Games |
- TimeCache 9.0.5. - Keep track of time and billing on projects. (Demo)
- Yate 2.0.1.1 - Tag and organize your audio files. (Shareware)
- Molecules, Vol. 18, Pages 2483-2500: Anti-Inflammatory and Anti-Allergic Activities of Pentaherb Formula, Moutan Cortex (Danpi) and Gallic Acid
- Molecules, Vol. 18, Pages 2469-2482: An Improved HPLC Method with the Aid of a Chemometric Protocol: Simultaneous Determination of Atorvastatin and Its Metabolites in Plasma
- Molecules, Vol. 18, Pages 2458-2468: Cytotoxic and Antimalarial Amaryllidaceae Alkaloids from the Bulbs of Lycoris radiata
- Patchy Pop Culture: What Are 3 Songs You Own, But Shouldn't?
- Agriculture, Vol. 3, Pages 112-130: Protein Hydrolysates from Agricultural Crops—Bioactivity and Potential for Functional Food Development
- Finding Recognition In Football Checkers
- Diagnostics, Vol. 3, Pages 117-125: Strain Elastography Ultrasound: An Overview with Emphasis on Breast Cancer Diagnosis
- Polymers, Vol. 5, Pages 254-268: Application of Chondroitin Sulfate Derivatives for Understanding Axonal Guidance in the Nervous System during Development
- Life, Vol. 3, Pages 211-233: A Laboratory of Extremophiles: Iceland Coordination Action for Research Activities on Life in Extreme Environments (CAREX) Field Campaign
- iStat Menus 4.04 - Monitor your system right from the menubar. (Shareware)
- Mobile Monday
- Powerball Winning Numbers for 02/23/2013
- Powerball Estimated Jackpot for 02/27/2013
- Mega Millions Winning Numbers for 02/22/2013
- Mega Millions Estimated Jackpot for 02/26/2013
- Lotto Texas Winning Numbers for 02/23/2013
- Lotto Texas Estimated Jackpot for 02/27/2013
- Texas Two Step Winning Numbers for 02/21/2013
| TimeCache 9.0.5. - Keep track of time and billing on projects. (Demo) Posted: 25 Feb 2013 03:00 AM PST  TimeCache is for independent consultants and small companies who charge clients for their time. It lets you easily keep track of time and billing on projects you work on for different clients. It offers extensive reporting, exporting and printing capabilities. TimeCache 9.0.5:
OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Yate 2.0.1.1 - Tag and organize your audio files. (Shareware) Posted: 25 Feb 2013 02:52 AM PST  Yate was developed for people who are serious about tagging and organizing their audio files. The application was designed from the ground up for Mac users. It is a 100% Cocoa written application and uses its own tagging library. Yate will tag mp3, m4a, and FLAC files. This App has a long list of features, most importantly; an innovative scripting system called Actions. Actions can be used to update all of an album's tags with a single operation. Yate also supports integration with Discogs, MusicBrainz, and iTunes. All changes can be easily reverted and individual changes can be undone in any order. Whether you want to automatically or manually tag your files, Yate can do it all! Version 2.0.1.1:
OS X 10.6.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 25 Feb 2013 12:00 AM PST Pentaherb formula (PHF) has been proven to improve the quality of life of children with atopic dermatitis without side effects. The aim of this study was to elucidate the potential anti-inflammatory and anti-allergic activities of PHF, Moutan Cortex (Danpi/DP) and gallic acid (GA) using human basophils (KU812 cells), which are crucial effector cells in allergic inflammation. PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p < 0.05). With the combined use of dexamethasone (0.01 μg/mL) and GA (10 μg/mL), the suppression of ICAM-1 expression and CCL5 and IL-6 release of IL-33-activated KU812 cells were significantly greater than the use of GA alone (all p < 0.05). The suppression of the IL-33-induced activation of intracellular signalling molecules p38 mitogen activated protein kinase, nuclear factor-kB and c-Jun amino-terminal kinase in GA-treated KU812 cells could be the underlying mechanism for the suppression on ICAM-1, chemokines and cytokines. The combined use of dexamethasone with the natural products PHF or DP or GA might therefore enhance the development of a novel therapeutic modality for allergic inflammatory diseases with high potency and fewer side effects. |
| Posted: 25 Feb 2013 12:00 AM PST The aim of the present study was to optimize a chromatographic method for the analysis of atorvastatin (acid and lactone forms), ortho- and para-hydroxyatorvastatin by using an experimental design approach. Optimization experiments were conducted through a process of screening and optimization. The purpose of a screening design is to identify the factors that have significant effects on the selected chromatographic responses, and for this purpose a full 23 factorial design was used. The location of the true optimum was established by applying Derringer's desirability function, which provides simultaneously optimization of all seven responses. The ranges of the independent variables used for the optimization were content of acetonitrile in mobile phase (60–70%), temperature of column (30–40 °C) and flow rate (0.8–1.2 mL min−1). The influences of these independent variables were evaluated for the output responses: retention time of first peak (p-hydroxyatorvastatin) and of last peak (atorvastatin, lactone form), symmetries of all four peaks and relative retention time of p-hydroxyatorvastatin. The primary goal of this investigation was establishing a new simple and sensitive method that could be used in analysis of biological samples. The method was validated and successfully applied for determination of atorvastatin (acid and lactone forms) and its metabolites in plasma. |
| Posted: 25 Feb 2013 12:00 AM PST Phytochemical investigation of the 80% ethanol extract of the bulbs of Lycoris radiata resulted in the isolation of five new Amaryllidaceae alkaloids: (+)-5,6-dehydrolycorine (1), (+)-3α,6β-diacetyl-bulbispermine (2), (+)-3α-hydroxy-6β-acetyl- bulbispermine (3), (+)-8,9-methylenedioxylhomolycorine-N-oxide (5), and 5,6-dihydro-5- methyl-2-hydroxyphenanthridine (7), together with two known compounds, (+)-3α-methoxy- 6β-acetylbulbispermine (4) and (+)-homolycorine- N-oxide (6). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. Alkaloid 1 showed potent cytotoxicity against astrocytoma and glioma cell lines (CCF-STTG1, CHG-5, SHG-44, and U251), as well as HL-60, SMMC-7721, and W480 cell lines with IC50 values of 9.4–11.6 μM. Additonally, compound 1 exhibited antimalarial activity with IC50 values of 2.3 μM for D-6 strain and 1.9 μM for W-2 strain of Plasmodium falciparum. |
