Games |
- SeaMonkey for PPC 2.12.1 - PPC port of the popular SeaMonkey browser. . (Free)
- IJMS, Vol. 13, Pages 11323-11331: A Novel Collection of snRNA-Like Promoters with Tissue-Specific Transcription Properties
- IJMS, Vol. 13, Pages 11312-11322: Optimization of Supercritical CO2 Extraction of Fish Oil from Viscera of African Catfish (Clarias gariepinus)
- Sustainability, Vol. 4, Pages 2176-2208: A Climate Change Adaptation Planning Process for Low-Lying, Communities Vulnerable to Sea Level Rise
- Sustainability, Vol. 4, Pages 2146-2175: Empowering the Citizen-Consumer: Re-Regulating Consumer Information to Support the Transition to Sustainable and Health Promoting Food Systems in Canada
- Sensors, Vol. 12, Pages 12374: Correction: Chen, S. et al. The Tradeoff Analysis for Remote Sensing Image Fusion Using Expanded Spectral Angle Mapper. Sensors 2008, 8, 520-528
- War of Angels - Screenshots
- Future Internet, Vol. 4, Pages 830-851: Semantic Web Approach to Ease Regulation Compliance Checking in Construction Industry
- Water, Vol. 4, Pages 650-699: Upgrading of Wastewater Treatment Plants Through the Use of Unconventional Treatment Technologies: Removal of Lidocaine, Tramadol, Venlafaxine and Their Metabolites
- Toxins, Vol. 4, Pages 643-662: Comparative Immunohistochemical Analysis of Ochratoxin A Tumourigenesis in Rats and Urinary Tract Carcinoma in Humans; Mechanistic Significance of p-S6 Ribosomal Protein Expression
- Viruses, Vol. 4, Pages 1509-1514: Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?
- Metabolites, Vol. 2, Pages 596-613: Metabolic and Pharmacokinetic Differentiation of STX209 and Racemic Baclofen in Humans
- Metabolites, Vol. 2, Pages 567-595: Minimal Cut Sets and the Use of Failure Modes in Metabolic Networks
- Membranes, Vol. 2, Pages 665-686: Investigation of La1−xSrxCrO3−∂ (x ~ 0.1) as Membrane for Hydrogen Production
- IJERPH, Vol. 9, Pages 3318-3329: Organophosphorus and Carbamate Pesticide Residues Detected in Water Samples Collected from Paddy and Vegetable Fields of the Savar and Dhamrai Upazilas in Bangladesh
- Cells, Vol. 1, Pages 646-666: Virus-Heat Shock Protein Interaction and a Novel Axis for Innate Antiviral Immunity
- Antibodies, Vol. 1, Pages 239-258: Fluobodies against Bioactive Natural Products and their Application in Fluorescence-Linked Immunosorbent Assay
- Why We Need Wonder Woman
- Dark Souls: Prepare to Die Edition Review
- Video Review - Dark Souls: Prepare to Die Edition
| SeaMonkey for PPC 2.12.1 - PPC port of the popular SeaMonkey browser. . (Free) Posted: 11 Sep 2012 03:01 AM PDT  SeaMonkey for PPC ... Since Mozilla has stopped supporting PPC on Macs I have picked it up and provide the only SeaMonkey version runnable on G4/G5 based Macs SeaMonkey is a Web browser that shares much of the same base code as the popular Firefox Web browser. It also contains an advanced e-mail and newsgroup client, IRC chat client, and HTML editor. The SeaMonkey project is a community effort to deliver production-quality releases of code derived from the application formerly known as "Mozilla Application Suite". Whereas the main focus of the Mozilla Foundation is on Mozilla Firefox and Mozilla Thunderbird, our group of dedicated volunteers works to ensure that you can have "everything but the kitchen sink" and have it stable enough for corporate use. Get those PPCs out of the closets and back online ! |
| Posted: 11 Sep 2012 12:00 AM PDT We recently identified a novel dataset of snRNA-like trascriptional units in the human genome. The investigation of a subset of these elements showed that they play relevant roles in physiology and/or pathology. In this work we expand our collection of small RNAs taking advantage of a newly developed algorithm able to identify genome sequence stretches with RNA polymerase (pol) III type 3 promoter features thus constituting putative pol III binding sites. The bioinformatic analysis of a subset of these elements that map in introns of protein-coding genes in antisense configuration suggest their association with alternative splicing, similarly to other recently characterized small RNAs. Interestingly, the analysis of the transcriptional activity of these novel promoters shows that they are active in a cell-type specific manner, in accordance with the emerging body of evidence of a tissue/cell-specific activity of pol III. |
| Posted: 11 Sep 2012 12:00 AM PDT Fish oil was extracted from the viscera of African Catfish using supercritical carbon dioxide (SC-CO2). A Central Composite Design of Response Surface methodology (RSM) was employed to optimize the SC-CO2 extraction parameters. The oil yield (Y) as response variable was executed against the four independent variables, namely pressure, temperature, flow rate and soaking time. The oil yield varied with the linear, quadratic and interaction of pressure, temperature, flow rate and soaking time. Optimum points were observed within the variables of temperature from 35 °C to 80 °C, pressure from 10 MPa to 40 MPa, flow rate from 1 mL/min to 3 mL/min and soaking time from 1 h to 4 h. However, the extraction parameters were found to be optimized at temperature 57.5 °C, pressure 40 MPa, flow rate 2.0 mL/min and soaking time 2.5 h. At this optimized condition, the highest oil yields were found to be 67.0% (g oil/100 g sample on dry basis) in the viscera of catfish which was reasonable to the yields of 78.0% extracted using the Soxhlet method. |
