Games |
- Dark Summoner - Videos and Trailers
- Guns of Icarus Online - Videos and Trailers
- Ironworm - Videos and Trailers
- Solar Annihilation - Videos and Trailers
- Premier Manager 2012 - Screenshots
- Retro Racing - Videos and Trailers
- Black Space - Videos and Trailers
- Defend The Castle
- Molecules, Vol. 17, Pages 2367-2377: Beauvericin, a Bioactive Compound Produced by Fungi: A Short Review
- Top Five Strategy Games
- BitNami Cloud Tools 1.3-3 - Installer package for AWS command-line tools.. (Free)
- Molecules, Vol. 17, Pages 2351-2366: Syntheses and Cell-Based Phenotypic Screen of Novel 7-Amino pyrido[2,3-d]pyrimidine-6-carbonitrile Derivatives as Potential Antiproliferative Agents
- Molecules, Vol. 17, Pages 2335-2350: Comparative Studies of the (Anti) Mutagenicity of Baccharis dracunculifolia and Artepillin C by the Bacterial Reverse Mutation Test
- Cash-strapped UK local authorities spent £0.5B on CCTV in 4 years
- Molecules, Vol. 17, Pages 2330-2334: Determination of Antimicrobial Activity and Resistance to Oxidation of Moringa peregrina Seed Oil
- Molecules, Vol. 17, Pages 2316-2329: Acylated mono-, bis- and tris- Cinchona-Based Amines Containing Ferrocene or Organic Residues: Synthesis, Structure and in Vitro Antitumor Activity on Selected Human Cancer Cell Lines
- Molecules, Vol. 17, Pages 2298-2315: Experimental Methodologies and Evaluations of Computer-Aided Drug Design Methodologies Applied to a Series of 2-Aminothiophene Derivatives with Antifungal Activities
- Molecules, Vol. 17, Pages 2283-2297: Evaluation of Rheological Properties and Swelling Behaviour of Sonicated Scleroglucan Samples
- Molecules, Vol. 17, Pages 2271-2282: Determination of the Volatile Composition in Brown Millet, Milled Millet and Millet Bran by Gas Chromatography/Mass Spectrometry
- Ninja Frog
| Dark Summoner - Videos and Trailers Posted: 24 Feb 2012 03:17 AM PST iOS game Dark Summoner trailer. |
| Guns of Icarus Online - Videos and Trailers Posted: 24 Feb 2012 03:25 AM PST Guns of Icarus Online gameplay footage video. |
| Ironworm - Videos and Trailers Posted: 24 Feb 2012 03:07 AM PST Ironworm teaser trailer. |
| Solar Annihilation - Videos and Trailers Posted: 24 Feb 2012 03:04 AM PST Solar Annihilation trailer. |
| Premier Manager 2012 - Screenshots Posted: 24 Feb 2012 03:31 AM PST Premier Manager 2012 features: · Manage in any of the top European Leagues – Play in England, Scotland, Italy, Spain and Germany · Exciting Match Day Experience – Player movement and actions are impacted by your decisions · Tactical Unity System – Player positions, formation and style of play can affect individual and team performance · Transfers and Contracts – Scout and buy players to boost your team with the real-time graphical negotiation system (GNS) · Character Memories – Players and staff remember events and display realistic emotions and responses · Manager XP – Gain experience and build your reputation as a winning manager · Name Editor: Customise the names of players, clubs, managers, stadiums and competitions |
| Retro Racing - Videos and Trailers Posted: 24 Feb 2012 03:02 AM PST Retro Racing gameplay video. |
| Black Space - Videos and Trailers Posted: 24 Feb 2012 03:11 AM PST Black Space teaser trailer. |
| Posted: 24 Feb 2012 03:30 AM PST You are an archer who has to defend her castle against hordes of zombies. Utilise your skills against the waves and defeat the bosses to keep your k.. |
| Posted: 24 Feb 2012 12:00 AM PST Beauvericin is a cyclic hexadepsipeptide mycotoxin, which has insecticidal, antimicrobial, antiviral and cytotoxic activities. It is a potential agent for pesticides and medicines. This paper reviews the bioactivity, fermentation and biosynthesis of the fungal product beauvericin. |
