четверг, 9 февраля 2012 г.

Games

Games

Track Lapse - Screenshots

Posted: 09 Feb 2012 02:41 AM PST

Ideal for ages nine and up, Track Lapse becomes funnier and more absurd as you race through the levels, kicking chickens, shuffling through the disco, shooting zombies, blocking rockets, and detonating bombs. Encounter bizarre enemies as you jump and fight through strange distractions on your way to the finish line.

Keep Tim on track, avoid obstacles and win the race in record time! But that's just the beginning; more advanced modes and Time Trials will test your skills and mettle with new encounters and challenges in each difficulty mode.

Features:
- Beautiful Graphics - Creative, hand-drawn art pulls players into Tim's athletic world
- Innovative Gameplay - Easy to learn, but hard to master; learn new mechanics each level to advance
- Exciting Modes - Play on Easy, Normal, Hard or Insane to train your racing skills to perfection, experiencing unique obstacles with each difficulty
- Action-Packed Levels - Enjoy eleven levels, with additional bonus levels available, but the fun doesn't stop once the levels are completed. Experience hours of replay value with Timed Modes!
- Fierce Competition - Race for medals, fastest track times and compete against friends through Game Center
- Full Length Musical Masterpiece - Jam along to the original and official soundtrack of Track Lapse

Ball on a Wall - Screenshots

Posted: 09 Feb 2012 02:20 AM PST

DECEPTIVELY STRAIGHT-FORWARDS ON THE SURFACE BUT DEVILISHLY CHALLENGING UNDERNEATH
You'll need quick thinking, nimble fingers and a zen-like focus to succeed.

BUILT FOR iPAD
Designed for the iPad's larger screen and optimized to run as smooth as butter on either the iPad or iPad 2.

DIFFICULTY MODES THAT REALLY MAKE A DIFFERENCE
Normal Mode is enjoyable for gamers of any skill level. Advanced Mode will challenge even the most experienced player.

90 LEVELS ACROSS NINE WORLDS
Journey through paper, cardboard, pinewood, plastic, oak, rock, steel, carbon nanotubes and finally cubic boron nitride, each adding more hazards and challenges to overcome.

CUSTOMISE THE BALL
26 skins to unlock - including sports balls, fruit, planets and the eye ball.

FREE TO TRY
Ball on a Wall is a free app with the first 12 levels available. One single In-App-Purchase unlocks the remaining 78 levels.

Chocolate Covered and Sexy in Monclair

Posted: 09 Feb 2012 02:20 AM PST

You just read the headline and thought this article was about chocolate covered sex or people who have sex in chocolate didn't you? Nice.

This posting includes an audio/video/photo media file: Download Now

Sensors, Vol. 12, Pages 1738-1757: Finger Vein Recognition Based on a Personalized Best Bit Map

Posted: 09 Feb 2012 12:00 AM PST

Finger vein patterns have recently been recognized as an effective biometric identifier. In this paper, we propose a finger vein recognition method based on a personalized best bit map (PBBM). Our method is rooted in a local binary pattern based method and then inclined to use the best bits only for matching. We first present the concept of PBBM and the generating algorithm. Then we propose the finger vein recognition framework, which consists of preprocessing, feature extraction, and matching. Finally, we design extensive experiments to evaluate the effectiveness of our proposal. Experimental results show that PBBM achieves not only better performance, but also high robustness and reliability. In addition, PBBM can be used as a general framework for binary pattern based recognition.

Molecules, Vol. 17, Pages 1744-1750: The Incubation of 13a,17-Dihydroxystemodane with Cephalosporium aphidicola

Posted: 09 Feb 2012 12:00 AM PST

The biotransformation of 13a,17-dihydroxystemodane (3) with the fungus Cephalosporium aphidicola afforded 13a,17,18-trihydroxystemodane (4), 3b,13a,17-tri-hydroxystemodane (5), 13a,17-dihydroxy-stemodan-18-oic acid (6), 3b,11β,13a,17-tetra-hydroxystemodane (7), 11β,13a,17,18-tetrahydroxystemodane (8) and 3b,13a,17,18-tetra-hydroxystemodane (9). The hydroxylation at C-18 of the substrate points to a biosynthetically-directed transformation, because aphidicolin (2) is hydroxylated at this carbon. However, the C-3(b) and C-11(b) hydroxylations seem to indicate a xenobiotic biotransformation.

