Games |
- Street Fighter Monopoly coming soon - and you can help choose which characters are in it
- EVE Online 3.7 - Massive multiplayer online game set in outer space; demo available.. (Demo)
- Sonic the Hedgehog 4 Episode 2 - Videos and Trailers
- Denizen's Den - Videos and Trailers
- Munch Time - Videos and Trailers
- Atmosphere, Vol. 3, Pages 200-212: Anthropogenic Climate Change and Allergic Diseases
- BetterZip 2.2 - Archive inspection tool.. (Shareware)
- PhotoStyler 6.2 - Add a sense of realism to your digital photos.. (Shareware)
- eBookBinder 1.0.0 - Create your own ebooks using existing documents (beta).. (Shareware)
- IJMS, Vol. 13, Pages 2692-2706: Flavonoid Biosynthesis Genes Putatively Identified in the Aromatic Plant Polygonum minus via Expressed Sequences Tag (EST) Analysis
- Sensors, Vol. 12, Pages 2667-2692: Using SRAM Based FPGAs for Power-Aware High Performance Wireless Sensor Networks
- Sensors, Vol. 12, Pages 2654-2666: LOLS Research in Technology for the Development and Application of New Fiber-Based Sensors
- IJMS, Vol. 13, Pages 2676-2691: Sequence Analysis and Potentials of the Native RbcS Promoter in the Development of an Alternative Eukaryotic Expression System Using Green Microalga Ankistrodesmus convolutus
- IJMS, Vol. 13, Pages 2650-2675: Increased Activity of Cell Surface Peptidases in HeLa Cells Undergoing UV-Induced Apoptosis Is Not Mediated by Caspase 3
- Sensors, Vol. 12, Pages 2632-2653: Intelligent Control of a Sensor-Actuator System via Kernelized Least-Squares Policy Iteration
- IJMS, Vol. 13, Pages 2636-2649: Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation
- Molecules, Vol. 17, Pages 2437-2445: Flavone Enhances Dengue Virus Type-2 (NGC Strain) Infectivity and Replication in Vero Cells
- Appetite for Distraction - Cheese Tower, Parking Frenzy, Planet Runner
- Trials Evolution: The Game Trials Was Meant to Be
- Trials Evolution Screens
| Street Fighter Monopoly coming soon - and you can help choose which characters are in it Posted: 28 Feb 2012 04:06 AM PST
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| EVE Online 3.7 - Massive multiplayer online game set in outer space; demo available.. (Demo) Posted: 28 Feb 2012 03:30 AM PST  EVE Online is a massive multiplayer online game (MMOG) set in a science-fiction based, persistent world. Players take the role of spaceship pilots seeking fame, fortune, and adventure in a huge, complex, exciting, and sometimes hostile galaxy. A nominal monthly subscription is charged for each player's account; users are responsible for their own Internet service fees. EVE is not a stand-alone, single player game and can only be played online. Unlike most MMOGs that split a large player base up among small clones of the same game world (called "shards") containing no more than 3,000 people, EVE is unique in that all of its players inhabit the same game world. This is a free 14-day trial and no is credit card required; EVE Online costs $14.95 per month to play thereafter. Crashes
Download Now This posting includes an audio/video/photo media file: Download Now |
| Sonic the Hedgehog 4 Episode 2 - Videos and Trailers Posted: 28 Feb 2012 02:19 AM PST Reunited trailer. |
| Denizen's Den - Videos and Trailers Posted: 28 Feb 2012 01:36 AM PST Denizen's Den gameplay trailer. |
| Munch Time - Videos and Trailers Posted: 28 Feb 2012 01:41 AM PST Munch Time official trailer. |
| Atmosphere, Vol. 3, Pages 200-212: Anthropogenic Climate Change and Allergic Diseases Posted: 28 Feb 2012 12:00 AM PST Climate change is expected to have an impact on various aspects of health, including mucosal areas involved in allergic inflammatory disorders that include asthma, allergic rhinitis, allergic conjunctivitis and anaphylaxis. The evidence that links climate change to the exacerbation and the development of allergic disease is increasing and appears to be linked to changes in pollen seasons (duration, onset and intensity) and changes in allergen content of plants and their pollen as it relates to increased sensitization, allergenicity and exacerbations of allergic airway disease. This has significant implications for air quality and for the global food supply. |
| BetterZip 2.2 - Archive inspection tool.. (Shareware) Posted: 28 Feb 2012 03:04 AM PST  BetterZip lets you quickly inspect archives without first extracting their contents.
