вторник, 2 августа 2011 г.

Games

Games

Watch TalkRadar UK LIVE today at 11:30am BST (Xbox 360)

Posted: 02 Aug 2011 12:00 AM PDT

We're recording TalkRadar UK's 100th episode today, August 2nd 2011 at 11:30am, and you can watch us LIVE via the handy little window into our studio that you can see below. Enjoy!


Streaming by Ustream

Genes, Vol. 2, Pages 516-561: Reassessing Domain Architecture Evolution of Metazoan Proteins: Major Impact of Errors Caused by Confusing Paralogs and Epaktologs

Posted: 02 Aug 2011 12:00 AM PDT

In the accompanying paper (Nagy, Szláma, Szarka, Trexler, Bányai, Patthy, Reassessing Domain Architecture Evolution of Metazoan Proteins: Major Impact of Gene Prediction Errors) we showed that in the case of UniProtKB/TrEMBL, RefSeq, EnsEMBL and NCBI's GNOMON predicted protein sequences of Metazoan species the contribution of erroneous (incomplete, abnormal, mispredicted) sequences to domain architecture (DA) differences of orthologous proteins might be greater than those of true gene rearrangements. Based on these findings, we suggest that earlier genome-scale studies based on comparison of predicted (frequently mispredicted) protein sequences may have led to some erroneous conclusions about the evolution of novel domain architectures of multidomain proteins. In this manuscript we examine the impact of confusing paralogous and epaktologous multidomain proteins (i.e., those that are related only through the independent acquisition of the same domain types) on conclusions drawn about DA evolution of multidomain proteins in Metazoa. To estimate the contribution of this type of error we have used as reference UniProtKB/Swiss-Prot sequences from protein families with well-characterized evolutionary histories. We have used two types of paralogy-group construction procedures and monitored the impact of various parameters on the separation of true paralogs from epaktologs on correctly annotated Swiss-Prot entries of multidomain proteins. Our studies have shown that, although public protein family databases are contaminated with epaktologs, analysis of the structure of sequence similarity networks of multidomain proteins provides an efficient means for the separation of epaktologs and paralogs. We have also demonstrated that contamination of protein families with epaktologs increases the apparent rate of DA change and introduces a bias in DA differences in as much as it increases the proportion of terminal over internal DA differences.We have shown that confusing paralogous and epaktologous multidomain proteins significantly increases the apparent rate of DA change in Metazoa and introduces a positional bias in favor of terminal over internal DA changes. Our findings caution that earlier studies based on analysis of datasets of protein families that were contaminated with epaktologs may have led to some erroneous conclusions about the evolution of novel domain architectures of multidomain proteins. A reassessment of the DA evolution of multidomain proteins is presented in an accompanying paper [1].

Genes, Vol. 2, Pages 502-515: Chromatin Organization by Repetitive Elements (CORE): A Genomic Principle for the Higher-Order Structure of Chromosomes

Posted: 02 Aug 2011 12:00 AM PDT

Eukaryotic genomes contain a large amount of DNA repeats (also known as repetitive DNA, repetitive elements, and repetitive sequences). Here, I propose a role of repetitive DNA in the formation of higher-order structures of chromosomes. The central idea of this theory is that chromatin regions with repetitive sequences pair with regions harboring homologous repeats and that such somatic repeat pairing (RP) assembles repetitive DNA chromatin into compact chromosomal domains that specify chromatin folding in a site-directed manner. According to this theory, DNA repeats are not randomly distributed in the genome. Instead, they form a core framework that coordinates the architecture of chromosomes. In contrast to the viewpoint that DNA repeats are genomic 'junk', this theory advocates that repetitive sequences are chromatin organizer modules that determine chromatin-chromatin contact points within chromosomes. This novel concept, if correct, would suggest that DNA repeats in the linear genome encode a blueprint for higher-order chromosomal organization.

Both Sides Of NBA Labor Negotiations Prepare For Legal War

Posted: 02 Aug 2011 02:14 AM PDT

When NBA owners and players convene Monday for their first full-scale bargaining session since the lockout was imposed on July 1, the real news will be unfolding far from midtown Manhattan.

