Games |
- Sensors, Vol. 12, Pages 2018-2025: Highly Sensitive Detection of Naphthalene in Solvent Vapor Using a Functionalized PBG Refractive Index Sensor
- GameSpot AU's Shippin' Out - February 13, 2012
- IJMS, Vol. 13, Pages 2012-2024: Effect of the Leaving Group and Solvent Combination on the LFER Reaction Constants
- IJMS, Vol. 13, Pages 1951-2011: Tumor Heterogeneity: Mechanisms and Bases for a Reliable Application of Molecular Marker Design
- Cashculator 1.3.0 - Personal finance management application.. (Shareware)
- Cashculator Free 1.3.0 - Track your cashflow.. (Free)
- Harmony 2.5 - Dynamic lyric presentation for worship leaders and churches.. (Shareware)
- MacBiff 1.1.16 - Checks your IMAP server for new email.. (Free)
- PressPerCent 3.0.5 - Ink pre-setting solutions for offset presses.. (Shareware)
- Families celebrate an early Valentine's Day at Hagley
- Rebuild (iOS)
- Viruses, Vol. 4, Pages 280-308: Henipavirus Mediated Membrane Fusion, Virus Entry and Targeted Therapeutics
- Energies, Vol. 5, Pages 291-304: Low-Carbon Development Patterns: Observations of Typical Chinese Cities
- Catalysts, Vol. 2, Pages 139-170: Oxidation Catalysts for Elemental Mercury in Flue Gases—A Review
- OnyX 2.4.4 - Mac OS X maintenance and optimisation tool.. (Free)
- Sonora 0.90 - A new kind of music app (beta).. (Free)
- Molecules, Vol. 17, Pages 1830-1836: Two New Iridoid Glycosides from the Root Barks of Sambucus williamsii Hance
- Molecules, Vol. 17, Pages 1819-1829: Chemical and Biological Analyses of the Essential Oils and Main Constituents of Piper Species
- Parking Mania - Screenshots
- Materials, Vol. 5, Pages 278-301: Carbon Nanotubes: Solution for the Therapeutic Delivery of siRNA?
| Posted: 13 Feb 2012 12:00 AM PST We report an optical refractive index sensor system based on a planar Bragg grating which is functionalized by substituted -cyclodextrin to determine low concentrations of naphthalene in solvent vapor. The sensor system exhibits a quasi-instantaneous shift of the Bragg wavelength and is therefore capable for online detection. The overall shift of the Bragg wavelength reveals a linear relationship to the analyte concentration with a gradient of 12.5 ± 1.5 pm/ppm. Due to the spectral resolution and repeatability of the interrogation system, this corresponds to acquisition steps of 80 ppb. Taking into account the experimentally detected signal noise a minimum detection limit of 0.48 ± 0.05 ppm is deduced. |
| GameSpot AU's Shippin' Out - February 13, 2012 Posted: 12 Feb 2012 10:11 PM PST GameSpot AU community manager James Kozanecki tells you what games are coming out in Australia in the week beginning February 13, 2011!
Read and Post Comments | Get the full article at GameSpot "GameSpot AU's Shippin' Out - February 13, 2012" was posted by edmondt on Sun, 12 Feb 2012 22:11:37 -0800 |
| Posted: 13 Feb 2012 12:00 AM PST Fine effects that influence the variations of the reaction constants sf in LFER log k = sf(Nf + Ef) have been summarized here. Increasing solvent polarity in the series of binary mixtures increases the solvolysis rates for the same factor for all benzhydryl derivatives in which the solvation of the leaving group moiety in the transition state is substantial, i.e., log k vs. Ef correlation lines are parallel (same sf). For the substrates in which the demand for solvation of the leaving groups moiety is reduced, (e.g., carbonates) sf parameters decrease as the fraction of the water in a given solvent/water mixture increases (log k vs. Ef plots converge), due to decreasing solvation of the electrofuge moiety toward bigger electrofugality. The abscissa of the intersection of the converging plots might indicate the critical electrofugality above which the solvolysis rates should not depend of the water fraction. Larger reaction constant sf indicate later transition state for structurally related substrates only, while sf parameters for structurally different substrates cannot be compared likely due to different intrinsic barriers. Inversion in relative abilities of leaving groups is possible if they have similar reactivities and are characterized with different reaction constants. |
| Posted: 13 Feb 2012 12:00 AM PST Tumor heterogeneity is a confusing finding in the assessment of neoplasms, potentially resulting in inaccurate diagnostic, prognostic and predictive tests. This tumor heterogeneity is not always a random and unpredictable phenomenon, whose knowledge helps designing better tests. The biologic reasons for this intratumoral heterogeneity would then be important to understand both the natural history of neoplasms and the selection of test samples for reliable analysis. The main factors contributing to intratumoral heterogeneity inducing gene abnormalities or modifying its expression include: the gradient ischemic level within neoplasms, the action of tumor microenvironment (bidirectional interaction between tumor cells and stroma), mechanisms of intercellular transference of genetic information (exosomes), and differential mechanisms of sequence-independent modifications of genetic material and proteins. The intratumoral heterogeneity is at the origin of tumor progression and it is also the byproduct of the selection process during progression. Any analysis of heterogeneity mechanisms must be integrated within the process of segregation of genetic changes in tumor cells during the clonal expansion and progression of neoplasms. The evaluation of these mechanisms must also consider the redundancy and pleiotropism of molecular pathways, for which appropriate surrogate markers would support the presence or not of heterogeneous genetics and the main mechanisms responsible. This knowledge would constitute a solid scientific background for future therapeutic planning. |