Version 2.2: New Features
Mac OS X 10.6.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| PhotoStyler 6.2 - Add a sense of realism to your digital photos.. (Shareware) Posted: 28 Feb 2012 03:13 AM PST  PhotoStyler is the easiest way to style your digital photos with your Mac. This simple, fast and accurate native solution combines the powers of Apple's core technologies with the flexibility and efficiency of proprietary application-specific modules. PhotoStyler supports all image formats that are supported by MacOS including RAW images. PhotoStyler doesn't require any special skills or knowledge. Need a sepia? Drop the "Monochrome" filter to the chain and check the "Sepia" checkbox. Want some scratches on the photo to make it look old? Drop the "Scratches" filter to the chain. Need a glow, an annotation, shadows, 3D-look with perspective? Well, you know what to do... You can combine any number of filters and save the chain as a preset. A built-in presets library contains prepared styles so you can preview and adjust your photo variations in seconds. Features:
Version 6.2.
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| eBookBinder 1.0.0 - Create your own ebooks using existing documents (beta).. (Shareware) Posted: 28 Feb 2012 03:09 AM PST eBookBinder is the super-easy tool to create your own ebooks using your existing documents. There are just three major steps to your very own eBook: 1. Enter book details. Name of the book and its author, add an image for the book-cover, webpage of the publisher and other details can be entered. There is no need to fill all fields, at least you should enter a name for your book. 2. Add text-files as chapters to your book-project. Every single text-file you add to eBookBinder is treated as a single chapter. Give your chapters a name and order them per drag'n drop to your desired sequence of chapters. 3. Create your ebook. Just hit the "Bind Book"-Button and eBookBinder will compile the ebook for you. That's all! What can be added to eBookBinder eBookBinder supports several different types of text-files. Next to plain-text files also doc-, odt-, rtf-, rtfd-, html- and webarchive-files are supported by eBookBinder. Support of markup-languages eBookBinder also accepts plain-text files written in Markdown, MultiMarkdown, Textile, Wikitext and Smark as input. These will be converted on the fly when adding these as chapters to your book-process. Visit the preferences of eBookBinder to determine the file-extensions which should be treated for conversion. All files with appropriate file-extensions will be converted when imported. Qutput-formats When compiling your book-project, eBookBinder creates two different ebook-formats. Next to an epub-file also a mobi-file will be created. In-built editor eBookBinder also features an in-build editor which offers some basic editing features like setting text bold, inverse or underlined and alignment of text. However, the best feature of the editor is the reduce feature: Select the text you want to keep and hit the reduce button, anything not selected will be removed. This is ideal for editing web-articles to remove all the advertising- and navigation-stuff quickly. eBookBinder is currently in Beta, a price haven't been set yet. Additions:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 28 Feb 2012 12:00 AM PST P. minus is an aromatic plant, the leaf of which is widely used as a food additive and in the perfume industry. The leaf also accumulates secondary metabolites that act as active ingredients such as flavonoid. Due to limited genomic and transcriptomic data, the biosynthetic pathway of flavonoids is currently unclear. Identification of candidate genes involved in the flavonoid biosynthetic pathway will significantly contribute to understanding the biosynthesis of active compounds. We have constructed a standard cDNA library from P. minus leaves, and two normalized full-length enriched cDNA libraries were constructed from stem and root organs in order to create a gene resource for the biosynthesis of secondary metabolites, especially flavonoid biosynthesis. Thus, large‑scale sequencing of P. minus cDNA libraries identified 4196 expressed sequences tags (ESTs) which were deposited in dbEST in the National Center of Biotechnology Information (NCBI). From the three constructed cDNA libraries, 11 ESTs encoding seven genes were mapped to the flavonoid biosynthetic pathway. Finally, three flavonoid biosynthetic pathway-related ESTs chalcone synthase, CHS (JG745304), flavonol synthase, FLS (JG705819) and leucoanthocyanidin dioxygenase, LDOX (JG745247) were selected for further examination by quantitative RT-PCR (qRT-PCR) in different P. minus organs. Expression was detected in leaf, stem and root. Gene expression studies have been initiated in order to better understand the underlying physiological processes. |