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IJMS, Vol. 12, Pages 4885-4895: The Chemical Composition and Nitrogen Distribution of Chinese Yak (Maiwa) Milk

Posted: 02 Aug 2011 12:00 AM PDT

The paper surveyed the chemical composition and nitrogen distribution of Maiwa yak milk, and compared the results with reference composition of cow milk. Compared to cow milk, yak milk was richer in protein (especially whey protein), essential amino acids, fat, lactose and minerals (except phosphorus). The contents of some nutrients (total protein, lactose, essential amino acids and casein) were higher in the warm season than in the cold season. Higher ratios of total essential amino acids/total amino acids (TEAA/TAA) and total essential amino acids/total non essential amino acids (TEAA/TNEAA) were found in the yak milk from the warm season. However its annual average ratio of EAA/TAA and that of EAA/NEAA were similar to those of cow milk. Yak milk was rich in calcium and iron (p < 0.05), and thus may serve as a nutritional ingredient with a potential application in industrial processing.

IJMS, Vol. 12, Pages 4872-4884: Green Synthesis and Characterization of Silver/Chitosan/Polyethylene Glycol Nanocomposites without any Reducing Agent

Posted: 02 Aug 2011 12:00 AM PDT

This paper presents the green synthesis of silver nanoparticles (Ag NPs) in aqueous medium. This method was performed by reducing AgNO3 in different stirring times of reaction at a moderate temperature using green agents, chitosan (Cts) and polyethylene glycol (PEG). In this work, silver nitrate (AgNO3) was used as the silver precursor while Cts and PEG were used as the solid support and polymeric stabilizer. The properties of Ag/Cts/PEG nanocomposites (NCs) were studied under different stirring times of reaction. The developed Ag/Cts/PEG NCs were then characterized by the ultraviolet-visible (UV-Vis) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy.

IJMS, Vol. 12, Pages 4861-4871: Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells

Posted: 02 Aug 2011 12:00 AM PDT

Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated. Here, we evaluated the inhibitory proliferation effects of Silibinin in pancreatic carcinoma growth and examined whether Silibinin modulates cell cycle and apoptosis. Our results indicate that Silibinin effectively inhibited the pancreatic carcinoma AsPC-1, BxPC-3 and Panc-1 cells' proliferation and caused apoptosis. Silibinin induced a decrease in S phase and cell cycle arrest in G1 phase in AsPC-1 cells, but had no obvious changes in BxPC-3 and Panc-1 cell cycle. Furthermore, these results suggest that Silibinin might be a candidate chemopreventive agent for pancreatic carcinoma therapy.

Royal Envoy

Posted: 02 Aug 2011 02:29 AM PDT

The province of Islandshire was destroyed by a severe storm, this left the inhabitants homeless. You have been trusted by the King to rebuild the ho..

Potion Bar

Posted: 02 Aug 2011 02:29 AM PDT

The Potion Bar was created by a powerful witch, the mystical brews have enchanted the townsfolk and flock to the bar. The last bartender could not c..

Around The World In 80 Days

Posted: 02 Aug 2011 02:29 AM PDT

Phileas Fogg starts an epic adventure to travel around the world in 80 days. Assist Phileas by finding his missing items in this colourful puzzle ga..

upCast 7.6.0 - Microsoft Word to XML converter, now includes downCast.. (Demo)

Posted: 02 Aug 2011 01:49 AM PDT

upCast enables you to use Microsoft Word as an authoring application for XML documents. Take advantage of the widespread availability and familiar user interface of Word or any other RTF savvy office application for structured document authoring. upCast offers a cost-effective way to reuse existing tools for gaining all the benefits of a standardized markup language: XML.

Currently using downCast? It's included!

Version 7.6.0:

  • [UPL] Mechanism to retrieve the contents of the (pipeline) info window from UPL (key: $env:pipeline-info) UC-952
  • [CORE] New XSLT Extension function: logCustom( uid, level, code, message) to write to module log UC-979
  • [CORE, UPL] Add function to create symbolic links in the file system UC-971
  • [CORE] Allow log output forking with dedicated filters at the app's global log hub UC-944
  • [CORE] INCLUDE realm new parameter: "fallback" UC-1000
  • [EXPORTER, RTFI] Add new internal attribute on <table> to allow for per-table selection of desired output rendering (internal model, HTML or CALS)
  • [PIPELINE] Possibility to query a pipeline's build number via API programmatically UC-954
For more details, see full changelog.

