вторник, 5 февраля 2013 г.

Games

Games

GBP 2,196,410 Jackpot Win is Sure to Attract Players to Games at bet365

Posted: 05 Feb 2013 02:17 AM PST

After only a year with Games at bet365 , high-flying Slots fan Mr. S. Riddle swung onto a long list of jackpot winners with a spectacular prize of more than 2,000,000, scooped straight from the grim streets of Gotham on his "amazing" favourite game, The Dark Knight.

Remote Sensing, Vol. 5, Pages 808-809: GPS/GNSS Antennas. By B. Rama Rao, W. Kunysz, R. Fante and K. McDonald, Artech House, 2012; 420 Pages. Price£109.00, ISBN 978-1-59693-150-3

Posted: 05 Feb 2013 12:00 AM PST

This practical resource provides a current and comprehensive treatment of GPS/GNSS antennas, taking into account modernized systems and new and developing applications. The book presents a number of key applications, describing corresponding receiver architectures and antenna details. You find important discussions on antenna characteristics, including theory of operation, gain, bandwidth, polarization, phase center, mutual coupling effects, and integration with active components.

Remote Sensing, Vol. 5, Pages 716-807: Recent Trend and Advance of Synthetic Aperture Radar with Selected Topics

Posted: 05 Feb 2013 12:00 AM PST

The present article is an introductory paper in this special issue on synthetic aperture radar (SAR). A short review is presented on the the recent trend and development of SAR and related techniques with selected topics, including the fields of applications, specifications of airborne and spaceborne SARs, and information contents in and interpretations of amplitude data, interferometric SAR (InSAR) data, and polarimetric SAR (PolSAR) data. The review is by no means extensive, and as such only brief summaries of of each selected topics and key references are provided. For further details, the readers are recommended to read the literature given in the references theirin.

Remote Sensing, Vol. 5, Pages 687-715: Flood Mapping and Flood Dynamics of the Mekong Delta: ENVISAT-ASAR-WSM Based Time Series Analyses

Posted: 05 Feb 2013 12:00 AM PST

Satellite remote sensing is a valuable tool for monitoring flooding. Microwave sensors are especially appropriate instruments, as they allow the differentiation of inundated from non-inundated areas, regardless of levels of solar illumination or frequency of cloud cover in regions experiencing substantial rainy seasons. In the current study we present the longest synthetic aperture radar-based time series of flood and inundation information derived for the Mekong Delta that has been analyzed for this region so far. We employed overall 60 Envisat ASAR Wide Swath Mode data sets at a spatial resolution of 150 meters acquired during the years 2007–2011 to facilitate a thorough understanding of the flood regime in the Mekong Delta. The Mekong Delta in southern Vietnam comprises 13 provinces and is home to 18 million inhabitants. Extreme dry seasons from late December to May and wet seasons from June to December characterize people’s rural life. In this study, we show which areas of the delta are frequently affected by floods and which regions remain dry all year round. Furthermore, we present which areas are flooded at which frequency and elucidate the patterns of flood progression over the course of the rainy season. In this context, we also examine the impact of dykes on floodwater emergence and assess the relationship between retrieved flood occurrence patterns and land use. In addition, the advantages and shortcomings of ENVISAT ASAR-WSM based flood mapping are discussed. The results contribute to a comprehensive understanding of Mekong Delta flood dynamics in an environment where the flow regime is influenced by the Mekong River, overland water-flow, anthropogenic floodwater control, as well as the tides.

Molecules, Vol. 18, Pages 2081-2083: Molecules Best Paper Award 2013

Posted: 05 Feb 2013 12:00 AM PST

Molecules has started to institute a “Best Paper” award to recognize the most outstanding papers in the area of natural products, medicinal chemistry and molecular diversity published in Molecules. We are pleased to announce the second “Molecules Best Paper Award” for 2013.

