Games |
- Linkies - Screenshots
- Sensors, Vol. 12, Pages 12235-12264: Sensor Systems Based on FPGAs and Their Applications: A Survey
- Molecules, Vol. 17, Pages 10683-10707: Regiocontrolled Microwave Assisted Bifunctionalization of 7,8-Dihalogenated Imidazo[1,2-a]pyridines: A One Pot Double-Coupling Approach
- Molecules, Vol. 17, Pages 10675-10682: Activity-Guided Isolation of Antioxidant Compounds from Rhizophora apiculata
- Molecules, Vol. 17, Pages 10667-10674: Synthesis and Protective Effect of Scutellarein on Focal Cerebral Ischemia/Reperfusion in Rats
- Molecules, Vol. 17, Pages 10652-10666: Design, Practical Synthesis, and Biological Evaluation of Novel 6-(Pyrazolylmethyl)-4-quinoline-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors
- Molecules, Vol. 17, Pages 10614-10651: Advances in the Chemical Analysis and Biological Activities of Chuanxiong
- IJMS, Vol. 13, Pages 11102-11129: Erythropoietin: New Directions for the Nervous System
- Cincinnati casino to give construction update
- Drakerider - Screenshots
- Library Books 3.19b5 - Track your borrowed library books.. (Demo)
- Accordance 10.0 - Bible analysis and study resource.. (Demo)
- NCbackgrounder 1.2.0 - Customize Notification Center's background.. (Free)
- iExplorer 3.0.2.5 - View the files on your iPhone (was iPhone Explorer).. (Shareware)
- moApp AppDotNet 0.2 - Client for the new App.net.. (Free)
- Absolute Acey Deucey 5.8.8 - Backgammon game.. (Demo)
- VUWER 1.5.7 - Remotely track lost or stolen Macs.. (Free)
- IJMS, Vol. 13, Pages 11085-11101: Dual Targeting and Retrograde Translocation: Regulators of Plant Nuclear Gene Expression Can Be Sequestered by Plastids
- IJMS, Vol. 13, Pages 11071-11084: The Dual Role of Inflammation in Colon Carcinogenesis
- IJMS, Vol. 13, Pages 11063-11070: Successful Treatment of Liver Aspergilloma by Caspofungin Acetate First-Line Therapy in a Non-Immunocompromised Patient
| Posted: 06 Sep 2012 04:38 AM PDT An old, rusty robot from the dark ages has awoken and started spewing out shapes of toxic waste into the Linkies' cute little world. It is up to you to help the Linkies clean up the world and restore it to its former beauty. FEATURES -Simple draw controls -90 levels across 5 chapters -Blitz mode for hours of fun -Cute characters -Unique graphics with a never seen before art style -Game Center achievements and leaderboard -Challenge your friends through Facebook -Universal build; runs on both iPhone, iPad and iPod Touch. |
| Sensors, Vol. 12, Pages 12235-12264: Sensor Systems Based on FPGAs and Their Applications: A Survey Posted: 06 Sep 2012 12:00 AM PDT In this manuscript, we present a survey of designs and implementations of research sensor nodes that rely on FPGAs, either based upon standalone platforms or as a combination of microcontroller and FPGA. Several current challenges in sensor networks are distinguished and linked to the features of modern FPGAs. As it turns out, low-power optimized FPGAs are able to enhance the computation of several types of algorithms in terms of speed and power consumption in comparison to microcontrollers of commercial sensor nodes. We show that architectures based on the combination of microcontrollers and FPGA can play a key role in the future of sensor networks, in fields where processing capabilities such as strong cryptography, self-testing and data compression, among others, are paramount. |
| Posted: 06 Sep 2012 12:00 AM PDT The reactivity of the 7-chloro-8-iodo- and 8-chloro-7-iodoimidazo[1,2-a]pyridines 1a–e diversely substituted on the 2 position, towards Suzuki-Miyaura, Sonogashira, and Buchwald-Hartwig cross-coupling reactions as well as cyanation was evaluated. Various methodologies are proposed to introduce aryl, heteroaryl, alkyne, amine or cyano groups in the two positions depending on the nature of the substituent present in position 2. In both series, the substitution of the iodine atom was totally regioselective and the difficulty was to substitute the chlorine atom in a second step. Until now, only hetero(aryl) groups could be introduced though Suzuki-Miyaura cross-coupling. We overcame this problem evaluating both regioisomers in parallel. The double coupling approach was also studied allowing the one pot Suzuki/Suzuki, cyanation/Sonogashira and cyanation/Buchwald reactions leading to polyfunctionnalized imidazo[1,2-a]pyridines. |
