понедельник, 8 августа 2011 г.

Games

Games

The super-fast weekend gaming news catch-up video: July 25, 2011 (Sonic Generations)

Posted: 08 Aug 2011 12:00 AM PDT

Monday morning - time to get up to speed for the week ahead. Luckily, the GamesRadar UK team is here to tell you all about the five most important happenings of the weekend. Each topic gets 60 seconds of discussion, to make this catch-up video as superfast as its title implies. Today's news stories include: 3DS D-pad paint allegedly chipping off on some models, Sonic Generations' Chemical Plant Zone gameplay video and Zumba Fitness somehow managing to be the best-selling game in the UK all-formats chart for 8 weeks. All that and more when you push play...

'Breaking Bad' season 4, episode 4 recap, 'Bullet Points': Shuffle up and deal

Posted: 08 Aug 2011 03:06 AM PDT

On "Breaking Bad," Jesse has gone off the deep end since killing Gale. Though refraining from hard drugs, he turned his house into Skid Row for hobos and carelessly spends thousands of dollars earned from cooking meth with Walt.

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Cathode 0.9.8 - Vintage terminal emulator.. (Shareware)

Posted: 08 Aug 2011 03:18 AM PDT



Cathode is a graphically rich vintage terminal emulator.

Bask in the glow of over-bright phosphors that flash on and slowly fade away. Customize the screen's curvature, colors, and transparency. Slow the bit-rate to a crawl. Watch the strange dance of beam desyncs and shifting colors. Turn up the noise, jitter, and flicker to add a realistic warmth. Immerse yourself in full-screen mode.



Version 0.9.8:

Features:

  • Mac OS X 10.7 Lion-style fullscreen experience.
  • Shift + page up/down now work like in Terminal.app.
  • Locale environment variables can be disabled.
  • Open any image file to generate ascii art.
Bug fixes:
  • Keyboard combos for international characters have been restored.
  • Cursor disappearing bug has been fixed.
  • Issuing an exit command in a fullscreen window now works.
  • Terminal emulation continues to improve.



  • Intel Mac
  • Mac OS 10.6
  • OpenGL 2.0
  • Note: Intel GMA950/3100 and ATI Radeon X1600/X1900 are not supported.


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Adze 1.2.2 - View and edit GPX files from your GPS device.. (Shareware)

Posted: 08 Aug 2011 03:22 AM PDT



Adze is a utility for the Mac OS which makes viewing and editing your GPX files simple. Features include tools for cutting, joining and deleting your recorded GPS tracks, smart data optimizations, the ability to split tracks at rest-stops, statistics calculation, time offsetting and integration with Google Earth.

Version 1.2.2:

Major Changes:

  • Improved GPX format support, particularly integration with Garmin applications
Minor Changes:
  • Tracks with only one point are now drawn in the track view
  • Addressed an issue with range handling which resulted in points at the end of tracks being discarded during some operations
  • You can no longer select points in hidden tracks
  • Added 'Rename Track' to contextual menu



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AddressBook Cleaner 1.110 - Find and remove duplicate contacts from Address Book.. (Shareware)

Posted: 08 Aug 2011 03:04 AM PDT



AddressBook Cleaner is created for cleanup of Address Book on Mac to avoid duplicated contacts. Keep Address Book clean and contacts identical.

Sometimes the sync process is going wrong somewhere along the line and creating duplicate lists of some contacts to build up. You need to take time to find out and delete the duplicated contacts by hand. AddressBook Cleaner is exactly such utility to help you find out all the contacts match the predefined fields, and mark the ones to be thrown, what you need to do is just run the application and perform simple clicks.



Version 1.110:
  • Fixes a vital crash bug.


Mac OS X 10.5 or later.