| Cashculator 1.3.0 - Personal finance management application.. (Shareware) Posted: 13 Feb 2012 01:41 AM PST  Cashculator is a different kind of personal finance application - instead of focusing on the past and logging previous transactions, it focuses on future by forecasting your financial situation. Easier than a spreadsheet - it is the simplest way to manage your finance. Cashculator allows making better decisions regarding your personal finance or small business.Cashculator is available in English, French, German, Italian, Japanese and Russian languages. Watch the Cashculator Screencast Version 1.3.0: IMPORTANT: Dropped support for 10.5 (Leopard). If you're on anything earlier than 10.6 don't update!
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Cashculator Free 1.3.0 - Track your cashflow.. (Free) Posted: 13 Feb 2012 01:42 AM PST  Cashculator Free is the Mac way to track your cashflow! Do you care about your financial future? Let Cashculator help you! Keep track of your cash flow to make smarter financial decisions and reach your financial goals by planning your future. Tired of complex personal finance applications? Cashculator is the simplest way to manage your finances! Cashculator is not yet another personal finance application. It is different from other applications which are complex and focus on past transactions. Familiar spreadsheet concepts make Cashculator easy to use, visual and straightforward. There is no need to define your accounts and configure the application, no complex dialog boxes, no credits, debits or portfolio management. Just simple numbers: income and expenses. You will become an expert user in no time thanks to the interactive tutorials that will teach you every aspect of using Cashculator. Cashculator is not designed to maintain a detailed, daily records of their spending. Instead, it is designed for people who want to have a fast and easy way to keep track of their budget. Cashculator is the simplest way to manage your finance - easier than a spreadsheet. It is based on familiar spreadsheet concepts and improves them by: - Easy budgeting - separate planned expenses from actual ones. See where you stand compared to your budget - Fast "what-if" scenarios comparison - duplicate your existing financial plan, make changes (i.e. increase salary, add trip abroad), graphically compare to existing plan - Easily split a purchase into several payments - Forecasting based on budget or on average of your actual spending ************************************************************** Cashculator Free is limited to two scenarios and to planning only 3 months ahead. Full planning features can be unlocked with in-app purchase. ************************************************************** You can learn more about Cashculator on our website: http://www.apparentsoft.com/cashculator Cashculator is available in English, German, French, Italian, Russian and Japanese. Version 1.3.0:
Mac OS X 10.7 or later Download Now |
| Harmony 2.5 - Dynamic lyric presentation for worship leaders and churches.. (Shareware) Posted: 13 Feb 2012 01:40 AM PST  Harmony is dynamic lyric presentation for worship leaders and churches. Harmony makes worship presentation effortless. It automatically scales to your projector's size and aspect ratio and takes the hassle out of set-up. Harmony delivers SongSelect importing, and nursery call for children that need to be picked up during the service. It's innovations include: live search of your songs; a preview window for those occasions when you don't have a projector around; and motion lyrics with LyricDance. While supporting traditional video loop motion backgrounds, Harmony goes one step further by offering continuously animated backgrounds (Quartz Compositions) for a truly unique look to your presentation. Other features include:
Version 2.5
Download Now |
| MacBiff 1.1.16 - Checks your IMAP server for new email.. (Free) Posted: 13 Feb 2012 01:37 AM PST  MacBiff is a GPL'd "Biff" Program. It periodically checks your IMAP server for new email, and reports where in your folder hierarchy your new mail resides. Version 1.1.16:
Mac OS X 10.6 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
| PressPerCent 3.0.5 - Ink pre-setting solutions for offset presses.. (Shareware) Posted: 13 Feb 2012 01:38 AM PST  The development of PressPerCent application started in mid 1990's. The purpose was to create a simple ink key pre-setting software tool - a popular subject at the time when press manufacturers and printers were searching for less expensive, space-saving solutions to replace hardware plate scanners (that never were extremely reliable, among everything else). Since then PressPerCent evolved to include more features the customers and OEM partners required, such as: support for the job format of virtually every press type and model, total ink calculations, spot color preview, automatic job processing via hot folders, flexible press configurations, etc. Technically the application itself is just an area coverage calculator. It converts jobs in various input formats into bitmap images with relatively low resolution (its internal file format), then it counts number of pixels that have different color values in these bitmaps. This calculation is done for certain areas specified by user: entire printable area of the printing press, or page area of the job, or stripes that correspond to ink zones of offset (litho) printing press, or any rectangle that user drawn on screen using mouse.