| Posted: 28 Feb 2012 12:00 AM PST While for years traditional wireless sensor nodes have been based on ultra-low power microcontrollers with sufficient but limited computing power, the complexity and number of tasks of today's applications are constantly increasing. Increasing the node duty cycle is not feasible in all cases, so in many cases more computing power is required. This extra computing power may be achieved by either more powerful microcontrollers, though more power consumption or, in general, any solution capable of accelerating task execution. At this point, the use of hardware based, and in particular FPGA solutions, might appear as a candidate technology, since though power use is higher compared with lower power devices, execution time is reduced, so energy could be reduced overall. In order to demonstrate this, an innovative WSN node architecture is proposed. This architecture is based on a high performance high capacity state-of-the-art FPGA, which combines the advantages of the intrinsic acceleration provided by the parallelism of hardware devices, the use of partial reconfiguration capabilities, as well as a careful power-aware management system, to show that energy savings for certain higher-end applications can be achieved. Finally, comprehensive tests have been done to validate the platform in terms of performance and power consumption, to proof that better energy efficiency compared to processor based solutions can be achieved, for instance, when encryption is imposed by the application requirements. |
| Posted: 28 Feb 2012 12:00 AM PST This paper presents the research made at the Laboratory of Optics, Lasers and Systems (LOLS) of the Faculty of Sciences of University of Lisbon, Portugal, in the field of fiber-based sensors. Three areas are considered: sensor encapsulation for natural aqueous environments, refractive index modulation and laser micropatterning. We present the main conclusions on the issues and parameters to take in consideration for the encapsulation process and results of its design and application. Mid-infrared laser radiation was applied to produce long period fiber gratings and nanosecond pulses of near-infrared Q-switch laser were used for micropatterning. |
| Posted: 28 Feb 2012 12:00 AM PST The availability of highly active homologous promoters is critical in the development of a transformation system and improvement of the transformation efficiency. To facilitate transformation of green microalga Ankistrodesmus convolutus which is considered as a potential candidate for many biotechnological applications, a highly-expressed native promoter sequence of ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit (AcRbcS) has been used to drive the expression of β-glucuronidase (gusA) gene in this microalga. Besides the determination of the transcription start site by 5¢-RACE, sequence analysis revealed that AcRbcS promoter contained consensus TATA-box and several putative cis-acting elements, including some representative light-regulatory elements (e.g., G-box, Sp1 motif and SORLIP2), which confer light responsiveness in plants, and several potential conserved motifs (e.g., CAGAC-motif, YCCYTGG-motifs and CACCACA-motif), which may be involved in light responsiveness of RbcS gene in green microalgae. Using AcRbcS promoter::gusA translational fusion, it was demonstrated that this promoter could function as a light-regulated promoter in transgenic A. convolutus, which suggested that the isolated AcRbcS promoter was a full and active promoter sequence that contained all cis-elements required for developmental and light-mediated control of gene expression, and this promoter can be used to drive the expression of heterologous genes in A. convolutus. This achievement therefore advances the development of A. convolutus as an alternative expression system for the production of recombinant proteins. This is the first report on development of gene manipulation system for unicellular green alga A. convolutus. |
| Posted: 28 Feb 2012 12:00 AM PST We have previously shown that in HeLa cells treated with a variety of agents there is an increase in cell surface peptidase (CSP) activity in those cells undergoing apoptosis. The increase in CSP activity observed in UVB-irradiated cells undergoing apoptosis was unaffected when the cultures were treated with the aminopeptidase inhibitor bestatin, and matrix metalloprotease inhibitor BB3103, but greatly enhanced when treated with the caspase 3 inhibitor-DEVD, and reduced in the presence of the poly(ADP-ribose) polymerase (PARP) inhibitor-3-aminobenzamide (3AB). Neither 3AB nor DEVD had an effect on the gross morphology of the apoptotic cells observed under electron microscopy, nor did they have an effect on phosphatidylserine eversion on the cell membrane, or that of PARP cleavage. All the agents except for DEVD had no effect on the level of caspase 3 activity in the cells. The results suggest that other caspases may cleave PARP in these cells. Both 3AB and DEVD treatment reduced the level of actin cleavage seen in the apoptotic cells. The increase in CSP activity observed in cells undergoing UVB-induced apoptosis appears to involve PARP but not caspase 3. |
