Games |
- Amazing Adventures: The Forgotten Dynasty 1.0 - Unlock the clues, find the objects, and uncover the secrets of the forgotten dynasty.. (Demo)
- Skim 1.3.17 - PDF Reader and note-taker for scientific papers.. (Free)
- Molecules, Vol. 16, Pages 6916-6926: Selective Covalent Conjugation of Phosphorothioate DNA Oligonucleotides with Streptavidin
- Molecules, Vol. 16, Pages 6902-6915: Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes
- PixelStick 2.1 - Measure distances on your screen in pixels.. (Shareware)
- Entropy, Vol. 13, Pages 1481-1516: Thermodynamics of Thermoelectric Phenomena and Applications
- Sensors, Vol. 11, Pages 8045-8059: Height Compensation Using Ground Inclination Estimation in Inertial Sensor-Based Pedestrian Navigation
- MP accused of making charity worker cry
- Sensors, Vol. 11, Pages 8028-8044: A Noise-Aware Coding Scheme for Texture Classification
- Sensors, Vol. 11, Pages 8018-8027: Detection of Single-Nucleotide Polymorphism on uidA Gene of Escherichia coli by a Multiplexed Electrochemical DNA Biosensor with Oligonucleotide-Incorporated Nonfouling Surface
- IJERPH, Vol. 8, Pages 3299-3317: Spatial Variation of Surface Soil Available Phosphorous and Its Relation with Environmental Factors in the Chaohu Lake Watershed
- Sensors, Vol. 11, Pages 7993-8017: Field Programmable Gate Array Based Parallel Strapdown Algorithm Design for Strapdown Inertial Navigation Systems
- Pharmaceuticals, Vol. 4, Pages 1137-1157: Aptamer-Gated Nanoparticles for Smart Drug Delivery
- Sensors, Vol. 11, Pages 7992: Retraction: Eldefrawy, M.H.; Khan, M.K.; Alghathbar, K.; Tolba, A.S.; Kim, K.J. Authenticated Key Agreement with Rekeying for Secured Body Sensor Networks. Sensors 2011, 11, 5835-5849.
- Remote Sensing, Vol. 3, Pages 1680-1690: Timing Constraints on Remote Sensing of Wildland Fire Burned Area in the Southeastern US
- IJMS, Vol. 12, Pages 5157-5167: Self-Assembly of Protein Monolayers Engineered for Improved Monoclonal Immunoglobulin G Binding
- Biosensors, Vol. 1, Pages 118-133: Polycrystalline-Diamond MEMS Biosensors Including Neural Microelectrode-Arrays
- Adobe Flash Player 10.3.183.5 - Web browser plug-in (beta).. (Free)
- TrailRunner 3.7.656 - Route planning for hiking, biking, more.. (Shareware)
- Firefox 6.0 - Popular Web browser.. (Free)
| Posted: 15 Aug 2011 03:19 AM PDT  In Amazing Adventures: The Forgotten Dynasty, you'll investigate rumors of a forgotten Chinese dynasty that surfaced when ancient tiles appeared on the black market. Under the direction of the Museum you must travel across China in search of further clues. Can you uncover the secret of The Forgotten Dynasty? Travel to 25 exotic locations as you search for more than 2,200 hidden objects. Complete more than 100 levels and find the hidden Yin and Yang symbols to unlock 2 bonus game modes. Plus, play 9 unique mini-game puzzles and collect fascinating facts in your adventure journal. Features:
Version 1.0: Initial release. Mac OS X 10.4 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Skim 1.3.17 - PDF Reader and note-taker for scientific papers.. (Free) Posted: 15 Aug 2011 03:14 AM PDT  Skim is a PDF reader and note-taker for OS X. It is designed to help you read and annotate scientific papers in PDF, but is also great for viewing any PDF file. Skim includes many features and has a great user interface. Version 1.3.17:
Mac OS X 10.5 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 15 Aug 2011 12:00 AM PDT Protein-DNA conjugates have found numerous applications in the field of diagnostics and nanobiotechnology, however, their intrinsic susceptibility to DNA degradation by nucleases represents a major obstacle for many applications. We here report the selective covalent conjugation of the protein streptavidin (STV) with phosphorothioate oligonucleotides (psDNA) containing a terminal alkylthiolgroup as the chemically addressable linking unit, using a heterobifunctional NHS-/maleimide crosslinker. The psDNA-STV conjugates were synthesized in about 10% isolated yields. We demonstrate that the terminal alkylthiol group selectively reacts with the maleimide while the backbone sulfur atoms are not engaged in chemical conjugation. The novel psDNA-STV conjugates retain their binding capabilities for both biotinylated macromolecules and the complementary nucleic acid. Moreover, the psDNA-STV conjugate retained its binding capacity for complementary oligomers even after a nuclease digestion step, which effectively degrades deoxyribonucleotide oligomers and thus the binding capability of regular DNA-STV conjugates. The psDNA-STV therefore hold particular promise for applications e.g. in proteome research and novel biosensing devices, where interfering endogenous nucleic acids need to be removed from analytes by nuclease digestion. |
