среда, 10 августа 2011 г.

Games

Games

Rhyme Genie 3.1 - The first dynamic rhyming dictionary in the world.. (Shareware)

Posted: 10 Aug 2011 02:58 AM PDT



Rhyme Genie... Free your creative spirits with the world's first dynamic rhyming dictionary with 30 different rhyme types and over 300,000 entries including 170,000 phrases, 35,000 proper nouns and 48,000 titles of charted songs. Instantly find perfect rhymes as easily as entering a word and flex Rhyme Genie's muscle with a powerful intelligent rhyme algorithm. Change from one-syllabic to multi-syllabic rhymes with a single click and see a wealth of near rhymes appear by simply decreasing the similarity in sound. Command a freely scalable dictionary with more than 9 million phonetic references and break through creative bottlenecks with one of the largest collections of American sayings, idioms, popular names, places and trademarked brands. Find suitable rhymes more efficiently with a special Songwriter Dictionary compiled from over 600,000 song lyrics and a convenient wordfilter with over 130,000 parts of speech. Create song hooks, advertising slogans, headlines and titles by searching for phonetic similarities or exact word matches. Express yourself effortlessly with an integrated 115,000 word Webster's dictionary and an extensive thesaurus with over 2.5 million synonyms.

Version 3.1:
  • Rhyme Genie is now fully compatible with Mac OS X 10.7 Lion.


  • Mac OS X 10.5.7 or later.


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Vicomsoft FTP Client 4.6.4 - FTP client.. (Demo)

Posted: 10 Aug 2011 03:02 AM PDT



Vicomsoft FTP Client... From the makers of highly regarded Internet security and content filtering software for Mac OS X, Vicomsoft FTP Client offers extreme performance and unrivaled reliability, married with a sleek and intuitive user interface.

First released in 1997, the latest version of FTP Client represents the culmination of over 10 years experience in FTP transfers on the Mac platform. Now a Universal Binary, FTP Client v4.6 offers an incredible speed boost over its previous versions when running on Intel-based Macs. In addition, version 4.6 has a beautifully streamlined new user interface which fits perfectly with the visual excellence of Mac OS X.

Version 4.6.4:

  • Mac OS X 10.7 Lion compatibility update


Mac OS X 10.4 or later.

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Perfect CMS Icons 2011.5 - Icons for content management systems.. (Shareware)

Posted: 10 Aug 2011 02:59 AM PDT



Perfect CMS Icons is a collection of high-quality interface icons that were specifically designed for quick implementation in the back ends of content management systems of all kinds. Each icon in this collection comes in various formats (ICO, PNG, GIF and BMP) and color versions (256-color and 32-bit color with an alpha channel). The overall number of icons in Perfect CMS Icons reaches 300, so you will have plenty of variants to choose from!

Version 2011.5:

New icons were added into Perfect CMS Icons set:

  • 3d pie chart, Forms, Valid, Access key, Pay, Filters, Server synchronization, Search data, and Relations.


Mac OS X 10.1 or later.

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Membranes, Vol. 1, Pages 195-216: Monitoring Protein Fouling on Polymeric Membranes Using Ultrasonic Frequency-Domain Reflectometry

Posted: 10 Aug 2011 12:00 AM PDT

Novel signal-processing protocols were used to extend the in situ sensitivity of ultrasonic frequency-domain reflectometry (UFDR) for real-time monitoring of microfiltration (MF) membrane fouling during protein purification. Different commercial membrane materials, with a nominal pore size of 0.2 µm, were challenged using bovine serum albumin (BSA) and amylase as model proteins. Fouling induced by these proteins was observed in flat-sheet membrane filtration cells operating in a laminar cross-flow regime. The detection of membrane-associated proteins using UFDR was determined by applying rigorous statistical methodology to reflection spectra of ultrasonic signals obtained during membrane fouling. Data suggest that the total power reflected from membrane surfaces changes in response to protein fouling at concentrations as low as 14 μg/cm2, and results indicate that ultrasonic spectra can be leveraged to detect and monitor protein fouling on commercial MF membranes.