| Posted: 28 Feb 2012 12:00 AM PST In this paper a new framework, called Compressive Kernelized Reinforcement Learning (CKRL), for computing near-optimal policies in sequential decision making with uncertainty is proposed via incorporating the non-adaptive data-independent Random Projections and nonparametric Kernelized Least-squares Policy Iteration (KLSPI). Random Projections are a fast, non-adaptive dimensionality reduction framework in which high-dimensionality data is projected onto a random lower-dimension subspace via spherically random rotation and coordination sampling. KLSPI introduce kernel trick into the LSPI framework for Reinforcement Learning, often achieving faster convergence and providing automatic feature selection via various kernel sparsification approaches. In this approach, policies are computed in a low-dimensional subspace generated by projecting the high-dimensional features onto a set of random basis. We first show how Random Projections constitute an efficient sparsification technique and how our method often converges faster than regular LSPI, while at lower computational costs. Theoretical foundation underlying this approach is a fast approximation of Singular Value Decomposition (SVD). Finally, simulation results are exhibited on benchmark MDP domains, which confirm gains both in computation time and in performance in large feature spaces. |
| Posted: 28 Feb 2012 12:00 AM PST Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to understand the molecular mechanisms governing neural regeneration of the damaged motor cortex after the transplantation. Recent investigations disclosed that chemokines participated in the regulation of migration and maturation of neural cell grafts. In this review, we summarize the involvement of inflammatory chemokines including stromal cell derived factor 1 (SDF1) in neural regeneration after ES cell derived neural stem/progenitor cell transplantation in mouse stroke models. |
| Posted: 28 Feb 2012 12:00 AM PST This study investigates the effects of 2-phenyl-1-benzopyran-4-one (flavone) on DENV-2 infectivity in Vero cells. Virus adsorption and attachment and intracellular virus replication were investigated using a foci forming unit assay (FFUA) and quantitative RT-PCR, respectively. Addition of flavone (100 μg/mL) significantly increased the number of DENV-2 foci by 35.66% ± 1.52 and 49.66% ± 2.51 when added during and after virus adsorption to the Vero cells, respectively. The average foci size after 4 days of infection increased by 33% ± 2.11 and 89% ± 2.13. The DENV-2 specific RNA copy number in the flavone-treated infected cells increased by 6.41- and 23.1-fold when compared to the mock-treated infected cells. Flavone (100 μg/mL) did not promote or inhibit Vero cell proliferation. The CC50 value of flavone against Vero cells was 446 µg/mL. These results suggest that flavone might enhance dengue virus replication by acting antagonistically towards flavonoids known to inhibit dengue virus replication. |
| Appetite for Distraction - Cheese Tower, Parking Frenzy, Planet Runner Posted: 28 Feb 2012 02:17 AM PST Johnny and Mark take on some mice in Cheese Tower, park it like it's hot in Parking Frenzy, then jump over some stuff with Planet Runner, all available for free on Android. Read and Post Comments | Get the full article at GameSpot "Appetite for Distraction - Cheese Tower, Parking Frenzy, Planet Runner" was posted by sarahl on Tue, 28 Feb 2012 02:17:18 -0800 |
| Trials Evolution: The Game Trials Was Meant to Be Posted: 28 Feb 2012 02:23 AM PST In its motorbike racer sequel, RedLynx remedies Trials HD's shortcomings with intelligent design (decisions).
Back in 2009, RedLynx estimated its game Trials HD might shift 500,000 units in total. Here in 2012, the physics-based motorbike racer has some two million sales to its name, making it a surprise hit and one of Xbox Live Arcade's most successful ever titles. This success came of Trials HD's addictive, instant-restart action overshadowing some significant deficiencies. There were leader boards, but no multiplayer. There was a track creator, but no way to share tracks outside of your friends list. Environments were all variations on the same warehouse theme, limiting level furniture to the same old planks and barrels. It also caught flak for a difficulty curve as steep as the nigh-on vertical slopes of its tougher tracks.