| Posted: 11 Sep 2012 12:00 AM PDT While the province of British Columbia (BC), Canada, provides guidelines for flood risk management, it is local governments' responsibility to delineate their own flood vulnerability, assess their risk, and integrate these with planning policies to implement adaptive action. However, barriers such as the lack of locally specific data and public perceptions about adaptation options mean that local governments must address the need for adaptation planning within a context of scientific uncertainty, while building public support for difficult choices on flood-related climate policy and action. This research demonstrates a process to model, visualize and evaluate potential flood impacts and adaptation options for the community of Delta, in Metro Vancouver, across economic, social and environmental perspectives. Visualizations in 2D and 3D, based on hydrological modeling of breach events for existing dike infrastructure, future sea level rise and storm surges, are generated collaboratively, together with future adaptation scenarios assessed against quantitative and qualitative indicators. This 'visioning package' is being used with staff and a citizens' Working Group to assess the performance, policy implications and social acceptability of the adaptation strategies. Recommendations based on the experience of the initiative are provided that can facilitate sustainable future adaptation actions and decision-making in Delta and other jurisdictions. |
| Posted: 11 Sep 2012 12:00 AM PDT Both health and sustainability are stated public policy objectives in Canada, but food information rules and practices may not be optimal to support their achievement. In the absence of a stated consensus on the purposes of public information about food, the information provided is frequently determined by the marketers of product. No institution or agency has responsibility for determining the overall coherence of consumer food messages relative to these broader social goals of health and sustainability. Individual firms provide information that shows their products to best advantage, which may contradict what is provided about the product by another firm or government agency. Individual consumers do not have the resources to determine easily the completeness of any firm's messages, particularly in light of the size of food industry advertising budgets. Government rules confound this problem because there is also little coherence between the parts of government that have responsibility for point of purchase, advertising rules, and labelling. The healthy eating messages of health departments are often competing with contradictory messages permitted by the regulatory framework of other arms of government. Investments in programs that successfully promote environmental stewardship in agriculture are undercut in the market because consumers cannot support those efforts with their dollars. This problem exists despite the emergence of "citizen-consumers" who have a broader approach to food purchasing than individual maximization. Only recently have some health professionals and sustainable agriculture proponents turned their attention to these factors and designed interventions that take them into account. In this paper, which builds upon earlier work by MacRae [1], we outline key short, medium and long term initiatives to facilitate the citizen-consumer phenomenon and better support consumers in their efforts to promote health and sustainability in the Canadian food system. |
| Posted: 11 Sep 2012 12:00 AM PDT There are two mistakes in this article [1]. On page 523, lines 10–11, the sentence "the value of the SAM is 1, but the value of the ESAM is less than 1" should be "the value of the SAM is 0, but the value of the ESAM is great than 0". Line 12, "but the value of the ESAM is less than 1" should be "but the value of the ESAM is great than 0 for even n". |