| Posted: 15 Aug 2011 12:00 AM PDT Salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H2LASSBio-1064) and their complexes [Zn(LASSBio-466)H2O]2 (1) and [Zn(HLASSBio-1064)Cl]2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the anti-nociceptive activity was favored in the complex 1. H2LASSBio-466 inhibited only the first phase of the formalin test, while 1 was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered the pharmacological profile of H2LASSBio-466. H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile. |
| PixelStick 2.1 - Measure distances on your screen in pixels.. (Shareware) Posted: 15 Aug 2011 03:11 AM PDT  PixelStick is a tool for measuring distances, angles and colors on the screen. PhotoShop has distance, angle and color tools but they only work in PhotoShop. PixelStick works in any app and anywhere on screen anytime and costs a hundred times less. Its easy, simple and fast. PixelStick is a measuring tool you can pinch and stretch to measure anything on your screen. Use the eyedropper to copy colors in 4 formats (CSS, RGB, RGB hex, HTML) to the clipboard for use in any app. Its like an onscreen virtual ruler that you can use vertically, horizontally and at any angle to measure distances, angles and much more just by dragging. Supports the scaling in Google Maps, Yahoo Maps, and Photoshop. Also has Customized (user settable) scaling options. Most of what PixelStick does is obvious. Drag the endpoints to change the measurement. Click the locks to constrain the movement. Launch it, play around, no more limitations to just one app in measuring distance, angle and color.
Mac OS X 10.4 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
| Entropy, Vol. 13, Pages 1481-1516: Thermodynamics of Thermoelectric Phenomena and Applications Posted: 15 Aug 2011 12:00 AM PDT Fifty years ago, the optimization of thermoelectric devices was analyzed by considering the relation between optimal performances and local entropy production. Entropy is produced by the irreversible processes in thermoelectric devices. If these processes could be eliminated, entropy production would be reduced to zero, and the limiting Carnot efficiency or coefficient of performance would be obtained. In the present review, we start with some fundamental thermodynamic considerations relevant for thermoelectrics. Based on a historical overview, we reconsider the interrelation between optimal performances and local entropy production by using the compatibility approach together with the thermodynamic arguments. Using the relative current density and the thermoelectric potential, we show that minimum entropy production can be obtained when the thermoelectric potential is a specific, optimal value. |
| Posted: 15 Aug 2011 12:00 AM PDT In an inertial sensor-based pedestrian navigation system, the position is estimated by double integrating external acceleration. A new algorithm is proposed to reduce z axis position (height) error. When a foot is on the ground, a foot angle is estimated using accelerometer output. Using a foot angle, the inclination angle of a road is estimated. Using this road inclination angle, height difference of one walking step is estimated and this estimation is used to reduce height error. Through walking experiments on roads with different inclination angles, the usefulness of the proposed algorithm is verified. |
| MP accused of making charity worker cry Posted: 15 Aug 2011 02:13 AM PDT Besieged federal Labor MP Craig Thomson stands accused of reducing a charity worker to tears at a rally against poker machine reform on the NSW Central Coast. |