| Patchy Pop Culture: What Are 3 Songs You Own, But Shouldn't? Posted: 25 Feb 2013 02:09 AM PST Time was that saying you've seen Metallica six times in concert meant something. |
| Posted: 25 Feb 2013 12:00 AM PST There has been an unprecedented demand for inexpensive plant-derived protein hydrolysates in recent years, owing to their potential nutritional applications. This review examines existing evidence regarding protein hydrolysates from agricultural crops such as wheat, soy, rapeseed, sunflower and barley. The bioactivity of these protein hydrolysates, including antioxidant and anti-inflammatory capabilities are discussed. In addition to evidence regarding their potential to enhance human nutrition, the effect of the hydrolysates on the techno-functional properties of foods will be reviewed. |
| Finding Recognition In Football Checkers Posted: 25 Feb 2013 01:04 AM PST James Pickett is a fan of the movie, Flash of Genius . The movie chronicles the fight that Robert Kearns had to go through to be recognized as the inventor of intermittent windshield wipers. This posting includes an audio/video/photo media file: Download Now |
| Posted: 25 Feb 2013 12:00 AM PST Strain elastography (SE), which estimates tissue strain, is an adjunct to the conventional ultrasound B-mode examination. We present a short introduction to SE and its clinical use. Furthermore, we present an overview of the 10 largest studies performed on the diagnostic accuracy of SE in breast cancer diagnostics. Eight of 10 studies presented data for both SE and B-mode imaging. Seven studies showed better specificity and accuracy for SE than for B-mode imaging in breast cancer diagnosis. Four studies showed an increase in specificity and accuracy when combining B-mode imaging with SE. The ways of combining B-mode imaging with SE in the diagnosis of breast cancer differed between the five studies. We believe that further studies are needed to establish an optimal algorithm for the combination of B-mode ultrasound and SE in breast cancer. |
| Posted: 25 Feb 2013 12:00 AM PST Neuronal axons and their growth cones recognize molecular guidance cues within the local environment, forming axonal pathways to produce precise neuronal networks during nervous system development. Chondroitin sulfates (CS), carbohydrate chains on chondroitin sulfate proteoglycans, exhibit great structural diversity and exert various influences on axons and growth cones as guidance cues or their modulators; however, the relationship between their structural diversity and function in axonal guidance is not well known. To uncover the roles of CS in axonal guidance, artificially modified hybrid molecules: CS derivatives of biotinylated CS and lipid-derivatized CS, were used. The experiments with biotinylated CS suggest that the growing axons act on their environment, modifying CS, and rendering it more favorable for their growth. The experiments with lipid-derivatized CS demonstrated that growth cones distinguish types of CS with different unit contents and are likely to discriminate the structural diversity of CS. The application of CS derivatives is useful in uncovering axon–environment interaction and structure–function relationship of CS directly. |
| Posted: 25 Feb 2013 12:00 AM PST Existence of life in extreme environments has been known for a long time, and their habitants have been investigated by different scientific disciplines for decades. However, reports of multidisciplinary research are uncommon. In this paper, we report an interdisciplinary three-day field campaign conducted in the framework of the Coordination Action for Research Activities on Life in Extreme Environments (CAREX) FP7EU program, with participation of experts in the fields of life and earth sciences. In situ experiments and sampling were performed in a 20 m long hot springs system of different temperature (57 °C to 100 °C) and pH (2 to 4). Abiotic factors were measured to study their influence on the diversity. The CO2 and H2S concentration varied at different sampling locations in the system, but the SO2 remained the same. Four biofilms, mainly composed by four different algae and phototrophic protists, showed differences in photosynthetic activity. Varying temperature of the sampling location affects chlorophyll fluorescence, not only in the microbial mats, but plants (Juncus), indicating selective adaptation to the environmental conditions. Quantitative polymerase chain reaction (PCR), DNA microarray and denaturing gradient gel electrophoresis (DGGE)-based analysis in laboratory showed the presence of a diverse microbial population. Even a short duration (30 h) deployment of a micro colonizer in this hot spring system led to colonization of microorganisms based on ribosomal intergenic spacer (RISA) analysis. Polyphasic analysis of this hot spring system was possible due to the involvement of multidisciplinary approaches. |
| iStat Menus 4.04 - Monitor your system right from the menubar. (Shareware) Posted: 24 Feb 2013 08:59 PM PST  iStat Menus lets you monitor your system right from the menubar. Included are 8 menu extras that let you monitor every aspect of your system. Some features:
Version 4.04:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 24 Feb 2013 10:10 PM PST  Games featured this week: Plants vs. Zombies; MANOS - The Hands of Fate; Dragon Portals; The Sandbox — Chewed -up gum and knobby knees are the dominant mental images one may experience while reading this edition of Mobile Monday. That, and the incessant repetition of Torgo's four second theme song running over and over again, never stopping, just looping. Forever. Tagged as: blog, mobile, mobile-monday, news, previews |
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