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Cancers, Vol. 3, Pages 3169-3188: C-type Lectin Receptors for Tumor Eradication: Future Directions

Posted: 08 Aug 2011 12:00 AM PDT

Dendritic cells are key regulators in directing immune responses and therefore are under extensive research for the induction of anti-tumor responses. DCs express a large array of receptors by which they scan their surroundings for recognition and uptake of pathogens. One of the receptor-families is the C-type lectins (CLR), which bind carbohydrate structures and internalize antigens upon recognition. Intracellular routing of antigen through CLR enhances loading and presentation of antigen through MHC class I and II, inducing antigen-specific CD4+ and CD8+ T-cell proliferation and skewing T-helper cells. These characteristics make CLRs very interesting targets for DC-based immunotherapy. Profound research has been done on targeting specific tumor antigens to CLR using either antibodies or the natural ligands such as glycan structures. In this review we will focus on the current data showing the potency of CLR-targeting and discuss improvements that can be achieved to enhance anti-tumor activity in the near future.

Molecules, Vol. 16, Pages 6667-6676: Green Synthesis and Antibacterial Effect of Silver Nanoparticles Using Vitex Negundo L.

Posted: 08 Aug 2011 12:00 AM PDT

Different biological methods are gaining recognition for the production of silver nanoparticles (Ag-NPs) due to their multiple applications. One of the most important applications of Ag-NPs is their use as an anti-bacterial agent. The use of plants in the synthesis of nanoparticles emerges as a cost effective and eco-friendly approach. In this study the biosynthesis of silver nanoparticles using Vitex negundo L. extract and its antimicrobial properties has been reported. The resulting silver particles are characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD) and UV–Visible (UV-Vis) spectroscopic techniques. The TEM study showed the formation of silver nanoparticles in the 10–30 nm range and average 18.2 nm in size. The XRD study showed that the particles are crystalline in nature, with a face centered cubic (fcc) structure. The silver nanoparticles showed the antimicrobial activity against Gram positive and Gram negative bacteria. Vitex negundo L. was found to display strong potential for the synthesis of silver nanoparticles as antimicrobial agents by rapid reduction of silver ions (Ag+ to Ag0).

Energies, Vol. 4, Pages 1148-1162: Analysis of Wind Generator Operations under Unbalanced Voltage Dips in the Light of the Spanish Grid Code

Posted: 08 Aug 2011 12:00 AM PDT

Operation of doubly fed induction generators subjected to transient unbalanced voltage dips is analyzed in this article to verify the fulfillment of the Spanish grid code. Akagi's p-q theory is not used for this study, because control of the electronic converter is not the main goal of the paper, but rather to know the physical phenomena involved in the wind turbine when voltage dips occur. Hence, the magnetizing reactive power of the induction generators and their components, which are related with the magnetic fields and determine operation of these machines, are expressed through the reactive power formulations established in the technical literature by three well-known approaches: the delayed voltage (DV) method, Czarnecki's Current's Physical Components (CPC) theory and Emanuel's approach. Non-fundamental and negative-sequence components of the magnetizing reactive power are respectively established to define the effects of the distortion and voltage imbalances on the magnetic fields and electromagnetic torques. Also, fundamental-frequency positive-sequence and negative-sequence reactive powers are decomposed into two components: due to the reactive loads and caused by the imbalances. This decomposition provides additional information about the effects of the imbalances on the main magnetic field and electromagnetic torque of the induction generator. All the above mentioned reactive powers are finally applied to one actual wind turbine subjected to a two-phase voltage dip in order to explain its operation under such transient conditions.

