пятница, 17 февраля 2012 г.

Games

Games

INDYCAR: Miller's Mailbag, 2.16

Posted: 16 Feb 2012 12:00 AM PST


Always genuine, never lite: It's Miller time. Here's the latest Q&A from SPEED.com's IndyCar guru.

BitNami DjangoStack 1.4b1-0 - Simplified deployment of the high-level Python Web framework.. (Free)

Posted: 16 Feb 2012 09:00 PM PST



BitNami DjangoStack greatly simplifies the development and deployment of Django applications. It includes ready-to-run versions of Apache, MySQL, PostgreSQL, SQLite, Python and Django and required dependencies. It can be deployed using a native installer, as a virtual machine or in the cloud. BitNami DjangoStack is distributed for free under the Apache 2.0 license.

Django is a high-level Python Web framework that encourages rapid development and clean, pragmatic design. Developed and used over two years by a fast-moving online-news operation, Django was designed to handle two challenges: the intensive deadlines of a newsroom and the stringent requirements of the experienced Web developers who wrote it. It lets you build high-performing, elegant Web applications quickly.

The BitNami DjangoStack native installers were packaged using BitRock's cross platform installer tool.

Version 1.4b1-0:

  • Django 1.4b1
  • Apache to 2.2.22


Mac OS X 10.4 or later

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xTeam 3.0.1 - Manage the people of your organization (was xTime Planning).. (Demo)

Posted: 17 Feb 2012 03:12 AM PST



xTeam (formerly FlexTeam) is an incredibly useful tool to manage the working schedule of people in your group or organization. Our goal is always to make the user's experience as intuitive and task oriented as possible.

xTeam is a really powerful schedule management tool that is visually appealing. It helps you share information, work jointly on schedules, and use all of your available human resources as efficiently as possible: you can create daily working schedules, manage days off for each person and track holidays.

xTeam is designed to automate the employee scheduling process. Manual scheduling can take hours or even days to create and maintain. xTeam can dramatically reduce this administrative expense, save time, optimize working hours, and eliminate schedule mistakes.

We designed xTeam to be very user-friendly. Instead of wasting your time figuring out how to decipher complex software, you can be more productive and efficient. Schedules are available in a printer / spreadsheet friendly format so you easily print them out to post on the wall or attach them in PDF format to any email.



Version 3.0.1:
  • Correction of bugs


Mac OS X 10.6.8 or later

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iNMR 5.0.5 - Process and visualize Nuclear Magnetic Resonance spectra.. (Demo)

Posted: 17 Feb 2012 03:09 AM PST



iNMR enables you to process andvisualize Nuclear Magnetic Resonance spectra.

Have you been longing for an NMR software as stylish as the iMac, as intuitive as the iPod, as resourceful as iLife and as cheap as iWork? Fast, interactive and perfectly integrated with Mac OS X 10.5? Look no further. iNMR is the only NMR software written expressly for Mac OS X. While others say: 'running on' we say: 'written for'. What a difference two words make!



Version 5.0.5:
  • The position of the unit label is fixed at the left of the plot.
  • The number of minor scale ticks is variable.
  • Option 'More Ticks' inside the dialog Axes and Scales.


Mac OS X 10.6 or later

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teletext 2.0.8 - Widget displays teletext for various channels around the world.. (Free)

Posted: 17 Feb 2012 03:23 AM PST



teletext displays pages of the following channels:
  • Austria: ORF
  • Belgium: één, vtm, RTBF
  • Germany: 3sat, ARD, BR, festival, hr, MDR, NDR, SR, WDR, Sat.1
  • Ireland: RTÉ Aertel
  • Italy: RAI
  • Netherlands: NOS, RTVNH, Noord, Oost
  • Portugal: RTP
  • Spain: TVE, Antena 3, TV3
  • Sweden: SVT, TV3, TV4
  • Switzerland: SF1, SF2, SFinfo, tsr1, tsr2, RSI1, RSI2

Access a page by typing its number or by one of 9 shortcuts.
Navigate through pages with the left and right arrow keys, through sub pages with the up and down arrow keys.