Sustainability, Vol. 3, Pages 1224-1233: Adaptability of Wheat Cultivars to a Late-Planted No-Till Fallow Production System

Posted: 10 Aug 2011 12:00 AM PDT

In Washington, over fifty percent of the wheat produced under rainfed conditions receives less than 300 mm of annual precipitation. Hence, a winter wheat-summer fallow cropping system has been adopted to obtain adequate moisture for winter wheat production. Current tilled fallow systems are exposed to significant soil degradation from wind and water erosion. As a result, late-planted no-till fallow systems are being evaluated to mitigate erosion concerns. The objective of this study was to evaluate current cultivars under late-planted no-till fallow systems to identify whether current breeding schemes in tilled fallow systems could select productive cultivars in late-planted no-till fallow systems. Thirty cultivars were planted in a split-plot design with fallow type as the main plot and genotype as the sub-plot. Fallow types evaluated were a tilled fallow system and a late planted no-till fallow system. Data were collected on heading date, plant height, grain volume weight, grain yield, and grain protein content. Analysis of variance was conducted on data across locations. Results were significant for all traits except for grain protein content. The late-planted no-till fallow system headed 16 days later was 5 cm shorter, yielded 36% less, and had a grain volume weight 3% less than the tilled fallow system. The lower yield and grain volume weight potential is hypothesized to be due to the 16 day delay in heading date leading to warmer temperatures during grain fill and a shorter duration. In order to breed wheat to be highly productive under a late-planted no-till fallow system, directly selecting in this system for early spring growth and earlier heading dates will be essential.

Sustainability, Vol. 3, Pages 1206-1223: Collaborative Plant Breeding for Organic Agricultural Systems in Developed Countries

Posted: 10 Aug 2011 12:00 AM PDT

Because organic systems present complex environmental stress, plant breeders may either target very focused regions for different varieties, or create heterogeneous populations which can then evolve specific adaptation through on-farm cultivation and selection. This often leads to participatory plant breeding (PPB) strategies which take advantage of the specific knowledge of farmers. Participatory selection requires increased commitment and engagement on the part of the farmers and researchers. Projects may begin as researcher initiatives with farmer participation or farmer initiatives with researcher participation and over time evolve into true collaborations. These projects are difficult to plan in advance because by nature they change to respond to the priorities and interests of the collaborators. Projects need to provide relevant information and analysis in a time-frame that is meaningful for farmers, while remaining scientifically rigorous and innovative. This paper presents two specific studies: the first was a researcher-designed experiment that assessed the potential adaptation of landraces to organic systems through on-farm cultivation and farmer selection. The second is a farmer-led plant breeding project to select bread wheat for organic systems in France. Over the course of these two projects, many discussions among farmers, researchers and farmers associations led to the development of methods that fit the objectives of those involved. This type of project is no longer researcher-led or farmer-led but instead an equal collaboration. Results from the two research projects and the strategy developed for an ongoing collaborative plant breeding project are discussed.

Nutrients, Vol. 3, Pages 735-755: Metabolic Agents that Enhance ATP can Improve Cognitive Functioning: A Review of the Evidence for Glucose, Oxygen, Pyruvate, Creatine, and l-Carnitine

Posted: 10 Aug 2011 12:00 AM PDT

Over the past four or five decades, there has been increasing interest in the neurochemical regulation of cognition. This field received considerable attention in the 1980s, with the identification of possible cognition enhancing agents or "smart drugs". Even though many of the optimistic claims for some agents have proven premature, evidence suggests that several metabolic agents may prove to be effective in improving and preserving cognitive performance and may lead to better cognitive aging through the lifespan. Aging is characterized by a progressive deterioration in physiological functions and metabolic processes. There are a number of agents with the potential to improve metabolic activity. Research is now beginning to identify these various agents and delineate their potential usefulness for improving cognition in health and disease. This review provides a brief overview of the metabolic agents glucose, oxygen, pyruvate, creatine, and l-carnitine and their beneficial effects on cognitive function. These agents are directly responsible for generating ATP (adenosine triphosphate) the main cellular currency of energy. The brain is the most metabolically active organ in the body and as such is particularly vulnerable to disruption of energy resources. Therefore interventions that sustain adenosine triphosphate (ATP) levels may have importance for improving neuronal dysfunction and loss. Moreover, recently, it has been observed that environmental conditions and diet can affect transgenerational gene expression via epigenetic mechanisms. Metabolic agents might play a role in regulation of nutritional epigenetic effects. In summary, the reviewed metabolic agents represent a promising strategy for improving cognitive function and possibly slowing or preventing cognitive decline.

