Games |
- Horcrux Email Backup 1.5 - Automatically backup your IMAP email. (Demo)
- InPreflight Studio 2.9.3 - Comprehensive quality control and reporting solution for Adobe InDesign. (Demo)
- Scida 1.0.1 - Organize your e-books and manage your Kindle. (Commercial)
- JavaScript Blocker 3.2.5 - Safari extension controls which scripts run on Web sites. (Free)
- Sync Folders Pro 2.7.1 - Automatically sync any number of folders. (Demo)
- Sustainability, Vol. 5, Pages 779-788: Inequality and Trust: Testing a Mediating Relationship for Environmental Sustainability
- Toxins, Vol. 5, Pages 431-444: Shiga Toxin 1, as DNA Repair Inhibitor, Synergistically Potentiates the Activity of the Anticancer Drug, Mafosfamide, on Raji Cells
- Toxins, Vol. 5, Pages 396-430: Modulation of Intestinal Functions Following Mycotoxin Ingestion: Meta-Analysis of Published Experiments in Animals
- IJERPH, Vol. 10, Pages 742-746: Comments on: Chari, R.; Burke, T.A.; White, R.H.; Fox, M.A. Integrating Susceptibility into Environmental Policy: An Analysis of the National Ambient Air Quality Standard for Lead. Int. J. Environ. Res. Public Health 2012, 9, 1077–1096
- IJERPH, Vol. 10, Pages 729-741: Changes in Tobacco Use, Susceptibility to Future Smoking, and Quit Attempts among Canadian Youth over Time: A Comparison of Off-Reserve Aboriginal and Non-Aboriginal Youth
- Track Cutting Back on Races
- Free The Mem 2.0.1 - Clears inactive RAM. (Free)
- Sony: "Used games can play on PS4"
- Energies, Vol. 6, Pages 1125-1141: A Materials Life Cycle Assessment of a Net-Zero Energy Building
- Energies, Vol. 6, Pages 1101-1124: Game Optimization Theory and Application in Distribution System Expansion Planning, Including Distributed Generation
- Energies, Vol. 6, Pages 1068-1100: A Photovoltaic Power System Using a High Step-up Converter for DC Load Applications
- IJMS, Vol. 14, Pages 4361-4371: Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs
- IJMS, Vol. 14, Pages 4349-4360: PG-2, a Potent AMP against Pathogenic Microbial Strains, from Potato (Solanum tuberosum L cv. Gogu Valley) Tubers Not Cytotoxic against Human Cells
- IJMS, Vol. 14, Pages 4334-4348: Cyclic Stretch Induces Inducible Nitric Oxide Synthase and Soluble Guanylate Cyclase in Pulmonary Artery Smooth Muscle Cells
- IJMS, Vol. 14, Pages 4326-4333: Molecular Typing of Mastitis-Causing Staphylococcus aureus Isolated from Heifers and Cows
| Horcrux Email Backup 1.5 - Automatically backup your IMAP email. (Demo) Posted: 21 Feb 2013 03:51 AM PST  Horcrux Email Backup lets you automatically backup your mails from any IMAP supported email accounts with great ease. The best part is, you have an option to restore the backup'ed emails to any other email account, retaining all your tags/folder hierarchy. Note: The first backup usually takes a lot of time. So, please do wait if you have a large email account. Features:
Version 1.5:
Download Now |
| Posted: 21 Feb 2013 03:45 AM PST  InPreflight is a comprehensive quality control and reporting solution for Adobe InDesign. It quickly gathers extensive information about document fonts, colors and links and lets you instantly locate potential problems according to user-defined settings. InPreflight saves you hours of checking your documents manually and dealing with consequences of costly mistakes. InPreflight also lets users print graphic preflight reports and save them as fully searchable interactive PDF files, providing an easy way to analyze, archive and send reports to service providers. The full version, InPreflight Pro, includes advanced packaging solutions with the ability to package multiple documents automatically. Version 2.9.3:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Scida 1.0.1 - Organize your e-books and manage your Kindle. (Commercial) Posted: 21 Feb 2013 03:34 AM PST  Scida is an e-book library management app for Mac that helps you organize your e-book collections and manage your Kindle. Books cannot only be copied between your computer and Kindle but Scida also provides usage statistics about your Kindle, and you can edit your Kindle's collections for certain devices (Kindle Keyboard, Kindle 4 and Kindle black). Features:
Version 1.0.1:
Download Now |