Molecules, Vol. 18, Pages 2061-2080: Antioxidant Capacity and HPLC-DAD-MS Profiling of Chilean Peumo (Cryptocarya alba) Fruits and Comparison with German Peumo (Crataegus monogyna) from Southern Chile

Posted: 05 Feb 2013 12:00 AM PST

Liquid chromatography (LC) coupled with UV detection and electrospray ionization (ESI) tandem mass spectrometry (MS/MS) was used for the generation of chemical fingerprints and the identification of phenolic compounds in peumo fruits and aerial parts from southern Chile. Thirty three compounds (19 of these detected in C. alba and 23 in C. monogyna) were identified, mainly flavonoid glycosides, phenolic acids, anthocyanins and flavonoid aglycons. Total phenolic content and total flavonoid content was measured for both species, and were higher in the extracts from C. monogyna fruits and aerial parts than extracts from C. alba. The fruits of Cryptocarya alba (Chilean peumo) presented high antioxidant capacity (9.12 ± 0.01 mg/mL in the DPPH assay), but was three times lower to that of Crataegus monogyna (German peumo) (3.61 ± 0.01 mg/mL in the DPPH assay).

Gaming's most magnificently murderous medical practitioners

Posted: 05 Feb 2013 02:10 AM PST

Is it safe? No. No it's not

Molecules, Vol. 18, Pages 2052-2060: Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model

Posted: 05 Feb 2013 12:00 AM PST

The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.

Molecules, Vol. 18, Pages 2029-2051: Structural Requirements for the Antifungal Activities of Natural Drimane Sesquiterpenes and Analogues, Supported by Conformational and Electronic Studies

Posted: 05 Feb 2013 12:00 AM PST

Seventeen drimanes including polygodial (1), isopolygodial (2), drimenol (3) and confertifolin (4) obtained from natural sources and the semi-synthetic derivatives 5–17 obtained from 1–3, were evaluated in vitro for antifungal properties against a unique panel of fungi with standardized procedures by using two end-points, MIC100 and MIC50. A SAR analysis of the whole series, supported by conformational and electronic studies, allowed us to show that the Δ7,8 -double bond would be one of the key structural features related to the antifungal activity. The MEPs obtained for active compounds exhibit a clear negative minimum value (deep red zone) in the vicinity of the Δ7,8 -double bond, which is not present in the inactive ones. Apart of this negative zone, a positive region (deep blue) appears in 1, which is not observed either in its epimer 2 nor in the rest of the active compounds. The LogP of active compounds varies between 2.33 and 3.84, but differences in MICs are not correlated with concomitant variations in LogP values.

Molecules, Vol. 18, Pages 2018-2028: The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction

Posted: 05 Feb 2013 12:00 AM PST

Atractyloside (ATR) is found in many Asteraceae plants that are commonly used as medicinal herbs in China and other eastern Asian countries. ATR binds specifically to the adenine nucleotide translocator in the inner mitochondrial membrane and competitively inhibits ADP and ATP transport. The toxicity of ATR in medical herbs can be reduced by hydrothermal processing, but the mechanisms of ATR degradation are not well understood. In this study, GC-MS coupled with SPE and TMS derivatisation was used to detect ATR levels in traditional Chinese medicinal herbs. Our results suggest that ATR molecules were disrupted by decomposition, hydrolysis and saponification after heating with water (decoction) for a long period of time. Hydrothermal processing could decompose the endogenous toxic compounds and also facilitate the detoxification of raw materials used in the Chinese medicine industry.

Molecules, Vol. 18, Pages 2005-2017: Antioxidant Activity of the Extracts of Some Cowpea (Vigna unguiculata (L) Walp.) Cultivars Commonly Consumed in Pakistan

Posted: 05 Feb 2013 12:00 AM PST

The present investigation has been carried out to determine the antioxidant activity of the methanolic extracts obtained from four cultivars of cowpea (Vigna unguiculata (L) Walp.) seeds. Phenolic compounds present in the extracts showed the antioxidant and antiradical properties when investigated using a linoleic acid peroxidation model, FRAP, ORAC and TRAP assays, as well as DPPH, hydroxyl, nitric oxide and superoxide radical scavenging activity. The HPLC analysis of the cowpea extracts showed the presence of neochlorogenic acid, chlorogenic acid and caffeic acids. The results indicated that methanolic extract of the cowpea resembled in the aforementioned activities those from other leguminous seeds and pulses. Phenolic constituents contained in cowpea may have a future role as ingredients in the development of functional foods.

