Games

Grudger - Screenshots
Edge of Space - Screenshots
Molecules, Vol. 18, Pages 2243-2254: Growth of Fullerene Fragments Using the Diels-Alder Cycloaddition Reaction: First Step towards a C60 Synthesis by Dimerization
Sustainability, Vol. 5, Pages 695-710: Stakeholder Engagement: Achieving Sustainability in the Construction Sector
San Jose and Casino M8trix: A history
Materials, Vol. 6, Pages 517-534: A Review of Aspects of Oxidative Hair Dye Chemistry with Special Reference to N-Nitrosamine Formation
Materials, Vol. 6, Pages 500-516: Extraordinary Magnetoresistance in Semiconductor/Metal Hybrids: A Review
IJMS, Vol. 14, Pages 3874-3900: Chemical Inhibitors and microRNAs (miRNA) Targeting the Mammalian Target of Rapamycin (mTOR) Pathway: Potential for Novel Anticancer Therapeutics
Adobe Flash Player 11.6.602.167 - Multimedia Web browser plug-in. (Free)
evasi0n 1.3 - Untethered jailbreak for all iOS 6 devices. (Free)
Angry Birds 3.0.1 - Popular physics-based puzzle game. (Commercial)
Microsoft Office 2011 14.3.1 - Popular productivity suite; demo available. (Updater)
BBEdit 10.5.2 - Powerful text and HTML editor. (Demo)
Powerball Winning Numbers for 02/09/2013
Powerball Estimated Jackpot for 02/13/2013
Mega Millions Winning Numbers for 02/12/2013
Mega Millions Estimated Jackpot for 02/15/2013
Lotto Texas Winning Numbers for 02/09/2013
Lotto Texas Estimated Jackpot for 02/13/2013
Texas Two Step Winning Numbers for 02/11/2013

Posted: 13 Feb 2013 02:30 AM PST

Grudger puts his life on the line for the morally ambiguous strangers he calls his customers. He's a lowlife free runner in a dangerous steampunk world, and he always delivers the goods.

There is no life bar in this game; only the sound of crushed bones. Run, jump, roll, slide and bounce off walls to proceed. Use your environment to master all thirty levels with parkour.

Features:
-Swipe to act; never have to slip on a pseudo-button
-Collect aluminum bars to unlock survival mode
-30 levels (more coming soon)
-Find hidden easter eggs
-Compete for high scores in survival mode

Edge of Space - Screenshots

Posted: 13 Feb 2013 02:25 AM PST

Molecules, Vol. 18, Pages 2243-2254: Growth of Fullerene Fragments Using the Diels-Alder Cycloaddition Reaction: First Step towards a C60 Synthesis by Dimerization

Posted: 13 Feb 2013 12:00 AM PST

Density Functional Theory has been used to model the Diels-Alder reactions of the fullerene fragments triindenetriphenilene and pentacyclopentacorannulene with ethylene and 1,3-butadiene. The purpose is to prove the feasibility of using Diels-Alder cycloaddition reactions to grow fullerene fragments step by step, and to dimerize fullerene fragments, as a way to obtain C60. The dienophile character of the fullerene fragments is dominant, and the reaction of butadiene with pentacyclopentacorannulene is favored.

Sustainability, Vol. 5, Pages 695-710: Stakeholder Engagement: Achieving Sustainability in the Construction Sector

Posted: 13 Feb 2013 12:00 AM PST

Achieving sustainability-related targets in construction projects is increasingly becoming a key performance driver. Yet sustainability is a complex concept in projects and there are many diverse stakeholders. Some stakeholders are generally recognized as important, i.e., the client and main contractor, yet there are others not always perceived as such and whose absence from the decision-making processes may result in a failure to address sustainability issues. Hence there is a need for a systematic approach to engage with stakeholders with high salience in relation to sustainability. This paper reports the results of an exploratory study involving interviews with construction project practitioners that are involved in sustainability in some way. Data were collected from the practitioners in terms of the processes for engaging with stakeholders to deliver sustainability. The data suggests six steps to a stakeholder engagement process: (i) identification; (ii) relating stakeholders to different sustainability-related targets; (iii) prioritization; (iv) managing; (v) measuring performance; and (vi) putting targets into action. The results suggest that understanding the different sustainability agendas of stakeholders and measuring their performance using key performance indicators are important stages to be emphasized in any stakeholder engagement process to achieve sustainability-related goals.