| JavaScript Blocker 3.2.5 - Safari extension controls which scripts run on Web sites. (Free) Posted: 21 Feb 2013 03:29 AM PST  JavaScript Blocker is a Safari extension that puts you in control of which scripts are allowed on any given website-similar to NoScript for Firefox. Extra features include the frame, embed, object, video, DOM images, and JavaScript annoyances blocker. It will make your browsing experience safer, more secure, and more enjoyable. It's even featured on Apple's Safari Extensions Gallery under Security. Version 3.2.5:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Sync Folders Pro 2.7.1 - Automatically sync any number of folders. (Demo) Posted: 21 Feb 2013 03:18 AM PST  Sync Folders Pro synchronizes any number of folders on the fly at the same time when there are changes, or connecting external drives at a set time or manually. The app synchronizes folders with or without filter for folder names and / or file names. Sync Folders Pro is perfect for backup to USB, memory cards, disks on remote computers on your network, folders on Cloud services (Dropbox, etc.) TRY IT FOR FREE with the free version which is available on the website and compare the sync speed and stability vs the similar apps (for the number of files > 50 000). Version 2.x is a new application vs version 1.x from a technical point of view. Completely changed the core of the application and algorithm of comparison of files structure which increased the speed of comparing 4-10 times for folders with many files and improved stability of the application. Left unchanged only the application interface that was liked many customers by an easy-to-use. Implemented a parallel analysis of all tasks. The comparison of two folders (6.24 GB and 92 470 files in each folder) is one minute. Video help for Sync Folders Pro on www.greenworldsoft.com:
Features:
Version 2.7.1:
Download Now |
| Posted: 21 Feb 2013 12:00 AM PST Instrumental arguments linking inequality to environmental sustainability often suppose a negative relationship between inequality and social cohesion. While social cohesion is difficult to measure, there are measures of a narrower concept, social trust, and empirical studies have shown that social trust is negatively related to inequality. In this paper we test whether at least part of the observed relationship may be explained by income level, rather than income distribution. We use individual response data from the World Values Survey at the income decile level, and find evidence that income level is indeed important in explaining differences in levels of social trust, but it is insufficient to explain all of the dependence. In the sample used for the study, we find that both income level and income distribution help explain differences in social trust between countries. |
| Posted: 21 Feb 2013 12:00 AM PST Shiga toxin 1 (Stx1), produced by pathogenic Escherichia coli, targets a restricted subset of human cells, which possess the receptor globotriaosylceramide (Gb3Cer/CD77), causing hemolytic uremic syndrome. In spite of the high toxicity, Stx1 has been proposed in the treatment of Gb3Cer/CD77-expressing lymphoma. Here, we demonstrate in a Burkitt lymphoma cell model expressing this receptor, namely Raji cells, that Stx1, at quasi-non-toxic concentrations (0.05–0.1 pM), inhibits the repair of mafosfamide-induced DNA alkylating lesions, synergistically potentiating the cytotoxic activity of the anticancer drug. Conversely, human promyelocytic leukemia cells HL-60, which do not express Gb3Cer/CD77, were spared by the toxin as previously demonstrated for CD34+ human progenitor cells, and hence, in this cancer model, no additive nor synergistic effects were observed with the combined Stx1/mafosfamide treatment. Our findings suggest that Stx1 could be used to improve the mafosfamide-mediated purging of Gb3Cer/CD77+ tumor cells before autologous bone marrow transplantation. |
| Posted: 21 Feb 2013 12:00 AM PST Mycotoxins are secondary metabolites of fungi that can cause serious health problems in animals, and may result in severe economic losses. Deleterious effects of these feed contaminants in animals are well documented, ranging from growth impairment, decreased resistance to pathogens, hepato- and nephrotoxicity to death. By contrast, data with regard to their impact on intestinal functions are more limited. However, intestinal cells are the first cells to be exposed to mycotoxins, and often at higher concentrations than other tissues. In addition, mycotoxins specifically target high protein turnover- and activated-cells, which are predominant in gut epithelium. Therefore, intestinal investigations have gained