Toxins, Vol. 3, Pages 991-1003: Molecular Analysis of the Interaction of the Snake Venom Rhodocytin with the Platelet Receptor CLEC-2

Posted: 10 Aug 2011 12:00 AM PDT

The Malayan pit viper, Calloselasma rhodostoma, produces a potent venom toxin, rhodocytin (aggretin) which causes platelet aggregation. Rhodocytin is a ligand for the receptor CLEC-2 on the surface of platelets. The interaction of these two molecules initiates a signaling pathway which results in platelet activation and aggregation. We have previously solved the crystal structures of CLEC-2 and of rhodocytin, and have proposed models by which tetrameric rhodocytin may interact with either two monomers of CLEC-2, or with one or two copies of dimeric CLEC-2. In the current study we use a range of approaches to analyze the molecular interfaces and dynamics involved in the models of the interaction of rhodocytin with either one or two copies of dimeric CLEC-2, and their implications for clustering of CLEC-2 on the platelet surface.

Pharmaceuticals, Vol. 4, Pages 1101-1136: The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction

Posted: 10 Aug 2011 12:00 AM PDT

The endocannabinoid system (ECS) has been implicated in many physiological functions, including the regulation of appetite, food intake and energy balance, a crucial involvement in brain reward systems and a role in psychophysiological homeostasis (anxiety and stress responses). We first introduce this important regulatory system and chronicle what is known concerning the signal transduction pathways activated upon the binding of endogenous cannabinoid ligands to the Gi/0-coupled CB1 cannabinoid receptor, as well as its interactions with other hormones and neuromodulators which can modify endocannabinoid signaling in the brain. Anorexia nervosa (AN) and bulimia nervosa (BN) are severe and disabling psychiatric disorders, characterized by profound eating and weight alterations and body image disturbances. Since endocannabinoids modulate eating behavior, it is plausible that endocannabinoid genes may contribute to the biological vulnerability to these diseases. We present and discuss data suggesting an impaired endocannabinoid signaling in these eating disorders, including association of endocannabinoid components gene polymorphisms and altered CB1-receptor expression in AN and BN. Then we discuss recent findings that may provide new avenues for the identification of therapeutic strategies based on the endocannabinod system. In relation with its implications as a reward-related system, the endocannabinoid system is not only a target for cannabis but it also shows interactions with other drugs of abuse. On the other hand, there may be also a possibility to point to the ECS as a potential target for treatment of drug-abuse and addiction. Within this framework we will focus on enzymatic machinery involved in endocannabinoid inactivation (notably fatty acid amide hydrolase or FAAH) as a particularly interesting potential target. Since a deregulated endocannabinoid system may be also related to depression, anxiety and pain symptomatology accompanying drug-withdrawal states, this is an area of relevance to also explore adjuvant treatments for improving these adverse emotional reactions.

Symmetry, Vol. 3, Pages 541-563: Symmetry Aspects of the Band Structure and Motion Equations Applied in Calculating the Cyclotron Frequency of Electrons in Metals

Posted: 10 Aug 2011 12:00 AM PDT

Cyclotron frequency of a crystal electron is, in general, not an easily accessible parameter. Nevertheless, its calculation can be simplified when the symmetry properties of the band structure and those of the motion equations in the magnetic field are simultaneously taken into account. In effect, a combined symmetry of the electron Hamiltonian and that of the Lorentz equation provide us with a non-linear oscillator problem of high symmetry. In the next step, the kinetic energy of the oscillator can be separated from the whole of electron energy and applied in a new kind of calculation of the cyclotron frequency which is much more simple than before. In consequence, a detailed approach to the electron circulation, also in more complex band structures, becomes a relatively easy task. For different crystal lattices of cubic symmetry taken as examples the cyclotron frequency of the present and a former method are compared numerically giving the same results.