Molecules, Vol. 17, Pages 1716-1743: Chemisorption and Reactions of Small Molecules on Small Gold Particles

Posted: 09 Feb 2012 12:00 AM PST

The activity of supported gold particles for a number of oxidations and hydrogenations starts to increase dramatically as the size falls below ~3 nm. This is accompanied by an increased propensity to chemisorption, especially of oxygen and hydrogen. The explanation for these phenomena has to be sought in kinetic analysis that connects catalytic activity with the strength and extent of chemisorption of the reactants, the latter depending on the electronic structure of the gold atoms constituting the active centre. Examination of the changes to the utilisation of electrons as particle size is decreased points to loss of metallic character at about 3 nm, as energy bands are replaced by levels, and a band gap appears. Detailed consideration of the Arrhenius parameters (E and ln A) for CO oxidation points clearly to a step-change in activity at the point where metallic character is lost, as opposed to there being a monotonic dependence of rate on a physical property such as the fraction of atoms at corners or edges of particles. The deplorable scarcity of kinetic information on other reactions makes extension of this analysis difficult, but non-metallic behaviour is an unavoidable property of very small gold particles, and therefore cannot be ignored when seeking to explain their exceptional activity.

Molecules, Vol. 17, Pages 1698-1715: Ergosterol-Induced Sesquiterpenoid Synthesis in Tobacco Cells

Posted: 09 Feb 2012 12:00 AM PST

Plants have the ability to continuously respond to microbial signals in their environment. One of these stimuli is a steroid from fungal membranes, ergosterol, which does not occur in plants, but acts as a pathogen-associated molecular pattern molecule to trigger defence mechanisms. Here we investigated the effect of ergosterol on the secondary metabolites in tobacco (Nicotiana tabacum) cells by profiling the induced sesquiterpenoids. Suspensions of tobacco cells were treated with different concentrations (0–1,000 nM) of ergosterol and incubated for different time periods (0–24 h). Metabolites were extracted with a selective dispersive liquid-liquid micro-extraction method. Thin layer chromatography was used as a screening method for identification of sesquiterpenoids in tobacco extracts. Liquid chromatography coupled to mass spectrometry was used for quantitative and qualitative analyses. The results showed that ergosterol triggered differential changes in the metabolome of tobacco cells, leading to variation in the biosynthesis of secondary metabolites. Metabolomic analysis through principal component analysis-scores plots revealed clusters of sample replicates for ergosterol treatments of 0, 50, 150, 300 and 1,000 nM and time-dependent variation at 0, 6, 12, 18 and 24 h. Five bicyclic sesquiterpenoid phytoalexins, capsidiol, lubimin, rishitin, solavetivone and phytuberin, were identified as being ergosterol-induced, contributing to the altered metabolome.

Polymers, Vol. 4, Pages 408-447: Polysilane Dendrimers

Posted: 09 Feb 2012 12:00 AM PST

The synthesis, structure and electronic properties of polysilane dendrimers, a relatively new class of highly branched and silicon-rich molecular architectures is reviewed. After a detailed discussion of main synthetic strategies to well-defined single-core and double-core polysilane dendrimers, important structural and conformational features determined by single crystal X-ray crystallography and 29Si-NMR spectroscopy are presented. The last part highlights the most interesting photochemical properties of polysilane dendrimers such as UV absorption and emission behavior, which are compared with those of linear and branched polysilanes.