significant interest over the last decade, and some publications have demonstrated that mycotoxins are able to compromise several key functions of the gastrointestinal tract, including decreased surface area available for nutrient absorption, modulation of nutrient transporters, or loss of barrier function. In addition some mycotoxins facilitate persistence of intestinal pathogens and potentiate intestinal inflammation. By contrast, the effect of these fungal metabolites on the intestinal microbiota is largely unknown. This review focuses on mycotoxins which are of concern in terms of occurrence and toxicity, namely: aflatoxins, ochratoxin A and Fusarium toxins. Results from nearly 100 published experiments (in vitro, ex vivo and in vivo) were analyzed with a special attention to the doses used. |
| Posted: 21 Feb 2013 12:00 AM PST A recent publication in International Journal of Environmental Research and Public Health by Chari et al. [1] provides no basis for changing the National Ambient Air Quality Standard (NAAQS) for lead in the U.S. to protect children in low socio-economic (SES) populations. The studies selected by Chari et al. for analysis do not provide comparable information on regression coefficients for the blood lead level-IQ relationship. The coefficients differ from one another more on the basis of unequal blood lead metrics, ages of blood lead measurement, and differences in covariate adjustments and standardization, than the difference postulated by Chari et al. to correspond to low vs. high SES populations. |
| Posted: 21 Feb 2013 12:00 AM PST The purpose of this study was to determine whether there is a growing inequity in tobacco use, susceptibility to future smoking, and quit attempts among Off-Reserve Aboriginal (ORA) youth in Canada relative to Non-Aboriginal youth. Current smoking, susceptibility to future smoking and quit attempts were examined among a nationally representative sample of ORA and Non-Aboriginal Canadian youth. Data are from cross-sectional surveys of 88,661 respondents in Grades 6 to 9 across the 2004, 2006 and 2008 survey waves of the Youth Smoking Survey (YSS). At each wave, ORA youth were more likely to be current smokers (overall OR = 3.91, 95% CI 3.47 to 4.41), to be susceptible to future smoking (overall OR = 1.37, 95% CI 1.27 to 1.48), and less likely to have ever made a quit attempt compared to Non-Aboriginal youth (overall OR = 0.74, 95% CI 0.57 to 0.96). Although susceptibility to future smoking declined for Non-Aboriginal youth, the prevalence of susceptibility remained stable among ORA youth. The percentage of ORA youth reporting making a quit attempt increased, however, current smoking rates among ORA youth did not decline. These findings suggest that the disparity in susceptibility to future tobacco use among ORA and Non-Aboriginal youth has increased over time. Despite increased rates of quit attempts, current smoking rates remain significantly higher among ORA youth. Tobacco control programs for Aboriginal youth should be a public health priority. |
| Posted: 21 Feb 2013 03:03 AM PST Needing to cut costs in the face of formidable competition from new facilities in both Ohio and Pennsylvania, Wheeling Island Hotel-Casino-Racetrack is reducing its number of greyhound races. This posting includes an audio/video/photo media file: Download Now |
| Free The Mem 2.0.1 - Clears inactive RAM. (Free) Posted: 21 Feb 2013 02:54 AM PST  Free The Mem will automatically free inactive RAM upon launch. Rather than wasting time rebooting, just launch the app and watch your inactive RAM go away. "It just works!" Free The Mem works best when you have closed a memory-intensive app like Final Cut Pro. Version 2.0.1:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Sony: "Used games can play on PS4" Posted: 21 Feb 2013 02:31 AM PST Shuhei Yoshida, boss of Sony Worldwide Studios, has gone on-record to confirm that PS4 will be able to play used games. Speaking to Eurogamer, he said: |
