вторник, 21 февраля 2012 г.

Games

Games

Time Up 1.0.4 - Activity timer with multiple alarms.. (Commercial)

Posted: 21 Feb 2012 03:19 AM PST



Time Up is your countdown timer.
  • Fine tune your times, activity and start.
  • Manage your times, export import to CSV
  • Select differents alarms : Voice, Sound, Visual


Version 1.0.4:
  • Addition of an alert message option.
  • Correction of CSV separator.
  • Correction of translations.
  • Correction of interface.
  • Correction of preferences save.


Mac OS X 10.6.6 or later

Download Now

F1: Drivers Upbeat As Mercedes Reveals New W3

Posted: 21 Feb 2012 12:00 AM PST


Mercedes has officially unveiled its new W03...

Marine Drugs, Vol. 10, Pages 509-520: Cyanobacterial Neurotoxin β-N-Methylamino-L-alanine (BMAA) in Shark Fins

Posted: 21 Feb 2012 12:00 AM PST

Sharks are among the most threatened groups of marine species. Populations are declining globally to support the growing demand for shark fin soup. Sharks are known to bioaccumulate toxins that may pose health risks to consumers of shark products. The feeding habits of sharks are varied, including fish, mammals, crustaceans and plankton. The cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) has been detected in species of free-living marine cyanobacteria and may bioaccumulate in the marine food web. In this study, we sampled fin clips from seven different species of sharks in South Florida to survey the occurrence of BMAA using HPLC-FD and Triple Quadrupole LC/MS/MS methods. BMAA was detected in the fins of all species examined with concentrations ranging from 144 to 1836 ng/mg wet weight. Since BMAA has been linked to neurodegenerative diseases, these results may have important relevance to human health. We suggest that consumption of shark fins may increase the risk for human exposure to the cyanobacterial neurotoxin BMAA.

Materials, Vol. 5, Pages 350-363: Carbon Nanomaterials: Efficacy and Safety for Nanomedicine

Posted: 21 Feb 2012 12:00 AM PST

Carbon nanomaterials, including fullerenes, carbon nanohorns, and carbon nanotubes, are increasingly being used in various fields owing to these materials' unique, size-dependent functions and physicochemical properties. Recently, because of their high variability and stability, carbon nanomaterials have been explored as a novel tool for the delivery of therapeutic molecules including peptide and nucleic acid cancer drugs. However, insufficient information is available regarding the safety of carbon nanomaterials for human health, even though such information is vital for the development of safe and effective nanomedicine technologies. In this review, we discuss currently available information regarding the safety of carbon nanomaterials in nanomedicine applications, including information obtained from our own studies; and we discuss types of carbon nanomaterials that demonstrate particular promise for safe nanomedicine technologies.

Energies, Vol. 5, Pages 371-385: Development and Evaluation of an Economic-Driving Assistance Program for Transit Vehicles

Posted: 21 Feb 2012 12:00 AM PST

This paper focuses on development and evaluation of an economic-driving assistance program for transit vehicles (EDTV) which can minimize energy consumption, air pollution emission of buses, and improve the level of service of transit system as well. Taking advantage of the latest advances in information and communication technologies, the EDTV system can provide bus drivers with optimal recommended bus holding times at near-side bus stops and dynamic bus speed to adapt to the real-time traffic control plan at downstream intersections. In order to address the impacts of the stochastic variation of bus dwell time, the total link between adjacent intersections is divided into three parts: upstream of bus stop part; bus stop part; and downstream of bus stop part. The methods for calculating recommended parameters, including bus holding time and bus speed in each of the three parts are proposed based on real-time bus status and signal status at downstream intersections. A VISSIM-based simulation platform was designed and used for simulating and evaluating the proposed EDTV system. Extensive experimental analyses have shown that the proposed EDTV system can improve the performance of a transit system in terms of reducing fuel consumption, air pollution emissions and level of service of the transit system.