San Jose and Casino M8trix: A history

Posted: 13 Feb 2013 01:13 AM PST

Casino M8trix, the former Garden City Casino card room in San Jose, has sued the city in state and federal court over permit delays and refusal to allow gaming on the top floor of its eight-story tower.

Materials, Vol. 6, Pages 517-534: A Review of Aspects of Oxidative Hair Dye Chemistry with Special Reference to N-Nitrosamine Formation

Posted: 13 Feb 2013 12:00 AM PST

This review discusses a new aspect to the safety profile of oxidative hair dyes using data already in the public domain. These dyes contain secondary amines that are capable of forming potentially carcinogenic nitrosamine derivatives when exposed to atmospheric pollution. Numerous scientific articles confirm the existence of secondary amines in hair dyes (and their intermediates), the possibility of nitrosation by atmospheric NOx of secondary amines to give the N-nitrosamines, and the significant safety risks on N-nitrosamines. It is believed that such nitrosamine derivatives should be investigated more fully in the interests of consumer safety.

Materials, Vol. 6, Pages 500-516: Extraordinary Magnetoresistance in Semiconductor/Metal Hybrids: A Review

Posted: 13 Feb 2013 12:00 AM PST

The Extraordinary Magnetoresistance (EMR) effect is a change in the resistance of a device upon the application of a magnetic field in hybrid structures, consisting of a semiconductor and a metal. The underlying principle of this phenomenon is a change of the current path in the hybrid structure upon application of a magnetic field, due to the Lorentz force. Specifically, the ratio of current, flowing through the highly conducting metal and the poorly conducting semiconductor, changes. The main factors for the device’s performance are: the device geometry, the conductivity of the metal and semiconductor, and the mobility of carriers in the semiconductor. Since the discovery of the EMR effect, much effort has been devoted to utilize its promising potential. In this review, a comprehensive overview of the research on the EMR effect and EMR devices is provided. Different geometries of EMR devices are compared with respect to MR ratio and output sensitivity, and the criteria of material selection for high-performance devices are discussed.

IJMS, Vol. 14, Pages 3874-3900: Chemical Inhibitors and microRNAs (miRNA) Targeting the Mammalian Target of Rapamycin (mTOR) Pathway: Potential for Novel Anticancer Therapeutics

Posted: 13 Feb 2013 12:00 AM PST

The mammalian target of rapamycin (mTOR) is a critical regulator of many fundamental features in response to upstream cellular signals, such as growth factors, energy, stress and nutrients, controlling cell growth, proliferation and metabolism through two complexes, mTORC1 and mTORC2. Dysregulation of mTOR signalling often occurs in a variety of human malignant diseases making it a crucial and validated target in the treatment of cancer. Tumour cells have shown high susceptibility to mTOR inhibitors. Rapamycin and its derivatives (rapalogs) have been tested in clinical trials in several tumour types and found to be effective as anticancer agents in patients with advanced cancers. To block mTOR function, they form a complex with FKBP12 and then bind the FRB domain of mTOR. Furthermore, a new generation of mTOR inhibitors targeting ATP-binding in the catalytic site of mTOR showed potent and more selective inhibition. More recently, microRNAs (miRNA) have emerged as modulators of biological pathways that are essential in cancer initiation, development and progression. Evidence collected to date shows that miRNAs may function as tumour suppressors or oncogenes in several human neoplasms. The mTOR pathway is a promising target by miRNAs for anticancer therapy. Extensive studies have indicated that regulation of the mTOR pathway by miRNAs plays a major role in cancer progression, indicating a novel way to investigate the tumorigenesis and therapy of cancer. Here, we summarize current findings of the role of mTOR inhibitors and miRNAs in carcinogenesis through targeting mTOR signalling pathways and determine their potential as novel anti-cancer therapeutics.

