пятница, 28 сентября 2012 г.

Games

Games

Neon Blitz - Screenshots

Posted: 28 Sep 2012 04:16 AM PDT

Neon Blitz packs in hundreds of signs and fantastic social features as well as new weekly challenges for endless replayability. Have you got what it takes to Blitz it as a quick draw champ?

Features:
- Super simple addictive gameplay with over 800 levels
- Get the highest score possible in a minute
- Unlock constantly updated weekly contests and challenges
- Collect boosts and power ups to max out your score
- Challenge your friends via Facebook
- Check your standing in the global rankings
- Play along to your own soundtrack - choose from from your device's music collection

A Space Shooter Blitz - Screenshots

Posted: 28 Sep 2012 04:30 AM PDT

A Space Shooter Blitz features:
- Fast One-Minute "Blitz" Rounds -  With a one minute blitz, take down as many enemy waves before time runs out!
- "BURN THEM ALIENS!"-  Build the score multiplier while wiping off the scum of the galaxy. Avoid damage to the USS Eradicator to keep racking up points!
- Cross Platform to a galaxy far far away- Share progress, achievements, and score across all platforms and compete against others to reach the top of the weekly leaderboards.
- Put the "Epic" in Boss fights-  Random Boss Fights emerge to give an epic battle against Commander P. Jefferson. Fire away to annihilate them quickly and cash in your extra points.

Marine Drugs, Vol. 10, Pages 2181-2207: Marine Cyanobacteria Compounds with Anticancer Properties: A Review on the Implication of Apoptosis

Posted: 28 Sep 2012 12:00 AM PDT

Marine cyanobacteria have been considered a rich source of secondary metabolites with potential biotechnological applications, namely in the pharmacological field. Chemically diverse compounds were found to induce cytoxicity, anti-inflammatory and antibacterial activities. The potential of marine cyanobacteria as anticancer agents has however been the most explored and, besides cytotoxicity in tumor cell lines, several compounds have emerged as templates for the development of new anticancer drugs. The mechanisms implicated in the cytotoxicity of marine cyanobacteria compounds in tumor cell lines are still largely overlooked but several studies point to an implication in apoptosis. This association has been related to several apoptotic indicators such as cell cycle arrest, mitochondrial dysfunctions and oxidative damage, alterations in caspase cascade, alterations in specific proteins levels and alterations in the membrane sodium dynamics. In the present paper a compilation of the described marine cyanobacterial compounds with potential anticancer properties is presented and a review on the implication of apoptosis as the mechanism of cell death is discussed.

Animals, Vol. 2, Pages 529-539: Pet Ownership and Evacuation Prior to Hurricane Irene

Posted: 28 Sep 2012 12:00 AM PDT

Pet ownership has historically been one of the biggest risk factors for evacuation failure prior to natural disasters. The forced abandonment of pets during Hurricane Katrina in 2005 made national headlines and led to the passage of the Pet Evacuation and Transportation Standards Act (PETS, 2006) which mandated local authorities to plan for companion animal evacuation. Hurricane Irene hit the East Coast of the United States in 2011, providing an excellent opportunity to examine the impact of the PETS legislation on frequency and ease of evacuation among pet owners and non-pet owners. Ninety pet owners and 27 non-pet owners who lived in mandatory evacuation zones completed questionnaires assessing their experiences during the hurricane and symptoms of depression, PTSD, dissociative experiences, and acute stress. Pet ownership was not found to be a statistical risk factor for evacuation failure. However, many pet owners who failed to evacuate continue to cite pet related reasons.

Sensors, Vol. 12, Pages 13249-13283: Towards a Ubiquitous User Model for Profile Sharing and Reuse

Posted: 28 Sep 2012 12:00 AM PDT

People interact with systems and applications through several devices and are willing to share information about preferences, interests and characteristics. Social networking profiles, data from advanced sensors attached to personal gadgets, and semantic web technologies such as FOAF and microformats are valuable sources of personal information that could provide a fair understanding of the user, but profile information is scattered over different user models. Some researchers in the ubiquitous user modeling community envision the need to share user model's information from heterogeneous sources. In this paper, we address the syntactic and semantic heterogeneity of user models in order to enable user modeling interoperability. We present a dynamic user profile structure based in Simple Knowledge Organization for the Web (SKOS) to provide knowledge representation for ubiquitous user model. We propose a two-tier matching strategy for concept schemas alignment to enable user modeling interoperability. Our proposal is proved in the application scenario of sharing and reusing data in order to deal with overweight and obesity.