Cancers, Vol. 3, Pages 3156-3168: Upregulation of Leukotriene Receptors in Gastric Cancer

Posted: 08 Aug 2011 12:00 AM PDT

Background: Leukotrienes (LT) mediate allergic and inflammatory processes. Previously, we identified significant changes in the expression pattern of LT receptors in the gastric mucosa after eradication of Helicobacter pylori infection. The aim of the present study was to evaluate the expression of 5-lipoxygenase (5-LOX) and LT receptors in gastric cancer (GC). Methods: The expression of 5-LOX and receptors for LTB4 (BLT-1, BLT-2) and cysteinyl-LT (CysLT-1, CysLT-2) were analyzed by immunohistochemistry (IHC) in GC samples of 35 consecutive patients who underwent gastrectomy and in 29 tumor-free tissue specimens from gastric mucosa. Results: Male-to-female ratio was 24:11. The median age was 70 years (range 34–91). Twenty-two patients had GC of intestinal, six of diffuse, six of mixed and one of undifferentiated type. The IHC analysis showed a nearly ubiquitous expression of studied proteins in GC (88–97%) and in tumor-free specimens as well (89–100%). An increase in the immunoreactive score of both BLT receptors and CysLT-1 was observed in GC compared to tumor-free gastric mucosa (p < 0.001 for BLT-1; p < 0.01 for BLT-2 and CysLT-1, Mann-Whitney U-test). No differences in the IHC expression of 5-LOX and CsyLT-2 were observed between GC and tumor-free mucosa. The expression of BLT-2, CysLT-1 and CysLT-2 was increased in GC of intestinal type when compared to the diffuse type (p < 0.05; Mann-Whitney U-test). Conclusions: LTB4 receptors and CysLT-1 are up-regulated in GC tissue implying a role in gastric carcinogenesis.

JFB, Vol. 2, Pages 155-172: Influence of Porcine Intervertebral Disc Matrix on Stem Cell Differentiation

Posted: 08 Aug 2011 12:00 AM PDT

For back disorders, cell therapy is one approach for a real regeneration of a degenerated nucleus pulposus. Human mesenchymal stem cells (hMSC) could be differentiated into nucleus pulposus (NP)-like cells and used for cell therapy. Therefore it is necessary to find a suitable biocompatible matrix, which supports differentiation. It could be shown that a differentiation of hMSC in a microbial transglutaminase cross-linked gelatin matrix is possible, but resulted in a more chondrocyte-like cell type. The addition of porcine NP extract to the gelatin matrix caused a differentiation closer to the desired NP cell phenotype. This concludes that a hydrogel containing NP extract without any other supplements could be suitable for differentiation of hMSCs into NP cells. The NP extract itself can be cross-linked by transglutaminase to build a hydrogel free of NP atypical substrates. As shown by side-specific biotinylation, the NP extract contains molecules with free glutamine and lysine residues available for the transglutaminase.

Polymers, Vol. 3, Pages 1255-1267: Spontaneous Vesicles Modulated by Polymers

Posted: 08 Aug 2011 12:00 AM PDT

Vesicles are widely used in technological applications including cosmetic products, in microencapsulation for drug delivery, as anticancer agents and in the technology of adhesives, paints and inks. The vesicle size and the surface charge are very important properties from a technological point of view. Thus, the challenge in formulation is to find inexpensive stable vesicles with well-defined sizes and to modulate the surface charge of these aggregates. In this work we analyze the effect of different polymers on the structural properties of vesicles of the biodegradable surfactant sodium bis(2-ethyl-hexyl) sulfosuccinate, Aerosol OT. Using fluorescence, conductivity, electrophoretic mobility and dynamic light scattering measurements we study the effect of the polymer nature, molecular weight and polymer concentration on the stability and the vesicle size properties. Results demonstrate that it is possible to modulate both the size and the electric surface charge of spontaneous vesicles of Aerosol OT by the addition of very small percentages of poly(allylamine) and poly(maleic anhydride-alt-1-octadecen).

Kickin' Momma

Posted: 07 Aug 2011 03:48 PM PDT

More pachinko, anyone? Kickin' Momma is the latest from Hothead Games, the team that is perhaps most famous for creating the Penny Arcade adventure episodes beginning with On the Rain-Slick Precipice of Darkness. Now, though, the studio is focusing some efforts on the iOS market, creating a crazy sort of game that's very similar to Peggle.

