Games |
- Blade & Soul - Screenshots
- MechWarrior: Tactical Command - Screenshots
- Space Holiday - Screenshots
- U BEAUTY! It’s the GamesRadar UK Podcast Question Box
- IJMS, Vol. 13, Pages 11584-11592: Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies
- IJMS, Vol. 13, Pages 11569-11583: Is DNA Damage Response Ready for Action Anywhere?
- IJMS, Vol. 13, Pages 11543-11568: α-Tocopherol at Nanomolar Concentration Protects PC12 Cells from Hydrogen Peroxide-Induced Death and Modulates Protein Kinase Activities
- IJMS, Vol. 13, Pages 11530-11542: Effects of Sorafenib on C-Terminally Truncated Androgen Receptor Variants in Human Prostate Cancer Cells
- IJMS, Vol. 13, Pages 11520-11529: New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew
- Geosciences, Vol. 2, Pages 157-177: Homology and Potential Cellular and Molecular Mechanisms for the Development of Unique Feather Morphologies in Early Birds
- Soldier vs. Aliens - Screenshots
- Bridge column, September 14: Play the right card; read that card
- Snappy Dragons 2 - Screenshots
- Religions, Vol. 3, Pages 880-886: Plato’s Visible God: The Cosmic Soul Reflected in the Heavens
- Insects, Vol. 3, Pages 870-888: Biological Control of Tephritid Fruit Flies in Argentina: Historical Review, Current Status, and Future Trends for Developing a Parasitoid Mass-Release Program
- Metals, Vol. 2, Pages 377-398: Thermodynamic Database for Mg Alloys—Progress in Multicomponent Modeling
- Metals, Vol. 2, Pages 353-376: Magnesium-Based Sacrificial Anode Cathodic Protection Coatings (Mg-Rich Primers) for Aluminum Alloys
- Molecules, Vol. 17, Pages 11089-11102: Enhancement of Gene Silencing Effect and Membrane Permeability by Peptide-Conjugated 27-Nucleotide Small Interfering RNA
- Remote Sensing, Vol. 4, Pages 2694-2735: Operational Automatic Remote Sensing Image Understanding Systems: Beyond Geographic Object-Based and Object-Oriented Image Analysis (GEOBIA/GEOOIA). Part 1: Introduction
- Novus AEterno - Planet Population and Capture Gameplay
| Posted: 14 Sep 2012 04:13 AM PDT Bringing to life the fantasy style and signature character movement made popular by the classic martial arts adventure films House of Flying Daggers and Crouching Tiger, Hidden Dragon, Blade & Soul allows players to embrace the essence of historic martial arts combat, set in a beautiful world inspired by the stunning art of renowned artist Hyung-Tae Kim, Team Bloodlust's Blade & Soul lead artist. Kim's strong international manga following and his unique style of blending Japanese anime and Korean art will expand Blade & Soul's appeal to a broad audience. |
| MechWarrior: Tactical Command - Screenshots Posted: 14 Sep 2012 04:21 AM PDT MechWarrior: Tactical Command features: - Real Time Tactics on the go: MechWarrior: Tactical Command brings a true mobile RTS experience with Personae's unique controls for iOS devices. Players can initiate precise, advanced commands with quick responses to get the most immersive BattleTech experience ever. - Authentic BattleTech Mechanics: MechWarrior: Tactical Command stays very close to the original boardgame. Heat acts as stamina and Mech's limbs have individual sources of health-watch Mechs cripple other robots as they destroy their limbs and bodyparts! - Massive Damage: Players will fight through waves of Elementals, Tanks, and other heavy armored mechs with a squad of four warriors in 21 levels set across three planets, including Twycross, where a number of the events from the series occur. - Massive Mechs: With 30 mechs taken from the series lore, there are a variety of Battle Mechs with different classes to deploy onto the battlefield. Charge in with a Mad Cat, annihilate the opposition with the Atlas, or wreak havoc with the Hatamoto-Chi. - Massive Customization: Players earn C-bills and tech resources from missions to upgrade their lance of mechs. Increase a mech's arsenal, tune their BattleMech's accuracy, or enhance their weapon systems-MechWarrior: Tactical Command lets players build their mechs and squad members whichever way they desire. |