  • Mac OS X 10.5 or later
  • Java 5 Runtime


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BitNami OSQA Stack 0.9.0beta3-0 - Easy-to-install distribution of the OSQA application.. (Free)

Posted: 02 Aug 2011 01:58 AM PDT



BitNami OSQA Stack Native Installer is an easy-to-install distribution of the OSQA application. It includes pre-configured, ready-to-run versions of Apache, PostgreSQL and Django so users can get a OSQA installation up and running in minutes after answering a few questions. Windows, Linux and Mac OS X operating systems are supported.

OSQA is a sophisticated Open Source Question and Answer System that can help you manage and grow online communities. OSQA is written in Python and powered by the Django application framework.



Version 0.9.0beta3-0: Initial release.

Mac OS X 10.4 or later.

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Passenger 4.0.1 - Server password generator.. (Shareware)

Posted: 02 Aug 2011 02:02 AM PDT



Passenger is a server account creation and password generation tool that will import tab and comma-delimited text, ASIP 6.3 and Mac OS X XML and create account information and passwords for Mac OS X Server 10.2 and newer, Macintosh Manager, Web, Master Key, and Master Spell. It includes tools migrate account folders, set permissions in batch and Eudora client settings customization and distribution.

Version 4.0.1:
  • Permissions now properly exits and reports when no valid folders can be found to set permissions
  • Folders export now reports when the export folder is not writable
  • Master Key, Master Spell and Folders export now allow a preview
  • Fixed some small interface bugs in Permissions


Mac OS X 10.4 or later.

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sArchiver 3.8.5 - File archiving and extraction.. (Shareware)

Posted: 02 Aug 2011 01:50 AM PDT



sArchiver the lord of archives.
  • Complete RAR support (compress, decompress, password protected, split volumes)
  • Compress, Extract, Test, Split: rar, zip, 7z, ARJ, LHA, gzip, bzip2, tar
  • Compress & Upload to FTP with ease and automation
  • Send email notification with link (optional) when FTP upload complete
  • Integrated DMG image creation
  • Unique SFX (self-extracting) technology. sArchiver is able to create independent self-extracting archives. The SFX archive doesn't need any application to extract it self. That's freedom.
  • Integrated backup system. sArchiver can backup your Applications Preferences and personal Documents. The backups are totally independent. You don't need sArchiver to restore your information.
  • Integrated archive converter. You can convert rar, zip, 7z, LHA, ARJ, gzip, bzip2, tar to rar, zip, 7z.
  • sArchiver can preview your archived picture collection without extracting the archive.
  • sArchiver is able to extract multiple archive files directly from finder. (select all files and double click on one of them while they are all still selected).


Version 3.8.5:
  • Interface completely redesigned for Lion compatibility
  • interface background changed
  • Fixed archive test function
  • Fixed "Open with Finder" in file preview drawer
  • Fixed registration check procedure
  • Added "Open archive folder" button


Mac OS X 10.5 or later

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Sensors, Vol. 11, Pages 7644-7655: Suppression of Air Refractive Index Variations in High-Resolution Interferometry

Posted: 02 Aug 2011 12:00 AM PDT

The influence of the refractive index of air has proven to be a major problem on the road to improvement of the uncertainty in interferometric displacement measurements. We propose an approach with two counter-measuring interferometers acting as a combination of tracking refractometer and a displacement interferometer referencing the wavelength of the laser source to a mechanical standard made of a material with ultra-low thermal expansion. This technique combines length measurement within a specified range with measurement of the refractive index fluctuations in one axis. Errors caused by different position of the interferometer laser beam and air sensors are thus eliminated. The method has been experimentally tested in comparison with the indirect measurement of the refractive index of air in a thermal controlled environment. Over a 1 K temperature range an agreement on the level of 5 × 10−8 has been achieved.

Sensors, Vol. 11, Pages 7625-7643: Enhanced Precision Time Synchronization for Wireless Sensor Networks

Posted: 02 Aug 2011 12:00 AM PDT

Time synchronization in wireless sensor networks (WSNs) is a fundamental issue for the coordination of distributed entities and events. Nondeterministic latency, which may decrease the accuracy and precision of time synchronization can occur at any point in the network layers. Specially, random back-off by channel contention leads to a large uncertainty. In order to reduce the large nondeterministic uncertainty from channel contention, we propose an enhanced precision time synchronization protocol in this paper. The proposed method reduces the traffic needed for the synchronization procedure by selectively forwarding the packet. Furthermore, the time difference between sensor nodes increases as time advances because of the use of a clock source with a cheap crystal oscillator. In addition, we provide a means to maintain accurate time by adopting hardware-assisted time stamp and drift correction. Experiments are conducted to evaluate the performance of the proposed method, for which sensor nodes are designed and implemented. According to the evaluation results, the performance of the proposed method is better than that of a traditional time synchronization protocol.

