Games |
- Sync Folders Pro 2.7 - Automatically sync any number of folders.. (Commercial)
- ACDSee Pro 2.2 - Fast and effective image viewer and browser.. (Demo)
- ClickBeatz Pro 2.0.2 - Tag your music library with BPM values.. (Free)
- PowerTunes 1.2.5 - Create, organize, and share multiple iTunes libraries.. (Shareware)
- ZOC Terminal 6.46 - Telnet/SSH/SSH2 client and terminal emulator.. (Shareware)
- Molecules, Vol. 18, Pages 2122-2134: PF2401-SF, Standardized Fraction of Salvia miltiorrhiza, Induces Apoptosis of Activated Hepatic Stellate Cells in Vitro and in Vivo
- Molecules, Vol. 18, Pages 2110-2121: Simultaneous Determination of Multiple Sesquiterpenes in Curcuma wenyujin Herbal Medicines and Related Products with One Single Reference Standard
- Molecules, Vol. 18, Pages 2096-2109: Palladium-Catalyzed Amination of Dichloroquinolines with Adamantane-Containing Amines
- Molecules, Vol. 18, Pages 2084-2095: The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate
- Entropy, Vol. 15, Pages 606-623: Comparing Surface and Mid-Tropospheric CO2 Concentrations from Central U.S. Grasslands
- IJERPH, Vol. 10, Pages 638-659: The Influence of Fish Length on Tissue Mercury Dynamics: Implications for Natural Resource Management and Human Health Risk
- Real Racing 3 - Screenshots
- Molbank, Vol. 2013, Pages M793: Benzyl 3-deoxy-3-(3,4,5-trimethoxybenzylamino)-β-L-xylopyranoside
- Sustainability, Vol. 5, Pages 643-653: Valuing the Unmarketable: An Ecological Approach to the Externalities Estimate in Fishing Activities
- Societies, Vol. 3, Pages 104-116: Double Marginalized Livelihoods: Invisible Gender Inequality in Pastoral Societies
- Toxins, Vol. 5, Pages 315-326: Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis
- Water, Vol. 5, Pages 239-342: Sustainable Water Systems
- Water, Vol. 5, Pages 224-238: Enhanced Effects of Flood Disasters Due to Hillside Development in Urban Areas
- Pharmaceuticals, Vol. 6, Pages 251-268: NMDA Receptor Modulators in the Treatment of Drug Addiction
- Pharmaceuticals, Vol. 6, Pages 223-250: RNAi Therapeutic Platforms for Lung Diseases
| Sync Folders Pro 2.7 - Automatically sync any number of folders.. (Commercial) Posted: 06 Feb 2013 03:34 AM PST  Sync Folders Pro synchronizes any number of folders on the fly at the same time when there are changes, or connecting external drives at a set time or manually. The app synchronizes folders with or without filter for folder names and / or file names. The Sync Folders Pro is perfect for backup to USB, memory cards, disks on remote computers on your network, folders on Cloud services (Dropbox, etc.) TRY IT FOR FREE with the free version which is available on the website and compare the sync speed and stability vs the similar apps (for the number of files > 50 000). Version 2.x is a new application vs version 1.x from a technical point of view. Completely changed the core of the application and algorithm of comparison of files structure which increased the speed of comparing 4-10 times for folders with many files and improved stability of the application. Left unchanged only the application interface that was liked many customers by an easy-to-use. Implemented a parallel analysis of all tasks. The comparison of two folders (6.24 GB and 92 470 files in each folder) is one minute. Video help for Sync Folders Pro on www.greenworldsoft.com:
Features:
Version 2.7:
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| ACDSee Pro 2.2 - Fast and effective image viewer and browser.. (Demo) Posted: 06 Feb 2013 03:17 AM PST  ACDSee Pro accelerate your photography workflow. Manage and view your images with speed and ease. ACDSee Pro is the photography software with the flexibility to adapt to the way you work; helping you optimize every aspect of your workflow. Unlike catalog-based photo applications, you don't need to spend valuable time importing files that are already on your hard drive and connected devices. ACDSee Pro automatically detects your devices, including cameras, photo frames and external memory. Browse these devices directly, and simply drag and drop to copy the images onto your hard drive. Access folders and files live, in real time. When you browse a folder, ACDSee Pro instantly populates the file list with thumbnails of your photos. This posting includes an audio/video/photo media file: Download Now |
| ClickBeatz Pro 2.0.2 - Tag your music library with BPM values.. (Free) Posted: 06 Feb 2013 03:08 AM PST  ClickBeatz Pro helps musicians to tag their music library with BPM values. Use it as clicker and save the detected BPMs into your library. ClickBeatz Pro also browses your music library, plays your songs and fetches lyrics for the song that is playing. Since we have gone "Pro" ClickBeatz Pro also shares your song lists with by using the integrated web service at port 11111. You can also allow and disallow download of the songs listed. Version 2.0.2:
