вторник, 12 февраля 2013 г.

Games

Games

Vinoteka 3.1.0 - Manage wine cellar inventories. (Shareware)

Posted: 12 Feb 2013 03:31 AM PST



Vinoteka is the ultimate wine cellar management software for Mac. In a unique and gorgeous interface showing bottles, cellars, wine fridges and tasting notes, Vinoteka brings the best wine cellar management experience to Mac users.

Now featuring the complete synchronization with the iPhone/iPod Touch application Vinoteka Touch, Vinoteka has become the most advanced wine and cellar management software for the Mac platform. From now on, synchronize both applications and transfer data to your iPhone/iPod touch in few clicks. Its very easy, it's secure, you can now carry your cellar in your pocket, have a look at it and modify it everywhere, any time.

Extremely easy and fun to use, Vinoteka offers a fantastic and realistic environment to manage your references, your bottles (wine, liquors or spirits), recreate your cellar or wine fridge, save your tasting notes and add your own food and wine pairings. The many different powerful features of Vinoteka (large database of appellations, countries, varietals, types of wines, shapes of bottles, racks and shelves, etc.) provide users with the most advanced technology in terms of wine management. Customizable and user-friendly, straight-to-the point and nevertheless very professional, Vinoteka is the ultimate companion every wine lover needs.

Vinoteka, other than being as intuitive as possible, is based on the lastest Mac technologies and brings a wealth of high-performing and innovative features. Vinoteka is now the most professional tool to manage your cellar and is the the typical and most thought Mac-friendly application for wine management.



Version 3.1.0:
  • [Feature] : Added Reference Search in the VinotekaSoft WinePlace database (Beta)
  • [Feature] : Added iPad Mini and iPad 4 synchronization
  • [Feature] : Added new fridge shelves and new racks
  • [Feature] : Added drinkability badges on the reference
  • [Feature] : Added reference table view background row color with drinkability
  • [Feature] : Producer link to Apple AddressBook has been removed
  • [Feature] : Added Adjust tool to the Label Image Editor
  • [Feature] : Added message when image cannot be loaded into the Label Image Editor
  • [Feature] : Added back to label browse from the Label Image Editor
  • [Enhancement] : Reference Smart search contains "In Stock", "Not In Stock" and drinkability indicators
  • [Enhancement] : Shape Selector browsing has been enhanced
  • [Enhancement] : Added new appellations, varietals
  • [Bug] : Rack and fridges minor display issues have been fixed
  • [Bug] : Localization improvement
  • [Bug] : Label size issue fixed when syncing with iPhone 4/4S
  • [Bug] : Minor print issues fixed
  • [Bug] : License validation could be broken in 10.6.8


OS X 10.6 or later

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Cut Down Keys Gameplay Video Aliens: Colonial Marines

Posted: 12 Feb 2013 01:00 AM PST

Keys is encrusted into an Aliens retrofitted section of the Sulaco and it's up to Winters to free him.

 

Read and Post Comments | Get the full article at GameSpot

"Cut Down Keys Gameplay Video Aliens: Colonial Marines" was posted by JimM on Tue, 12 Feb 2013 01:00:00 -0800

Cargo Bay Gameplay Video - Aliens: Colonial Marines

Posted: 12 Feb 2013 01:00 AM PST

Getting to the Cargo was only part of the objective, surviving the wall scurrying aliens is the other part.

 

Read and Post Comments | Get the full article at GameSpot

"Cargo Bay Gameplay Video - Aliens: Colonial Marines" was posted by JimM on Tue, 12 Feb 2013 01:00:00 -0800

Abandon Ship Gameplay Video - Aliens: Colonial Marines

Posted: 12 Feb 2013 01:00 AM PST

The Sulaco is ripping apart and these Marines need to survive the trek to an escape pod to get away.

 

Read and Post Comments | Get the full article at GameSpot

"Abandon Ship Gameplay Video - Aliens: Colonial Marines" was posted by JimM on Tue, 12 Feb 2013 01:00:00 -0800

Video Review - Aliens: Colonial Marines

Posted: 12 Feb 2013 01:00 AM PST

Kevin VanOrd makes aliens cry in this review for Aliens: Colonial Marines.

 

Read and Post Comments | Get the full article at GameSpot

"Video Review - Aliens: Colonial Marines" was posted by JimM on Tue, 12 Feb 2013 01:00:00 -0800

Hicks Distress Call Gameplay Video - Aliens: Colonial Marines

Posted: 12 Feb 2013 01:00 AM PST

Corporal Hicks sends out a distress call and the Marines answer by sending in the troops in this opening to Aliens: Colonial Marines.