| Posted: 24 Feb 2012 02:59 AM PST If you like to spend your spare time with your mobile by plotting and managing your resources then you need strategy games before you become a Bond villain! Over the years, we've reviewed a lot of strategy games at All About Symbian, and here are the most notable strategiec game titles. This posting includes an audio/video/photo media file: Download Now |
| BitNami Cloud Tools 1.3-3 - Installer package for AWS command-line tools.. (Free) Posted: 23 Feb 2012 09:00 PM PST BitNami Cloud Tools packages the Amazon Web Services command line tools together with preconfigured Java, Ruby and Perl language runtimes. It is a self-contained, easy to use distribution with one goal in mind: to make it simple to get started using AWS services from the command line. Version 1.3-3:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 24 Feb 2012 12:00 AM PST A series of N-3-substituted 7-aminopyrido[2,3-d]pyrimidin-6-carbonitrile derivatives was readily synthesized and their anti-proliferative activities on five types of tumor cells were evaluated through a cell-based phenotypic screening approach. Compound 3k was found to be potent on human colon cancer SW620 cells with an IC50 value of 12.5 mM. Structural optimization of compound 3k led to compound 4a with improved anti-proliferative potency on SW620 cells with an IC50 value of 6.9 mM. Further cell-cycle analyses suggested that compound 4a induced apoptosis of SW620 cells in a concentration-dependent manner. |
| Posted: 24 Feb 2012 12:00 AM PST Baccharis dracunculifolia is a plant native from Brazil, commonly known as 'Alecrim-do-campo' and 'Vassoura' and used in alternative medicine for the treatment of inflammation, hepatic disorders and stomach ulcers. Previous studies reported that artepillin C (ArtC, 3-{4-hydroxy-3,5-di(3-methyl-2-butenyl)phenyl}-2(E)-propenoic acid), is the main compound of interest in the leaves. This study was undertaken to assess the mutagenic effect of the ethyl acetate extract of B. dracunculifolia leaves (Bd-EAE: 11.4–182.8 µg/plate) and ArtC (0.69–10.99 µg/plate) by the Ames test using Salmonella typhimurium strains TA98, TA97a, TA100 and TA102, and to compare the protective effects of Bd-EAE and ArtC against the mutagenicity of a variety of direct and indirect acting mutagens such as 4-nitro-O-phenylenediamine, sodium azide, mitomycin C, benzo[a]pyrene, aflatoxin B1, 2-aminoanthracene and 2-aminofluorene.The mutagenicity test showed that Bd-EAE and ArtC did not induce an increase in the number of revertant colonies indicating absence of mutagenic activity. ArtC showed a similar antimutagenic effect to that of Bd-EAE in some strains of S. typhimurium, demonstrating that the antimutagenic activity of Bd-EAE can be partially attributed to ArtC. The present results showed that the protective effect of whole plant extracts is due to the combined and synergistic effects of a complex mixture of phytochemicals, the total activity of which may result in health benefits. |
| Cash-strapped UK local authorities spent £0.5B on CCTV in 4 years Posted: 24 Feb 2012 02:20 AM PST "The Price of Privacy: How local authorities spent £515m on CCTV in four years" is a new report from Britain's Big Brother Watch, and it documents how the skyrocketing expansion of Britain's police and local government surveillance has resulted in over 4,000 fewer patrolling police officers, less privacy, and no appreciable reduction in crime.