| Posted: 06 Sep 2012 12:00 AM PDT Rhizophora apiculata (R. apiculata) contains an abundance of biologically active compounds due its special salt-tolerant living surroundings. In this study, the total phenolic content and antioxidant activities of various extract and fractions of stem of R. apiculata were investigated. Results indicated that butanol fraction possesses the highest total phenolic content (181.84 mg/g GAE/g dry extract) with strongest antioxidant abilities. Following in vitro antioxidant activity-guided phytochemical separation procedures, lyoniresinol-3α-O-β-arabinopyranoside (1), lyoniresinol-3α-O-β-rhamnoside (2), and afzelechin-3-O-L-rhamno-pyranoside (3) were separated from the butanol fraction. These compounds showed more noticeable antioxidant activity than a BHT standard in the DPPH, ABTS and hydroxyl radical scavenging assays. HPLC analysis results showed that among different plant parts, the highest content of 1–3 was located in the bark (0.068%, 0.066% and 0.011%, respectively). The results imply that the R. apiculata might be a potential source of natural antioxidants and 1–3 are antioxidant ingredients in R. apiculata. |
| Posted: 06 Sep 2012 12:00 AM PDT Scutellarein, the main metabolite of scutellarin in vivo, has relatively better solubility, bioavailability and bio-activity than scutellarin. However, compared with scutellarin, it is very difficult to obtain scutellarein from Nature. Therefore, the present study focused on establishing an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin. Neurological deficit score and cerebral infarction volume with the administration of scutellarein were then used to compare its neuroprotective effects on focal cerebral ischemia/reperfusion in rats induced by middle cerebral artery occlusion (MCAO) with those of scutellarin. The results showed that scutellarein had better protective effect on focal cerebral ischemia/reperfusion than scutellarin, which laid the foundation for further research and development of scutellarein as a promising candidate for ischemic cerebro-vascular disease. |
| Posted: 06 Sep 2012 12:00 AM PDT A series of novel 6-(pyrazolylmethyl)-4-oxo-4H-quinoline-3-carboxylic acid derivatives bearing different substituents on the N-position of quinoline ring were designed and synthesized as potential HIV-1 integrase (IN) inhibitors, based on the structurally related GS-9137 scaffold. The structures of all new compounds were confirmed by 1H-NMR, 13C-NMR and ESI (or HRMS) spectra. Detailed synthetic protocols and the anti-IN activity studies are also presented. |
| Posted: 06 Sep 2012 12:00 AM PDT Chuanxiong Rhizoma (Chuan-Xiong, CX), the dried rhizome of Ligusticum chuanxiong Hort. (Umbelliferae), is one of the most popular plant medicines in the World. Modern research indicates that organic acids, phthalides, alkaloids, polysaccharides, ceramides and cerebrosides are main components responsible for the bioactivities and properties of CX. Because of its complex constituents, multidisciplinary techniques are needed to validate the analytical methods that support CX's use worldwide. In the past two decades, rapid development of technology has advanced many aspects of CX research. The aim of this review is to illustrate the recent advances in the chemical analysis and biological activities of CX, and to highlight new applications and challenges. Emphasis is placed on recent trends and emerging techniques. |
| IJMS, Vol. 13, Pages 11102-11129: Erythropoietin: New Directions for the Nervous System Posted: 06 Sep 2012 12:00 AM PDT New treatment strategies with erythropoietin (EPO) offer exciting opportunities to prevent the onset and progression of neurodegenerative disorders that currently lack effective therapy and can progress to devastating disability in patients. EPO and its receptor are present in multiple systems of the body and can impact disease progression in the nervous, vascular, and immune systems that ultimately affect disorders such as Alzheimer's disease, Parkinson's disease, retinal injury, stroke, and demyelinating disease. EPO relies upon wingless signaling with Wnt1 and an intimate relationship with the pathways of phosphoinositide 3-kinase (PI 3-K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR). Modulation of these pathways by EPO can govern the apoptotic cascade to control b-catenin, glycogen synthase kinase-3b, mitochondrial permeability, cytochrome c release, and caspase activation. Yet, EPO and each of these downstream pathways require precise biological modulation to avert complications associated with the vascular system, tumorigenesis, and progression of nervous system disorders. Further understanding of the intimate and complex relationship of EPO and the signaling pathways of Wnt, PI 3-K, Akt, and mTOR are critical for the effective clinical translation of these cell pathways into robust treatments for neurodegenerative disorders. |
| Cincinnati casino to give construction update Posted: 06 Sep 2012 02:57 AM PDT Leaders of Ohio's fourth voter-approved casino in downtown Cincinnati are ready to give a construction update on the $400 million facility. |