| Posted: 11 Sep 2012 03:06 AM PDT War of Angels is a high fantasy MMORPG situating players in a colossal struggle between good and evil. Players must choose their destiny as they battle to aid or prevent the resurrection of the evil fallen angel, Dertgotz. Gamers who engage in this epic tale will find a distinctive experience with several dynamic features: * City Construction – Guilds can occupy locations, set up merchant stores to gain profit and branch out with their own cities. As economic activity takes place, guilds may find themselves in constant battle to control vital trade hubs from their neighbors. * Good vs. Evil – Players will be enraptured in the core of War of Angels content, which enables players to develop their characters as either good or evil. Certain points throughout the game will determine a character's alignment based on their actions. Upon completing the main story quest, players will be judged as good or evil, which opens up end-game player-versus-player options (PvP). Once alignment is determined, characters are locked in constant battle during quests and while hunting monsters in high level areas of the map. * Deathblow Attacks – Turn the tide of battle with savage attacks. Player build the deathblow gauge by successfully wounding ferocious monsters, eventually unleashing different levels of devastating attacks when it's needed most. * Expansive Crafting System – As players level up their characters they will gain the ability to enchant their weapons and armor. Additionally, the unique Constellation system allows players to create exceptional and powerful items that are not attainable through enchanting alone. * Item Store – Players can purchase many items via War of Angel's online marketplace. As players gain Honor points within the Good/Evil systems, rare ... |
| Posted: 11 Sep 2012 12:00 AM PDT Regulations in the Building Industry are becoming increasingly complex and involve more than one technical area, covering products, components and project implementations. They also play an important role in ensuring the quality of a building, and to minimize its environmental impact. Control or conformance checking are becoming more complex every day, not only for industrials, but also for organizations charged with assessing the conformity of new products or processes. This paper will detail the approach taken by the CSTB (Centre Scientifique et Technique du Bâtiment) in order to simplify this conformance control task. The approach and the proposed solutions are based on semantic web technologies. For this purpose, we first establish a domain-ontology, which defines the main concepts involved and the relationships, including one based on OWL (Web Ontology Language) [1]. We rely on SBVR (Semantics of Business Vocabulary and Business Rules) [2] and SPARQL (SPARQL Protocol and RDF Query Language) [3] to reformulate the regulatory requirements written in natural language, respectively, in a controlled and formal language. We then structure our control process based on expert practices. Each elementary control step is defined as a SPARQL query and assembled into complex control processes "on demand", according to the component tested and its semantic definition. Finally, we represent in RDF (Resource Description Framework) [4] the association between the SBVR rules and SPARQL queries representing the same regulatory constraints. |
| Posted: 11 Sep 2012 12:00 AM PDT The occurrence and removal efficiencies of the pharmaceuticals lidocaine (LDC), tramadol (TRA) and venlafaxine (VEN), and their major active metabolites monoethylglycinexylidide (MEGX), O-desmethyltramadol (ODT) and O-desmethylvenlafaxine (ODV) were studied at four wastewater treatment plants (WWTPs) equipped with activated sludge treatment technologies. In parallel to activated sludge treatment, the removal efficiency of the compounds in pilot- and full-scale projects installed at the WWTPs was investigated. Within these projects two different treatment methods were tested: adsorption onto powdered/granulated activated carbon (PAC/GAC) and ozonation. The metabolite MEGX was not detected in any sample. The concentrations of the target analytes in wastewater effluents resulting from activated sludge treatment ranged from 55 to 183 (LDC), 88 to 416 (TRA), 50 to 245 (ODT), 22 to 176 (VEN) and 77 to 520 ng L−1 (ODV). In the pilot project with subsequent treatment with PAC/GAC, the mean concentrations of the analytes were between |
| Posted: 11 Sep 2012 12:00 AM PDT Ochratoxin A (OTA) is considered to be a possible human urinary tract carcinogen, based largely on a rat model, but no molecular genetic changes in the rat carcinomas have yet been defined. The phosphorylated-S6 ribosomal protein is a marker indicating activity of the mammalian target of rapamycin, which is a serine/threonine kinase with a key role in protein biosynthesis, cell proliferation, transcription, cellular metabolism and apoptosis, while being functionally deregulated in cancer. To assess p-S6 expression we performed immunohistochemistry on formalin-fixed and paraffin-embedded tumours and normal tissues. Marked intensity of p-S6 expression was observed in highly proliferative regions of rat renal carcinomas and a rare angiosarcoma, all of which were attributed to prolonged exposure to dietary OTA. Only very small OTA-generated renal adenomas were negative for p-S6. Examples of rat subcutaneous fibrosarcoma and testicular seminoma, as well as of normal renal tissue, showed no or very weak positive staining. In contrast to the animal model, human renal cell carcinoma, upper urinary tract transitional cell carcinoma from cases of Balkan endemic nephropathy, and a human angiosarcoma were negative for p-S6. The combined findings are reminiscent of constitutive changes in the rat tuberous sclerosis gene complex in the Eker strain correlated with renal neoplasms, Therefore rat renal carcinogenesis caused by OTA does not obviously mimic human urinary tract tumourigenesis. |