Version 2.0.8:
  • Fix for SF and some other channels


Mac OS X 10.4 or later

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Kintraks 3.01.06 - Record system for breeders and animal enthusiasts.. (Free)

Posted: 17 Feb 2012 03:29 AM PST



Kintraks is an animal record system which is useful for any breeder or animal enthusiast. Simply enter the species and breed to customize it to any animal of your choice. Use a variety of storage options and functions to enhance and simplify your animal breeding and record keeping.

Version 3.01.06:
  • Recompiled for Mac Intel systems, now much more stable on Mac OS X 10.7 Lion.
  • Versions for older Macs available from the Kintraks website.


Mac OS X 10.4 or later

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Default Folder X 4.4.9 - Enhances Open and Save dialogs.. (Shareware)

Posted: 17 Feb 2012 03:20 AM PST



Default Folder X attaches a toolbar to the right side of the Open and Save dialogs in any Mac OS X-native application. The toolbar gives you fast access to various folders and commands. You just click on the buttons to go to your favorite and recently used folders, manage the folders and files shown in the list, and make changes to your settings.

Default Folder also fixes a number of problems in Open and Save dialogs, "rebounding" back to the last selected file, putting the path listing back in the top menu, and correcting bugs in scrolling column views.

Check out the screencast by clicking here!

Features:

  • Directory assistant: You can access the contents of your recent, favorite, and open folders right from Default Folder X's toolbar. Its hierarchical pop-up menus expand as you mouse over them, letting you navigate your folders to get to your files. To work faster, you can assign a keyboard shortcut for all of your favorite folders. If an Open and Save dialog isn't open, then you can use Default Folder X's menu bar, Dock icon, or keyboard shortcuts.
  • Real time saving: If you're constantly saving things inside the same folder, Default Folder X can remember that folder for you. You can even set a different default folder for each application you use. That way, you'll already be in the right folder when you're working.
  • Finder management: Have you ever wanted to save a file to an open Finder window? Default Folder X lets you open up or save to any Finder window with a single click. It also lets you get info on, rename, and delete existing files, putting the Finder's power in every Open and Save dialog.
  • Instant Recall: To help you quickly return to folders you've recently used, Default Folder X remembers them for you. It can even rebound to the last file you used in all your recent folders. With Default Folder X, you'll never forget where you put something.
  • Spotlight on the spot: Mac OS X delivers amazing search capabilities with Spotlight, but adding your own search keywords requires a trip to the Finder's Get Info window or to an application like Tags, Fresh, or Tag Folders. No more! Default Folder X lets you add Spotlight keywords, OpenMeta tags, and Finder labels on the spot, while you're still in the Save dialog. It even remembers keywords you've used before and automatically completes them as you type.
  • Information central: Leopard delivers amazing previews with QuickLook, but in Open dialogs they're small and you can only see them in column view. With Default Folder X you get previews below every Open dialog, expanded to fill the available space. Need to see more detail? Click on the image and it zooms up to full size. And if you'd rather have words instead of pictures, Default Folder X delivers those details too. The file's size, the date you created and modified it, the Finder label, Spotlight comments, OpenMeta tags, access permissions - they're all there too.
  • Workflow without work: Rather than make you learn and set up a new application, Default Folder X blends into Mac OS X. Its pop-up menus and Finder integration will start saving you time immediately, and it will put your pre-existing Favorite folders in its toolbar right away. When you do decide to start customizing it, Default Folder X lets you set default folders and assign shortcuts right from its toolbar. Finally, effortless workflow.


Version 4.4.9:
  • A new "Add to Default Folder X Favorites" command in the Finder's contextual menus lets you quickly add the selected folder as a favorite. After installing Default Folder X, you must enable the Service in the Keyboard Shortcuts tab of the Keyboard preferences in System Preferences.
  • Default Folder X now supports Automator workflows in Lion, and will support the next version of Automatic Duck's Pro Import AE plugin for AfterEffects.
  • A bug that caused crashes when applications opened http URLs has been fixed. This resolves problems with Sandvox, among other applications.
  • Updated the click-to-copy-filenames feature so it only works when the correct modifier keys are held down.
  • Resolved problems with Default Folder X forgetting favorite folders on some networked drives.
  • Fixed the way Default Folder X locates the file shown in the frontmost document of Carbon applications running under Mac OS X 10.7.