Trials Evolution, the sequel due this spring, squares up to those shortcomings pretty convincingly. The game world has exploded out of the gloomy warehouse, there's local and online multiplayer, and now there's proper sharing for created tracks. All of which potentially makes this not just the next branch on Trials' evolutionary tree, but the very game Trials HD should have been. Though the superbly tuned physics of the previous game are left all but untouched, the graphics engine has been souped up to render Evolution's newly expansive landscapes. The 60 or so tracks are set across portions of a huge map, whose eight square kilometres take in hills, valleys, rivers, and roads, as well as urban and industrial-looking areas. The upshot is a visual variety lacking in Trials HD, with each of Evolution's track given some visual gimmick or light 'story' hook. One level, Downhill Dominator, stars a colossal wooden rollercoaster of a track, featuring some of the biggest jumps and drops in the game (the suspension on the bikes has been tweaked to better handle long falls). Freed from the confines of HD's narrow warehouse, Evolutions' driving lines also weave into and out of the screen, though the action is still primarily left to right. Another track is a ride across the top of a collapsing dam. Another is set on a wrecked oil field, fighter jets zooming overhead. One track bizarrely recreates Saving Private Ryan's Omaha landing, stretching from bombed-out shoreline to concrete beach bunker. And then there's a swamp, sewage works, and a graveyard of ancient stone giants. Even for players with zero interest in sharing their own tracks or multiplayer racing, the diversity of tracks makes a world of difference between Trials HD and Evolution. For those itching to race real people, there's four-player action available locally and online, across 12 tracks with four parallel lanes. If you drop off the left side of the screen, you respawn on the right with a point deducted from your score, keeping everyone on the same screen. It's a lot of fun, especially with a risky bailout finish--you can overtake the lead racer at the last moment by with a bailout, which still punts your rider off the bike like an invisible ejector seat. But bail too soon and you won't cross the finish line or respawn, leaving you with no points at all.
The four-lane racing is also an exercise in concentration. When all four players are bunched up, crashing a lot, and obscuring each other's riders, it's tricky to be the guy on the furthest lane--but you at least take it in turns to be on the lane closest to the camera. Away from the dedicated, four-lane tracks, you can race other players online in ranked matches (across the tracks that come with the game) and unranked matches (across any custom-made track). Here you race on the usual single lane against real-time "ghosts"--that is, just a marker indicating your online opponent's real-time position. Like the game world, Trials' track editor has expanded almost beyond recognition. In the "Lite" editor, you just place a start and end marker somewhere on the game map, so your ride is dictated by the terrain along the line between them. To that basic track you can add custom-coloured ramps and obstacles, or any other of the thousands of bits of track furniture. The "Pro" editor, on the other hand, contains the exact tools with which RedLynx's own designers create tracks. There's a terrain editor for forming hills and the like, and a visual scripting system to let would-be level designers create a sophisticated, triggered series of events. With full camera control to boot, the editor's power and flexibility appear equivalent to that of LittleBigPlanet 2, letting creative types cook up games from entirely different genres. So far we've been shown a jury-rigged first-person shooter (with bull's-eye targets rather than zombies or what have you), a side-scrolling jetpack game, an Angry Birds clone, and a top-down spaceship shoot-em-up, all built with Trials track props. More important than those exotica is RedLynx's new system for sharing and discovering user-made tracks. The previous game had no server storage for custom tracks, so these could only be shared directly with Xbox Live friends--a frustration for players and apparently the developer alike. That's been fixed none too soon; created tracks can now be found sorted by Most Downloaded, Highest Rated, and the like in Track Central, or searched for by difficulty, creator, and theme tags.
As for remedying the exponential difficulty curve of Trials HD, Evolution adds new layers of meta-game rather than producing easier tracks. Now there are set events (themed groups of tracks of comparable difficulty) and licences that must be earned to access them; the idea is that meting out players' progress and teaching them new tricks in licence tests will keep them from scraping hurriedly through tough tracks to find themselves stuck in the expert-level content. For all its flaws, Trials HD had a skill-obsessed purity. The simple, samey locations took a backseat, while skilful, physics-based riding came to the fore. In its new diversity, Evolutions might have a few dud curiosities--like the wobbly, droopy handling in its UFO-flying skill game--but we're betting they'll be eclipsed by the improvements everywhere else and other, more spectacular curiosities. One track resembles a motorbike stunt course through Inception's impossibly curving, shifting cityscape, so there's that to look forward to. Like HD, Evolution is destined only for Xbox 360's download store--for now, at least. RedLynx's creative director Antti Ilvessuo doesn't rule out more Trials titles for other platforms, and points to the studio's enthusiastically multi-platform history: 'We have always been a multi-platform studio, RedLynx has been making [games] for PC, PSN, DS, you name it, every platform. So let's see what the future brings." Read and Post Comments | Get the full article at GameSpot "Trials Evolution: The Game Trials Was Meant to Be" was posted by Jane Douglas on Tue, 28 Feb 2012 02:23:02 -0800 |
| Posted: 28 Feb 2012 01:31 AM PST 34 new shots posted.
Get the full article at GameSpot "Trials Evolution Screens" was posted on Tue, 28 Feb 2012 01:31:37 -0800 |
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