Mac OS X 10.4 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Families celebrate an early Valentine's Day at Hagley Posted: 13 Feb 2012 02:00 AM PST Victorine's Valentine's Day at Hagley Museum: Visitors to the Hagley Museum on Sunday had to chance to do a variety of crafts and activities for Valentine's Day. This posting includes an audio/video/photo media file: Download Now |
| Posted: 12 Feb 2012 10:25 AM PST [Platform: Mobile (iOS)] Surviving in a town overrun with zombies is tough. We get that. Scavenging for food, desperately hailing survivors, and attempting to expand your territory while fighting off infected hordes can tax just about anyone's resolve. And let's not even get into drafting a constitution with the undead knocking on your door! In the iOS version of Rebuild, the captivating zombie survival strategy simulation browser game from Sarah Northway, you get to do all of those things, plus repair a broken helicopter, raid a bar, and help scientists work on secret research projects! |
| Posted: 13 Feb 2012 12:00 AM PST The Paramyxoviridae genus Henipavirus is presently represented by the type species Hendra and Nipah viruses which are both recently emerged zoonotic viral pathogens responsible for repeated outbreaks associated with high morbidity and mortality in Australia, Southeast Asia, India and Bangladesh. These enveloped viruses bind and enter host target cells through the coordinated activities of their attachment (G) and class I fusion (F) envelope glycoproteins. The henipavirus G glycoprotein interacts with host cellular B class ephrins, triggering conformational alterations in G that lead to the activation of the F glycoprotein, which facilitates the membrane fusion process. Using the recently published structures of HeV-G and NiV-G and other paramyxovirus glycoproteins, we review the features of the henipavirus envelope glycoproteins that appear essential for mediating the viral fusion process, including receptor binding, G-F interaction, F activation, with an emphasis on G and the mutations that disrupt viral infectivity. Finally, recent candidate therapeutics for henipavirus-mediated disease are summarized in light of their ability to inhibit HeV and NiV entry by targeting their G and F glycoproteins. |
| Posted: 13 Feb 2012 12:00 AM PST Threatened by the huge pressure caused by climate change, low-carbon cities have become an inevitable part of urban evolution. It is essential to evaluate urban low-carbon development levels to smoothly promote the construction of low-carbon cities. This paper proposes an evaluation index system for urban low-carbon development from the points of view of economic development and social progress, energy structure and usage efficiency, living consumption, and development surroundings. A weighted sum model was also established. Selecting 12 typical Chinese cities as cases studies, an integrated evaluation was conducted based on the index system and the assessment model. The development speed and limiting factors of different cities were also analyzed. The 12 cities were ultimately classified into three groups in terms of their low-carbon development patterns by integrating all of the analysis results. Furthermore, suitable regulation and management for different patterns were suggested. This study both aids in assessing the executive effect of low-carbon city construction and helps to determine existing problems and suggest effective solutions. |
| Catalysts, Vol. 2, Pages 139-170: Oxidation Catalysts for Elemental Mercury in Flue Gases—A Review Posted: 13 Feb 2012 12:00 AM PST The removal of mercury from flue gases in scrubbers is greatly facilitated if the mercury is present as water-soluble oxidized species. Therefore, increased mercury oxidation upstream of scrubber devices will improve overall mercury removal. For this purpose heterogeneous catalysts have recently attracted a great deal of interest. Selective catalytic reduction (SCR), noble metal and transition metal oxide based catalysts have been investigated at both the laboratory and plant scale with this objective. A review article published in 2006 covers the progress in the elemental mercury (Hgel) catalytic oxidation area. This paper brings the review in this area up to date. To this end, 110 papers including several reports and patents are reviewed. For each type of catalyst the possible mechanisms as well as the effect of flue gas components on activity and stability are examined. Advantages and main problems are analyzed. The possible future directions of catalyst development in this environmental research area are outlined. |