IJERPH, Vol. 9, Pages 3454-3464: Oral Care during Pregnancy: Attitudes of Brazilian Public Health Professionals

Posted: 28 Sep 2012 12:00 AM PDT

There is little information about health professionals' behavior regarding oral health care during pregnancy. We evaluated attitudes of obstetricians/gynecologists, nurses, and dentists working at a public community service towards pregnant women's oral health. Health professionals responded to a self-applied questionnaire. Cluster analysis identified two clusters of respondents; Chi-square, Student's t test, and logistic regression were used to compare the two clusters in terms of the independent variables. Respondents were categorized into cluster 1 'less favorable' (n = 159) and cluster 2 'more favorable' (n = 124) attitudes. Professionals that had attended a residency or specialization program (OR = 2.08, 95% CI = 1.15–3.77, p = 0.016) and worked exclusively at the public service (OR = 2.15, 95% CI = 1.10–4.20, p = 0.025) presented more favorable attitudes. Obstetricians/gynecologists (OR = 0.22, 95% CI = 0.09–0.54, p = 0.001) and nurses (OR = 0.50, 95% CI = 0.29–0.86, p = 0.013) showed less favorable attitudes than dentists. Health care providers' attitudes regarding pregnant women's oral health were related to their occupation, qualification, and dedication to the public service.

Rise to Fame: The Music RPG - Screenshots

Posted: 28 Sep 2012 03:40 AM PDT

Features:
• Five original rock songs and tough 3D-graphics
• Adjust the music with special skills
• Do a rocking gig and earn money and fame
• Get the best out of your band with money you've earned:
- Buy instruments, drinks and more
- Dress your band with outrages outfits
- Get access to the best instruments to lift your band to the highest level
- More than 20 skills which you can improve on over and over
- 7 stages to rock out
- 22 levels to rock your way to the top

Dead or Alive 5: Faces of Pain

Posted: 28 Sep 2012 02:43 AM PDT

The free camera in Dead or Alive 5's CPU vs CPU battle mode is a great way to show off the game. No timeouts, no health bars; just an interminable battle

Brothers: A Tale of Two Sons - Screenshots

Posted: 28 Sep 2012 03:25 AM PDT

Insects, Vol. 3, Pages 912-929: Spread of a Gammabaculovirus within Larval Populations of Its Natural Balsam Fir Sawfly (Neodiprion abietis) Host Following Its Aerial Application

Posted: 28 Sep 2012 12:00 AM PDT

Field trials and assessments of the balsam fir sawfly (Neodiprion abietis) nucleopolyhedrovirus (NeabNPV: Baculoviridae, Gammabaculovirus) against its natural host were conducted in July and August 2002 near Corner Brook, Newfoundland and Labrador, Canada, in naturally regenerated, precommercially thinned stands dominated by balsam fir (Abies balsamea). Two experimental blocks, each with its own untreated control, were established. The purpose of the Island Pond block was to examine the spread of NeabNPV from a 313-ha aerial treatment block out into adjacent populations of balsam fir sawflies. The purpose of the Old Man's Pond block (2,093 ha) was to determine whether NeabNPV could disperse into populations of balsam fir sawflies within a 200-m zone between spray swaths. NeabNPV was applied to treatment blocks by a Cessna 188B AgTruck aircraft equipped with MicronAir AU4000 rotary atomizers at an application rate equivalent to 1 × 109 NeabNPV occlusion bodies/ha in 2.5 L of 20% aqueous molasses. At Island Pond, NeabNPV infection increased with time following the spray, especially for individuals close to the treatment block, and infection rate decreased to a measured distance of 400 m from the treatment block. At Old Man's Pond, NeabNPV infection rose higher (80% vs. 15%) and sawfly densities declined more (84% vs. 60%) in the area between spray swaths than in the control block.

