrotoxicity. The present study investigated the possible protective effect of selenium (Se) against CP-induced oxidative stress in the rat kidneys. Male Wistar albino rats were injected with a single dose of cisplatin (7 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.), alone or in combination. The obtained results showed that CP increased lipid peroxidation (LPO) and decreased reduced glutathione (GSH) concentrations, suggesting the CP-induced oxidative stress, while Se treatment reversed this change to control values. Acute intoxication of rats with CP was followed by statistically significant decreased activity of antioxidant defense enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST). Treatment with Se reversed CP-induced alterations of antioxidant defense enzyme activities and significantly prevented the CP-induced kidney damage. |
| Posted: 08 Feb 2012 12:00 AM PST Cinnamic acid and its derivatives have shown a variety of pharmacologic properties. However, little is known about the antiglycation properties of cinnamic acid and its derivatives. The present study sought to characterize the protein glycation inhibitory activity of cinnamic acid and its derivatives in a bovine serum albumin (BSA)/fructose system. The results demonstrated that cinnamic acid and its derivatives significantly inhibited the formation of advanced glycation end products (AGEs) by approximately 11.96–63.36% at a concentration of 1 mM. The strongest inhibitory activity against the formation of AGEs was shown by cinnamic acid. Furthermore, cinnamic acid and its derivatives reduced the level of fructosamine, the formation of Nε-(carboxymethyl) lysine (CML), and the level of amyloid cross β-structure. Cinnamic acid and its derivatives also prevented oxidative protein damages, including effects on protein carbonyl formation and thiol oxidation of BSA. Our findings may lead to the possibility of using cinnamic acid and its derivatives for preventing AGE-mediated diabetic complications. |
| Posted: 08 Feb 2012 12:00 AM PST In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent. |
| Cancers, Vol. 4, Pages 113-129: Medical Treatment of Gastroenteropancreatic Neuroendocrine Tumors Posted: 08 Feb 2012 12:00 AM PST Treatment of the clinically and prognostically heterogeneous neuroendocrine neoplasms (NEN) should be based on a multidisciplinary approach, including surgical, interventional, medical and nuclear medicine-based therapeutic options. Medical therapies include somatostatin analogues, interferon-a, mTOR inhibitors, multikinase inhibitors and systemic chemotherapy. For the selection of the appropriate medical treatment the hormonal activity, primary tumor localization, tumor grading and growth behaviour as well as the extent of the disease must be considered. Somatostatin analogues are mainly indicated in hormonally active tumors for symptomatic relief, but antiproliferative effects have also been demonstrated, especially in well-differentiated intestinal NET. The efficacy of everolimus and sunitinib in patients with pancreatic neuroendocrine tumors (pNET) has been demonstrated in large placebo-controlled clinical trials. pNETs are also chemosensitive. Streptozocin-based chemotherapeutic regimens are regarded as current standard of care. Temozolomide in combination with capecitabine is an alternative that has shown promising results that need to be confirmed in larger trials. Currently, no comparative studies and no molecular markers are established that predict the response to medical treatment. Therefore the choice of treatment for each pNET patient is based on individual parameters taking into account the patient's preference, expected side effects and established response criteria such as proliferation rate and tumor load. Platin-based chemotherapy is still the standard treatment for poorly differentiated neuroendocrine carcinomas. Clearly, there is an unmet need for new systemic treatment options in patients with extrapancreatic neuroendocrine tumors. |
| Posted: 08 Feb 2012 12:00 AM PST Positron emission tomography (PET) with 11C-labeled 5-hydroxytryptophane (5-HTP) is a sensitive technique to visualize neuroendocrine tumours (NETs), due to high intracellular uptake of amine-precursors like L-dihydroxyphenylalanine (L-DOPA) and 5-HTP. NETs are often small and difficult to localize in spite of overt clinical symptoms due to hormonal excess. In our study, 38 consecutive NET patients underwent 11C-5-HTP-PET and morphological imaging by CT within 12 weeks prior to surgery. Surgical, histopathological and 5-HTP PET findings were correlated. 11C-5-HTP-PET corresponded to the surgical findings in 31 cases, was false negative in six, and true negative in one case resulting in 83.8% sensitivity and 100% specificity. Positive predicted value was 100%. In 11 patients 11C-5-HTP-PET was the only imaging method applied to localize the tumour. Thus, we could demonstrate that functional imaging by 11C-5-HTP-PET in many cases adds vital preoperative diagnostic information and in more than every fourth patient was the only imaging method that will guide the surgeon in finding the NET-lesion. Although the present results demonstrates that 11C-5-HTP may be used as an universal NET tracer, the sensitivity to visualize benign insulinomas and non functioning pancreatic NETs was lower. |