| Posted: 14 Sep 2012 04:28 AM PDT Space Holiday features: - Massive Levels – Complete 80 challenging levels, aiming to collect three stars on each level - Utilize Special Stars – Use the Ninja, Plunger, Angel, and Piñata stars to help clear asteroids and safety open the star portal - Fun Animations – Hand-drawn, cartoon animations create an enjoyable game environment that's perfect for all ages - Call in the Big Guns – Stuck on a level? Use the Space Ray, available via in-app purchase, to transform the evil asteroids into helpful stars - Worldwide Availability – Space Holiday is available in nine languages, including English, Chinese, French, German, Italian, Japanese, Korean, Portuguese, and Spanish - Active Leaderboards – Compete with friends and see who is the greatest galaxy explorer - Free Version Available – Check out the game before buying, with the free version of Space Holiday on iPhone and iPad, each featuring 9 playable levels |
| U BEAUTY! It’s the GamesRadar UK Podcast Question Box Posted: 14 Sep 2012 03:26 AM PDT Welcome to the GamesRadar UK Podcast Question Box, our bi-weekly regular receptacle for all of your ponderances and musings. If you have a question or a |
| Posted: 14 Sep 2012 12:00 AM PDT α-Synucleinopathies are neurodegenerative disorders that are characterized by progressive decline of motor and non-motor dysfunctions. α-Synuclein (αS) has been shown to play a causative role in neurodegeneration, but the pathogenic mechanisms are still unclear. Thus, there are no radical therapies that can halt or reverse the disease's progression. β-Synuclein (βS), the non-amyloidogenic homologue of αS, ameliorates the neurodegeneration phenotype of αS in transgenic (tg) mouse models, as well as in cell free and cell culture systems, which suggests that βS might be a negative regulator of neurodegeneration caused by αS, and that "loss of function" of βS might be involved in progression of α-synucleinopathies. Alternatively, it is possible that "toxic gain of function" of wild type βS occurs during the pathogenesis of sporadic α-synucleinopathies, since tg mice expressing dementia with Lewy bodies-linked P123H βS develop progressive neurodegeneration phenotypes, such as axonal pathology and dementia. In this short review, we emphasize the aspects of "toxic gain of function" of wild type βS during the pathogenesis of sporadic α-synucleinopathies. |
| IJMS, Vol. 13, Pages 11569-11583: Is DNA Damage Response Ready for Action Anywhere? Posted: 14 Sep 2012 12:00 AM PDT Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin hinders a proper DDR. However, the condensation state of chromatin is not the only barrier to DDR. In this review, we have collected data regarding the presence of DDR factors on micronuclear DNA lesions that indicate that micronuclei are almost incapable of generating an effective DDR because of defects in their nuclear envelope. Finally, considering the recent observations about the reincorporation of micronuclei to the main bulk of chromosomes, we suggest that, under certain circumstances, micronuclei carrying DNA damage might be a source of chromosome instability. |
| Posted: 14 Sep 2012 12:00 AM PDT The aim of this work was to compare protective and anti-apoptotic effects of α-tocopherol at nanomolar and micromolar concentrations against 0.2 mM H2O2-induced toxicity in the PC12 neuronal cell line and to reveal protein kinases that contribute to α-tocopherol protective action. The protection by 100 nM α-tocopherol against H2O2-induced PC12 cell death was pronounced if the time of pre-incubation with α-tocopherol was 3–18 h. For the first time, the protective effect of α-tocopherol was shown to depend on its concentration in the nanomolar range (1 nM < 10 nM < 100 nM), if the pre-incubation time was 18 h. Nanomolar and micromolar α-tocopherol decreased the number of PC12 cells in late apoptosis induced by H2O2 to the same extent if pre-incubation time was 18 h. Immunoblotting data showed that α-tocopherol markedly diminished the time of maximal activation of extracellular signal-regulated kinase 1/2 (ERK 1/2) and protein kinase B (Akt)-induced in PC12 cells by H2O2. Inhibitors of MEK 1/2, PI 3-kinase and protein kinase C (PKC) diminished the protective effect of α-tocopherol against H2O2-initiated toxicity if the pre-incubation time was long. The modulation of ERK 1/2, Akt and PKC activities appears to participate in the protection by α-tocopherol against H2O2-induced death of PC12 cells. The data obtained suggest that inhibition by α-tocopherol in late stage ERK 1/2 and Akt activation induced by H2O2 in PC12 cells makes contribution to its protective effect, while total inhibition of these enzymes is not protective. |