| Posted: 11 Sep 2012 12:00 AM PDT Varicella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of varicella-induced apoptosis in non‑neuronal cells. Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV. |
| Posted: 11 Sep 2012 12:00 AM PDT STX209 is an exploratory drug comprising the single, active R-enantiomer of baclofen which is in later stage clinical trials for the treatment of fragile x syndrome (FXS) and autism spectrum disorders (ASD). New clinical data in this article on the metabolism and pharmacokinetics of the R- and S-enantiomers of baclofen presents scientific evidence for stereoselective metabolism of only S-baclofen to an abundant oxidative deamination metabolite that is sterically resolved as the S-enantiomeric configuration. This metabolite undergoes some further metabolism by glucuronide conjugation. Consequences of this metabolic difference are a lower Cmax and lower early plasma exposure of S-baclofen compared to R-baclofen and marginally lower urinary excretion of S-baclofen after racemic baclofen administration. These differences introduce compound-related exposure variances in humans in which subjects dosed with racemic baclofen are exposed to a prominent metabolite of baclofen whilst subjects dosed with STX209 are not. For potential clinical use, our findings suggest that STX209 has the advantage of being a biologically defined and active enantiomer. |
| Posted: 11 Sep 2012 12:00 AM PDT A minimal cut set is a minimal set of reactions whose inactivation would guarantee a failure in a certain network function or functions. Minimal cut sets (MCSs) were initially developed from the metabolic pathway analysis method (MPA) of elementary modes (EMs); they provide a way of identifying target genes for eliminating a certain objective function from a holistic perspective that takes into account the structure of the whole metabolic network. The concept of MCSs is fairly new and still being explored and developed; the initial concept has developed into a generalized form and its similarity to other network characterizations are discussed. MCSs can be used in conjunction with other constraints-based methods to get a better understanding of the capability of metabolic networks and the interrelationship between metabolites and enzymes/genes. The concept could play an important role in systems biology by contributing to fields such as metabolic and genetic engineering where it could assist in finding ways of producing industrially relevant compounds from renewable resources, not only for economical, but also for sustainability, reasons. |
| Posted: 11 Sep 2012 12:00 AM PDT Various inorganic membranes have demonstrated good capability to separate hydrogen from other gases at elevated temperatures. Hydrogen-permeable, dense, mixed proton-electron conducting ceramic oxides offer superior selectivity and thermal stability, but chemically robust candidates with higher ambipolar protonic and electronic conductivity are needed. In this work, we present for the first time the results of various investigations of La1−xSrxCrO3−∂ membranes for hydrogen production. We aim in particular to elucidate the material's complex transport properties, involving co-ionic transport of oxide ions and protons, in addition to electron holes. This opens some new possibilities for efficient heat and mass transfer management in the production of hydrogen. Conductivity measurements as a function of pH2 at constant pO2 exhibit changes that reveal a significant hydration and presence of protons. The flux and production of hydrogen have been measured under different chemical gradients. In particular, the effect of water vapor in the feed and permeate gas stream sides was investigated with the aim of quantifying the ratio of hydrogen production by hydrogen flux from feed to permeate and oxygen flux the opposite way ("water splitting"). Deuterium labeling was used to unambiguously prove flux of hydrogen species. |