Bodycount: Co-op and single-player hands-on will explode excitement all over your mind (Bodycount)

Posted: 08 Aug 2011 12:00 AM PDT

Apparently, Asia is full of buildings that explode lots - at least if the latest area of Bodycount is anything to go by. But if you've been following our coverage up until now, you know all about the explosions, the exploding barrels and the fragile buildings standing next to teh exploding barrels. What you don't know about is the co-op mode, or the single-player's most important feature - which is why I'm here. So step right this way. Oh, and watch out for the proximity mines on the floor. Good man.

Polymers, Vol. 3, Pages 1243-1254: Evaluation of the Biological Effects of Externally Tunable, Hydrogel Encapsulated Quantum Dot Nanospheres in Escherichia coli

Posted: 08 Aug 2011 12:00 AM PDT

Quantum Dots (QDs) have become an interesting subject of study for labeling and drug delivery in biomedical research due to their unique responses to external stimuli. In this paper, the biological effects of a novel hydrogel based QD nano-structure on E. coli bacteria are presented. The experimental evidence reveals that cadmium telluride (CdTe) QDs that are encapsulated inside biocompatible polymeric shells have reduced or negligible toxicity to this model cell system, even when exposed at higher dosages. Furthermore, a preliminary gene expression study indicates that QD-hydrogel nanospheres do not inhibit the Green Fluorescent Protein (GFP) gene expression. As the biocompatible and externally tunable polymer shells possess the capability to control the QD packing density at nanometer scales, the resulting luminescence efficiency of the nanostructures, besides reducing the cytotoxic potential, may be suitable for various biomedical applications.

Atmosphere, Vol. 2, Pages 271-302: Surface Flux Modeling for Air Quality Applications

Posted: 08 Aug 2011 12:00 AM PDT

For many gasses and aerosols, dry deposition is an important sink of atmospheric mass. Dry deposition fluxes are also important sources of pollutants to terrestrial and aquatic ecosystems. The surface fluxes of some gases, such as ammonia, mercury, and certain volatile organic compounds, can be upward into the air as well as downward to the surface and therefore should be modeled as bi-directional fluxes. Model parameterizations of dry deposition in air quality models have been represented by simple electrical resistance analogs for almost 30 years. Uncertainties in surface flux modeling in global to mesoscale models are being slowly reduced as more field measurements provide constraints on parameterizations. However, at the same time, more chemical species are being added to surface flux models as air quality models are expanded to include more complex chemistry and are being applied to a wider array of environmental issues. Since surface flux measurements of many of these chemicals are still lacking, resistances are usually parameterized using simple scaling by water or lipid solubility and reactivity. Advances in recent years have included bi-directional flux algorithms that require a shift from pre-computation of deposition velocities to fully integrated surface flux calculations within air quality models. Improved modeling of the stomatal component of chemical surface fluxes has resulted from improved evapotranspiration modeling in land surface models and closer integration between meteorology and air quality models. Satellite-derived land use characterization and vegetation products and indices are improving model representation of spatial and temporal variations in surface flux processes. This review describes the current state of chemical dry deposition modeling, recent progress in bi-directional flux modeling, synergistic model development research with field measurements, and coupling with meteorological land surface models.

Cancers, Vol. 3, Pages 3143-3155: Current Perspectives on Desmoid Tumors: The Mayo Clinic Approach

Posted: 08 Aug 2011 12:00 AM PDT

Desmoid tumors are a rare group of locally aggressive, non malignant tumors of fibroblastic origin that can lead to significant morbidity due to local invasion. Despite advances in the understanding of these tumors, their natural history is incompletely understood and the optimal treatment is still a matter of debate. Local control is the main goal of treatment and there has been a change in philosophy regarding the management of these tumors from aggressive surgical resection to function preservation. A multidisciplinary approach is essential to plan local control with acceptable morbidity. The current Mayo Clinic algorithm for the treatment of these tumors is based on institutional experience and the available evidence in the literature: asymptomatic/non progressive lesions away from vital structures are managed with observation and regular imaging; primary or recurrent desmoid tumors which are symptomatic or progressive or near vital structures are managed with wide surgical resection when wide surgical margins are possible with minimal functional and cosmetic loss. When positive or close surgical margins are likely, surgical resection with adjuvant radiotherapy or definitive radiotherapy is preferred. If likely functional or cosmetic deficit is unacceptable, radiotherapy is the treatment of choice. Unresectable lesions are considered for radiotherapy, chemotherapy or newer modalities however an unresectable lesion associated with a painful, functionless, infected extremity is managed with an amputation.