| Posted: 14 Sep 2012 12:00 AM PDT Recent evidence suggests that the development of castration resistant prostate cancer (CRPCa) is commonly associated with an aberrant, ligand-independent activation of the androgen receptor (AR). A putative mechanism allowing prostate cancer (PCa) cells to grow under low levels of androgens, is the expression of constitutively active, C-terminally truncated AR lacking the AR-ligand binding domain (LBD). Due to the absence of a LBD, these receptors, termed ARΔLBD, are unable to respond to any form of anti-hormonal therapies. In this study we demonstrate that the multikinase inhibitor sorafenib inhibits AR as well as ARΔLBD-signalling in CRPCa cells. This inhibition was paralleled by proteasomal degradation of the AR- and ARΔLBD-molecules. In line with these observations, maximal antiproliferative effects of sorafenib were achieved in AR and ARΔLBD-positive PCa cells. The present findings warrant further investigations on sorafenib as an option for the treatment of advanced AR-positive PCa. |
| Posted: 14 Sep 2012 12:00 AM PDT Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 µg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 µg/mL), Pseudomonas aeruginosa (MIC, 50 µg/mL) and Salmonella typhi (MIC, 50 µg/mL). |
| Posted: 14 Sep 2012 12:00 AM PDT At least two lineages of Mesozoic birds are known to have possessed a distinct feather morphotype for which there is no neornithine (modern) equivalent. The early stepwise evolution of apparently modern feathers occurred within Maniraptora, basal to the avian transition, with asymmetrical pennaceous feathers suited for flight present in the most basal recognized avian, Archaeopteryx lithographica. The number of extinct primitive feather morphotypes recognized among non-avian dinosaurs continues to increase with new discoveries; some of these resemble feathers present in basal birds. As a result, feathers between phylogenetically widely separated taxa have been described as homologous. Here we examine the extinct feather morphotypes recognized within Aves and compare these structures with those found in non-avian dinosaurs. We conclude that the "rachis dominated" tail feathers of Confuciusornis sanctus and some enantiornithines are not equivalent to the "proximally ribbon-like" pennaceous feathers of the juvenile oviraptorosaur Similicaudipteryx yixianensis. Close morphological analysis of these unusual rectrices in basal birds supports the interpretation that they are modified pennaceous feathers. Because this feather morphotype is not seen in living birds, we build on current understanding of modern feather molecular morphogenesis to suggest a hypothetical molecular developmental model for the formation of the rachis dominated feathers of extinct basal birds. |
| Soldier vs. Aliens - Screenshots Posted: 14 Sep 2012 03:35 AM PDT Carry out dozens of missions with gradual challenges in Campaign mode, or face the Queen and her ravenous children in Survival mode. What better way to blow off some steam for the end of summer? And best of all, you can test all of your nifty weapons against hordes of bloodthirsty aliens! Features: - Fight in two modes: Campaign and Survival - An off-the-wall, rough n' tough universe. - Battles with an "alienating" rhythm - fight against the Queen and four other alien classes - Explore 9 worlds and complete more than 50 levels and missions - Equip your Soldier with seven interchangeable armors and arm yourself with nine upgradeable, super-powerful weapons - Game Center - Universal Application compatible with iPad Retina Display Support! |
| Bridge column, September 14: Play the right card; read that card Posted: 14 Sep 2012 02:18 AM PDT Winston Churchill said, "This report, by its very length, defends itself against the risk of being read." This column, by its very shortness, increases its chance of being read. This posting includes an audio/video/photo media file: Download Now |