Chroma Factory

Posted: 10 Aug 2011 01:55 AM PDT

A fun multi-tasking game with a factory theme! Take the role of the factory's artificial intelligence and manage all processes.

Pharmaceutics, Vol. 3, Pages 474-484: Effects of Chemical and Physical Enhancement techniques on Transdermal Delivery of Cyanocobalamin (Vitamin B12) In Vitro

Posted: 10 Aug 2011 12:00 AM PDT

Vitamin B12 deficiency, which may result in anemia and nerve damage if left untreated, is currently treated by administration of cyanocobalamin via oral or intramuscular routes. However, these routes are associated with absorption and compliance issues which have prompted us to investigate skin as an alternative site of administration. Delivery through skin, however, is restricted to small and moderately lipophilic molecules due to the outermost barrier, the stratum corneum (SC). In this study, we have investigated the effect of different enhancement techniques, chemical enhancers (ethanol, oleic acid, propylene glycol), iontophoresis (anodal iontophoresis) and microneedles (soluble maltose microneedles), which may overcome this barrier and improve cyanocobalamin delivery. Studies with different chemical enhancer formulations indicated that ethanol and oleic acid decreased the lag time while propylene glycol based formulations increased the lag time. The formulation with ethanol (50%), oleic acid (10%) and propylene glycol (40%) showed the maximum improvement in delivery. Iontophoresis and microneedle treatments resulted in enhanced permeation levels compared to passive controls. These enhancement approaches can be explored further to develop alternative treatment regimens.

Insects, Vol. 2, Pages 400-411: Are Adult Crambid Snout Moths (Crambinae) and Larval Stages of Lepidoptera Suitable Tools for an Environmental Monitoring of Transgenic Crops? — Implications of a Field Test

Posted: 10 Aug 2011 12:00 AM PDT

Butterflies and moths (Lepidoptera) have been suggested for the environmental monitoring of genetically modified (GM) crops due to their suitability as ecological indicators, and because of the possible adverse impact of the cultivation of current transgenic crops. The German Association of Engineers (VDI) has developed guidelines for the standardized monitoring of Lepidoptera describing the use of light traps for adult moths, transect counts for adult butterflies, and visual search for larvae. The guidelines suggest recording adults of Crambid Snout Moths during transect counts in addition to butterflies, and present detailed protocols for the visual search of larvae. In a field survey in three regions of Germany, we tested the practicability and effort-benefit ratio of the latter two VDI approaches. Crambid Snout Moths turned out to be suitable and practical indicators, which can easily be recorded during transect counts. They were present in 57% of the studied field margins, contributing a substantial part to the overall Lepidoptera count, thus providing valuable additional information to the monitoring results. Visual search of larvae generated results in an adequate effort-benefit ratio when searching for lepidopteran larvae of common species feeding on nettles. Visual search for larvae living on host plants other than nettles was time-consuming and yielded much lower numbers of recorded larvae. Beating samples of bushes and trees yielded a higher number of species and individuals. This method is especially appropriate when hedgerows are sampled, and was judged to perform intermediate concerning the relationship between invested sampling effort and obtained results for lepidopteran larvae. In conclusion, transect counts of adult Crambid Moths and recording of lepidopteran larvae feeding on nettles are feasible additional modules for an environmental monitoring of GM crops. Monitoring larvae living on host plants other than nettles and beating samples of bushes and trees can be used as a supplementary tool if necessary or desired.

jj

Posted: 10 Aug 2011 12:52 AM PDT

Divided into two camps, R's and D's so bent on making your point you've done nothing to change anything.