 

Read and Post Comments | Get the full article at GameSpot

"Hicks Distress Call Gameplay Video - Aliens: Colonial Marines" was posted by JimM on Tue, 12 Feb 2013 01:00:00 -0800

Abandon Ship Gameplay Video Aliens: Colonial Marines

Posted: 12 Feb 2013 01:00 AM PST

Winters and his fellow Marines try to escape the Sulaco before it is torn apart under their feet.

 

Read and Post Comments | Get the full article at GameSpot

"Abandon Ship Gameplay Video Aliens: Colonial Marines" was posted by JimM on Tue, 12 Feb 2013 01:00:00 -0800

Aliens: Colonial Marines Review

Posted: 12 Feb 2013 01:00 AM PST

The dull, unattractive Aliens: Colonial Marines is a functional shooter, but little more.

     

Score: 4.5 / poor

Get the full article at GameSpot

"Aliens: Colonial Marines Review" was posted by Kevin VanOrd on Tue, 12 Feb 2013 01:00:00 -0800

Kissing Aliens Gameplay Video - Aliens: Colonial Marines

Posted: 12 Feb 2013 01:00 AM PST

After getting a kiss from a face grabbing alien, Winters tries to find O'Neil.

 

Read and Post Comments | Get the full article at GameSpot

"Kissing Aliens Gameplay Video - Aliens: Colonial Marines" was posted by JimM on Tue, 12 Feb 2013 01:00:00 -0800

Shooting Aliens Gameplay - Video Aliens: Colonial Mari

Posted: 12 Feb 2013 01:00 AM PST

Aliens stand still for you to shoot them over and over again as you make your way to the air purifier.

 

Read and Post Comments | Get the full article at GameSpot

"Shooting Aliens Gameplay - Video Aliens: Colonial Mari" was posted by JimM on Tue, 12 Feb 2013 01:00:00 -0800

Aliens: Colonial Marines Review

Posted: 12 Feb 2013 01:00 AM PST

The dull, unattractive Aliens: Colonial Marines is a functional shooter, but little more.

     

Score: 4.5 / poor

Get the full article at GameSpot

"Aliens: Colonial Marines Review" was posted by Kevin VanOrd on Tue, 12 Feb 2013 01:00:00 -0800

MacLoc 3.0 - Protect your Mac while you are away. (Free)

Posted: 12 Feb 2013 03:16 AM PST



MacLoc is the perfect solution for a busy work environment as well as at home where wandering hands can create a bothersome reduction in productivity. This simple application activates the Fast User Switching feature built-in to Mac OS X. After clicking on MacLoc, it will appear that you've logged out, however upon entering your username and password, all open documents and applications will be right where you left them. MacLoc is the perfect solution when you need to step out of the room for a moment. Simply add MacLoc to your dock for quick and easy access.

Version 3.0:
  • Updated for OS X 10.8


  • OS X 10.8 or later


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Mou 0.8.2 - Markdown editor for Web developers. (Free)

Posted: 12 Feb 2013 03:10 AM PST



Mou is a Markdown editor - with a difference: where most, if not all, currently available Markdown editors are almost all for general writers, Mou is different: It's for Web developers. Syntax highlighting, live preview, sync scroll, fullscreen mode, auto save, powerful actions, auto pair, custom themes and CSS, HTML and PDF export, enhanced CJK support. I know, it's exactly the app you want.

Version 0.8.2:
  • Floating Window ( View > Toggle Floating ⇧⌘F ), make Window always floating on top of other apps.
  • Inline Math formula support. Check the updated document ( Help > Math Syntax Help ) for more info.
  • Updated GitHub and GitHub2 CSS. Now the Code Blocks won't be cut in PDF export. The GitHub2 CSS now also works with table alignement syntax. Please note Mou won't overwrite your old CSS automatically (to keep your customized CSS safe). If you want to use the new CSS, you need to delete the old CSS files under ~/Library/Application Support/Mou/CSS/ folder manually, and then relaunch Mou to take effect.


OS X 10.7 or later

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This posting includes an audio/video/photo media file: Download Now