IJMS, Vol. 13, Pages 2354-2367: Supercritical Carbon Dioxide Extraction of the Oak Silkworm (Antheraea pernyi) Pupal Oil: Process Optimization and Composition Determination

Posted: 21 Feb 2012 12:00 AM PST

Supercritical carbon dioxide (SC-CO2) extraction of oil from oak silkworm pupae was performed in the present research. Response surface methodology (RSM) was applied to optimize the parameters of SC-CO2 extraction, including extraction pressure, temperature, time and CO2 flow rate on the yield of oak silkworm pupal oil (OSPO). The optimal extraction condition for oil yield within the experimental range of the variables researched was at 28.03 MPa, 1.83 h, 35.31 °C and 20.26 L/h as flow rate of CO2. Under this condition, the oil yield was predicted to be 26.18%. The oak silkworm pupal oil contains eight fatty acids, and is rich in unsaturated fatty acids and α-linolenic acid (ALA), accounting for 77.29% and 34.27% in the total oil respectively.

Polymers, Vol. 4, Pages 617-629: A New Esterase from Thermobifida halotolerans Hydrolyses Polyethylene Terephthalate (PET) and Polylactic Acid (PLA)

Posted: 21 Feb 2012 12:00 AM PST

A new esterase from Thermobifida halotolerans (Thh_Est) was cloned and expressed in E. coli and investigated for surface hydrolysis of polylactic acid (PLA) and polyethylene terephthalate (PET). Thh_Est is a member of the serine hydrolases superfamily containing the -GxSxG- motif with 85–87% homology to an esterase from T. alba, to an acetylxylan esterase from T. fusca and to various Thermobifida cutinases. Thh_Est hydrolyzed the PET model substrate bis(benzoyloxyethyl)terephthalate and PET releasing terephthalic acid and mono-(2-hydroxyethyl) terephthalate in comparable amounts (19.8 and 21.5 mmol/mol of enzyme) while no higher oligomers like bis-(2-hydroxyethyl) terephthalate were detected. Similarly, PLA was hydrolyzed as indicated by the release of lactic acid. Enzymatic surface hydrolysis of PET and PLA led to a strong hydrophilicity increase, as quantified with a WCA decrease from 90.8° and 75.5° to 50.4° and to a complete spread of the water drop on the surface, respectively.

Polymers, Vol. 4, Pages 600-616: Characterizations of Polyamidoamine Dendrimers with Scattering Techniques

Posted: 21 Feb 2012 12:00 AM PST

Dendrimers are highly branched, open, covalent assemblies of branch cells (monomers) radially attached to a core in successive layers or generations. Major types of dendrimers include polyamidoamine, polypropylenimine, multiple antigen peptide, chiral, and Fréchet-type dendrimers. Their structure and dynamics can be explored by various techniques, such as scattering, spectrometry, and microscopy techniques. Specifically, the scattering techniques include small-angle neutron scattering (SANS), quasi-elastic neutron scattering (QENS), small-angle X-ray scattering (SAXS), and light scattering. Examples of their properties that can be explored by scattering techniques include: inter-molecular structure, intra-molecular cavity, radius-of-gyration (RG), hydrodynamic radius (RH), molecular weight, effective charge number of a single dendrimer molecule, water penetration into the interior of the dendrimers, and the internal dynamics. Of these properties, the hydrodynamic radius and molecular weight may be explored by DLS; the internal dynamics of dendrimers may be studied by QENS; and the others may be explored through SAXS and SANS. During the past several years, SANS and QENS have been used to study the structural properties and internal dynamics of various generations of polyamidoamine dendrimers (PAMAMs). Their potential prospects as anticancer polymer drug carriers are also discussed.

IJMS, Vol. 13, Pages 2331-2353: Epigenetic Disregulation in Oral Cancer

Posted: 21 Feb 2012 12:00 AM PST

Squamous cell carcinoma of the oral region (OSCC) is one of the most common and highly aggressive malignancies worldwide, despite the fact that significant results have been achieved during the last decades in its detection, prevention and treatment. Although many efforts have been made to define the molecular signatures that identify the clinical outcome of oral cancers, OSCC still lacks reliable prognostic molecular markers. Scientific evidence indicates that transition from normal epithelium to pre-malignancy, and finally to oral carcinoma, depends on the accumulation of genetic and epigenetic alterations in a multistep process. Unlike genetic alterations, epigenetic changes are heritable and potentially reversible. The most common examples of such changes are DNA methylation, histone modification, and small non-coding RNAs. Although several epigenetic changes have been currently linked to OSCC initiation and progression, they have been only partially characterized. Over the last decade, it has been demonstrated that especially aberrant DNA methylation plays a critical role in oral cancer. The major goal of the present paper is to review the recent literature about the epigenetic modifications contribution in early and later phases of OSCC malignant transformation; in particular we point out the current evidence of epigenetic marks as novel markers for early diagnosis and prognosis as well as potential therapeutic targets in oral cancer.

