Games |
- Pope to resign
- ACTPrinter 2.0.4 - Send documents from Mac to iOS device. (Free)
- LaunchControl 1.0.2 - Manage running services on your Mac. (Commercial)
- Themes for iBooks Author 1.5 - Professionally developed templates for iBooks Author. (Commercial)
- UK Chart: Dead Space 3 shoots to No.1
- Backup Extractor 1.1.1.0.0 - Extract iOS device backups from iTunes backups. (Demo)
- Viruses, Vol. 5, Pages 654-662: Low Copper and High Manganese Levels in Prion Protein Plaques
- Get your game on
- Metal Gear Rising: The Desperado Elite Trailer
- Molecules, Vol. 18, Pages 2236-2242: New Spiral γ-Lactone Enantiomers from the Plant Endophytic Fungus Pestalotiopsis foedan
- Molecules, Vol. 18, Pages 2222-2235: Preparation of an Immunoaffinity Column with Amino-Silica Gel Microparticles and Its Application in Sample Cleanup for Aflatoxin Detection in Agri-Products
- Molecules, Vol. 18, Pages 2212-2221: An Efficient Chemoselective Reduction of Furan Series Unsaturated Dinitriles
- Molecules, Vol. 18, Pages 2200-2211: Gelam Honey Protects against Gamma-Irradiation Damage to Antioxidant Enzymes in Human Diploid Fibroblasts
- IJMS, Vol. 14, Pages 3834-3859: Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
- Sensors, Vol. 13, Pages 2399-2406: An Infrastructureless Approach to Estimate Vehicular Density in Urban Environments
- Sensors, Vol. 13, Pages 2384-2398: Rapid Characterization of Vegetation Structure with a Microsoft Kinect Sensor
- Biomolecules, Vol. 3, Pages 168-179: Soybean Hydrophobic Protein Response to External Electric Field: A Molecular Modeling Approach
- Biomolecules, Vol. 3, Pages 157-167: MicroRNA Expression in Cystic Fibrosis Airway Epithelium
- Sandvox 2.7.5 - Easily build eye-catching Web sites. (Demo)
- AUTOS: BMW Adding 3-Series GT
| Posted: 11 Feb 2013 03:16 AM PST The BBC reports that Benedict XVI is unexpectedly resigning as pope. I guess you could call it an ex cathedra announcement. /caruso |
| ACTPrinter 2.0.4 - Send documents from Mac to iOS device. (Free) Posted: 11 Feb 2013 03:24 AM PST  ACTPrinter is the free companion application to the PAID iOS / Android application ACTPrinter. ACTPrinter allows you to "print" any document from your Mac to your iOS / Android device. Finally your documents travel with you! Ever wondered why you always end up printing those so-called electronic tickets, boarding passes, ...? No more!
Version 2.0.4:
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| LaunchControl 1.0.2 - Manage running services on your Mac. (Commercial) Posted: 11 Feb 2013 03:11 AM PST  LaunchControl — Harness the power of launchd(8). It allows you to manage system- and user services on your Mac. Use it to:
See the big picture… See all services and their respective status at a glance. Services which have not been configured properly are highlighted. Enable or disable services with a single click. Long list of jobs may be filtered. You find what you are looking for in an instant. …and the gory details LaunchControl is not just another .plist editor. It provides a dedicated interface for every single launchd configuration key. The interface is adaptive. It displays only information that is relevant for the selected job. Discover what's possible launchd(8) currently supports some 36+ documented keys. LaunchControl makes it easy to discover them. Every key in the palette panel is annotated, so you don't have to consult the man page. Search them by category, name or description. Once found, drag an item from the palette section to the configuration section to add this key. Version 1.0.2:
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| Themes for iBooks Author 1.5 - Professionally developed templates for iBooks Author. (Commercial) Posted: 11 Feb 2013 02:58 AM PST  Themes for iBooks Author is a collection of 125 compelling templates for Apple's new application for book creation and publishing. Browse the wide range of designs to find the perfect look, add your text and images, and publish your own book to iBookstore! The 125 available templates cover various book categories, from business and travel to arts and cooking. Each design is easily customizable and allows you to make the best of the book creation capabilities provided by iBooks Author. Version 1.5:
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| UK Chart: Dead Space 3 shoots to No.1 Posted: 11 Feb 2013 03:06 AM PST Dead Space 3 has entered the UK all formats chart at No.1.Retail monitor Chart-Track said the game enjoyed the biggest launch of 2013 so far, but that |
| Backup Extractor 1.1.1.0.0 - Extract iOS device backups from iTunes backups. (Demo) Posted: 11 Feb 2013 02:54 AM PST  Backup Extractor recovers lost iPhone/iPad/iPod Touch Safari's bookmarks, Calendar entries, Call History, Contacts, Notes, Recordings, SMS & MMS & iMessage messages (with attachments), Photos and Videos from iTunes backups. Backup Extractor for iPhone/iPad/iPod Touch extracts data into CSV, HTML, iCalendar, or VCard formats, that able to import into Google Chrome, Firefox, Internet Explorer, Excel, Outlook, or Webmail easily. iTunes backs up iPhone/iPad/iPod Touch data into unreadable databases and files. Backup Extractor for iPhone/iPad/iPod Touch loads and parses iTunes backups, then extracts them into readable or import format. Features:
You may view the HOW-TO video at http://youtu.be/wY16JKS7i9g. Free version limits to 2 data or files extraction per items only. Please register your copy today to enjoy full data extraction.
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| Viruses, Vol. 5, Pages 654-662: Low Copper and High Manganese Levels in Prion Protein Plaques Posted: 11 Feb 2013 12:00 AM PST Accumulation of aggregates rich in an abnormally folded form of the prion protein characterize the neurodegeneration caused by transmissible spongiform encephalopathies (TSEs). The molecular triggers of plaque formation and neurodegeneration remain unknown, but analyses of TSE-infected brain homogenates and preparations enriched for abnormal prion protein suggest that reduced levels of copper and increased levels of manganese are associated with disease. The objectives of this study were to: (1) assess copper and manganese levels in healthy and TSE-infected Syrian hamster brain homogenates; (2) determine if the distribution of these metals can be mapped in TSE-infected brain tissue using X-ray photoelectron emission microscopy (X-PEEM) with synchrotron radiation; and (3) use X-PEEM to assess the relative amounts of copper and manganese in prion plaques in situ. In agreement with studies of other TSEs and species, we found reduced brain levels of copper and increased levels of manganese associated with disease in our hamster model. We also found that the in situ levels of these metals in brainstem were sufficient to image by X-PEEM. Using immunolabeled prion plaques in directly adjacent tissue sections to identify regions to image by X-PEEM, we found a statistically significant relationship of copper-manganese dysregulation in prion plaques: copper was depleted whereas manganese was enriched. These data provide evidence for prion plaques altering local transition metal distribution in the TSE-infected central nervous system. |
| Posted: 11 Feb 2013 01:02 AM PST Time to get out your favorite family board game - Monopoly, Scrabble or Go Fish. This posting includes an audio/video/photo media file: Download Now |
| Metal Gear Rising: The Desperado Elite Trailer Posted: 11 Feb 2013 12:01 AM PST Meet the elite enemy soldiers that will try to stop Raiden in his tracks.