| Posted: 08 Feb 2012 12:00 AM PST An experimental investigation was carried out to study the NOx formation and reduction by primary measures for five types of biomass (straw, peat, sewage sludge, forest residues/Grot, and wood pellets) and their mixtures. To minimize the NOx level in biomass-fired boilers, combustion experiments were performed in a laboratory scale multifuel fixed grate reactor using staged air combustion. Flue gas was extracted to measure final levels of CO, CO2, CxHy, O2, NO, NO2, N2O, and other species. The fuel gas compositions between the first and second stage were also monitored. The experiments showed good combustion quality with very low concentrations of unburnt species in the flue gas. Under optimum conditions, a NOx reduction of 50–80% was achieved, where the highest reduction represents the case with the highest fuel-N content. The NOx emission levels were very sensitive to the primary excess air ratio and an optimum value for primary excess air ratio was seen at about 0.9. Conversion of fuel nitrogen to NOx showed great dependency on the initial fuel-N content, where the blend with the highest nitrogen content had lowest conversion rate. Between 1–25% of the fuel-N content is converted to NOx depending on the fuel blend and excess air ratio. Sewage sludge is suggested as a favorable fuel to be blended with straw. It resulted in a higher NOx reduction and low fuel-N conversion to NOx. Tops and branches did not show desirable NOx reduction and made the combustion also more unstable. N2O emissions were very low, typically below 5 ppm at 11% O2 in the dry flue gas, except for mixtures with high nitrogen content, where values up to 20 ppm were observed. The presented results are part of a larger study on problematic fuels, also considering ash content and corrosive compounds which have been discussed elsewhere. |
| QuickBooks Pro 2012 13.0.7 R8 - Financial management and accounting for small businesses.. (Demo) Posted: 07 Feb 2012 08:59 PM PST  QuickBooks Pro helps you manage your business easily and efficiently. Organize your finances all in one place, track money going in and out of your business, and spot areas where you can save.
Version 13.0.7 R8:
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| Apple iMac EFI Firmware Update 1.8 - For mid 2010 iMacs.. (Updater) Posted: 07 Feb 2012 08:59 PM PST Apple iMac EFI Firmware Update 1.8 enables Lion Recovery from an Internet connection on iMac (Mid 2010) models. Mac OS X 10.7.3 or later, mid 2010 iMac. Download Now This posting includes an audio/video/photo media file: Download Now |
| ForkLift 2.5 Alpha 8 - Powerful file manager: FTP, WebDAV, S3, Bluetooth, more.. (Shareware) Posted: 07 Feb 2012 08:59 PM PST  ForkLift is a powerful file manager and ferociously fast FTP client clothed in a clean and versatile UI that offers the combination of absolute simplicity and raw power expected from a well-executed Mac software. ForkLift will connect to any remote server FTP, SFTP, Amazon S3, WebDAV, the SMB, NIS and AFP shares on your local network, or your Bluetooth mobile phone- pretty much anything you can plug into or hook up to a Mac. ForkLift also carries a complete toolbox for managing your files, including Folder Synchronization, Batch Renaming, Archive handling, Application deleter, editing files over remote connections and many more. All these power features are packaged into a Finder-like, dual-pane interface that delivers superior workflow while remaining absolutely familiar to use, along with QuickLook, Spotlight search and all. Key features:
One of MacUpdate's favorite features is called "FXP." It allows you to copy files from one remote FTP server to another, without first downloading it to your Mac and then uploading it to the destination server. As you can imagine, this direct connect ability can save a ton of time moving files between servers and making fast backups. Version 2.5 Alpha 8:
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| MacBook Pro EFI Firmware Update 2.6 - For early 2010 MacBook Pros.. (Updater) Posted: 07 Feb 2012 08:59 PM PST MacBook Pro EFI Firmware Update enables Lion Recovery from an Internet connection on MacBook Pro (Early 2010) models. This posting includes an audio/video/photo media file: Download Now |
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