Molbank, Vol. 2012, Pages M780: 2-(4-Diethoxymethylphenyl)-6-(4-nitrophenyl)-4-phenyl-1,3-diazabicyclo[3.1.0]hex-3-ene

Posted: 28 Sep 2012 12:00 AM PDT

The photochromic compound was obtained from 4-diethoxymethyl-benzaldehyde and trans-2-benzoyl-3-(4-nitrophenyl)aziridine via a three component reaction. The structure of this compound was characterized by elemental analysis, 1H-NMR, 13C-NMR and UV-Visible spectral data.

Marine Drugs, Vol. 10, Pages 2166-2180: Sarcophine-Diol Inhibits Expression of COX-2, Inhibits Activity of cPLA2, Enhances Degradation of PLA2 and PLCγ1 and Inhibits Cell Membrane Permeability in Mouse Melanoma B16F10 Cells

Posted: 28 Sep 2012 12:00 AM PDT

Sarcophine-diol (SD) is a semi-synthetic derivative of sarcophine with a significant chemopreventive effect against non-melanoma skin cancer both in vitro and in vivo. Recently, we have studied the effect of SD on melanoma development using the mouse melanoma B16F10 cell line. In this study, our findings show that SD suppresses cell multiplication and diminishes membrane permeability for ethidium bromide (EB), a model marker used to measure cell permeability for Ca2+ ions. SD also decreases protein levels of COX-2, and increases degradation of phospholipases PLA2 and PLCγ1 and diminishes enzymatic activity of the Ca2+-dependent cPLA2. This lower membrane permeability for Ca2+-ions, associated with SD, is most likely due to the diminished content of lysophosphosphatidylcholine (lysoPC) within cell membranes caused by the effect of SD on PLA2. The decrease in diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) due to inhibition of PLCγ1, leads to the downregulation of Ca2+-dependent processes within the cell and also inhibits the formation of tumors. These findings support our previous data suggesting that SD may have significant potential in the treatment of melanoma.

JSAN, Vol. 1, Pages 166-182: Low Cost Multisensor Kinematic Positioning and Navigation System with Linux/RTAI

Posted: 28 Sep 2012 12:00 AM PDT

Despite its popularity, the development of an embedded real-time multisensor kinematic positioning and navigation system discourages many researchers and developers due to its complicated hardware environment setup and time consuming device driver development. To address these issues, this paper proposed a multisensor kinematic positioning and navigation system built on Linux with Real Time Application Interface (RTAI), which can be constructed in a fast and economical manner upon popular hardware platforms. The authors designed, developed, evaluated and validated the application of Linux/RTAI in the proposed system for the integration of the low cost MEMS IMU and OEM GPS sensors. The developed system with Linux/RTAI as the core of a direct geo-referencing system provides not only an excellent hard real-time performance but also the conveniences for sensor hardware integration and real-time software development. A software framework is proposed in this paper for a universal kinematic positioning and navigation system with loosely-coupled integration architecture. In addition, general strategies of sensor time synchronization in a multisensor system are also discussed. The success of the loosely-coupled GPS-aided inertial navigation Kalman filter is represented via post-processed solutions from road tests.

Entropy, Vol. 14, Pages 1842-1863: A Survey on Interference Networks: Interference Alignment and Neutralization

Posted: 28 Sep 2012 12:00 AM PDT

In recent years, there has been rapid progress on understanding Gaussian networks with multiple unicast connections, and new coding techniques have emerged. The essence of multi-source networks is how to efficiently manage interference that arises from the transmission of other sessions. Classically, interference is removed by orthogonalization (in time or frequency). This means that the rate per session drops inversely proportional to the number of sessions, suggesting that interference is a strong limiting factor in such networks. However, recently discovered interference management techniques have led to a paradigm shift that interference might not be quite as detrimental after all. The aim of this paper is to provide a review of these new coding techniques as they apply to the case of time-varying Gaussian networks with multiple unicast connections. Specifically, we review interference alignment and ergodic interference alignment for multi-source single-hop networks and interference neutralization and ergodic interference neutralization for multi-source multi-hop networks. We mainly focus on the "degrees of freedom" perspective and also discuss an approximate capacity characterization.