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Watchmac 1.6.3 - Monitors your Mac for possible security infringements.. (Shareware)

Posted: 10 Aug 2011 12:15 AM PDT



Watchmac... Your Mac can already stop unwanted access out of the box. Sometimes it is desirable, however, to know when someone tries to circumvent these measures. This is where Watchmac comes into play.

Watchmac monitors your Mac for possible infringements. For instance, when someone tries to unlock your screensaver but fails to enter the correct password, Watchmac will record this event and can even take pictures using the built-in (or an externally connected iSight). Best of all, Watchmac can even send you an email alerting you about the infringement.

And remember: Some intruders are even in the family. Even though you probably wouldn't count your children among them, Watchmac is nevertheless a great tool for detecting when your children don't play by the rules.



Version 1.6.3:
  • Fixes a bug that prevented the Watchmac preference panel to be opened for new users.
  • Other minor bugfixes.


  • M Mac OS X 10.5 Leopard (10.5.4 or later recommended). Monitoring authentication is fully supported on Mac OS X 10.5 Leopard only. Screen unlock authentication can be monitored on Mac OS X 10.6 Snow Leopard when having Watchmac lock the screen.
  • For taking pictures: Integrated or external iSight (works with MacBook, MacBook Air and MacBook Pro, as well as with iMac).
  • For sudden motion detection: MacBook, MacBook Air, MacBook Pro or PowerBook G4 (Early 2005) or iBook (Mid 2005).
  • The authentication sensor is currently only supported on Mac OS X 10.5 Leopard.


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Gnome Runner 1.0 - Platform arcade game.. (Free)

Posted: 09 Aug 2011 11:40 PM PDT



Gnome Runner is a free arcade game for Mac. Playing as a gnome, you will have to get through levels collecting treasures. Watch out for the monsters! They will prevent you from completing the task. You will be really amused with unexpectedly appearing magic mushrooms. After eating such mushrooms the monsters get the ability to run very fast, finding the shortest way to the gnome. You will need quick reflexes not to fall into the monsters' traps, and to get through levels successfully.

Brief description of the game rules:

In order to pass each level the player has to pick up all the treasures while trying to avoid collision with the monsters. With each collision the player will lose one life. Every magic mushroom brings the player additional points. The monsters can pick up such mushrooms too. In this case they will improve their abilities, running very fast and preventing the gnome from collecting the treasures. Every time the player passes a level without losing a life, he gets a silver cup. In order to get a gold cup, the player should not only pass a level and save all lives, but also pick up the necessary number of magic mushrooms.

Mac OS X 10.5 or later.

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Panoply 3.0.4 - Plot raster images of latitude/longitude-gridded data.. (Free)

Posted: 09 Aug 2011 11:47 PM PDT



Panoply plots geo-gridded arrays of latitude-longitude, latitude-vertical or time-latitude data encoded in netCDF, HDF and GRIB format.

Features include:

  • Slice specific 2D arrays from multidimensional variables which have more than two dimensions.
  • Combine two arrays in one plot by differencing, summing or averaging.
  • Menu of 80+ global and regional map projections for lon-lat plots.
  • Draw continents outlines or masks on lon-lat plots.
  • Apply any CPT, GGR, PAL, or ACT color table for scale colorbar.
  • Save plots to disk using GIF, JPEG, PDF, PNG, PS or TIFF format.


Version 3.0.4:
  • Bugfix: Arrays that had dimensions of time and latitude and no others wererecognized as plottable, but could not be plotted.
  • Bugfix: Fill value in unsigned integral data array could be misinterpreted.
  • Refactored NcAxis to better trap and report bad values on array axes.
  • Re-wrote handing and display of vertical axis for lat-vert and lon-vertplots when longitudinal ticks selected.
  • Dataset treetable in sources window now shows variable groups as branchesif they are present (as in, e.g., some HDF files). NcNode and subclassesrefactored so that toggling show-only-plottables would carry down to allchild nodes in treetable.
  • Bugfix: Creation of color tables from HDF palettes missing a step, therebyblocking subsequent creation of plot windows.
  • Library: (Mac) Quaqua FC updated to v. 7.4.2.
  • Library: netCDF-Java updated to v. 4.2.26.