| Energies, Vol. 6, Pages 1125-1141: A Materials Life Cycle Assessment of a Net-Zero Energy Building Posted: 21 Feb 2013 12:00 AM PST This study analyzed the environmental impacts of the materials phase of a net-zero energy building. The Center for Sustainable Landscapes (CSL) is a three-story, 24,350 square foot educational, research, and administrative office in Pittsburgh, PA, USA. This net-zero energy building is designed to meet Living Building Challenge criteria. The largest environmental impacts from the production of building materials is from concrete, structural steel, photovoltaic (PV) panels, inverters, and gravel. Comparing the LCA results of the CSL to standard commercial structures reveals a 10% larger global warming potential and a nearly equal embodied energy per square feet, largely due to the CSL’s PV system. As a net-zero energy building, the environmental impacts associated with the use phase are expected to be very low relative to standard structures. Future studies will incorporate the construction and use phases of the CSL for a more comprehensive life cycle perspective. |
| Posted: 21 Feb 2013 12:00 AM PST Based on Game Theory and Multi-objective optimization problems (MOP), Game Optimization Theory (GOT) is discussed in this paper. Optimization Stability Analysis (OSA), Distance Entropy Multi-Objective Particle Swarm Optimization (DEMPSO) and Fuzzy Multi-weights Decision-making Method (FMW) are proposed as well. Game Optimization Theory, which is a comprehensive system, could not only handle multi-objective optimization problems effectively, but also could offset the disadvantages of traditional optimization theories, such as lack of framework and the insufficient consideration of relevant elements. In this paper GOT is used for the first time in solving the distribution systems planning (DSP) issue by implementing distributed generation. The proposed model integrates costs, losses, and voltage index to achieve optimal size and site of distributed generation. The model allows minimizing total system costs, system power losses and maximizing voltage improvement. A detailed DSP example is used for verifying the effectiveness and reasonableness of GOT in this context. |
| Posted: 21 Feb 2013 12:00 AM PST This paper presents a power system using a high step-up converter for dc load applications. The high step-up converter adopts a boost converter with interleaved mode and a coupled inductor to raise its powering ability and increase its step-up voltage ratio, respectively. In order to increase conversion efficiency, an active clamp circuit is introduced into the proposed one to provide soft-switching features to reduce switching losses. Moreover, switches in the converter and active clamp circuit are integrated with a synchronous switching technique to reduce circuit complexity and component counts, resulting in a lower cost and smaller volume. A perturb and observe method is adopted to extract the maximum power from photovoltaic (PV) arrays. Furthermore, a microchip associated with PWM IC is used to implement maximum power point tracking operation, voltage regulation and power management. Finally, a prototype PV power system with 400 V/6 A has been implemented for verifying the feasibility of the proposed PV power system. It is shown to be suitable for PV energy conversion applications when the duty ratios of switches in the dc/dc converter are less than 0.5. |
| IJMS, Vol. 14, Pages 4361-4371: Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs Posted: 21 Feb 2013 12:00 AM PST Tendon adhesions are one of the most concerning complications after surgical repair of flexor tendon injury. Extracellular signal-regulated kinase (ERK) 2 plays crucial roles in fibroblast proliferation and collagen expression which contributes to the formation of tendon adhesions after flexor tendon surgery. Using a chicken model, we have examined the effects of a small interfering RNA (siRNA) targeting ERK2 delivered by a lentiviral system on tendon adhesion formation with an adhesion scoring system, histological assessment, and biomechanical evaluation. It was found that ERK2 siRNA effectively suppressed the increase of fibroblasts and the formation of tendon adhesions (p < 0.05 compared with the control group). Moreover, no statistically significant reduction in breaking force was detected between the ERK2 siRNA group and the control group. These results show that the lentiviral-mediated siRNA system is effective in preventing tendon adhesion formation but not to tendon healing, and may be used for tendon repair after confirmation and improvement by future detailed studies. |