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| PowerTunes 1.2.5 - Create, organize, and share multiple iTunes libraries.. (Shareware) Posted: 06 Feb 2013 03:04 AM PST  PowerTunes allows iTunes users to create multiple libraries, organize their music among multiple music folders, and share music and libraries between multiple users on a machine. In addition to simply creating and keeping track of your libraries, PowerTunes also offers many additional features to help organize your music. Users can copy music back and forth between their libraries while maintaining all their ratings, play counts, and other information stored in iTunes. This allows libraries to be split up into smaller ones, or merged together into larger ones. PowerTunes also offers a one-step solution for sharing iTunes libraries and music among multiple user accounts on a machine, allows users to fix dead tracks whose files have gone missing, finds orphaned music files in their music folders, and much more.
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| ZOC Terminal 6.46 - Telnet/SSH/SSH2 client and terminal emulator.. (Shareware) Posted: 06 Feb 2013 02:56 AM PST  ZOC Terminal is a best-of-its-kind telnet/SSH/SSH2 client and terminal emulator. Brimming with functions like tabbed sessions, typed command history, scrollback and multi-window support, ZOC Terminal's implemented emulations have made it the preferred tool for anyone who needs to access Unix shell accounts from a Windows or Mac OS X platform. Emulate widely-used or specialized terminals
Version 6.46:
OS X 10.4.7 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 06 Feb 2013 12:00 AM PST During the course of our attempts to develop a potential herbal medicine, we had previously prepared PF2401-SF, a standardized fraction of S. miltiorrhiza, and reported its hepatoprotective activity in vitro as well as in vivo. Since apoptosis of activated hepatic stellate cells (HSCs) is a well-accepted anti-fibrotic strategy, in this study, we investigated the direct effect of PF2401-SF on t-HSC/Cl-6 cells in vitro and on CCl4-induced liver injury in vivo. We evaluated the activation and cleavage of hallmarkers of apoptosis, namely, caspase 3, 8, 9 and PARP. Upregulation of the pro-apoptotic Bax protein and downregulation of the anti-apoptotic Bcl2 protein were also analyzed. Furthermore, in the PF2401-SF treated rats, apoptosis induction of activated HSCs was demonstrated by reduced distribution of α-SMA-positive cells and the presence of high number of TUNEL-positive cells in vivo. Our data suggest that PF2401-SF can mediate HSCs apoptosis induction, and may be a potential herbal medicine for the treatment of liver fibrosis. |
| Posted: 06 Feb 2013 12:00 AM PST Some Curcuma species are widely used as herbal medicines. Sesquiterpenes are their important bioactive compounds and their quantitative analysis is generally accomplished by gas chromatography (GC) or high performance liquid chromatography (HPLC), but the instability and high cost of some sesquiterpene reference standards have limited their application. It is necessary to find a practicable means to control the quality of herbal medicines. Using one stable component contained in Curcuma species to determine multiple analogues should be a practical option. In this study, a simple HPLC method for determination of sesquiterpenes using relative response factors (RRFs) has been developed. The easily available and stable active component curdione was selected as the reference compound for calculating the RRFs of the other eight sesquiterpenes, including zedoarondiol (Zedo), isozedoarondiol (Isoz), aerugidiol (Aeru), (4S,5S)-(+)-germacrone-4,5-epoxide (Epox), curcumenone (Curc), neocurdione (Neoc), germacrone (Germ) and furanodiene (Fura). Their RRFs against curdione were between 0.131–1.301, with a good reproducibility. By using the RRFs, the quantification of sesquiterpenes in Curcuma wenyujin herbal medicines and related products was carried out. The method is especially useful for the determination of (4S,5S)-(+)-germacrone-4,5-epoxide, curcumenone, germacrone and furanodiene, which often are regarded as the principle components in Curcuma species, but unstable when were purified. It is an ideal means to analyze the components for which reference standards are not readily available. |