| Posted: 06 Sep 2012 03:37 AM PDT The game lets you take the reins with a battle system like no other. Instead of entering commands, control the chains to execute your strategy. Easing off the reins will allow Eckhardt the freedom to unleash powerful attacks. Too much leeway, however, will trigger his primal instincts, endangering Aran. Led by Akifumi Kaneko, the game is developed by WITCHCRAFT Inc., famous for their work on various anime and other RPGs. This title maintains the high quality and integrity for which they are known. The characters are voiced by an array of talented artists, including Ryohei Kimura, Nana Mizuki, Shinichiro Miki, Kana Hanazawa, Keiji Fujiwara, and many others. The powerful theme song "unleash," performed by Shoujyo Byou, accentuates the powerful storyline and intense battles. There are five chapters in total, the first of which may be enjoyed free of charge, so why not delve into an original and finely crafted RPG adventure? |
| Library Books 3.19b5 - Track your borrowed library books.. (Demo) Posted: 21 Aug 2012 07:17 AM PDT  Library Books is an application for keeping track of the library books you have borrowed. It will work with libraries using most of the popular catalogue systems. Visit the Library Books website to see if your library is supported. Please note that the free version is a beta trial. Those needing a stable version should opt for the Mac App Store version. Version 3.19b8: Release notes were unavailable when this listing was updated. Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Accordance 10.0 - Bible analysis and study resource.. (Demo) Posted: 02 Sep 2012 08:17 AM PDT  Accordance continues to be on the leading edge of Bible Software, both for the power of the searches and analysis of the texts, the unique original language texts available, and the wide range of available tools such as lexicons, commentaries, and journals. The interactive and customizable Atlas and Timeline integrate with different collections of images to illustrate the background of the Bible. Version 10.0.2: We fixed many reported bugs, and we also responded to user feedback and made the following changes:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| NCbackgrounder 1.2.0 - Customize Notification Center's background.. (Free) Posted: 27 Aug 2012 10:24 AM PDT  NCbackgrounder lets you customize the Notification Center on OS X 10.8 Mountain Lion. If you like NCbackgrounder, please make a donation. Any amount will be highly appreciated! Version 1.2.1:
Download Now This posting includes an audio/video/photo media file: Download Now |
| iExplorer 3.0.2.5 - View the files on your iPhone (was iPhone Explorer).. (Shareware) Posted: 05 Sep 2012 08:51 PM PDT  iExplorer (was iPhone Explorer) is an iPhone browser for Mac lets you view the files on your iOS device. By using a drag and drop interface, you can quickly copy files and folders between your Mac and your iPhone or iTouch. It works with both jailbreaked and non-jailbreaked iPhones and works quickly with a standard USB cable. Feature Highlights:
Version 3.1:
Download Now This posting includes an audio/video/photo media file: Download Now |
| moApp AppDotNet 0.2 - Client for the new App.net.. (Free) Posted: 05 Sep 2012 02:55 AM PDT  moApp AppDotNet ... This is a (very) first version. It is already stable - but, of course, not feature complete and unpolished. For example: The infinite scrolling decided not to work. I'm working on it - but sometimes even a nerd like I needs some sleep. Should you run into problems - please let me know. It is already Retina-ware and tested under OS X 10.8 Mountain Lion. It should work under 10.7 as well, though "App.net is a different kind of social platform. We're building a real-time social service where users and developers come first, not advertisers. Our team has more than 9 years of experience building social services, developer platforms, mobile applications and more. We believe that advertising-supported social services are so consistently and inextricably at odds with the interests of users and developers that something must be done. Help us create the service we all wish existed." Version 0.7.4:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Absolute Acey Deucey 5.8.8 - Backgammon game.. (Demo) Posted: 02 Sep 2012 09:11 PM PDT  Absolute Acey Deucey (was Absolute Acey Deucey Plus) is a collection of 6 backgammon variations (backgammon, american acey deucey, dutch backgammon, european acey deucey and Nackgammon) that has many features including 4 different methods to move the pieces, 5 skill levels. For those concerned that the dice rolls might not be random, the game has an option to save the dice rolls, to be used in the game, to a file in the game folder before the game starts. There is also an option to ask if you want to use your dice rolls or the computer's dice rolls. With these 2 options selected, even the most skeptical can be assured that the game is not cheating. Also, you can check the stats that the game keeps to assure you that the dice rolls are random and not favoring either player.