Diversity, Vol. 3, Pages 390-404: No Evidence for Temporal Variation in a Cryptic Species Community of Freshwater Amphipods of the Hyalella azteca Species Complex

Posted: 08 Aug 2011 12:00 AM PDT

The co-occurrence of cryptic species of Hyalella amphipods is a challenge to our traditional views of how species assemble. Since these species have similar morphologies, it is not evident that they have developed phenotypic differences that would allow them to occupy different ecological niches. We examined the structure of a community of Hyalella amphipods in the littoral zone of a boreal lake to verify if temporal variation was present in relative abundances. Morphological and molecular analyses using the mitochondrial cytochrome c oxidase I (COI) gene enabled us to detect three cryptic species at the study site. No temporal variation was observed in the community, as one cryptic species was always more abundant than the two others. The relative abundances of each species in the community appeared constant at least for the open-water season, both for adult and juvenile amphipods. Niche differences are still to be found among these species, but it is suggested that migration from nearby sites may be an important factor explaining the species co-occurrence.

Diversity, Vol. 3, Pages 375-389: Genetic Risk Assessment of a Threatened Remnant Population of Hairy Prairie-Clover (Dalea villosa var. villosa) in the Canadian Prairie

Posted: 08 Aug 2011 12:00 AM PDT

Hairy prairie-clover [Dalea villosa (Nutt.) Spreng. var. villosa] is a threatened Canadian wildflower. To facilitate the efforts of conserving this threatened plant, amplified fragment length polymorphism (AFLP) technique was applied to assess genetic diversity in a remnant hairy prairie-clover population in the Canadian Prairie. Three AFLP primer pairs were employed to genotype 610 individual plants from the population and 15 plants from a North Dakota composite population, and 100 polymorphic AFLP bands were analyzed. The assayed plants displayed 23% AFLP variation present between the remnant population and the North Dakota composite population, but maintained a high level (91%) of AFLP variation within patches of the remnant population. The individual genetic distinctiveness measured by average AFLP dissimilarity was positively associated with latitude and negatively with elevation. The among-patch AFLP variation was significantly related to inter-patch distance, indicating local genetic differentiation within the remnant population. However, the proportions of within-patch AFLP variation were not associated with any patch characteristics assessed (i.e., patch size, perimeter, nearest neighbor distance, mean inter-patch distance). No fine-scale genetic structure was found within three large patches, suggesting little genetic correlations present for plants five meters apart. Some genetically distinctive and diverse patches were also identified. These findings indicate that the genetic risk of the remnant hairy prairie-clover population in the Canadian Prairie is low.

Education, Vol. 1, Pages 4-14: E-Learning in Pharmacology and Pharmacy

Posted: 08 Aug 2011 12:00 AM PDT

Computer-based learning facilitates a shift from externally controlled to self-directed learning. Universities and other educational institutions are challenged by these developments and must react appropriately to meet the requirements of education. The term e-learning has been coined to describe a wide range of diverse learning and teaching strategies based on the use of electronic devices. Recently developed concepts in the science of education and learning provide appropriate frameworks for novel e-learning scenarios. The present review introduces strategies and concepts for the implementation of e-learning in academic and non-academic programs and gives an overview of current e-learning activities in pharmacology.

Wedding Troubles

Posted: 07 Aug 2011 10:54 PM PDT

Complete lots of cool missions on your way to the perfect magical wedding!
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