Pharmaceuticals, Vol. 5, Pages 1063-1078: Statistical Estimation of the Protein-Ligand Binding Free Energy Based On Direct Protein-Ligand Interaction Obtained by Molecular Dynamics Simulation

Posted: 28 Sep 2012 12:00 AM PDT

We have developed a method for estimating protein-ligand binding free energy (DG) based on the direct protein-ligand interaction obtained by a molecular dynamics simulation. Using this method, we estimated the DG value statistically by the average values of the van der Waals and electrostatic interactions between each amino acid of the target protein and the ligand molecule. In addition, we introduced fluctuations in the accessible surface area (ASA) and dihedral angles of the protein-ligand complex system as the entropy terms of the DG estimation. The present method included the fluctuation term of structural change of the protein and the effective dielectric constant. We applied this method to 34 protein-ligand complex structures. As a result, the correlation coefficient between the experimental and calculated DG values was 0.81, and the average error of DG was 1.2 kcal/mol with the use of the fixed parameters. These results were obtained from a 2 nsec molecular dynamics simulation.

1. Fiat gambles on black to sell more citycars

Posted: 28 Sep 2012 01:34 AM PDT

N EXT to the loud and vibrant paint colours that are available on modern cars in various shiny finishes, matt black sounds like a bit of a come down.

This posting includes an audio/video/photo media file: Download Now

BasketBalls

Posted: 27 Sep 2012 01:38 AM PDT

Aim and shoot the BasketBalls in this addictive physics sport game!

Pharmaceuticals, Vol. 5, Pages 1053-1062: Cell-Penetrating Recombinant Peptides for Potential Use in Agricultural Pest Control Applications

Posted: 28 Sep 2012 12:00 AM PDT

Several important areas of interest intersect in a class of peptides characterized by their highly cationic and partly hydrophobic structure. These molecules have been called cell-penetrating peptides (CPPs) because they possess the ability to translocate across cell membranes. This ability makes these peptides attractive candidates for delivery of therapeutic compounds, especially to the interior of cells. Compounds with characteristics similar to CPPs and that, in addition, have antimicrobial properties are being investigated as antibiotics with a reduced risk of causing resistance. These CPP-like membrane-acting antimicrobial peptides (MAMPs) are α-helical amphipathic peptides that interact with and perturb cell membranes to produce their antimicrobial effects. One source of MAMPs is spider venom. Because these compounds are toxic to insects, they also show promise for development as biological agents for control of insecticide-resistant agricultural pests. Spider venom is a potential source of novel insect-specific peptide toxins. One example is the small amphipathic α-helical peptide lycotoxin-1 (Lyt-1 or LCTX) from the wolf spider (Lycosa carolinensis). One side of the α-helix has mostly hydrophilic and the other mainly hydrophobic amino acid residues. The positive charge of the hydrophilic side interacts with negatively charged prokaryotic membranes and the hydrophobic side associates with the membrane lipid bilayer to permeabilize it. Because the surface of the exoskeleton, or cuticle, of an insect is highly hydrophobic, to repel water and dirt, it would be expected that amphipathic compounds could permeabilize it. Mutagenized lycotoxin 1 peptides were produced and expressed in yeast cultures that were fed to fall armyworm (Spodoptera frugiperda) larvae to identify the most lethal mutants. Transgenic expression of spider venom toxins such as lycotoxin-1 in plants could provide durable insect resistance.

Entropy, Vol. 14, Pages 1829-1841: On Extracting Probability Distribution Information from Time Series

Posted: 28 Sep 2012 12:00 AM PDT

Time-series (TS) are employed in a variety of academic disciplines. In this paper we focus on extracting probability density functions (PDFs) from TS to gain an insight into the underlying dynamic processes. On discussing this "extraction" problem, we consider two popular approaches that we identify as histograms and Bandt–Pompe. We use an information-theoretic method to objectively compare the information content of the concomitant PDFs.

Entropy, Vol. 14, Pages 1813-1828: Network Coding for Line Networks with Broadcast Channels

Posted: 28 Sep 2012 12:00 AM PDT

An achievable rate region for line networks with edge and node capacity constraints and broadcast channels (BCs) is derived. The region is shown to be the capacity region if the BCs are orthogonal, deterministic, physically degraded, or packet erasure with one-bit feedback. If the BCs are physically degraded with additive Gaussian noise then independent Gaussian inputs achieve capacity.
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