Mac OS X 10.5 or later

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IJMS, Vol. 13, Pages 2196-2207: Using Support Vector Machine and Evolutionary Profiles to Predict Antifreeze Protein Sequences

Posted: 17 Feb 2012 12:00 AM PST

Antifreeze proteins (AFPs) are ice-binding proteins. Accurate identification of new AFPs is important in understanding ice-protein interactions and creating novel ice-binding domains in other proteins. In this paper, an accurate method, called AFP_PSSM, has been developed for predicting antifreeze proteins using a support vector machine (SVM) and position specific scoring matrix (PSSM) profiles. This is the first study in which evolutionary information in the form of PSSM profiles has been successfully used for predicting antifreeze proteins. Tested by 10-fold cross validation and independent test, the accuracy of the proposed method reaches 82.67% for the training dataset and 93.01% for the testing dataset, respectively. These results indicate that our predictor is a useful tool for predicting antifreeze proteins. A web server (AFP_PSSM) that implements the proposed predictor is freely available.

IJMS, Vol. 13, Pages 2176-2195: Computational Studies of Difference in Binding Modes of Peptide and Non-Peptide Inhibitors to MDM2/MDMX Based on Molecular Dynamics Simulations

Posted: 17 Feb 2012 12:00 AM PST

Inhibition of p53-MDM2/MDMX interaction is considered to be a promising strategy for anticancer drug design to activate wild-type p53 in tumors. We carry out molecular dynamics (MD) simulations to study the binding mechanisms of peptide and non-peptide inhibitors to MDM2/MDMX. The rank of binding free energies calculated by molecular mechanics generalized Born surface area (MM-GBSA) method agrees with one of the experimental values. The results suggest that van der Waals energy drives two kinds of inhibitors to MDM2/MDMX. We also find that the peptide inhibitors can produce more interaction contacts with MDM2/MDMX than the non-peptide inhibitors. Binding mode predictions based on the inhibitor-residue interactions show that the π–π, CH–π and CH–CH interactions dominated by shape complimentarity, govern the binding of the inhibitors in the hydrophobic cleft of MDM2/MDMX. Our studies confirm the residue Tyr99 in MDMX can generate a steric clash with the inhibitors due to energy and structure. This finding may theoretically provide help to develop potent dual-specific or MDMX inhibitors.

Ninja Frog

Posted: 17 Feb 2012 03:10 AM PST

Guide Kaeru, the prince turned Frog turned Ninja through 48 levels of deadly puzzles and crazy acrobatics. Will you gather the magical gems that wil..

MuteMyMic 1.6 - Control selected input volume from your status bar.. (Demo)

Posted: 17 Feb 2012 03:06 AM PST



MuteMyMic is a simple, yet useful application

It allows you to control the volume of currently selected input. MuteMyMic shows its presence by adding a new icon into the menu bar. This icon allows you to adjust the volume of the input exactly the same way as output volume adjustment works. In addition to that, MuteMyMic provides keyboard shortcuts to decrease (F5) and increase volume (F6).

You can also use fast-mute (option+F5) and fast-max-volume (option+F6).

One great benefit of the application is that it works in background and allows you to control the input's volume with a single key or mouse click while at the same time you can enjoy your favorite applications that require your mic. So, now you can adjust volume of your Internet phone calls right from the keyboard shortcuts.

You can always quit the application by performing secondary click on the menu icon (Right-Click/Ctrl+Click).

Ability to show/hide application with Dock. You can set this settings via Preferences menu.

If you prefer PayPal or would like to check the application before you buy it, it is still available via product page: http://mutemymic.com

Note! If you are not sure whether application fits your requirements you can always try it before buying it. PayPal and AppStore versions have both the same features.