Read and Post Comments | Get the full article at GameSpot "Metal Gear Rising: The Desperado Elite Trailer" was posted by marcom on Mon, 11 Feb 2013 00:01:00 -0800 |
| Posted: 11 Feb 2013 12:00 AM PST (−)-(4S, 8S)-Foedanolide (1a) and (+)-(4R, 8R)-foedanolide (1b), a pair of new spiro-γ-lactone enantiomers, were isolated from the fermentation broth of the plant endophytic fungus Pestalotiopsis foedan by HPLC using a chiral column, achieving over 7% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the electronic circular dichroism (ECD) and optical rotation (OR). Compounds 1a and 1b showed moderate activities against HeLa, A-549, U-251, HepG2 and MCF-7 tumor cell lines. |
| Posted: 11 Feb 2013 12:00 AM PST This study established an immunoaffinity column for selective extraction of aflatoxins in agri-products. Specifically, the immunoaffinity column was developed by covalently coupling monoclonal antibody 1C11 against aflatoxins to amino-silica gel microparticles and then packing these into a cartridge. The extraction conditions were thoroughly optimized in terms of loading, washing and eluting solutions. Under the optimal conditions, the immunoaffinity column had a capacity of 200 ng of aflatoxins. The detection limits (S/N = 3) for aflatoxin G1, B1, G2 and B2 were 0.03, 0.07, 0.05 and 0.09 μg·kg−1, and the corresponding quantification limits (S/N = 10) were 0.10, 0.25, 0.18 and 0.30 μg·kg−1, respectively. The recoveries of aflatoxins in samples were 90.1%–104.4% and RSDs were <4.4%. The developed method was further applied to the determination of aflatoxins in peanut, vegetable oil and tea samples, and the results indicated that peanut (26.9%), vegetable oils (28.0%) and tea (5.3%) samples were contaminated with aflatoxins, with levels ranging from 0.49 to 20.79 μg·kg−1. |
| Posted: 11 Feb 2013 12:00 AM PST An efficient reduction of double bonds conjugated with nitrile groups and acid or base sensitive furan rings with 2-phenylbenzimidazoline generated in situ has been successfully accomplished with high yields and excellent selectivity. The employed reducing agent was prepared in one step from ordinary chemicals. The other advantages of the presented method include mild and convenient reaction conditions, a benign and cost effective reagent, simple work-up and separation of the products. As this process does neither affect cyano and nitro groups nor furan rings, it is a valuable alternative when metal-catalyzed hydrogenations or borohydride reductions have failed. |
| Posted: 11 Feb 2013 12:00 AM PST The present study was designed to determine the radioprotective effects of Malaysian Gelam honey on gene expression and enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) of human diploid fibroblasts (HDFs) subjected to gamma-irradiation. Six groups of HDFs were studied: untreated control, irradiated HDFs, Gelam honey-treated HDFs and HDF treated with Gelam honey pre-, during- and post-irradiation. HDFs were treated with 6 mg/mL of sterilized Gelam honey (w/v) for 24 h and exposed to 1 Gray (Gy) of gamma rays at the dose rate of 0.25 Gy/min. Gamma-irradiation was shown to down-regulate SOD1, SOD2, CAT and GPx1 gene expressions (p < 0.05). Conversely, HDFs treated with Gelam honey alone showed up-regulation of all genes studied. Similarly, SOD, CAT and GPx enzyme activities in HDFs decreased with gamma-irradiation and increased when cells were treated with Gelam honey (p < 0.05). Furthermore, of the three different stages of study treatment, pre-treatment with Gelam honey caused up-regulation of SOD1, SOD2 and CAT genes expression and increased the activity of SOD and CAT. As a conclusion, Gelam honey modulates the expression of antioxidant enzymes at gene and protein levels in irradiated HDFs indicating its potential as a radioprotectant agent. |
| Posted: 11 Feb 2013 12:00 AM PST Increased oxidative stress has been associated with the aging process. However, recent studies have revealed that a low-level oxidative stress can even extend the lifespan of organisms. Reactive oxygen species (ROS) are important signaling molecules, e.g., being required for autophagic degradation. SIRT1, a class III protein deacetylase, is a crucial cellular survival protein, which is also involved in combatting oxidative stress. For instance, SIRT1 can stimulate the expression of antioxidants via the FoxO pathways. Moreover, in contrast to ROS, SIRT1 inhibits NF-κB signaling which is a major inducer of inflammatory responses, e.g., with inflammasome pathway. Recent studies have demonstrated that an increased level of ROS can both directly and indirectly control the activity of SIRT1 enzyme. For instance, ROS can inhibit SIRT1 activity by evoking oxidative modifications on its cysteine residues. Decreased activity of SIRT1 enhances the NF-κB signaling, which supports inflammatory responses. This crosstalk between the SIRT1 and ROS signaling provokes in a context-dependent manner a decline in autophagy and a low-grade inflammatory phenotype, both being common hallmarks of ageing. We will review the major mechanisms controlling the signaling balance between the ROS production and SIRT1 activity emphasizing that this crosstalk has a crucial role in the regulation of the aging process. |