| Snappy Dragons 2 - Screenshots Posted: 14 Sep 2012 03:23 AM PDT Play one of the 5 dragons, and deliver your babies caught in cages by evil wizards. Throw fireballs at them, but be careful not to hit your little ones! Travel the 4 brand new colorful worlds of SNAPPY DRAGONS 2 with more than 95 exciting levels and up to 6 different game modes! Features: - Take a journey in 4 new unique worlds - Play in More than 95 levels - Use one of the 5 skilled dragons with special abilities - Have fun with the 6 different types of thrilling gameplay - Destroy the world and find secret paths |
| Religions, Vol. 3, Pages 880-886: Plato’s Visible God: The Cosmic Soul Reflected in the Heavens Posted: 14 Sep 2012 12:00 AM PDT Although Plato states that the perceptible god that he describes in Timaeus is visible to the human eye, the reflection of the Cosmic Soul in the heavens has largely been explained away or forgotten in the Western mind. But Roman texts, early Christian testimony, and Imperial coins illustrate that Plato's intersection in the heavens played a major role in Hellenistic cosmology and soteriology. |
| Posted: 14 Sep 2012 12:00 AM PDT In Argentina there are two tephritid fruit fly species of major economic and quarantine importance: the exotic Ceratitis capitata that originated from Southeast Africa and the native Anastrepha fraterculus. In recent years, the use of fruit fly parasitoids as biocontrol agents has received renewed attention. This increasing interest has recently led to the establishment of a program for the mass rearing of five million Diachasmimorpha longicaudata parasitoids per week in the BioPlanta San Juan facility, San Juan, Argentina. The first augmentative releases of D. longicaudata in Argentina are currently occurring on commercial fig crops in rural areas of San Juan as part of an integrated fruit fly management program on an area-wide basis. In this context, research is ongoing to assess the suitability of indigenous parasitoid species for successful mass rearing on larvae of either C. capitata or A. fraterculus. The purpose of this article is to provide a historical overview of the biological control of the fruit fly in Argentina, report on the strategies currently used in Argentina, present information on native parasitoids as potential biocontrol agents, and discuss the establishment of a long-term fruit fly biological control program, including augmentative and conservation modalities, in Argentina's various fruit growing regions. |
| Posted: 14 Sep 2012 12:00 AM PDT Progress in systematic development of a thermodynamic database for Mg alloys with 21 components is reported. Models for multicomponent alloys are built in a methodical approach from quantitative descriptions of unary, binary and ternary subsystems. For a large number of ternary—and some higher—alloy systems, an evaluation of the modeling depth is made with concise reference to experimental work validating these thermodynamic descriptions. A special focus is on ternary intermetallic phase compositions. These comprise solutions of the third component in a binary compound as well as truly ternary solid solution phases, in addition to the simple ternary stoichiometric phases. Concise information on the stability ranges is given. That evaluation is extended to selected quaternary and even higher alloy systems. Thermodynamic descriptions of intermetallic solution phases guided by their crystal structure are also elaborated and the diversity of such unified phases is emphasized. |
| Posted: 14 Sep 2012 12:00 AM PDT Magnesium is electrochemically the most active metal employed in common structural alloys of iron and aluminum. Mg is widely used as a sacrificial anode to provide cathodic protection of underground and undersea metallic structures, ships, submarines, bridges, decks, aircraft and ground transportation systems. Following the same principle of utilizing Mg characteristics in engineering advantages in a decade-long successful R&D effort, Mg powder is now employed in organic coatings (termed as Mg-rich primers) as a sacrificial anode pigment to protect aerospace grade aluminum alloys against corrosion. Mg-rich primers have performed very well on aluminum alloys when compared against the current chromate standard, but the carcinogenic chromate-based coatings/pretreatments are being widely used by the Department of Defense (DoD) to protect its infrastructure and fleets against corrosion damage. Factors such as reactivity of Mg particles in the coating matrix during exposure to aggressive corrosion environments, interaction of atmospheric gases with Mg particles and the impact of Mg dissolution, increases in pH and hydrogen gas liberation at coating-metal interface, and primer adhesion need to be considered for further development of Mg-rich primer technology. |