Adobe Flash Player 11.6.602.167 - Multimedia Web browser plug-in. (Free)

Posted: 12 Feb 2013 08:59 PM PST

Adobe Flash Player is a cross-platform, browser-based application runtime that provides uncompromised viewing of expressive applications, content, and videos across browsers and operating systems.

Version 11.6.602.167:

Fixed Issues

On Android OS, AIR apps streaming MP4 audio hang when pausing and resuming multiple times.(3331239)
In applications which utilize the Concurrency feature, a crash can occur when sending a large amount of shared properties between workers.(3367973)
On OS X, AIR application fail to load PDF files when Acrobat is updated to 11.0.1(3397427)
On Windows XP, microphone is not recognized for an input to a stream.(3342418)
On Windows XP, in some circumstances, FlashMediaServer streams deliver choppy streams.(3301447)
In Microsoft Internet Explorer, when protected mode is on, non-administrator profiles fail to load Flash content.(3365525)
On Windows 7, under certain conditions, webcam feeds do not render properly(3350899)
On OS X, some large image fail to load.(3364103)
In Internet explorer, when hardware acceleration is disabled, the "allow fullscreen" dialog fails to exit completely.(3364774)
On OS X, In an AIR application has multiple windows open, and CMD+Q is entered, AIR crashes(3348569)
On iOS, attempting to play local MP4 videos with the StageVideo object sometimes fails.(3367579)
On Microsoft Windows, looped FLV videos fail to show the last frame.(3343606)
On Apple Macbooks or Apple iMacs with external displays connected, protected content fails to play(3366540)
On Microsoft Windows, gotoAndStop calls sometimes function incorrectly.(3345174)

New Features

Graphics Data Query
Improved permissions UI for full screen keyboard access
Multiple SWF support(iOS)
Setting device specific Retina Display resolution(iOS)
Updated File API following App store guidelines(iOS)
HiDpi support for FlashPro

OS X 10.6 or later
Browser compatibility:
- Safari 5.0 or later
- Mozilla Firefox 4.0 or later
- Google Chrome
- Opera 11 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

evasi0n 1.3 - Untethered jailbreak for all iOS 6 devices. (Free)

Posted: 12 Feb 2013 08:59 PM PST

evasi0n is an untethered jailbreak for all iPhone, iPod touch, iPad and iPad mini models running iOS 6.0 through 6.1

Instructions:

Backup your device using iTunes (or iCloud) before using evasi0n. If something breaks, you'll always be able to recover your data.
Those who use backup passwords in iTunes must disable them for now. After doing so, iTunes makes a brand new backup. Please wait for that backup to complete before proceeding! Feel free to re-enable your backup password after jailbreaking.
Please disable the lock passcode of your iOS device before using evasi0n. It can cause issues.
Launch evasi0n, plug in your device, and click "Jailbreak". Just sit back and observe its progress. Watch for any steps you may be asked to perform.
Avoid all iOS and iTunes related tasks until evasi0n is complete. Why not just enjoy a brief break from the computer to stretch your legs?
If the process gets stuck somewhere, it's safe to restart the program, reboot the device (if necessary by holding down Power and Home until it shuts down), and rerun the process.

Version 1.3:

Updated for iOS 6.1.1 for the iPhone 4S

OS X 10.5 or later
Any iOS 6 device (except AppleTV 3)

Download Now

Angry Birds 3.0.1 - Popular physics-based puzzle game. (Commercial)

Posted: 12 Feb 2013 08:59 PM PST

The survival of the Angry Birds is at stake. Dish out revenge on the green pigs who stole the Birds' eggs. Use the unique destructive powers of the Angry Birds to lay waste to the pigs' fortified castles. Angry Birds features hours of gameplay, challenging physics-based castle demolition, and lots of replay value. Each of the levels requires logic, skill, and brute force to crush the enemy.