Sensors, Vol. 11, Pages 7606-7624: Indoor Pedestrian Navigation Using Foot-Mounted IMU and Portable Ultrasound Range Sensors

Posted: 02 Aug 2011 12:00 AM PDT

Many solutions have been proposed for indoor pedestrian navigation. Some rely on pre-installed sensor networks, which offer good accuracy but are limited to areas that have been prepared for that purpose, thus requiring an expensive and possibly time-consuming process. Such methods are therefore inappropriate for navigation in emergency situations since the power supply may be disturbed. Other types of solutions track the user without requiring a prepared environment. However, they may have low accuracy. Offline tracking has been proposed to increase accuracy, however this prevents users from knowing their position in real time. This paper describes a real time indoor navigation system that does not require prepared building environments and provides tracking accuracy superior to previously described tracking methods. The system uses a combination of four techniques: foot-mounted IMU (Inertial Motion Unit), ultrasonic ranging, particle filtering and model-based navigation. The very purpose of the project is to combine these four well-known techniques in a novel way to provide better indoor tracking results for pedestrians.

Sensors, Vol. 11, Pages 7568-7605: Semantically-Enabled Sensor Plug & Play for the Sensor Web

Posted: 02 Aug 2011 12:00 AM PDT

Environmental sensors have continuously improved by becoming smaller, cheaper, and more intelligent over the past years. As consequence of these technological advancements, sensors are increasingly deployed to monitor our environment. The large variety of available sensor types with often incompatible protocols complicates the integration of sensors into observing systems. The standardized Web service interfaces and data encodings defined within OGC's Sensor Web Enablement (SWE) framework make sensors available over the Web and hide the heterogeneous sensor protocols from applications. So far, the SWE framework does not describe how to integrate sensors on-the-fly with minimal human intervention. The driver software which enables access to sensors has to be implemented and the measured sensor data has to be manually mapped to the SWE models. In this article we introduce a Sensor Plug & Play infrastructure for the Sensor Web by combining (1) semantic matchmaking functionality, (2) a publish/subscribe mechanism underlying the SensorWeb, as well as (3) a model for the declarative description of sensor interfaces which serves as a generic driver mechanism. We implement and evaluate our approach by applying it to an oil spill scenario. The matchmaking is realized using existing ontologies and reasoning engines and provides a strong case for the semantic integration capabilities provided by Semantic Web research.

Sensors, Vol. 11, Pages 7554-7567: Stress Wave Signal Denoising Using Ensemble Empirical Mode Decomposition and an Instantaneous Half Period Model

Posted: 02 Aug 2011 12:00 AM PDT

Stress-wave-based techniques have been proven to be an accurate nondestructive test means for determining the quality of wood based materials and they been widely used for this purpose. However, the results are usually inconsistent, partially due to the significant difficulties in processing the nonlinear, non-stationary stress wave signals which are often corrupted by noise. In this paper, an ensemble empirical mode decomposition (EEMD) based approach with the aim of signal denoising was proposed and applied to stress wave signals. The method defined the time interval between two adjacent zero-crossings within the intrinsic mode function (IMF) as the instantaneous half period (IHP) and used it as a criterion to detect and classify the noise oscillations. The waveform between the two adjacent zero-crossings was retained when the IHP was larger than the predefined threshold, whereas the waveforms with smaller IHP were set to zero. Finally the estimated signal was obtained by reconstructing the processed IMFs. The details of threshold choosing rules were also discussed in the paper. Additive Gaussian white noise was embedded into real stress wave signals to test the proposed method. Butterworth low pass filter, EEMD-based low pass filter and EEMD-based thresholding filter were used to compare filtering performance. Mean square error between clean and filtered stress waves was used as filtering performance indexes. The results demonstrated the excellent efficiency of the proposed method.

Urban Terror 4.1.1 (updated)

Posted: 02 Aug 2011 01:09 AM PDT

Urban Terror is a total conversion/stand-alone FPS

More about Urban Terror
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