| Sensors, Vol. 11, Pages 8028-8044: A Noise-Aware Coding Scheme for Texture Classification Posted: 15 Aug 2011 12:00 AM PDT Texture-based analysis of images is a very common and much discussed issue in the fields of computer vision and image processing. Several methods have already been proposed to codify texture micro-patterns (texlets) in images. Most of these methods perform well when a given image is noise-free, but real world images contain different types of signal-independent as well as signal-dependent noises originated from different sources, even from the camera sensor itself. Hence, it is necessary to differentiate false textures appearing due to the noises, and thus, to achieve a reliable representation of texlets. In this proposal, we define an adaptive noise band (ANB) to approximate the amount of noise contamination around a pixel up to a certain extent. Based on this ANB, we generate reliable codes named noise tolerant ternary pattern (NTTP) to represent the texlets in an image. Extensive experiments on several datasets from renowned texture databases, such as the Outex and the Brodatz database, show that NTTP performs much better than the state-of-the-art methods. |
| Posted: 15 Aug 2011 12:00 AM PDT We report here a practical application of a multiplexed electrochemical DNA sensor for highly specific single-nucleotide polymorphism (SNP) detection. In this work, a 16-electrode array was applied with an oligonucleotide-incorporated nonfouling surfaces (ONS) on each electrode for the resistance of unspecific absorption. The fully matched target DNA templated the ligation between the capture probe assembled on gold electrodes and the tandem signal probe with a biotin moiety, which could be transduced to peroxidase-based catalyzed amperometric signals. A mutant site (T93G) in uidA gene of E. coli was analyzed in PCR amplicons. 10% percentage of single mismatched mutant gene was detected, which clearly proved the selectivity of the multiplexed electrochemical DNA biosensor when practically applied. |
| Posted: 15 Aug 2011 12:00 AM PDT The study presented in this paper attempts to evaluate the spatial pattern of soil available phosphorus, as well as the relation between soil available phosphorus and environment factors including elevation, slope, precipitation, percentage of cultivated land, percentage of forest land, percentage of construction land and NDVI using statistical methods and GIS spatial analysis techniques. The results showed that the Spline Tension method performed the best in the prediction of soil available phosphorus in the Chaohu Lake watershed. The spatial variation of surface soil available phosphorus was high in Chaohu Lake watershed and the upstream regions around Chaohu Lake, including the west of Chaohu lake (e.g., southwest of Feixi county, east of Shucheng county and north of Lujiang county) and to the north of Chaohu Lake (e.g., south of Hefei city, south of Feidong county, southwest of Juchao district), had the highest soil available phosphorus content. The mean and standard deviation of soil available phosphorus content gradually decreased as the elevation or slope increased. The cultivated land comprised 60.11% of the watershed and of that land 65.63% belonged to the medium to very high SAP level classes, and it played a major role in SAP availability within the watershed and a potential source of phosphorus to Chaohu Lake resulting in eutrophication. Among the land use types, paddy fields have some of the highest maximum values and variation of coefficients. Subwatershed scale soil available phosphorus was significantly affected by elevation, slope, precipitation, percentage of cultivated land and percentage of forest land and was decided by not only these environmental factors but also some other factors such as artificial phosphorus fertilizer application. |
| Posted: 15 Aug 2011 12:00 AM PDT A new generalized optimum strapdown algorithm with coning and sculling compensation is presented, in which the position, velocity and attitude updating operations are carried out based on the single-speed structure in which all computations are executed at a single updating rate that is sufficiently high to accurately account for high frequency angular rate and acceleration rectification effects. Different from existing algorithms, the updating rates of the coning and sculling compensations are unrelated with the number of the gyro incremental angle samples and the number of the accelerometer incremental velocity samples. When the output sampling rate of inertial sensors remains constant, this algorithm allows increasing the updating rate of the coning and sculling compensation, yet with more numbers of gyro incremental angle and accelerometer incremental velocity in order to