| Posted: 14 Sep 2012 12:00 AM PDT Two different sizes of siRNAs, of which one type was 21-nucleotide (nt) siRNA containing 2-nt dangling ends and the other type was 27-nt siRNA with blunt ends, were conjugated with a nuclear export signal peptide of HIV-1 Rev at the 5′-sense end. Processing by Dicer enzyme, cell membrane permeability, and RNAi efficiency of the peptide-conjugated siRNAs were examined. Dicer cleaved the peptide-conjugated 27-nt siRNA leading to the release of 21-nt siRNA, whereas the peptide-conjugated 21-nt siRNA was not cleaved. High membrane permeability and cytoplasmic localization was found in the conjugates. Moreover, the peptide-conjugated 27-nt siRNA showed increased potency of RNAi in comparison with the nonmodified 21-nt and 27-nt siRNAs, whereas the peptide-conjugated 21-nt siRNA showed decreased RNAi efficacy. This potent RNAi efficacy is probably owing to acceleration of RISC through recognition by Dicer, as well as to the improvement of cell membrane permeability and intracellular accumulation. |
| Posted: 14 Sep 2012 12:00 AM PDT According to existing literature and despite their commercial success, state-of-the-art two-stage non-iterative geographic object-based image analysis (GEOBIA) systems and three-stage iterative geographic object-oriented image analysis (GEOOIA) systems, where GEOOIA É GEOBIA, remain affected by a lack of productivity, general consensus and research. To outperform the degree of automation, accuracy, efficiency, robustness, scalability and timeliness of existing GEOBIA/GEOOIA systems in compliance with the Quality Assurance Framework for Earth Observation (QA4EO) guidelines, this methodological work is split into two parts. The first part of this work provides a multi-disciplinary Strengths, Weaknesses, Opportunities and Threats (SWOT) analysis of the GEOBIA/GEOOIA approaches that augments similar analyses proposed in recent years. In line with constraints stemming from human vision, this SWOT analysis promotes a shift of learning paradigm in the pre-attentive vision first stage of a remote sensing (RS) image understanding system (RS-IUS), from sub-symbolic statistical model-based (inductive) image segmentation to symbolic physical model-based (deductive) image preliminary classification. Hence, a symbolic deductive pre-attentive vision first stage accomplishes image sub-symbolic segmentation and image symbolic pre-classification simultaneously. In the second part of this work a novel hybrid (combined deductive and inductive) RS-IUS architecture featuring a symbolic deductive pre-attentive vision first stage is proposed and discussed in terms of: (a) computational theory (system design); (b) information/knowledge representation; (c) algorithm design; and (d) implementation. As proof-of-concept of symbolic physical model-based pre-attentive vision first stage, the spectral knowledge-based, operational, near real-time Satellite Image Automatic Mapper™ (SIAM™) is selected from existing literature. To the best of these authors' knowledge, this is the first time a symbolic syntactic inference system, like SIAM™, is made available to the RS community for operational use in a RS-IUS pre-attentive vision first stage, to accomplish multi-scale image segmentation and multi-granularity image pre-classification simultaneously, automatically and in near real-time. |
| Novus AEterno - Planet Population and Capture Gameplay Posted: 13 Sep 2012 08:56 PM PDT A planet population and capture gameplay video for Novus AEterno.
Read and Post Comments | Get the full article at GameSpot "Novus AEterno - Planet Population and Capture Gameplay" was posted by MikeTao on Thu, 13 Sep 2012 20:56:10 -0700 |
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