The Price of Privacy: How local authorities spent £515m on CCTV in four years |
| Posted: 24 Feb 2012 12:00 AM PST The antimicrobial activity of the oil extracted with n-hexane from the seeds of Moringa peregrina was tested against Staphylococcus aureus, S. epidermidis, Pseudomonas aeruginosa, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, Candida albicans, C. tropicalis and C. glabrata. The oil proved effective against all of the tested microorganisms. Standard antibiotics (netilmycin, 5-flucytocine, intraconazole and 7-amino-4-methylcoumarin-3-acetic acid) were used for comparison. The resistance to oxidation of the extracted seed oil was also determined. |
| Posted: 24 Feb 2012 12:00 AM PST A series of novel functionalized mono-, bis- and tris-(S)-{[(2S,4R,8R)-8-ethyl-quinuclidin-2-yl](6-methoxyquinolin-4-yl)}methanamines including ferrocene-containing derivatives was obtained by the reaction of the precursor amine with a variety of acylation agents. Their in vitro antitumor activity was investigated against human leukemia (HL-60), human neuroblastoma (SH-SY5Y), human hepatoma (HepG2) and human breast cancer (MCF-7) cells by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-assay and the 50% inhibitory concentration (IC50) values were determined. Our data indicate that the precursor amine has no antitumor activity in vitro, but the bis-methanamines with ureido-, thioureido and amide-type linkers display attractive in vitro cytotoxicity and cytostatic effects on HL-60, HepG2, MCF-7 and SH-SY5Y cells. Besides 1H- and 13C-NMR methods the structures of the new model compounds were also studied by DFT calculations. |
| Posted: 24 Feb 2012 12:00 AM PST Fifty 2-[(arylidene)amino]-4,5-cycloalkyl[b]thiophene-3-carbonitrile derivatives were screened for their in vitro antifungal activities against Candida krusei and Cryptococcus neoformans. Based on experimentally determined minimum inhibitory concentration (MIC) values, we conducted computer-aided drug design studies [molecular modelling, chemometric tools (CPCA, PCA, PLS) and QSAR-3D] that enable the prediction of three-dimensional structural characteristics that influence the antifungal activities of these derivatives. These predictions provide direction with regard to the syntheses of new derivatives with improved biological activities, which can be used as therapeutic alternatives for the treatment of fungal infections. |
| Posted: 24 Feb 2012 12:00 AM PST Scleroglucan is a natural polysaccharide that has been proposed for various applications. However there is no investigation on its property variations when the molecular weight of this polymer is reduced. Scleroglucan was sonicated at two different polymer concentrations for different periods of time and the effect of sonication was investigated with respect to molecular weight variations and rheological properties. Molar mass, estimated by viscometric measurements, was drastically reduced already after a sonication for a few min. Sonicated samples were used for the preparation of gels in the presence of borate ions. The effect of borax on the new samples was investigated by recording the mechanical spectra and the flow curves. A comparison with the system prepared with the dialysed polymer was also carried out. The anisotropic elongation, observed with tablets of scleroglucan and borax, was remarkably reduced when the sonicated samples were used for the preparation of the gels. |
| Posted: 24 Feb 2012 12:00 AM PST The volatile compounds from brown millet (BM), milled millet (MM) and millet bran (MB) were extracted using simultaneous distillation/extraction with a Likens-Nickerson apparatus. The extracts were analysed using gas chromatography coupled with mass spectrometry (GC-MS). A total of 65 volatile compounds were identified in all of the samples. Among these compounds, 51, 51 and 49 belonged to BM, MM and MB, respectively. Aldehydes and benzene derivatives were the most numerous among all of the compounds. Three compounds (hexanal, hexadecanoic acid and 2-methylnaphthalene) were dominant in the BM and MM materials. Eight compounds (hexanal, nonanal, (E)-2-nonenal, naphthalene, 2-methylnaphthalene, 1-methylnaphthalene, hexadecanoic acid and 2-pentylfuran) were dominant in the MB materials. Apart from the aromatic molecules, which were present in all fractions, compounds present only in BM, MM or MB were also identified. |
| Posted: 23 Feb 2012 10:40 AM PST [Platform: Flash] When a prince is turned into a frog then trained into a ninja, what do you get? A puzzle platformer that's a bit like Sticky Ninja Academy only less sticky and more... green. Help Kaeru collect enough magic gems to reverse the curse by using physics and mouse-driven controls to navigate surfaces, avoiding those hazards that make you go "Splat!" Ninja Frog starts out easy then quickly becomes a lesson in discipline and diligence yet it remains compelling and fun for those who take great satisfaction in their accomplishments. Aah, Grasshopper, you have learned well. |
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