Viruses, Vol. 4, Pages 309-324: Novel Approaches to Inhibit HIV Entry

Posted: 21 Feb 2012 12:00 AM PST

Human Immunodeficiency Virus (HIV) entry into target cells is a multi-step process involving binding of the viral glycoprotein, Env, to its receptor CD4 and a coreceptor—either CCR5 or CXCR4. Understanding the means by which HIV enters cells has led to the identification of genetic polymorphisms, such as the 32 base-pair deletion in the ccr5 gene (ccr5∆32) that confers resistance to infection in homozygous individuals, and has also resulted in the development of entry inhibitors—small molecule antagonists that block infection at the entry step. The recent demonstration of long-term control of HIV infection in a leukemic patient following a hematopoietic stem cell transplant using cells from a ccr5∆32 homozygous donor highlights the important role of the HIV entry in maintaining an established infection and has led to a number of attempts to treat HIV infection by genetically modifying the ccr5 gene. In this review, we describe the HIV entry process and provide an overview of the different classes of approved HIV entry inhibitors while highlighting novel genetic strategies aimed at blocking HIV infection at the level of entry.

ELIGIUM - The Chosen One - Screenshots

Posted: 21 Feb 2012 02:37 AM PST

Game Features:
- Five playable race/class combinations including panda fighters
- High degree of customisation through special skill system, crafting and extensive item upgrading
- Challenging group instances and dungeons as well as open world opponents
- PvP and guild systems featuring wars between fractions and guilds, player housing, ranking system and much more
- Mount-hatching system and pets that aid players

Kingdom Hearts 3D special anniversary box announced for Japan

Posted: 21 Feb 2012 01:43 AM PST

Package to include upcoming game and Kingdom Hearts 358/2 Days, alongside other exclusives.

 

The last time gamers heard about Kingdom Hearts 3D for the 3DS, Square Enix announced that the game would be out on March 29 in Japan and that it would also release a special 3DS with the game's design and patterns. The company recently announced that it would also release a tenth anniversary box for the Japanese market to commemorate the release of the upcoming action RPG.

The anniversary box will contain Kingdom Hearts 3D, Kingdom Hearts 358/2 Days for the DS, Kingdom Hearts Re:coded for the DS, a protection case, 12 Kingdom Hearts-themed postcards, and a special box to house the content in. The set will run gamers in Japan 15,000 yen ($188). There is no official word on whether this set will be available for North American and European markets.

Kingdom Hearts 3D focuses on series protagonists Sora and Riku; the game's story takes place after the event of Kingdom Hearts Re:coded. The North American and European versions of the game will be out later in 2012 after the Japanese release.

Read and Post Comments | Get the full article at GameSpot

"Kingdom Hearts 3D special anniversary box announced for Japan" was posted by Jonathan Leo Toyad on Tue, 21 Feb 2012 01:43:51 -0800

Nutrients, Vol. 4, Pages 132-150: Current Challenges in Detecting Food Allergens by Shotgun and Targeted Proteomic Approaches: A Case Study on Traces of Peanut Allergens in Baked Cookies

Posted: 21 Feb 2012 12:00 AM PST

There is a need for selective and sensitive methods to detect the presence of food allergens at trace levels in highly processed food products. In this work, a combination of non-targeted and targeted proteomics approaches are used to illustrate the difficulties encountered in the detection of the major peanut allergens Ara h 1, Ara h 2 and Ara h 3 from a representative processed food matrix. Shotgun proteomics was employed for selection of the proteotypic peptides for targeted approaches via selective reaction monitoring. Peanut presence through detection of the proteotypic Ara h 3/4 peptides AHVQVVDSNGNR (m/z 432.5, 3+) and SPDIYNPQAGSLK (m/z 695.4, 2+) was confirmed and the developed method was able to detect peanut presence at trace levels (≥10 μg peanut g−1 matrix) in baked cookies.