Viruses, Vol. 5, Pages 708-731: Oxidative Stress and HPV Carcinogenesis

Posted: 12 Feb 2013 12:00 AM PST

Extensive experimental work has conclusively demonstrated that infection with certain types of human papillomaviruses, the so-called high-risk human papillomavirus (HR-HPV), represent a most powerful human carcinogen. However, neoplastic growth is a rare and inappropriate outcome in the natural history of HPV, and a number of other events have to concur in order to induce the viral infection into the (very rare) neoplastic transformation. From this perspective, a number of putative viral, host, and environmental co-factors have been proposed as potential candidates. Among them oxidative stress (OS) is an interesting candidate, yet comparatively underexplored. OS is a constant threat to aerobic organisms being generated during mitochondrial oxidative phosphorylation, as well as during inflammation, infections, ionizing irradiation, UV exposure, mechanical and chemical stresses. Epithelial tissues, the elective target for HPV infection, are heavily exposed to all named sources of OS. Two different types of cooperative mechanisms are presumed to occur between OS and HPV: I) The OS genotoxic activity and the HPV-induced genomic instability concur independently to the generation of the molecular damage necessary for the emergence of neoplastic clones. This first mode is merely a particular form of co-carcinogenesis; and II) OS specifically interacts with one or more molecular stages of neoplastic initiation and/or progression induced by the HPV infection. This manuscript was designed to summarize available data on this latter hypothesis. Experimental data and indirect evidences on promoting the activity of OS in viral infection and viral integration will be reviewed. The anti-apoptotic and pro-angiogenetic role of NO (nitric oxide) and iNOS (inducible nitric oxide synthase) will be discussed together with the OS/HPV cooperation in inducing cancer metabolism adaptation. Unexplored/underexplored aspects of the OS interplay with the HPV-driven carcinogenesis will be highlighted. The aim of this paper is to stimulate new areas of study and innovative approaches.

Sustainability, Vol. 5, Pages 664-694: Ten Reasons to Take Peak Oil Seriously

Posted: 12 Feb 2013 12:00 AM PST

Forty years ago, the results of modeling, as presented in The Limits to Growth, reinvigorated a discussion about exponentially growing consumption of natural resources, ranging from metals to fossil fuels to atmospheric capacity, and how such consumption could not continue far into the future. Fifteen years earlier, M. King Hubbert had made the projection that petroleum production in the continental United States would likely reach a maximum around 1970, followed by a world production maximum a few decades later. The debate about “peak oil”, as it has come to be called, is accompanied by some of the same vociferous denials, myths and ideological polemicizing that have surrounded later representations of The Limits to Growth. In this review, we present several lines of evidence as to why arguments for a near-term peak in world conventional oil production should be taken seriously—both in the sense that there is strong evidence for peak oil and in the sense that being societally unprepared for declining oil production will have serious consequences.

First Wasteland 2 gameplay video

Posted: 12 Feb 2013 02:42 AM PST

inXile has released the first early gameplay footage of Wasteland 2, the sequel to the 1988 RPG classic which is credited as the spiritual successor to

Aliens: Colonial Marines collectibles guide

Posted: 12 Feb 2013 01:21 AM PST

Audio logs not only provide minor insight on the events leading up to the start of Aliens: Colonial Marines, finding these recordings also increases your

Aliens: Colonial Marines review

Posted: 12 Feb 2013 01:21 AM PST

Words.

IJMS, Vol. 14, Pages 3860-3873: Effect of Artocarpus communis Extract on UVB Irradiation-Induced Oxidative Stress and Inflammation in Hairless Mice

Posted: 12 Feb 2013 12:00 AM PST

Administration of antioxidants and anti-inflammatory agents is an effective strategy for preventing ultraviolet (UV) irradiation-induced skin damage. Artocarpus communis possesses several pharmacological activities, such as antioxidant, anticancer and anti-inflammation. However, the photoprotective activity of methanol extract of A. communis heartwood (ACM) in ultraviolet irradiation-induced skin damage has not yet been investigated. The present study was performed using ultraviolet absorption, histopathological observation, antioxidant and anti-inflammation assays to elucidate the mechanism of the photoprotective activity of ACM. Our results indicated that ACM displayed a UVA and UVB absorption effect and then effectively decreased scaly skin, epidermis thickness and sunburn cells during ultraviolet irradiation in hairless mice. ACM not only decreased ultraviolet irradiation-mediated oxidative stress, including lowering the overproduction of reactive oxygen species and lipid peroxidation (p < 0.05), but also reduced the levels of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin 1β. Additionally, ACM can decrease the synthesis of cytosolic phospholipase A2, cyclooxygenase, inducible nitric oxide synthase and vascular cell adhesion molecular-1 via inhibiting TNF-α-independent pathways (p < 0.05) in UVB-mediated inflammation and formation of sunburn cells. Consequently, we concluded that ACM extract has a photoprotective effect against UVB-induced oxidative stress and inflammation due to its sunscreen property, and its topical formulations may be developed as therapeutic and/or cosmetic products in further studies.

For tech startup Qonqr, calling off quest for capital pays off

Posted: 12 Feb 2013 12:10 AM PST

Scott Davis ' business partners gave him strict instructions: During standard working hours, you will do nothing but try to raise capital.
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