Country Dance All Stars - Screenshots

Posted: 09 Feb 2012 01:41 AM PST

Country Dance All Stars, the next iteration in the top-selling Country Dance™ video game franchise, brings a whole new hands-free experience to the dance party. Your body becomes the controller as you kick up your boots and dance your way through over 30 hot routines and songs. Challenge a friend to a dance off with simultaneous competitive play or work together to pull off the moves and collectively build a top score. Boost your boot-scootin' skills with all new line-dancing routines, and don't be afraid to belt it out with scrolling sing-a-long lyrics. Share the fun with friends as the Kinect sensor snaps photos throughout each routine. Plus, all new downloadable content (DLC) support allows you to keep the party going with downloadable song packs featuring new choreography that will be released post launch.

IJMS, Vol. 13, Pages 1846-1857: The -308G/A of Tumor Necrosis Factor (TNF)-α and 825C/T of Guanidine Nucleotide Binding Protein 3 (GNB3) are Associated with the Onset of Acute Myocardial Infarction and Obesity in Taiwan

Posted: 09 Feb 2012 12:00 AM PST

Acute myocardial infarction is a highly prevalent cardiovascular disease in Taiwan. Among several etiological risk factors, obesity and inflammation are strongly associated with the frequency of hypertension, cardiovascular disease, diabetes, and myocardial infarction. To discriminate obesity- and inflammation-related genes and the onset of acute myocardial infarction (AMI), a case-control study was conducted to investigate the association of the -308G/A polymorphisms of tumor necrosis factor (TNF)-α and the C825T polymorphism of guanidine nucleotide binding protein 3 (GNB3) with the onset of AMI among Taiwanese cohorts. A total of 103 AMI patients and 163 matched normal control samples were enrolled in the present study. The genomic DNA was extracted and subjected into polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis. An association between the A homozygosity of the TNF-α-308G/A polymorphism and the onset of AMI was observed among the male subjects (p = 0.026; Spearman index = 0.200, p = 0.008). An association between the T homozygosity of GNB3 C825T polymorphism and obesity was also observed (Fisher's exact, p = 0.009). The TT genotype has a protective effect against acquiring AMI among the obese female population in Taiwan (Fisher's exact, p = 0.032). In conclusion, TNF-α-308G/A and the GNB3 C825T polymorphisms are associated with obesity and AMI in the Taiwanese population.

IJMS, Vol. 13, Pages 1832-1845: Isolation and Characterization of Activators of ERK/MAPK from Citrus Plants

Posted: 09 Feb 2012 12:00 AM PST

Extracellular signal-regulated kinases 1/2 (ERK1/2), components of the mitogen-activated protein kinase (MAPK) signaling cascade, have been recently shown to be involved in synaptic plasticity and in the development of long-term memory in the central nervous system (CNS). We therefore examined the ability of Citrus compounds to activate ERK1/2 in cultured rat cortical neurons, whose activation might have a protective effect against neurodegenerative neurological disorders. Among the samples tested, extracts prepared from the peels of Citrus grandis (Kawachi bankan) were found to have the greatest ability to activate ERK1/2. The active substances were isolated by chromatographic separation, and one of them was identified to be 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF). HMF significantly induced the phosphorylation of cAMP response element-binding protein (CREB), a downstream target of activated ERK1/2, which appears to be a critical step in the signaling cascade for the structural changes underlying the development of long-term potentiation (LTP). In addition, the administration of HMF into mice treated with NMDA receptor antagonist MK-801 restored the MK-801-induced deterioration of spatial learning performance in the Morris mater-maze task. Taken together, these results suggest that HMF is a neurotrophic agent for treating patients with memory disorders.

IJMS, Vol. 13, Pages 1805-1831: Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System