improve the accuracy of system. Then, in order to implement the new strapdown algorithm in a single FPGA chip, the parallelization of the algorithm is designed and its computational complexity is analyzed. The performance of the proposed parallel strapdown algorithm is tested on the Xilinx ISE 12.3 software platform and the FPGA device XC6VLX550T hardware platform on the basis of some fighter data. It is shown that this parallel strapdown algorithm on the FPGA platform can greatly decrease the execution time of algorithm to meet the real-time and high precision requirements of system on the high dynamic environment, relative to the existing implemented on the DSP platform. |
| Pharmaceuticals, Vol. 4, Pages 1137-1157: Aptamer-Gated Nanoparticles for Smart Drug Delivery Posted: 15 Aug 2011 12:00 AM PDT Aptamers are functional nucleic acid sequences which can bind specific targets. An artificial combinatorial methodology can identify aptamer sequences for any target molecule, from ions to whole cells. Drug delivery systems seek to increase efficacy and reduce side-effects by concentrating the therapeutic agents at specific disease sites in the body. This is generally achieved by specific targeting of inactivated drug molecules. Aptamers which can bind to various cancer cell types selectively and with high affinity have been exploited in a variety of drug delivery systems for therapeutic purposes. Recent progress in selection of cell-specific aptamers has provided new opportunities in targeted drug delivery. Especially functionalization of nanoparticles with such aptamers has drawn major attention in the biosensor and biomedical areas. Moreover, nucleic acids are recognized as an attractive building materials in nanomachines because of their unique molecular recognition properties and structural features. A active controlled delivery of drugs once targeted to a disease site is a major research challenge. Stimuli-responsive gating is one way of achieving controlled release of nanoparticle cargoes. Recent reports incorporate the structural properties of aptamers in controlled release systems of drug delivering nanoparticles. In this review, the strategies for using functional nucleic acids in creating smart drug delivery devices will be explained. The main focus will be on aptamer-incorporated nanoparticle systems for drug delivery purposes in order to assess the future potential of aptamers in the therapeutic area. Special emphasis will be given to the very recent progress in controlled drug release based on molecular gating achieved with aptamers. |
| Posted: 15 Aug 2011 12:00 AM PDT It has been brought to our attention by a reader of Sensors that substantial portions of this article [1] have been copied from earlier publications without credit. After confirming this plagiarism with the authors, we have determined that indeed this manuscript clearly violates our policy on originality of all material submitted for publication and the generally accepted ethics of scientific publication. |
| Posted: 15 Aug 2011 12:00 AM PDT Remote sensing using Landsat Thematic Mapper (TM) satellite imagery is increasingly used for mapping wildland fire burned area and burn severity, owing to its frequency of collection, relatively high resolution, and availability free of charge. However, rapid response of vegetation following fire and frequent cloud cover pose challenges to this approach in the southeastern US. We assessed these timing constraints by using a series of Landsat TM images to determine how rapidly the remotely sensed burn scar signature fades following prescribed burns in wet flatwoods and depression swamp community types in the Apalachicola National Forest, Florida, USA during 2006. We used both the Normalized Burn Ratio (NBR) of reflectance bands sensitive to vegetation and exposed soil cover, as well as the change in NBR from before to after fire (dNBR), to estimate burned area. We also determined the average and maximum amount of time following fire required to obtain a cloud-free image for burns in each month of the year, as well as the predicted effect of this time lag on percent accuracy of burn scar estimates. Using both NBR and dNBR, the detectable area decreased linearly 9% per month on average over the first four months following fire. Our findings suggest that the NBR and dNBR methods for monitoring burned area in common southeastern US vegetation community types are limited to an average of 78–90% accuracy among months of the year, with individual burns having values as low as 38%, if restricted to use of Landsat 5 TM imagery. However, the majority of burns can still be mapped at accuracies similar to those in other regions of the US, and access to additional sources of satellite imagery would improve overall accuracy. |