Version 3.0.1:

Addressed some minor issues in order to improve the user experience

OS X 10.6 or later

Download Now

Microsoft Office 2011 14.3.1 - Popular productivity suite; demo available. (Updater)

Posted: 12 Feb 2013 08:59 PM PST

Microsoft Office 2011 helps you create professional documents and presentations. And since Office for Mac 2011 is compatible with Office for Windows, you can work on documents with virtually anyone, anywhere.

Work well with others. Be on the same page with Office for Mac and Office for Windows, including new features in Office 2010. Whether you're looking to share files or work together online, now you can do it with complete confidence, knowing that Office for Mac is most compatible with Office for Windows. With Office being used on more than 1 billion Macs and PCs worldwide, you can work with practically anyone you want, how you want, wherever you want-with no worries.

Save time with software you already know. Learning new software can be time-consuming. Office for Mac 2011 contains the familiar commands, formats, and interfaces you already know, so you can start working right away. It's never been easier to switch from Mac to PC and back again, wherever and however you need to work.

Use what the pros use. Create great-looking documents in a snap. Office for Mac 2011 offers the most complete feature set, with everything you'd expect from top-of-the-line software. If delivering impressive, professional-looking documents matters to you, then you need Office for Mac 2011. There is no substitute.

Version 14.3.1:

Stability is improved. This update fixes an issue that may cause Office 2011 applications to report a problem with Licensing even though the applications continue to run unaffected.

OS X 10.5.8 or later
Microsoft Office 2011 SP2 (14.2.3-14.2.5)

Download Now

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BBEdit 10.5.2 - Powerful text and HTML editor. (Demo)

Posted: 12 Feb 2013 08:59 PM PST

BBEdit is the leading professional HTML and text editor for the Mac. Specifically crafted in response to the needs of Web authors and software developers, this award-winning product provides a plethora of features for editing, searching, and manipulation of text. BBEdit transforms text with high performance.

An intelligent interface provides easy access to BBEdit's best of class features including grep pattern matching, search and replace across multiple files, function navigation and syntax coloring for numerous source code languages, FTP and SFTP open and save, AppleScript, Perl and Mac OS X Unix scripting support, glossary support, and a complete set of HTML tools.

Version 10.5.2:

Additions

This release consists entirely of fixes for reported issues, and contains no new features, nor changes to existing features.