Posted: 09 Feb 2012 12:00 AM PST

Computational toxicology combines data from high-throughput test methods, chemical structure analyses and other biological domains (e.g., genes, proteins, cells, tissues) with the goals of predicting and understanding the underlying mechanistic causes of chemical toxicity and for predicting toxicity of new chemicals and products. A key feature of such approaches is their reliance on knowledge extracted from large collections of data and data sets in computable formats. The U.S. Environmental Protection Agency (EPA) has developed a large data resource called ACToR (Aggregated Computational Toxicology Resource) to support these data-intensive efforts. ACToR comprises four main repositories: core ACToR (chemical identifiers and structures, and summary data on hazard, exposure, use, and other domains), ToxRefDB (Toxicity Reference Database, a compilation of detailed in vivo toxicity data from guideline studies), ExpoCastDB (detailed human exposure data from observational studies of selected chemicals), and ToxCastDB (data from high-throughput screening programs, including links to underlying biological information related to genes and pathways). The EPA DSSTox (Distributed Structure-Searchable Toxicity) program provides expert-reviewed chemical structures and associated information for these and other high-interest public inventories. Overall, the ACToR system contains information on about 400,000 chemicals from 1100 different sources. The entire system is built using open source tools and is freely available to download. This review describes the organization of the data repository and provides selected examples of use cases.

Monster Capture! - Screenshots

Posted: 09 Feb 2012 12:54 AM PST

Players simply tap and bind the same color monsters together until reach target points during limited time against several naughty monsters who try to obstacle players.

Moreover, several different game modes, such as wave mode and hell mode, make players feel funny and excitement and unique items enhance the playing of the game.

Crazy Cheebo Puzzle Party - Screenshots

Posted: 09 Feb 2012 12:45 AM PST

NFL Kicker! - Screenshots

Posted: 09 Feb 2012 12:37 AM PST

GAMEPLAY:
Get in the zone kicking FIELD GOALS with ultimate accuracy in two games based around kicking accuracy. Hit gold bars for bonus score, clear score bands between the uprights for big points. Take them out in the right order for legendary scores. Play against the clock or focus on accuracy with increasing wind and distance.

PUNT the ball out of bounds as close to the end zone as possible. Score huge bonuses for bouncing close to the corner. Coffin Corner is a true test of football skill.

Finally, the ultimate test of your kicking accuracy in the bonus game mode HIT THE UPRIGHTS! Feel the adrenaline as you hit an upright from 50 yards in high wind!

FEATURES:
- Kick field goals like a pro NFL footballer
- Punt coffin corner kicks with casual and pro game modes
- Hit the uprights in a true test of Kicker skill
- Pick your favorite team and customize your jersey, name and number
- Interactive tutorial
- Play in the Super Bowl XLVI Lucas Oil Stadium
- XP Level up system based on your kicking skill
- Live NFL news feed ticker
- Dancing cheerleaders before the game
- Game Center leaderboards and achievements
- Superb high resolution graphics
- Stunningly enhanced for iPhone 4S

IJMS, Vol. 13, Pages 1804: Retraction: Zhong Ye, Darya O. Mishchuk, Natasha S. Stephens and Carolyn M. Slupsky.Dextran Sulfate Sodium Inhibits Alanine Synthesis in Caco-2 Cells. Int. J. Mol. Sci. 2011, 12, 2325-2335.

Posted: 09 Feb 2012 12:00 AM PST

It has been brought to our attention by the corresponding author that the results presented this article [1] are in error due to the fact that the media supplement glutaMAX was used in place of L-glutamine for culture of the control cells, while L-glutamine was used for culture of the treated cells. All authors have confirmed that the reported result could not be reproduced using the correct culture conditions. We would like to thank the authors for pointing out this error thereby upholding the ethics of scientific publication. The Editorial Team and Publisher have agreed with the authors that this manuscript should be retracted. We apologize for any inconvenience this may have caused.

Materials, Vol. 5, Pages 258-277: Ceramic Laser Materials

Posted: 09 Feb 2012 12:00 AM PST

Ceramic laser materials have come a long way since the first demonstration of lasing in 1964. Improvements in powder synthesis and ceramic sintering as well as novel ideas have led to notable achievements. These include the first Nd:yttrium aluminum garnet (YAG) ceramic laser in 1995, breaking the 1 KW mark in 2002 and then the remarkable demonstration of more than 100 KW output power from a YAG ceramic laser system in 2009. Additional developments have included highly doped microchip lasers, ultrashort pulse lasers, novel materials such as sesquioxides, fluoride ceramic lasers, selenide ceramic lasers in the 2 to 3 μm region, composite ceramic lasers for better thermal management, and single crystal lasers derived from polycrystalline ceramics. This paper highlights some of these notable achievements.