Symmetry, Vol. 5, Pages 86-118: Frame Transformation Relations and Symmetry Analysis of Fluxional Symmetric Rotor Dimers

Posted: 05 Feb 2013 12:00 AM PST

The theory of Frame transformation relations between the states of Born Oppenheimer and the weak coupling approximations is developed for polyatomic molecules. The symmetry relations are a generalization of the frame transformation relations derived by Harter and Crogman for coupled rotor molecules. A key internal symmetry label (named “soul”) is defined so that it remains a constant label for frame transformation relations, and is conserved during vibronic transitions, ionization, and even dissociation provided the nuclear spin-rotation interaction is relatively small. Simplified procedures are given for obtaining selection rules, statistical weights, and matrix elements of multipole operators for common molecules having various point symmetries.

Life, Vol. 3, Pages 149-160: Periplasmic Binding Proteins in Thermophiles: Characterization and Potential Application of an Arginine-Binding Protein from Thermotoga maritima: A Brief Thermo-Story

Posted: 05 Feb 2013 12:00 AM PST

Arginine-binding protein from the extremophile Thermotoga maritima is a 27.7 kDa protein possessing the typical two-domain structure of the periplasmic binding proteins family. The protein is characterized by a very high specificity and affinity to bind to arginine, also at high temperatures. Due to its features, this protein could be taken into account as a potential candidate for the design of a biosensor for arginine. It is important to investigate the stability of proteins when they are used for biotechnological applications. In this article, we review the structural and functional features of an arginine-binding protein from the extremophile Thermotoga maritima with a particular eye on its potential biotechnological applications.

Biology, Vol. 2, Pages 317-330: The Dynamic Arctic Snow Pack: An Unexplored Environment for Microbial Diversity and Activity

Posted: 05 Feb 2013 12:00 AM PST

The Arctic environment is undergoing changes due to climate shifts, receiving contaminants from distant sources and experiencing increased human activity. Climate change may alter microbial functioning by increasing growth rates and substrate use due to increased temperature. This may lead to changes of process rates and shifts in the structure of microbial communities. Biodiversity may increase as the Arctic warms and population shifts occur as psychrophilic/psychrotolerant species disappear in favor of more mesophylic ones. In order to predict how ecological processes will evolve as a function of global change, it is essential to identify which populations participate in each process, how they vary physiologically, and how the relative abundance, activity and community structure will change under altered environmental conditions. This review covers aspects of the importance and implication of snowpack in microbial ecology emphasizing the diversity and activity of these critical members of cold zone ecosystems.

The Witcher 3: Wild Hunt announced for 2014

Posted: 05 Feb 2013 01:10 AM PST

The Witcher 3: Wild Hunt has been announced by CD Projekt RED.The game is the subject of the cover feature in Game Informer's March issue, which will be

Geosciences, Vol. 3, Pages 114-139: Evolution of Endemic Species, Ecological Interactions and Geographical Changes in an Insular Environment: A Case Study of Quaternary Mammals of Sicily (Italy, EU)

Posted: 05 Feb 2013 12:00 AM PST

The Quaternary mammals of Sicily are well known, and five faunal complexes have been distinguished on the basis of bioevents (extinctions and new arrivals) and evolution of endemic species. It is clear that the composition of mammal faunas is strictly related to the dispersal ability of each species and to the paleogeography of the area. Until now, researches have chiefly attributed paleogeographical changes as controlling these dispersals: the sea strait between the island and the Italian peninsula has had different widths and depths over time, operating different kinds of filters on the spreading of terrestrial mammals. Moreover, Sicily and its nearby mainland underwent changes in paleogeography. Some incongruence in bioevents has been attributed to the filter operated by the marine strait, which could have acted in differential ways on large and small mammals. However, the roles of ecological interactions among vertebrate species and their control on bioevents have been greatly underestimated. In this critical review, changes in mammals’ associations are reconsidered not only in terms of biochronology and dispersal ability of taxa through the marine strait, evolution of endemic features, in addition to the paleogeography of the island, but also considering the ecological role of each species and the interactions among the species with each faunal complex.