| Posted: 15 Aug 2011 12:00 AM PDT Bacterial outer membrane proteins, along with a filling lipid molecule can be modified to form stable self-assembled monolayers on gold. The transmembrane domain of Escherichia coli outer membrane protein A has been engineered to create a scaffold protein to which functional motifs can be fused. In earlier work we described the assembly and structure of an antibody-binding array where the Z domain of Staphylococcus aureus protein A was fused to the scaffold protein. Whilst the binding of rabbit polyclonal immunoglobulin G (IgG) to the array is very strong, mouse monoclonal IgG dissociates from the array easily. This is a problem since many immunodiagnostic tests rely upon the use of mouse monoclonal antibodies. Here we describe a strategy to develop an antibody-binding array that will bind mouse monoclonal IgG with lowered dissociation from the array. A novel protein consisting of the scaffold protein fused to two pairs of Z domains separated by a long flexible linker was manufactured. Using surface plasmon resonance the self-assembly of the new protein on gold and the improved binding of mouse monoclonal IgG were demonstrated. |
| Posted: 15 Aug 2011 12:00 AM PDT Diamond is a material of interest due to its unique combination of properties, including its chemical inertness and biocompatibility. Polycrystalline diamond (poly-C) has been used in experimental biosensors that utilize electrochemical methods and antigen-antibody binding for the detection of biological molecules. Boron-doped poly-C electrodes have been found to be very advantageous for electrochemical applications due to their large potential window, low background current and noise, and low detection limits (as low as 500 fM). The biocompatibility of poly-C is found to be comparable, or superior to, other materials commonly used for implants, such as titanium and 316 stainless steel. We have developed a diamond-based, neural microelectrode-array (MEA), due to the desirability of poly-C as a biosensor. These diamond probes have been used for in vivo electrical recording and in vitro electrochemical detection. Poly-C electrodes have been used for electrical recording of neural activity. In vitro studies indicate that the diamond probe can detect norepinephrine at a 5 nM level. We propose a combination of diamond micro-machining and surface functionalization for manufacturing diamond pathogen-microsensors. |
| Adobe Flash Player 10.3.183.5 - Web browser plug-in (beta).. (Free) Posted: 14 Aug 2011 08:59 PM PDT Adobe Flash Player is a lightweight browser plug-in and rich Internet application (RIA) runtime that delivers consistent and engaging user experiences, stunning audio/video playback, and pervasive reach. Flash Player 10 introduces new expressive features, visual performance improvements, and extensibility to unleash the creative potential of designers and developers so they can build richer and more immersive web experiences. Version 10.3.183.5: Fixes the following compatibility issue:
Download Now This posting includes an audio/video/photo media file: Download Now |
| TrailRunner 3.7.656 - Route planning for hiking, biking, more.. (Shareware) Posted: 14 Aug 2011 08:59 PM PDT  TrailRunner is the perfect companion for runners, bikers, hikers, and all people wandering under the sky. Plan routes on a geographical map. Import GPS or workout recordings and journalize your activities in a diary. Features:
Version 2.7.656:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Firefox 6.0 - Popular Web browser.. (Free) Posted: 14 Aug 2011 08:59 PM PDT  Firefox is a web browser that empowers you to accomplish your online activities faster, more safely and efficiently than any other browser, period. Built with Tab browsing, popup blocking and a number of other seamless innovations, Firefox stands out ahead. Version 6.0 (Stable/Final Release):
Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
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