  • Mac OS X 10.4 or later
  • Java SE 6 or later


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War Pinball HD 1.1 - Three unique, war-themed pinball tables.. (Commercial)

Posted: 09 Aug 2011 11:43 PM PDT



The amazing new War Pinball HD, developed in collaboration with MGM Studios.

Three unique, war-themed pinball tables based on all-time Hollywood hits:

  • The four-time Oscar winner "Platoon" (directed by Oliver Stone,starring Charlie Sheen as Chris)
  • "Navy Seals" (directed by Lewis Teague, starring Charlie Sheen as Dale Hawkins,Michael Biehn as James Curran)
  • "Missing in Action" (directed by Joseph Zito, starring Chuck Norris as James Braddock)
The magic of Hollywood mixed with the magic of the Gameprom 3D Engineto provide the best pinball action currently available for your Mac.

FEATURES

  • gameplay with a missions system
  • awesome 3D cinematic graphics
  • a unique soundtrack and voices from the movies
  • camera effects with different types of view
  • local and online high scores
  • hours and hours of pure action in your very own hands
Take a deep breath... and get it right now!

Version 1.1:
  • Fixed minor bugs
  • Added ability to disable sounds for muture audiences


Mac OS X 10.6.6 or later

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MacFamilyTree 6.1.3 - Genealogy application.. (Demo)

Posted: 09 Aug 2011 08:59 PM PDT



MacFamilyTree makes it easy to enter and then visualize your family history. Be it creating reports, diagrams or browsing your data in the innovative 3D view called Virtual Tree - MacFamilyTree offers a solution for every task. Get an overview of where you hail from and maybe enthuse your relatives about exploring your family's past at your upcoming family reunion. In its sixth iteration, MacFamilyTree 6 raises the bar even higher and offers a new user interface, more and better charts as well as reports, integration of "New FamilySearch", ToDo management, web research and several more features. MacFamilyTree 6 is built for Mac; and only for Mac using the latest Apple technologies.

With MacFamilyTree 6 you can:

  • Enter and visualize your family history
  • Choose from a large variety of reports and charts
  • Use New FamilySearch.org (currently in the beta phase) for research, no subscription fees!
  • Share genealogical data using the GEDCOM standard
  • Publish your family tree on the internet


Version 6.1.3:
  • Major performance enhancements for Mac OS X 10.7 Lion
  • Improved Family Tree edit mode
  • Now supports Fullscreen Mode in Mac OS X 10.7 Lion
  • More options added exporting GEDCOMs
  • Greatly improved compatibility importing GEDCOM files
  • Several bugfixes


Mac OS X 10.5 or later

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Bento 4.0.5 - Organize all your important information in one place.. (Demo)

Posted: 09 Aug 2011 08:59 PM PDT



Bento is a personal database from FileMaker that's as easy to use as a Mac. Bento organizes all your important information in one place, so you can manage your contacts, coordinate events, track projects, prioritize tasks, and more faster and easier than ever before.

Features:

  • Bring It All Together: From contacts and calendars, to projects and events, you can organize just about every type of information you have all from one place.
  • See Things Your Way: Just drag and drop or point and click to change the look of any form, and see information in a way that makes sense to you. Now seeing, searching, and sorting your information is simpler and faster than ever before
  • Designed For Leopard: Bento has direct links to the Mac OS X Address Book and iCal, and takes advantage of many new features of Leopard, including core animation, advanced find, Time Machine, backups, and multimedia features.

If you're already using FileMaker Pro, be sure to check out Bento for your personal organization and productivity needs. It's also a great way to organize all your after-work activities, community projects, school events and more.

Version 4.0.5:

  • Provides bug fixes and compatibility updates for Mac OS X 10.7 Lion.


Mac OS X 10.5.7 or later

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