Version 1.6:
  • new feature: tracks the changes of microphone volume done by other apps


  • Mac OS X 10.6 or later
  • 64-bit processor


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IJMS, Vol. 13, Pages 2160-2175: On the Electrophilic Character of Molecules Through Its Relation with Electronegativity and Chemical Hardness

Posted: 17 Feb 2012 12:00 AM PST

Electrophilicity is an intrinsic property of atoms and molecules. It probably originates logistically with the involvement in the physical process of electrostatics of soaked charge in electronic shells and the screened nuclear charge of atoms. Motivated by the existing view of conceptual density functional theory that similar to electronegativity and hardness equalization, there should be a physical process of equalization of electrophilicity during the chemical process of formation of hetero nuclear molecules, we have developed a new theoretical scheme and formula for evaluating the electrophilicity of hetero nuclear molecules. A comparative study with available bench marking reveals that the hypothesis of electrophilicity and equalization, and the present method of evaluating equalized electrophilicity, are scientifically promising.

Molecules, Vol. 17, Pages 2015-2029: 3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking

Posted: 17 Feb 2012 12:00 AM PST

Human mitotic kinesin Eg5 plays an essential role in mitoses and is an interesting drug target against cancer. To find the correlation between Eg5 and its inhibitors, structure-based 3D-quantitative structure–activity relationship (QSAR) studies were performed on a series of dihydropyrazole and dihydropyrrole derivatives using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods. Based on the LigandFit docking results, predictive 3D-QSAR models were established, with cross-validated coefficient values (q2) up to 0.798 for CoMFA and 0.848 for CoMSIA, respectively. Furthermore, the CoMFA and CoMSIA models were mapped back to the binding sites of Eg5, which could provide a better understanding of vital interactions between the inhibitors and the kinase. Ligands binding in hydrophobic part of the inhibitor-binding pocket were found to be crucial for potent ligand binding and kinases selectivity. The analyses may be used to design more potent EG5 inhibitors and predict their activities prior to synthesis.

Molecules, Vol. 17, Pages 2000-2014: Impact of Halogen Substituents on Interactions between 2-Phenyl-2,3-dihydroqulinazolin-4(1H)-one Derivatives and Human Serum Albumin

Posted: 17 Feb 2012 12:00 AM PST

A novel type of 2-(un)substituted phenyl-2,3-dihydroquinazolin-4(1H)-one (DQL) derivatives were designed and synthesized to study the impact of halogen substituents on interactions between DQL and human serum albumin (HSA) by comparison methodology. The interactions between DQL and HSA were studied by fluorescence spectroscopy. The intrinsic fluorescence of human serum albumin was quenched by DQL through a static quenching mechanism. Site marker competitive experiments showed that DQL bound to HSA in site II (subdomain IIIA). The binding constants, the numbers of binding sites and the thermodynamic parameters were measured too. The results indicated that the interactions were spontaneous, mainly through hydrophobic forces, and the substitution by halogen atoms in the benzene ring could increase the interactions between DQL and HSA. Furthermore, the binding affinity was enhanced gradually with the increasing of halogen atomic number.

Molecules, Vol. 17, Pages 1992-1999: Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives

Posted: 17 Feb 2012 12:00 AM PST

A series of simple heteroarylidene malonate-type bis(oxazoline) ligands 4 and 5 were applied to the Palladium-catalyzed allylic alkylation reaction, and the ligand 4a bearing a phenyl group afforded excellent enantioselectivity (up to 96% ee) for the allylic alkylation product. Other substrates were also examined, giving the allylic alkylated products in high yield but with poor ee values.