IJMS, Vol. 13, Pages 2314-2330: Antioxidant and Hepatoprotective Effects of the Red Ginseng Essential Oil in H2O2-Treated HepG2 Cells and CCl4-Treated Mice

Posted: 21 Feb 2012 12:00 AM PST

The aim of this study was to evaluate the antioxidant mechanisms of red ginseng essential oil (REO) in cells as well as in an animal model. REO was prepared by a supercritical CO2 extraction of waste-products generated after hot water extraction of red ginseng. In HepG2 cells, REO diminished the H2O2-mediated oxidative stress and also restored both the activity and expression of antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase. Administration of REO inhibited the phosphorylation of upstream mitogen-activated protein kinases (MAPKs) such as c-Jun N-terminal kinase, extracellular signal-regulated kinase, and p38. In mice, the CCl4-mediated elevation of serum aspartate transaminase and alanine transaminase as well as the induction of hepatic lipid peroxidation were decreased by REO administration. REO treatments also resulted in up-regulation of the antioxidant enzyme expression in the liver. Moreover, increased phosphorylations of MAPKs were inhibited after REO administration. Overall, REO seems to protect the liver from oxidative stress through the activation and induction of antioxidant enzymes via inhibition of MAPKs pathways.

IJMS, Vol. 13, Pages 2301-2313: Expression Patterns of Genes Involved in the Defense and Stress Response of Spiroplasma citri Infected Madagascar Periwinkle Catharanthus roseus

Posted: 21 Feb 2012 12:00 AM PST

Madagascar periwinkle is an ornamental and a medicinal plant, and is also an indicator plant that is highly susceptible to phytoplasma and spiroplasma infections from different crops. Periwinkle lethal yellows, caused by Spiroplasma citri, is one of the most devastating diseases of periwinkle. The response of plants to S. citri infection is very little known at the transcriptome level. In this study, quantitative real-time PCR (RT-qPCR) was used to investigate the expression levels of four selected genes involved in defense and stress responses in naturally and experimentally Spiroplasma citri infected periwinkles. Strictosidine β-glucosidase involved in terpenoid indole alkaloids (TIAs) biosynthesis pathway showed significant upregulation in experimentally and naturally infected periwinkles. The transcript level of extensin increased in leaves of periwinkles experimentally infected by S. citri in comparison to healthy ones. A similar level of heat shock protein 90 and metallothionein expression was observed in healthy, naturally and experimentally spiroplasma-diseased periwinkles. Overexpression of Strictosidine β-glucosidase demonstrates the potential utility of this gene as a host biomarker to increase the fidelity of S. citri detection and can also be used in breeding programs to develop stable disease-resistance varieties.

IJMS, Vol. 13, Pages 2290-2300: In Vitro Control of Post-Harvest Fruit Rot Fungi by Some Plant Essential Oil Components

Posted: 21 Feb 2012 12:00 AM PST

Eight substances that are main components of the essential oils from three Mediterranean aromatic plants (Verbena officinalis, Thymus vulgaris and Origanum vulgare), previously found active against some phytopathogenic Fungi and Stramenopila, have been tested in vitro against five etiological agents of post-harvest fruit decay, Botrytis cinerea, Penicillium italicum, P. expansum, Phytophthora citrophthora and Rhizopus stolonifer. The tested compounds were β-fellandrene, β-pinene, camphene, carvacrol, citral, o-cymene, γ-terpinene and thymol. Citral exhibited a fungicidal action against P. citrophthora; carvacrol and thymol showed a fungistatic activity against P. citrophthora and R. stolonifer. Citral and carvacrol at 250 ppm, and thymol at 150 and 250 ppm stopped the growth of B. cinerea. Moreover, thymol showed fungistatic and fungicidal action against P. italicum. Finally, the mycelium growth of P. expansum was inhibited in the presence of 250 ppm of thymol and carvacrol. These results represent an important step toward the goal to use some essential oils or their components as natural preservatives for fruits and foodstuffs, due to their safety for consumer healthy and positive effect on shelf life extension of agricultural fresh products.

