Games |
- DiagramPainter 1.0.5 - Extensive collection of diagrams at your fingertips.. (Demo)
- Movavi Video Converter 3.2.2 - Easy-to-use video & audio file converter.. (Demo)
- Sight Control 1.3 - Take control of your built-in iSight.. (Commercial)
- BookMacster 1.13.2 - Organize and manage bookmarks and sync across browsers.. (Demo)
- IJMS, Vol. 14, Pages 3824-3833: Interlamellar Organization of Phase Separated Domains in Multi-Component Lipid Multilayers: Energetic Considerations
- IJMS, Vol. 14, Pages 3817-3823: Role of Akirin in Skeletal Myogenesis
- IJMS, Vol. 14, Pages 3802-3816: Downregulation of miR-17~92 Expression Increase Paclitaxel Sensitivity in Human Ovarian Carcinoma SKOV3-TR30 Cells via BIM Instead of PTEN
- IJMS, Vol. 14, Pages 3786-3801: Core RNAi Machinery and Sid1, a Component for Systemic RNAi, in the Hemipteran Insect, Aphis glycines
- IJMS, Vol. 14, Pages 3773-3785: Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair
- IJMS, Vol. 14, Pages 3734-3772: Protein-Phospholipid Interactions in Nonclassical Protein Secretion: Problem and Methods of Study
- Biosensors, Vol. 3, Pages 108-115: Fast and Sensitive Interferon-γ Assay Using Supercritical Angle Fluorescence
- Pharmaceutics, Vol. 5, Pages 127-167: From Molecular to Nanotechnology Strategies for Delivery of Neurotrophins: Emphasis on Brain-Derived Neurotrophic Factor (BDNF)
- Now there's 50 Shades of game play
- Axioms, Vol. 2, Pages 10-19: Generalized q-Stirling Numbers and Their Interpolation Functions
- Energies, Vol. 6, Pages 921-933: System Identification and Integration Design of an Air/Electric Motor
- Energies, Vol. 6, Pages 900-920: Modeling Supermarket Refrigeration Systems for Demand-Side Management
- Energies, Vol. 6, Pages 884-899: High Level Ethanol Production by Nitrogen and Osmoprotectant Supplementation under Very High Gravity Fermentation Conditions
- IJERPH, Vol. 10, Pages 712-716: Comments on: Chari, R.; Burke, T.A.; White, R.H.; Fox, M.A. Integrating Susceptibility into Environmental Policy: An Analysis of the National Ambient Air Quality Standard for Lead. Int. J. Environ. Res. Public Health 2012, 9, 1077-1096
- Molecules, Vol. 18, Pages 2183-2199: Anti-Escherichia coli O157:H7 Properties of Purple Prairie Clover and Sainfoin Condensed Tannins
- Sensors, Vol. 13, Pages 2368-2388: Development of a Compact Wireless Laplacian Electrode Module for Electromyograms and Its Human Interface Applications
| DiagramPainter 1.0.5 - Extensive collection of diagrams at your fingertips.. (Demo) Posted: 08 Feb 2013 03:33 AM PST  DiagramPainter is an editor for quickly drawing all kinds of diagrams, from flowchart diagrams, mind mappings, organization charts, and more. With a few clicks, you can then integrate the diagram in your favourite program, by copying it to the clipboard as image, or saving it as file. It exports diagrams as .png, .jpg, and .bmp image files, and even has an integrated fast .pdf exporter. Features:
Version 1.0.5:
OS X 10.4 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Movavi Video Converter 3.2.2 - Easy-to-use video & audio file converter.. (Demo) Posted: 08 Feb 2013 03:18 AM PST  Movavi Video Converter is a video & audio file converter. Convert video & audio on your Mac. Save videos for watching on your portable device. Extract soundtracks from video. And much more... Here's just a taste of what you can do with Movavi Video Converter for Mac:
Version 3.2.2:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Sight Control 1.3 - Take control of your built-in iSight.. (Commercial) Posted: 08 Feb 2013 03:09 AM PST  Sight Control is a simple and user-friendly OS X application that will give you total control of your Mac's built-in webcam. Sight Control will allow you to easily adjust the image quality in real time while using webcam apps such as Skype or FaceTime. Sight Control will automatically identify Mac's built-in webcams, including Built-in iSight, Display iSight, FaceTime Camera (Built-in), FaceTime Camera (Display), FaceTime HD Camera (Built-in) and FaceTime HD Camera (Display). Sight Control communicates with Mac's built-in webcams and learns what settings they can support. You can adjust all these settings
* If you are using external UVC camera or plan to use one, please choose my other app - Webcam Settings.