| Posted: 11 Feb 2013 12:00 AM PST In Vehicular Networks, communication success usually depends on the density of vehicles, since a higher density allows having shorter and more reliable wireless links. Thus, knowing the density of vehicles in a vehicular communications environment is important, as better opportunities for wireless communication can show up. However, vehicle density is highly variable in time and space. This paper deals with the importance of predicting the density of vehicles in vehicular environments to take decisions for enhancing the dissemination of warning messages between vehicles. We propose a novel mechanism to estimate the vehicular density in urban environments. Our mechanism uses as input parameters the number of beacons received per vehicle, and the topological characteristics of the environment where the vehicles are located. Simulation results indicate that, unlike previous proposals solely based on the number of beacons received, our approach is able to accurately estimate the vehicular density, and therefore it could support more efficient dissemination protocols for vehicular environments, as well as improve previously proposed schemes. |
| Posted: 11 Feb 2013 12:00 AM PST The importance of vegetation structure and biomass in controlling land-atmosphere exchange is widely recognized, but measurements of canopy structure are challenging, time consuming, and often rely on destructive methods. The Microsoft Kinect is an infrared sensor designed for video gaming that outputs synchronized color and depth images and that has the potential to allow rapid characterization of vegetation structure. We compared depth images from a Kinect sensor with manual measurements of plant structure and size for two species growing in a California grassland. The depth images agreed well with the horizontal and vertical measurements of plant size made manually. Similarly, the plant volumes calculated with a three-dimensional convex hulls approach was well related to plant biomass. The Kinect showed some limitations for ecological observation associated with a short measurement range and daytime light contamination. Nonetheless, the Kinect’s light weight, fast acquisition time, low power requirement, and cost make it a promising tool for rapid field surveys of canopy structure, especially in small-statured vegetation. |
| Posted: 11 Feb 2013 12:00 AM PST The molecular dynamic (MD) modeling approach was applied to evaluate the effect of an external electric field on soybean hydrophobic protein and surface properties. Nominal electric field strengths of 0.002 V/nm and 0.004 V/nm had no major effect on the structure and surface properties of the protein isolate but the higher electric field strength of 3 V/nm significantly affected the protein conformation and solvent accessible surface area. The response of protein isolate to various external field stresses demonstrated that it is necessary to gain insight into protein dynamics under electromagnetic fields in order to be able to develop the techniques utilizing them for food processing and other biological applications. |
| Biomolecules, Vol. 3, Pages 157-167: MicroRNA Expression in Cystic Fibrosis Airway Epithelium Posted: 11 Feb 2013 12:00 AM PST MicroRNAs (miRs) have emerged as major regulators of the protein content of a cell. In the most part, miRs negatively regulate target mRNA expression, with sets of miRs predicted to regulate certain signaling pathways. The miR expression profile of endobronchial brushings is altered in people with cystic fibrosis (CF) compared to those without CF. How this impacts on CF has important implications for our growing understanding of the pathophysiology of CF lung disease and the development of new therapeutics to treat its pulmonary manifestations. Herein we discuss the potential consequences of altered miR expression in CF airway epithelium particularly with respect to cystic fibrosis transmembrane conductance regulator (CFTR) expression, innate immunity and toll-like receptor signalling and explore how best to exploit these changes for therapeutic benefit. |
| Sandvox 2.7.5 - Easily build eye-catching Web sites. (Demo) Posted: 10 Feb 2013 08:59 PM PST  Sandvox is for Mac users who want to create a professional looking website quickly and easily. With Sandvox, you don't need to be a Web genius to build a stylish, feature-rich, standards-compliant website that's functional and user friendly. Sandvox's drag and drop interface lets you watch your website take shape and come to life as you build it. And, once finished, you can upload your site to your favorite host. Whether you're a new website creator or a seasoned professional, you can make use of Sandvox to build the website of your dreams. New users can build a professional looking website in minutes and professional users can build an advanced, multimedia-rich site in no time at all. Document and Media Handling
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| Posted: 10 Feb 2013 12:00 AM PST  Larger hatchback version of the German brand's compact lineup will launch this summer. |
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