Fixes

Made a change so that the "Restoring [BBEdit] state" panel at startup shows the name of each document as it's opened, and also gives various timer services a chance to run.
Fixed a collection of bugs in the Functions, Jump Points, and Markers palettes that would cause them to inappropriately change the selection range when making a document active, as well as unexpectedly lose their contents when closing an unrelated floating window.
Fixed incorrect number formatting in the Functions floater.
Fixed a bug in which "Sort Lines" did not release memory that it allocated during the operation.
Worked around apparent bug on 10.6 which would cause the application to crash in the guts of QuickLook when doing a "Close All Documents". Unfortunately the solution involves disabling QuickLook support entirely when running on 10.6; if this is important to you, consider upgrading your OS to 10.7 (or 10.8, if your hardware supports it).
Fixed bug in which the "Restoring BBEdit State" panel would remain on screen longer than was necessary (and in some situations would never go away).
Fixed bug in which the drag image when dragging text was not correct when the selection didn't begin at the beginning of a line. (The correct text was dragged in any event.)
Fixed bug in which using "Save a Copy" would trigger a sequence of events which could end in data loss if the wrong choices were made.
Fixed bug in which callouts (MARK, FIXME, etc) were not recognized when used in # comments in PHP.
Corrected a math error which eliminated the dead space between the line bar (or gutter) and the left edge of the text, causing misalignment when the editing view was split, and also making it impossible to do single-click line selection.
Increased the maximum allowed length for element names, so that folding in XML documents works with element names that were longer than the old limit (which was perfectly reasonable since 1995, but there you go).
Worked around a performance problem in the system foundation classes which would cause undesired delays when editing in very large syntax-colored documents.
The minimum OS requirement has been changed to 10.6.8 (for both BBEdit and TextWrangler); there's no particular reason not to update, and on the contrary some very good reasons to do so.
The application now uses NSOpenPanel and NSSavePanel for presenting file choosers (including the Open dialog) and "Save As" dialogs, rather than the legacy Navigation Services interfaces. This should resolve problems with accessory controls not working correctly on Retina machines, and perhaps may cure other lurking horrors in the Navigation Services APIs.
Fixed bug in which clicking on the application's icon in the Dock would not un-minimize the front window when it should have, unless the Application preferences were set to do something other than "Nothing" at startup.
Fixed bug in which right-clicking in a document that was HTML or XML but not properly formed would play a beep.
Fixed an internal exception that would occur when decoding text with entities in it. Since this could occur during function scanning, it would lead to the application malfunctioning in certain circumstances.
Changed the order in which BBEdit searches for Unix tools, to make allowance for nonstandard installations of svn and the refusal of xcrun --find to locate same. You should be able to remove the SubversionToolPathOverride expert preference (use defaults delete) and have things work.
Line breaks in results entry text are now turned into spaces, to improve readability and resolve appearance problems.
Fixed bug in which files added to folders within a project were not immediately visible to the "Open File by Name" window as they should have been.
Fixed bugs in which certain legacy scripting interfaces which relied on the "user focus" for targeting events would fail when the application was in the background.
Adjusted the properties of the PHP language module specification so that typographer's quotes aren't inappropriately entered while typing.
The "Compare Against Previous Versions" command on the Search menu is now always enabled (as long as you're editing a local file), which avoids performance problems caused by [NSFileVersion otherVersionsOfItemAtURL:] taking an unconscionably long time in some cases.
Made the XML guesser more strict, so as to reduce the chances of non-XML files with XML-ish innards being guessed as XML.
If you would like to open a particular Preview CSS, Preview Template, or Preview Filter file from the popup menu in a BBEdit preview window, you may do so by holding down the Option key as you choose the desired item.
Fixed bug in which the "Search and Replace" automator action would commit a malfunction when "Use Grep" was turned on in the action's options. (What other words can you think of that end with "-tion"?)
Corrected a small layout fault in the Character Inspector floater.
Navigation floaters (Functions, Jump Points, Markers) now use the "unwrapped" line number in the display, thus giving correct results in soft-wrapped documents when Use "Hard" Line Numbering is turned on.
Fixed bug in which the "#doctitle#" placeholder wasn't processed correctly by the document/site updater.
Fixed bug in which the Functions floater didn't update as the document's function list changed.
Fixed bug in which changing the list selection in the Functions floater would then cause the selected item to be deselected. This hindered navigation through the floater, particularly when using the keyboard.
Fixed bug in which a Unicode BOM present in text dragged in from certain sources (I'm looking at you, Microsoft Word) would be misinterpreted, resulting in junk text being inserted.
Fixed bug in which pre-comparison screening for multi-file Find Differences didn't return accurate results.
Only show the state restoration progress panel at startup if there's any state to restore.
The Site Settings panel for project documents now comes up with the General tab selected, rather than the Deployment tab.
Fixed a bug in which the link checker would not correctly resolve references that were relative to the document's base URL, in cases where it had been specified.
The width and visibility of the editing window sidebar is now remembered correctly when saving window state across a quit/relaunch, as well as for "Save Default Text Window".
Fixed bug in which some operations depending on the current Clipboard contents would return stale information in cases where a clipboard import (from an external application) was necessary.
Fixed bug in which type-to-select in list views didn't work correctly.
When FlashBalancePointsWhenNavigating is on (as it is by default), navigating over the closing delimiter will no longer cause the document to scroll.
Fixed bug in which user-defined names for FTP/SFTP items in projects were reset to the file's actual name when saving changes.
Worked around performance problems in some FUSE clients which would cause BBEdit to hang when opening an instaproject on a remote volume. (This could sometimes affect SMB and netatalk AFP volumes served up over extremely slow connections.)