Download Now This posting includes an audio/video/photo media file: Download Now |
| VUWER 1.5.7 - Remotely track lost or stolen Macs.. (Free) Posted: 01 Sep 2012 12:13 AM PDT  VUWER (pronounced like "viewer") is an application designed to remotely track your MacBook Air or MacBook Pro (or any other Apple computer) in the event that it is lost or stolen. VUWER is not foolproof, but it is reasonably secure, easy to implement, and costs nothing but a little time and effort to set up. (1) VUWER is free of charge, open source, and relies on standard OS X commands and readily available freeware applications for installation and operation. Also, since VUWER is written in Applescript, it is relatively easy to modify or enhance in any way you choose. (2) You are in complete control of where the captured data from your stolen laptop is sent and how it is accessed; data can be transmitted either by email or by secure file copy to another computer account. (3) You can remotely capture screenshots, iSight/FaceTime camera images, and IP geolocation data from your laptop, and separately choose their respective repetition intervals. (4) No third-party intermediary is required to track your laptop. VUWER eliminates any possibility of an unscrupulous person at a theft-recovery company snooping on you. See http://stumpy.vuse.vanderbilt.edu/vuwer.htm for more information. Please submit comments and bug reports to tim.holman (at) vanderbilt.edu.
Mac OS X 10.4.11 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 06 Sep 2012 12:00 AM PDT Changes in the developmental or metabolic state of plastids can trigger profound changes in the transcript profiles of nuclear genes. Many nuclear transcription factors were shown to be controlled by signals generated in the organelles. In addition to the many different compounds for which an involvement in retrograde signaling is discussed, accumulating evidence suggests a role for proteins in plastid-to-nucleus communication. These proteins might be sequestered in the plastids before they act as transcriptional regulators in the nucleus. Indeed, several proteins exhibiting a dual localization in the plastids and the nucleus are promising candidates for such a direct signal transduction involving regulatory protein storage in the plastids. Among such proteins, the nuclear transcription factor WHIRLY1 stands out as being the only protein for which an export from plastids and translocation to the nucleus has been experimentally demonstrated. Other proteins, however, strongly support the notion that this pathway might be more common than currently believed. |
| IJMS, Vol. 13, Pages 11071-11084: The Dual Role of Inflammation in Colon Carcinogenesis Posted: 06 Sep 2012 12:00 AM PDT Chronic inflammation characterizing patients with inflammatory bowel disease (IBD) represents a major risk factor for the development of colorectal cancer. Mechanisms underlying this neoplastic transformation are not fully understood though studies in experimental models of colon carcinogenesis suggest that inflammatory cell-derived cytokines either directly or indirectly stimulate the uncontrolled growth of cancer cells. Nevertheless, under specific inflammatory conditions, immune cells can boost an anti-tumor immune response with the down-stream effect of eliminating dysplastic and cancerous cells. This review outlines the beneficial and detrimental role of inflammation in colon carcinogenesis. |
| Posted: 06 Sep 2012 12:00 AM PDT Aspergillosis remains to be a life-threatening complication in immunocompromised patients. However, Aspergillus infection can be observed in non-immunocompromised individuals in rare cases. We report a case of liver aspergilloma in a chronic aplastic anemia patient under relatively intact immune status. Therapeutic strategy for this rare condition was extensively discussed and caspofungin acetate single agent first-line therapy was applied after careful consideration. Encouraging clinical and radiologic improvements were achieved in response to the antifungal salvage. Our long-term follow-up study also revealed a favorable prognosis. Based on this experience, we suggest caspofungin acetate as first-line therapy for treatment plans of liver aspergilloma. |
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