| Posted: 06 Feb 2013 12:00 AM PST Pd-catalyzed amination of isomeric 2,6-, 2,8-, 4,8- and 4,7-dichloroquinolines was studied using adamantane-containing amines in which substituents at the nitrogen atom differ in bulkiness. The selectivity of the amination of 2,6-dichloroquinoline was very low, substantially better results were obtained with 2,8-dichloroquinoline, and 4,8- and 4,7-dichloroquinolines provided the best yields of the amination products. Diamination of 4,8- and 4,7-dichloroquinolines was carried out with two amines which differ strongly in the bulkiness of the alkyl group. In the majority of cases BINAP ligand was successfully applied, however, it had to be replaced with DavePhos in certain reactions when using the most sterically hindered amine as well as for the diamination reactions. |
| Posted: 06 Feb 2013 12:00 AM PST Although salicylaldehyde azine (3) was reported in 1985 as the single product of the reaction of ethyl 2-oxo-2H-chromene-3-carboxylate (1) with hydrazine hydrate, we identified another main reaction product, besides 3, which was identified as malono-hydrazide (4). In the last two decades, however, some articles have claimed that this reaction afforded exclusively hydrazide 2 and they have reported the use of this hydrazide 2 as a precursor in the syntheses of several heterocyclic compounds and hydrazones 6. We reported herein a study of the formation of 2 and a facile route for the synthesis of the target compounds N'-arylidene-2-oxo-2H-chromene-3-carbohydrazides 6a–f. |
| Posted: 06 Feb 2013 12:00 AM PST Comparisons of eddy covariance (EC) tower measurements of CO2 concentration with mid-tropospheric observations from the Atmospheric Infrared Sounder (AIRS) allow for evaluation of the rising global signal of this greenhouse gas in relation to surface carbon dynamics. Using an information theory approach combining relative entropy and wavelet multi-resolution analysis, this study has explored correlations and divergences between mid-tropospheric and surface CO2 concentrations in grasslands of northeastern Kansas. Results show that surface CO2 measurements at the Kansas Field Station (KFS) and the Konza Prairie Biological Stations 1B (KZU) and 4B (K4B) with different land-cover types correlate well with mid-tropospheric CO2 in this region at the 512-day timescale between 2007 and 2010. Relative entropy further reveals that AIRS observations are indicative of surface CO2 concentrations for all land-cover types on monthly (32-day) and longer timescales. AIRS observations are also similar to CO2 concentrations at shorter timescales at sites KFS and K4B experiencing woody encroachment, though these results require further investigation. Differences in species composition and microclimate add to the variability of surface concentrations compared with mid-tropospheric observations. |
| Posted: 06 Feb 2013 12:00 AM PST Consumption of fish has well-known human health benefits, though some fish may contain elevated levels of mercury (Hg) that are especially harmful to developing children. Fish length is most often the basis for establishing fishery harvest regulations that determine which fish will ultimately be consumed by humans. It is, therefore, essential to quantify the relationship between fish length and Hg accumulation in regard to harvest regulations for effective fishery and public health policy. We examined this relationship for three sportfish from six lakes across North Carolina, USA. Bluegill (Lepomis macrochirus) had the lowest Hg levels and only the very largest fish in the most contaminated site exceeded the US Environmental Protection Agency (USEPA) Hg screening level. Black crappie (Pomoxis nigromaculatus) had an intermediate level of Hg and larger individuals exceeded the USEPA screening level; however, they tended not to exceed this level before reaching the harvest length limit. Largemouth bass (Micropterus salmoides) exceeded the USEPA screening level at sizes below the fishery length limit in two lakes, leaving only higher risk fish for anglers to harvest and consume. Removing the effects of fish age and trophic position, we found strong positive correlations between Hg and fish length for largemouth bass and black crappie. We suggest public health officials and wildlife managers collaborate to structure fishery regulations and length-based fish consumption advisories that protect consumers from Hg exposure and communicate the relative risk of fish consumption. |
| Posted: 06 Feb 2013 02:48 AM PST Features Real tracks: A first for the Real Racing series! Burn rubber around a full lineup of real tracks from the top names around the world including Mazda Raceway Laguna Seca, Indianapolis Motor Speedway, Silverstone, and more! More cars: The largest ever roster of cars available in a Real Racing title, from all-new manufacturers like Porsche, Dodge, and Audi. Experience a first in mobile racing with an authentic race grid of 22 cars. Race anyone, anywhere, any time: With Real Racing 3's Time Shifted Multiplayer™ you can challenge your friends at any time, even if they're offline! Bump and grind with your rival's time shifted double to win the race! Real Racing experience: Persistent car damage, fully functioning rear view mirrors, and dynamic reflections enhance the realism of the race day experience. Real Racing 3 delivers a rich, next-gen racing experience in the most advanced cross-platform social and competitive racing community ever. |