Entropy, Vol. 14, Pages 370-389: Optimal Design of ORC Systems with a Low-Temperature Heat Source

Posted: 21 Feb 2012 12:00 AM PST

A numerical model of subcritical and trans-critical power cycles using a fixed-flowrate low-temperature heat source has been validated and used to calculate the combinations of the maximum cycle pressure (Pev) and the difference between the source temperature and the maximum working fluid temperature (DT) which maximize the thermal efficiency (ηth) or minimize the non-dimensional exergy losses (β), the total thermal conductance of the heat exchangers (UAt) and the turbine size (SP). Optimum combinations of Pev and DT were calculated for each one of these four objective functions for two working fluids (R134a, R141b), three source temperatures and three values of the non-dimensional power output. The ratio of UAt over the net power output (which is a first approximation of the initial cost per kW) shows that R141b is the better working fluid for the conditions under study.

Remote Sensing, Vol. 4, Pages 532-560: Two Linear Unmixing Algorithms to Recognize Targets Using Supervised Classification and Orthogonal Rotation in Airborne Hyperspectral Images

Posted: 21 Feb 2012 12:00 AM PST

The goal of the paper is to detect pixels that contain targets of known spectra. The target can be present in a sub- or above pixel. Pixels without targets are classified as background pixels. Each pixel is treated via the content of its neighborhood. A pixel whose spectrum is different from its neighborhood is classified as a "suspicious point". In each suspicious point there is a mix of target(s) and background. The main objective in a supervised detection (also called "target detection") is to search for a specific given spectral material (target) in hyperspectral imaging (HSI) where the spectral signature of the target is known a priori from laboratory measurements. In addition, the fractional abundance of the target is computed. To achieve this we present two linear unmixing algorithms that recognize targets with known (given) spectral signatures. The CLUN is based on automatic feature extraction from the target's spectrum. These features separate the target from the background. The ROTU algorithm is based on embedding the spectra space into a special space by random orthogonal transformation and on the statistical properties of the embedded result. Experimental results demonstrate that the targets' locations were extracted correctly and these algorithms are robust and efficient.

Molecules, Vol. 17, Pages 2169-2177: Effects of Botulinum Toxin Type A on Collagen Deposition in Hypertrophic Scars

Posted: 21 Feb 2012 12:00 AM PST

A recent study reported that Botulinum toxin type A (BTXA) could inhibit the growth of hypertrophic scars and improve their appearance. However, the mechanism of BTXA's action on hypertrophic scars is still unknown. Some in vitro studies had shown BTXA could alleviate hypertrophic scars by acting on the biological behavior of fibroblasts, but there are few in vivo experiments, especially animal model experiments, supporting these findings. The aim of the study reported herein was to investigate the effect of BTXA on collagen deposition on hypertrophic scars in a rabbit ear model and partially clarify the mechanism of BTXA on the hypertrophy of scars. The rabbit hypertrophic scar model was used and eight rabbits were employed. BTXA was injected into the hypertrophic scar tissue of one ear; and the other ear in the same rabbit was the control without BTXA injection. The scar thickness and deposition of collagen was examined through immune histochemistry including haematoxylin and eosin (H&E) and Masson trichrome staining. The thicknesses of hypertrophic scars in the BTXA treatment group were obviously lower than in the control groups (P < 0.01). H&E and Masson staining showed that collagen fibers were stained blue. Compared with the treatment group, the collagen fibers were thicker and the arrangement of collagen fibers were disordered in the control group. This study used the rabbit ear model of hypertrophic scars to assess the effects of BTXA on scar hypertrophy. The application of BTXA may be useful for inhibiting hypertrophic scars.

A New Way to Experience Magic: Sorcerers of the Magic Kingdom

Posted: 21 Feb 2012 12:31 AM PST

Walt Disney World debutsA theirA new "Sorcerers of the Magic Kingdom" gameA February 22, 2012 at Magic Kingdom .A I had the chance to play this game twice whileA it was still being tested.A I love the Kim Possible game at Epcot , so I couldn't wait to try this new game.

This posting includes an audio/video/photo media file: Download Now

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