Geosciences, Vol. 3, Pages 102-113: Verde Macael: A Serpentinite Wrongly Referred to as a Marble

Posted: 05 Feb 2013 12:00 AM PST

Serpentinites are used in both exterior and interior locations, but not all serpentinites are equal: they vary in physical-mechanical behavior and are not all suitable for similar uses. The serpentinites most commonly used worldwide come from India, Pakistan or Egypt. Spain has traditionally quarried two ultramafic massifs, one in Galicia (Verde Pirineos) and one in Andalucía (Verde Macael). Some of these quarries were small family-run businesses. In both cases, these rocks are commercially available as “green marble.” These serpentinites commonly have a high degree of carbonation, but the process does not always take place with the same intensity. Carbonate can act as a cementing agent of the other phases, increasing the mechanical strength parameters. As a result, an improvement in the strength conditions is achieved, but a misinterpretation of the suitability of the rock may occur because a perception among users that “green marble” is similar to geologically defined marble. This may lead to inappropriate applications as an ornamental stone. At a time of economic crisis in Europe, the natural stone sector is encouraged to invest in research to identify the best quality products that can compete profitably with those currently being imported from other countries. This paper provides a comparison of properties of the Verde Macael serpentinite with a true marble in the hope of contributing to improving the natural stone industrial sector.

Polymers, Vol. 5, Pages 142-160: Multiscale Modeling of Chemical Vapor Deposition (CVD) Apparatus: Simulations and Approximations

Posted: 05 Feb 2013 12:00 AM PST

We are motivated to compute delicate chemical vapor deposition (CVD) processes. Such processes are used to deposit thin films of metallic or ceramic materials, such as SiC or a mixture of SiC and TiC. For practical simulations and for studying the characteristics in the deposition area, we have to deal with delicate multiscale models. We propose a multiscale model based on two different software packages. The large scales are simulated with computational fluid dynamics (CFD) software based on the transportreaction model (or macroscopic model), and the small scales are simulated with ordinary differential equations (ODE) software based on the reactive precursor gas model (or microscopic model). Our contribution is to upscale the correlation of the underlying microscale species to the macroscopic model and reformulate the fast reaction model. We obtain a computable model and apply a standard CFD software code without losing the information of the fast processes. For the multiscale model, we present numerical results of a real-life deposition process.

Pharmaceutics, Vol. 5, Pages 115-126: Analytical Electron Microscopy for Characterization of Fluid or Semi-Solid Multiphase Systems Containing Nanoparticulate Material

Posted: 05 Feb 2013 12:00 AM PST

The analysis of nanomaterials in pharmaceutical or cosmetic preparations is an important aspect both in formulation development and quality control of marketed products. Despite the increased popularity of nanoparticulate compounds especially in dermal preparations such as emulsions, methods and protocols of analysis for the characterization of such systems are scarce. This work combines an original sample preparation procedure along with different methods of analytical electron microscopy for the comprehensive analysis of fluid or semi-solid dermal preparations containing nanoparticulate material. Energy-filtered transmission electron microscopy, energy-dispersive X-ray spectroscopy, electron energy loss spectroscopy and high resolution imaging were performed on model emulsions and a marketed product to reveal different structural aspects of both the emulsion bulk phase and incorporated nanosized material. An innovative analytical approach for the determination of the physical stability of the emulsion under investigation is presented. Advantages and limitations of the employed analytical imaging techniques are highlighted.

Antibiotics, Vol. 2, Pages 28-45: Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus

Posted: 05 Feb 2013 12:00 AM PST

The paper focuses on recent achievements in the search for new chemical compounds able to inhibit multidrug resistance (MDR) mechanisms in Gram-positive pathogens. An analysis of the results of the search for new efflux pump inhibitors (EPIs) for Gram-positive bacteria, which have been performed over the last decade, indicates that almost all efforts are focused on the NorA (MFS) efflux pump in S. aureus. Considering the chemical structures of the NorA EPIs that have been identified, it can be observed that the most active agents belong to the families of compounds possessing conjugated double bonds, e.g., chalcones, piperine-like compounds, N-cinnamoylphenalkylamides or citral amide derivatives. Indole-, dihydronaphthyl-, 2-chloro-5-bromo-phenyl- or piperidine moieties seem to be profitable for the EPI properties, as well. These results, together with an increasing knowledge about a variety of efflux pumps that are involved in MDR of Gram-positive pathogens underline that further search for new EPIs should pay more attention to develop MDR efflux protein targets, including SMR, MATE, ABC or other members of the MFS family.
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