Pharmaceutics, Vol. 4, Pages 164-178: In Situ Focused Beam Reflectance Measurement (FBRM), Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Raman Characterization of the Polymorphic Transformation of Carbamazepine

Posted: 09 Feb 2012 12:00 AM PST

The objective of this work was to study the polymorphic transformation of carbamazepine from Form II to Form III in 1-propanol during seeded isothermal batch crystallization. First, the pure Form II and Form III were obtained and characterized. Then their solubilities and metastable zone limits were measured by in-situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and focused beam reflectance measurement (FBRM). A transition temperature at about 34.2 °C was deduced suggesting the enantiotropic nature of this compound over the studied temperature range. To quantify the polymorph ratio during the transformation process, a new in-situ quantitative method was developed to measure the fraction of Form II by Raman spectroscopy. Successful tracking of the nucleation of the stable form and the transformation from Form II to Form III during isothermal crystallization was achieved by Raman spectroscopy and FBRM. The results from these three in-situ techniques, FBRM, FTIR and Raman were consistent with each other. The results showed a strong dependency on the amount of seeds added during isothermal crystallization.

Symmetry, Vol. 4, Pages 39-115: Knots on a Torus: A Model of the Elementary Particles

Posted: 09 Feb 2012 12:00 AM PST

Two knots; just two rudimentary knots, the unknot and the trefoil. That's all we need to build a model of the elementary particles of physics, one with fermions and bosons, hadrons and leptons, interactions weak and strong and the attributes of spin, isospin, mass, charge, CPT invariance and more. There are no quarks to provide fractional charge, no gluons to sequester them within nucleons and no "colors" to avoid violating Pauli's principle. Nor do we require the importation of an enigmatic Higgs boson to confer mass upon the particles of our world. All the requisite attributes emerge simply (and relativistically invariant) as a result of particle conformation and occupation in and of spacetime itself, a spacetime endowed with the imprimature of general relativity. Also emerging are some novel tools for systemizing the particle taxonomy as governed by the gauge group SU(2) and the details of particle degeneracy as well as connections to Hopf algebra, Dirac theory, string theory, topological quantum field theory and dark matter. One exception: it is found necessary to invoke the munificent geometry of the icosahedron in order to provide, as per the group "flavor" SU(3), a scaffold upon which to organize the well-known three generations—no more, no less—of the particle family tree.

Atmosphere, Vol. 3, Pages 132-163: The Impact of Uncertainties in African Biomass Burning Emission Estimates on Modeling Global Air Quality, Long Range Transport and Tropospheric Chemical Lifetimes

Posted: 09 Feb 2012 12:00 AM PST

The chemical composition of the troposphere in the tropics and Southern Hemisphere (SH) is significantly influenced by gaseous emissions released from African biomass burning (BB). Here we investigate how various emission estimates given in bottom-up BB inventories (GFEDv2, GFEDv3, AMMABB) affect simulations of global tropospheric composition using the TM4 chemistry transport model. The application of various model parameterizations for introducing such emissions is also investigated. There are perturbations in near-surface ozone (O3) and carbon monoxide (CO) of ~60–90% in the tropics and ~5–10% in the SH between different inventories. Increasing the update frequency of the temporal distribution to eight days generally results in decreases of between ~5 and 10% in near-surface mixing ratios throughout the tropics, which is larger than the influence of increasing the injection heights at which BB emissions are introduced. There are also associated differences in the long range transport of pollutants throughout the SH, where the composition of the free troposphere in the SH is sensitive to the chosen BB inventory. Analysis of the chemical budget terms reveals that the influence of increasing the tropospheric CO burden due to BB on oxidative capacity of the troposphere is mitigated by the associated increase in NOx emissions (and thus O3) with the variations in the CO/N ratio between inventories being low. For all inventories there is a decrease in the tropospheric chemical lifetime of methane of between 0.4 and 0.8% regardless of the CO emitted from African BB. This has implications for assessing the effect of inter-annual variability in BB on the annual growth rate of methane.
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