| Posted: 11 Sep 2012 12:00 AM PDT Several types of organophosphorous and carbamate pesticides have been used extensively by the farmers in Bangladesh during the last few decades. Twenty seven water samples collected from both paddy and vegetable fields in the Savar and Dhamrai Upazilas in Bangladesh were analyzed to determine the occurrence and distribution of organo-phosphorus (chlorpyrifos, malathion and diazinon) and carbamate (carbaryl and carbofuran) pesticide residues. A high performance liquid chromatograph instrument equipped with a photodiode array detector was used to determine the concentrations of these pesticide residues. Diazinon and carbofuran were detected in water samples collected from Savar Upazila at 0.9 μg/L and 198.7 μg/L, respectively. Malathion was also detected in a single water sample at 105.2 μg/L from Dhamrai Upazila. Carbaryl was the most common pesticide detected in Dhamrai Upazila at 14.1 and 18.1 μg/L, while another water sample from Dhamrai Upazila was contaminated with carbofuran at 105.2 μg/L. Chlorpyrifos was not detected in any sample. Overall, the pesticide residues detected were well above the maximum acceptable levels of total and individual pesticide contamination, at 0.5 and 0.1 μg/L, respectively, in water samples recommended by the European Economic Community (Directive 98/83/EC). The presence of these pesticide residues may be attributed by their intense use by the farmers living in these areas. Proper handling of these pesticides should be ensured to avoid direct or indirect exposure to these pesticides. |
| Posted: 11 Sep 2012 12:00 AM PDT Virus infections induce heat shock proteins that in turn enhance virus gene expression, a phenomenon that is particularly well characterized for the major inducible 70 kDa heat shock protein (hsp70). However, hsp70 is also readily induced by fever, a phylogenetically conserved response to microbial infections, and when released from cells, hsp70 can stimulate innate immune responses through toll like receptors 2 and 4 (TLR2 and 4). This review examines how the virus-hsp70 relationship can lead to host protective innate antiviral immunity, and the importance of hsp70 dependent stimulation of virus gene expression in this host response. Beginning with the well-characterized measles virus-hsp70 relationship and the mouse model of neuronal infection in brain, we examine data indicating that the innate immune response is not driven by intracellular sensors of pathogen associated molecular patterns, but rather by extracellular ligands signaling through TLR2 and 4. Specifically, we address the relationship between virus gene expression, extracellular release of hsp70 (as a damage associated molecular pattern), and hsp70-mediated induction of antigen presentation and type 1 interferons in uninfected macrophages as a novel axis of antiviral immunity. New data are discussed that examines the more broad relevance of this protective mechanism using vesicular stomatitis virus, and a review of the literature is presented that supports the probable relevance to both RNA and DNA viruses and for infections both within and outside of the central nervous system. |
| Posted: 11 Sep 2012 12:00 AM PDT An enzyme-linked immunosorbent assay (ELISA) using monoclonal antibody (MAb), Fab antibody, and single-chain variable fragment (scFv) antibody has become one of the most promising analytical methods owing to its rapidity, sensitivity, and reliability. Recently, a chimera of green fluorescent protein (GFP) with a scFv antibody, named fluobody, was proposed as a probe for an alternative immunosorbent assay; i.e., fluorescence-linked immunosorbent assay (FLISA). In this FLISA, an even more sensitive, simple, and rapid immunoassay can be performed by detecting the highly sensitive fluorophore of GFP that is genetically and directly fused to the scFv antibody. In addition, the time- and cost-consuming secondary antibody reaction and the following enzyme-substrate reaction, necessary for conventional ELISA, can be avoided, making it possible to complete the assay more rapidly. Focusing on naturally occurring bioactive products, fluobody recognizing 1,4-naphthoquinone, plumbagin and triterpenoid saponin, ginsenosides were successfully expressed in Escherichia coli (E. coli) and applied to FLISA. The construction, the expression, and the potential use of fluobody in quantitative/qualitative analysis of bioactive natural products are reviewed in this article. |
| Posted: 11 Sep 2012 12:26 AM PDT Just when you thought that Hollywood might be sick of superhero movies, the boon continued this summer. |
| Dark Souls: Prepare to Die Edition Review Posted: 10 Sep 2012 07:36 PM PDT One of the greatest games of recent years makes its way to the PC with Dark Souls: Prepare to Die Edition.
Score: 9.5 / superb Get the full article at GameSpot "Dark Souls: Prepare to Die Edition Review" was posted by Carolyn Petit on Mon, 10 Sep 2012 19:36:35 -0700 |
| Video Review - Dark Souls: Prepare to Die Edition Posted: 10 Sep 2012 07:35 PM PDT Death is just a setback in this video review for Dark Souls: Prepare to Die Edition.
Read and Post Comments | Get the full article at GameSpot "Video Review - Dark Souls: Prepare to Die Edition" was posted by JimM on Mon, 10 Sep 2012 19:35:39 -0700 |
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