| Posted: 06 Feb 2013 12:00 AM PST Reaction of 3,4,5-trimethoxybenzylamine and benzyl 2,3-anhydro-β-L-ribopyranoside in refluxing ethanol produced benzyl 3-deoxy-3-(3,4,5-trimethoxybenzylamino)-β-L-xylopyranoside in 72.5% yield. An attempt to synthesize the title compound by reacting neat 3,4,5-trimethoxybenzylamine with benzyl 2,3-anhydro-β-L-ribopyranoside without a solvent produced a dark brown mixture with several decomposition products. The structure of benzyl 3-deoxy-3-(3,4,5-trimethoxybenzylamino)-β-L-xylopyranoside was determined using elemental analysis, 1H-NMR and 13C-NMR and its conformation is 1C4. |
| Posted: 06 Feb 2013 12:00 AM PST In a rapidly changing world, sustainability, if it can be said to exist at all, is concept that has attained mythic status, often pursued and rarely reached. In order to improve our capability to cope with environmental problems, adopting an Ecosystem Approach has been suggested. One of the major challenges in the implementation of this new paradigm relates to control of externalities. The recognition and quantification of externalities is often cast as valuing the unmarketable, and there are several approaches that have been proposed. Here, we analyze the opportunity to “feed” the economic valuation with ecological concepts. From an ecological perspective, the energy required to sustain a biomass unit at a given trophic level (TL) is the same, whatever the species. We build on this central tenet of ecology to assess the value of a TL unit for each trophic position using fish market data. The results obtained were then used to assign a value to each species living in a given habitat, together with consideration of their ecological role within the community. Estimates of both natural capital and functional value were applied to assess the ecological impacts of mechanical clam harvesting versus the multi-species artisanal fishery in the Venice lagoon. Results are discussed in relation to possible contribution to the implementation of a different management strategy. |
| Posted: 06 Feb 2013 12:00 AM PST Achieving gender equality is the Third Millennium Development Goal, and the major challenge to poverty reduction is the inability of governments to address this at grass root levels. This study is therefore aimed at assessing gender inequality as it pertains to socio-economic factors in (agro-) pastoral societies. It tries to explain how “invisible” forces perpetuate gender inequality, based on data collected from male and female household heads and community representatives. The findings indicate that in comparison with men, women lack access to control rights over livestock, land, and income, which are critical to securing a sustainable livelihood. However, this inequality remains invisible to women who appear to readily submit to local customs, and to the community at large due to a lack of public awareness and gender based interventions. In addition, violence against women is perpetuated through traditional beliefs and sustained by tourists to the area. As a result, (agro-) pastoral woman face double marginalization, for being pastoralist, and for being a woman. |
| Posted: 06 Feb 2013 12:00 AM PST The genes encoding Anthrax Toxin Receptors (ANTXRs) were originally identified based on expression in endothelial cells suggesting a role in angiogenesis. The focus of this review is to discuss what has been learned about the physiological roles of these receptors through evaluation of the Antxr knockout mouse phenotypes. Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication. |
| Water, Vol. 5, Pages 239-342: Sustainable Water Systems Posted: 06 Feb 2013 12:00 AM PST Sustainable water systems often comprise complex combinations of traditional and new system components that mimic natural processes. These green systems aim to protect public health and safety, and restore natural and human landscapes. Green infrastructure elements such as most sustainable drainage systems trap storm water but may contaminate groundwater. There is a need to summarize recent trends in sustainable water systems management in a focused document. The aim of this special issue is therefore to disseminate and share scientific findings on novel sustainable water systems addressing recent problems and opportunities. This special issue focuses on the following key topics: climate change adaptation and vulnerability assessment of water resources systems; holistic water management; carbon credits; potable water savings; sustainable water technologies; nutrient management; holistic storm water reuse; water and wastewater infrastructure planning; ecological status of watercourses defined by the Water Framework Directive. The combined knowledge output advances the understanding of sustainable water, wastewater and storm water systems in the developed and developing world. The research highlights the need for integrated decision-support frameworks addressing the impact of climate change on local and national water resources management strategies involving all relevant stakeholders at all levels. |
| Posted: 06 Feb 2013 12:00 AM PST In recent years, the Taiwan government has established a number of flood control facilities such as dikes, pumping stations and drainage systems to effectively reduce downstream flooding. However, with continued development and urbanization of catchment areas, the original designs of most flood control facilities have become outdated. Hillside lands in the upper and middle reaches of river basins have undergone urban development through unsound engineering practices, paving the way for heavy downstream flooding. Therefore, proper river basin management should include both upstream and downstream sides. The main purpose of the paper is to simulate non-urban inundation areas with various degrees of development (0%, 10%, 20%, 40% and 60%), over two different return periods of 25 years and 200 years, for intensive rainfall events in the Shi-Chi District, Taiwan. Through hydrological analysis and numerical simulations of inundation, quantitative data on inundation potential have been established based on the land development conditions along the hillsides on the upper and middle reaches of the Keelung River Basin. The simulated results show that the increase in the extent of land development in the upper reaches causes an increase in the area and depth of inundation, resulting in an increased risk of flooding in downstream areas. If the land-use policy makers in the upper reaches of the river basin’s hillsides do not properly manage the land development, the risk of flooding in downstream areas will increase. In such an event, the policy makers should first review the situation to understand the problem with the consideration of this study. Thus, proper development and flood mitigation in hillsides can be established. |
| Pharmaceuticals, Vol. 6, Pages 251-268: NMDA Receptor Modulators in the Treatment of Drug Addiction Posted: 06 Feb 2013 12:00 AM PST Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function, followed by a review of the mechanism of action, clinical efficacy, and side effect profile of NMDA receptor ligands that are currently in use or being explored for the treatment of drug addiction. These ligands include the NMDA receptor modulators memantine and acamprosate, as well as the partial NMDA agonist D-cycloserine. Data collected to date suggest that direct NMDA receptor modulators have relatively limited efficacy in the treatment of drug addiction, and that partial agonism of NMDA receptors may have some efficacy with regards to extinction learning during cue exposure therapy. However, the lack of consistency in results to date clearly indicates that additional studies are needed, as are studies examining novel ligands with indirect mechanisms for altering NMDA receptor function. |
| Pharmaceuticals, Vol. 6, Pages 223-250: RNAi Therapeutic Platforms for Lung Diseases Posted: 06 Feb 2013 12:00 AM PST RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions in many eukaryotes and holds promise for the development of therapeutic gene silencing. The induction of RNAi relies on small silencing RNAs, which affect specific messenger RNA (mRNA) degradation. Two types of small RNA molecules, i.e. small interfering RNAs (siRNAs) and microRNAs (miRNAs), are central to RNAi. Drug discovery studies and novel treatments of siRNAs are currently targeting a wide range of diseases, including various viral infections and cancers. Lung diseases in general are attractive targets for siRNA therapeutics because of their lethality and prevalence. In addition, the lung is anatomically accessible to therapeutic agents via the intrapulmonary route. Recently, increasing evidence indicates that miRNAs play an important role in lung abnormalities, such as inflammation and oncogenesis. Therefore, miRNAs are being targeted for therapeutic purposes. In this review, we present strategies for RNAi delivery and discuss the current state-of-the-art RNAi-based therapeutics for various lung diseases. |
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