| Posted: 21 Feb 2013 12:00 AM PST In an earlier study, we isolated potamin-1 (PT-1), a 5.6-kDa trypsin-chymotrypsin protease inhibitor, from the tubers of a potato strain (Solanum tuberosum L cv. Gogu Valley). We established that PT-1 strongly inhibits pathogenic microbial strains, but not human bacterial strains, and that its sequence shows 62% homology with a serine protease inhibitor. In the present study, we isolated an antifungal and antibacterial peptide with no cytotoxicity from tubers of the same potato strain. The peptide (peptide-G2, PG-2) was isolated using salt-extraction, ultrafiltration and reverse-phase high performance liquid chromatography (RP-HPLC). Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) showed the protein to have a molecular mass of 3228.5 Da, while automated Edman degradation showed the N-terminal sequence of PG-2 to be LVKDNPLDISPKQVQALCTDLVIRCMCCC-. PG-2 exhibited antimicrobial activity against Candida albicans, a human pathogenic yeast strain, and Clavibacter michiganensis subsp. michiganensis, a plant late blight strain. PG-2 also showed antibacterial activity against Staphylococcus aureus, but did not lyse human red blood cells and was thermostable. Overall, these results suggest PG-2 may be a good candidate to serve as a natural antimicrobial agent, agricultural pesticide and/or food additive. |
| Posted: 21 Feb 2013 12:00 AM PST In the pulmonary vasculature, mechanical forces such as cyclic stretch induce changes in vascular signaling, tone and remodeling. Nitric oxide is a potent regulator of soluble guanylate cyclase (sGC), which drives cGMP production, causing vasorelaxation. Pulmonary artery smooth muscle cells (PASMCs) express inducible nitric oxide synthase (iNOS), and while iNOS expression increases during late gestation, little is known about how cyclic stretch impacts this pathway. In this study, PASMC were subjected to cyclic stretch of 20% amplitude and frequency of 1 Hz for 24 h and compared to control cells maintained under static conditions. Cyclic stretch significantly increased cytosolic oxidative stress as compared to static cells (62.9 ± 5.9% vs. 33.3 ± 5.7% maximal oxidation), as measured by the intracellular redox sensor roGFP. Cyclic stretch also increased sGCβ protein expression (2.5 ± 0.9-fold), sGC activity (1.5 ± 0.2-fold) and cGMP levels (1.8 ± 0.2-fold), as well as iNOS mRNA and protein expression (3.0 ± 0.9 and 2.6 ± 0.7-fold, respectively) relative to control cells. An antioxidant, recombinant human superoxide dismutase (rhSOD), significantly decreased stretch-induced cytosolic oxidative stress, but did not block stretch-induced sGC activity. Inhibition of iNOS with 1400 W or an iNOS-specific siRNA inhibited stretch-induced sGC activity by 30% and 68% respectively vs. static controls. In conclusion, cyclic stretch increases sGC expression and activity in an iNOS-dependent manner in PASMC from fetal lambs. The mechanism that produces iNOS and sGC upregulation is not yet known, but we speculate these effects represent an early compensatory mechanism to counteract the effects of stretch-induced oxidative stress. A better understanding of the interplay between these two distinct pathways could provide key insights into future avenues to treat infants with pulmonary hypertension. |
| Posted: 21 Feb 2013 12:00 AM PST Staphylococcus aureus is among the main etiologic agents of bovine mastitis. A total of 83 isolates of S. aureus from mammary glands of primiparous heifers were collected in the prepartum, calving and during lactation. For lactating cows, a total of 27 isolates of S. aureus from mammary glands were collected during lactation. The samples were taken in two dairy farms located in Sao Paulo State, Brazil. The highest frequency of S. aureus isolation in heifers was at the end of lactation. Strains were typified through Pulsed-field gel electrophoresis (PFGE) and grouped according to patterns of restriction enzyme SmaI. PFGE generated seven clonal profiles that were grouped into three different lineages, with the LA lineage being predominant and identified in heifers, as well as in the cows from the two regions studied. It was concluded that the cows showed a significant source of dispersion of S. aureus. At the first lactation the heifers were infected by the same clonal profiles of S. aureus which were isolated from multiparous lactating cows. The heifers were infected during milking over the months of lactation. |
| You are subscribed to email updates from Games To stop receiving these emails, you may unsubscribe now. | Email delivery powered by Google |
| Google Inc., 20 West Kinzie, Chicago IL USA 60610 | |
Комментариев нет:
Отправить комментарий