| OnyX 2.4.4 - Mac OS X maintenance and optimisation tool.. (Free) Posted: 13 Feb 2012 01:32 AM PST  OnyX is a multifunctional utility for Mac OS X. It allows you to verify the Startup Disk and the structure of its System files, to run miscellaneous tasks of system maintenance, to configure the hidden parameters of the Finder, Dock, Spotlight, and of some of Apple's own applications, to delete caches, to remove a certain number of files and folders that may become cumbersome and more. Version 2.4.4:
Mac OS X 10.7 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Sonora 0.90 - A new kind of music app (beta).. (Free) Posted: 13 Feb 2012 01:34 AM PST  Sonora lets you enjoy your music again. Features:
This posting includes an audio/video/photo media file: Download Now |
| Posted: 13 Feb 2012 12:00 AM PST Two new iridoid glycosides, named williamsoside C (1) and williamsoside D (2) were isolated from the root barks of Sambucus williamsii Hance. Their structures were established on the basis of extensive spectroscopic analysis (1D, 2D NMR and HRESIMS) and chemical studies as α-D-glucopyranosyl (1→2)-β-D-fructofuranosyl (4→6)-β-morroniside (1) and 7β-O-ethyl morroniside-(6′-O-7′′)-β-morroniside (2), respectively. |
| Posted: 13 Feb 2012 12:00 AM PST The essential oils obtained from leaves of Piper duckei and Piper demeraranum by hydrodistillation were analyzed by gas chromatography-mass spectrometry. The main constituents found in P. demeraranum oil were limonene (19.3%) and β-elemene (33.1%) and in P. duckei oil the major components found were germacrene D (14.7%) and trans-caryophyllene (27.1%). P. demeraranum and P. duckei oils exhibited biological activity, with IC50 values between 15 to 76 μg mL−1 against two Leishmania species, P. duckei oil being the most active. The cytotoxicity of the essential oils on mice peritoneal macrophage cells was insignificant, compared with the toxicity of pentamidine. The main mono- and sesquiterpene, limonene (IC50 = 278 μM) and caryophyllene (IC50 = 96 μM), were tested against the strains of Leishmania amazonensis, and the IC50 values of these compounds were lower than those found for the essential oils of the Piper species. The HET-CAM test was used to evaluate the irritation potential of these oils as topical products, showing that these oils can be used as auxiliary medication in cases of cutaneous leishmaniasis, with less side effects and lower costs. |
| Posted: 13 Feb 2012 12:51 AM PST ENGROSSING AND ADDICTIVE Parking Mania captures that great, 'easy to learn, hard to master' style of gameplay that will keep you coming back for more. With hidden areas and pick-ups, time-based bonuses and a driving experience that ranges from exhilaratingly smooth to devilishly tricky, there's always more to explore, and higher speeds to hit! PERFECT CONTROL Parking Mania is a game about precision, style and skill, so it makes sense that Parking Mania offers three different, beautifully balanced control schemes to fit every player: you can steer by tilting the iPhone, or with an on-screen steering wheel, or using a smooth slider bar. Experiment, find your comfort zone, and choose the control scheme you prefer! ENDLESS VARIETY With over 80 vehicles ranging from sports cars to big-rigs, playable in varied, multi-objective levels, across night and day, and traveling from parking lots through city streets and highways – all with random AI-controlled traffic – Parking Mania's huge variety of gameplay will give you hours upon hours of entertainment. FEEL THE FUN Parking Mania's chock-full of fun extras, from vibrations when you collide, to being able to play your own music tracks as well as the Parking Mania tunes, to earning star-ratings of levels you've completed based on your accuracy. Show off your skills by competing on the integrated online leaderboards, and win achievements as you raise your game! |
| Materials, Vol. 5, Pages 278-301: Carbon Nanotubes: Solution for the Therapeutic Delivery of siRNA? Posted: 13 Feb 2012 12:00 AM PST Carbon nanotubes have many unique physical and chemical properties that are being widely explored for potential applications in biomedicine especially as transporters of drugs, proteins, DNA and RNA into cells. Specifically, single-walled carbon nanotubes (SWCNT) have been shown to deliver siRNA to tumors in vivo. The low toxicity, the excellent membrane penetration ability, the protection afforded against blood breakdown of the siRNA payload and the good biological activity seen in vivo suggests that SWCNT may become universal transfection vehicles for siRNA and other RNAs for therapeutic applications. This paper will introduce a short review of a number of therapeutic applications for carbon nanotubes and provide recent data suggesting SWCNT are an excellent option for the delivery of siRNA clinically. |
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Hi there! Nice stuff, do keep me posted when you post again something like this!
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