Nutrients, Vol. 4, Pages 91-111: Pro- and Synbiotics to Prevent Sepsis in Major Surgery and Severe Emergencies

Posted: 17 Feb 2012 12:00 AM PST

Septic morbidity associated with advanced surgical and medical treatments is unacceptably high, and so is the incidence of complications occurring in connection with acute emergencies such as severe trauma and severe acute pancreatitis. Only considering the US, it will annually affect approximately (app) 300 million (mill) of a population of almost one million inhabitants and cause the death of more than 200,000 patients, making sepsis the tenth most common cause of death in the US. Two major factors affect this, the lifestyle-associated increased weakness of the immune defense systems, but more than this the artificial environment associated with modern treatments such as mechanical ventilation, use of tubes, drains, intravascular lines, artificial nutrition and extensive use of synthetic chemical drugs, methods all known to reduce or eliminate the human microbiota and impair immune functions and increase systemic inflammation. Attempts to recondition the gut by the supply of microorganisms have sometimes shown remarkably good results, but too often failed. Many factors contribute to the lack of success: unsuitable choice of probiotic species, too low dose, but most importantly, this bio-ecological treatment has never been given the opportunity to be tried as an alternative treatment. Instead it has most often been applied as complementary to all the other treatments mentioned above, including antibiotic treatment. The supplemented lactic acid bacteria have most often been killed already before they have reached their targeted organs.

Gas Station Parking

Posted: 17 Feb 2012 02:49 AM PST

Drive your car at the gas station and try to park your car at the designated place. Please note it isn't easy because there are many obstacles that ..

Materials, Vol. 5, Pages 327-335: Influence of Carbon Nanotubes on Thermal Stability of Water-Dispersible Nanofibrillar Polyaniline/Nanotube Composite

Posted: 17 Feb 2012 12:00 AM PST

Significant influence on the thermal stability of polyaniline (PANI) in the presence of multi-walled carbon nanotubes (MWCNTs) is reported. By means of in-situ rapid mixing approach, water-dispersible nanofibrillar PANI and composites, consisting of MWCNTs uniformly coated with PANI in the state of emeraldine salt, with a well-defined core-shell heterogeneous structure, were prepared. The de-protonation process in PANI occurs at a lower temperature under the presence of MWCNTs on the polyaniline composite upon thermal treatment. However, it is found that the presence of MWCNTs significantly enhances the thermal stability of PANI's backbone upon exposure to laser irradiation, which can be ascribed to the core-shell heterogeneous structure of the composite of MWCNTs and PANI, and the high thermal conductivity of MWCNTs.

Convicted sex offender lives in Benton County

Posted: 17 Feb 2012 02:01 AM PST

A convicted sex offender who used his position as a Girl Scout leader to sexually assault young girls now is living in Benton County.

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Metabolites, Vol. 2, Pages 178-194: Intracellular Metabolite Pool Changes in Response to Nutrient Depletion Induced Metabolic Switching in Streptomyces coelicolor

Posted: 17 Feb 2012 12:00 AM PST

A metabolite profiling study of the antibiotic producing bacterium Streptomyces coelicolor A3(2) has been performed. The aim of this study was to monitor intracellular metabolite pool changes occurring as strains of S. coelicolor react to nutrient depletion with metabolic re-modeling, so-called metabolic switching, and transition from growth to secondary metabolite production phase. Two different culture media were applied, providing depletion of the key nutrients phosphate and L-glutamate, respectively, as the triggers for metabolic switching. Targeted GC-MS and LC-MS methods were employed to quantify important primary metabolite groups like amino acids, organic acids, sugar phosphates and other phosphorylated metabolites, and nucleotides in time-course samples withdrawn from fully-controlled batch fermentations. A general decline, starting already in the early growth phase, was observed for nucleotide pools and phosphorylated metabolite pools for both the phosphate and glutamate limited cultures. The change in amino acid and organic acid pools were more scattered, especially in the phosphate limited situation while a general decrease in amino acid and non-amino organic acid pools was observed in the L-glutamate limited situation. A phoP deletion mutant showed basically the same metabolite pool changes as the wild-type strain M145 when cultivated on phosphate limited medium. This implies that the inactivation of the phoP gene has only little effect on the detected metabolite levels in the cell. The energy charge was found to be relatively constant during growth, transition and secondary metabolite production phase. The results of this study and the employed targeted metabolite profiling methodology are directly relevant for the evaluation of precursor metabolite and energy supply for both natural and heterologous production of secondary metabolites in S. coelicolor.
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