Download Now |
| BookMacster 1.13.2 - Organize and manage bookmarks and sync across browsers.. (Demo) Posted: 08 Feb 2013 02:59 AM PST  BookMacster is the Bookmarks Master for the Mac. In addition to being able to use BookMacster directly via a global shortcut key or Status Menulet, BookMacster can keep bookmarks in sync among Safari, Firefox, Chrome, Camino, iCab, Roccat, Opera and OmniWeb, on the Web with Diigo, Delicious, Pinboard, and Google Bookmarks, and on into your iPhone, iPad, or iPod Touch, via Apple's iCloud. Used with an online file syncing service such as Dropbox, BookMacster takes cross-browser bookmark syncing to all of your Macs. BookMacster keeps bookmarks alphabetized (sorted), verified, and checked for duplicates. BookMacster supports tags, comments, and shortcuts. BookMacster users can add bookmarks directly from within browsers, and access all bookmarks while in any app from the menu bar and, under OS X 10.7 Lion, access to past bookmarks via Lion's Auto Save and Versions features. Version 1.13.2:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 08 Feb 2013 12:00 AM PST A recent experimental study [1] has demonstrated the alignment of phase separated domains across hundreds of bilayer units in multicomponent stacked lipid bilayers. The origin of this alignment is the interlamellar coupling of laterally phase separated domains. Here, we develop a theoretical model that presents the energetics description of this phenomenon based on the minimization of the free energy of the system. Specifically, we use solution theory to estimate the competition between energy and entropy in different stacking configurations. The model furnishes an elemental phase diagram, which maps the domain distributions in terms of the strength of the intra- and inter-layer interactions and estimates the value of inter-layer coupling for complete alignment of domains in the stacks of five and ten bilayers. The area fraction occupied by co-existing phases was calculated for the system of the minimum free energy, which showed a good agreement with experimental observations. |
| IJMS, Vol. 14, Pages 3817-3823: Role of Akirin in Skeletal Myogenesis Posted: 08 Feb 2013 12:00 AM PST Akirin is a recently discovered nuclear factor that plays an important role in innate immune responses. Beyond its role in innate immune responses, Akirin has recently been shown to play an important role in skeletal myogenesis. In this article, we will briefly review the structure and tissue distribution of Akirin and discuss recent advances in our understanding of its role and signal pathway in skeletal myogenesis. |
| Posted: 08 Feb 2013 12:00 AM PST To better understand the molecular mechanisms of paclitaxel resistance in ovarian carcinoma, we evaluated the expression of miRNAs using miRNA microarray between human ovarian carcinoma SKOV3 cells and paclitaxel resistant SKOV3-TR30 cells. Results showed that 69 miRNAs were upregulated while 102 miRNAs were downregulated in SKOV3-TR30 cells. Using real-time PCR, we further clarified that miR-17~92 was overexpressed in SKOV3-TR30 cells compared with that in SKOV3 cells. We then established stable virally transduced SKOV3-TR30-m-PTIP-Sponge all SKOV3-TR30 cells and its vector-only control SKOV3-TR30-m-PTIP-GFP cells. Real time-PCR revealed that SKOV3-TR30-m-PTIP-Sponge all cells expressed approximately 6.18-fold lower levels of miR-17~92 compared with the control group. Decreased expression of miR-17~92 resulted in cell cycle arrest in the G2/M phase and growth inhibition. After the transduction, the BIM protein level was increased in SKOV3-TR30 cells and luciferase reporter assays revealed that miR-17~92 binds directly to the 3'-UTR of BIM. Results of luciferase reporter assays accompanied with Western Blot showed that although miR-17~92 binds directly to the 3'-UTR of PTEN, the PTEN protein expression level was upregulated slightly while the result is of no statistical significance. Our results showed that miR-17~92 could be a causal factor of the downregulation of BIM in SKOV3-TR30 cells and thus induce the paclitaxel resistance in SKOV3-TR30 cells. |
| Posted: 08 Feb 2013 12:00 AM PST RNA interference (RNAi) offers a novel tool to manage hemipteran pests. For the success of RNAi based pest control in the field, a robust and systemic RNAi response is a prerequisite. We identified and characterized major genes of the RNAi machinery, Dicer2 (Dcr2), Argonaute2 (Ago2), and R2d2 in Aphis glycines, a serious pest of soybean. The A. glycines genome encodes for at least one copy of Dcr2, R2d2 and Ago2. Comparative and molecular evolution analyses (dN/dS) showed that domain regions of encoded proteins are highly conserved, whereas linker (non-domain) regions are diversified. Sequence homology and phylogenetic analyses suggested that the RNAi machinery of A. glycines is more similar to that of Tribolium casteneum as compared to that of Drosophila melanogaster. We also characterized Sid1, a major gene implicated in the systemic response for RNAi-mediated gene knockdown. Through qPCR, Dcr2, R2d2, Ago2, and Sid1 were found to be expressed at similar levels in various tissues, but higher expression of Dcr2, R2d2, and Ago2 was seen in first and second instars. Characterization of RNAi pathway and Sid1 in A. glycines will provide the foundation of future work for controlling one of the most important insect pests of soybean in North America. |
| Posted: 08 Feb 2013 12:00 AM PST Pharmacologic inhibitors of poly(ADP-ribose) polymerase (PARP) putatively enhance radiation toxicity in cancer cells. Although there is considerable information on the molecular interactions of PARP and BRCA1- and BRCA2-deficient cancers, very little is known of the PARP inhibition effect upon cancers proficient in DNA double-strand break repair after ionizing radiation or after stalled replication forks. In this work, we investigate whether PARP inhibition by ABT-888 (veliparib) augments death-provoking effects of ionizing radiation, or of the topoisomerase I poison topotecan, within uterine cervix cancers cells harboring an unfettered, overactive ribonucleotide reductase facilitating DNA double-strand break repair and contrast these findings with ovarian cancer cells whose regulation of ribonucleotide reductase is relatively intact. Cell lethality of a radiation-ABT-888 combination is radiation and drug dose dependent. Data particularly highlight an enhanced topotecan-ABT-888 cytotoxicity, and corresponds to an increased number of unrepaired DNA double-strand breaks. Overall, our findings support enhanced radiochemotherapy toxicity in cancers proficient in DNA double-strand break repair when PARP is inhibited by ABT-888. |
| Posted: 08 Feb 2013 12:00 AM PST Extracellular proteins devoid of signal peptides use nonclassical secretion mechanisms for their export. These mechanisms are independent of the endoplasmic reticulum and Golgi. Some nonclassically released proteins, particularly fibroblast growth factors (FGF) 1 and 2, are exported as a result of their direct translocation through the cell membrane. This process requires specific interactions of released proteins with membrane phospholipids. In this review written by a cell biologist, a structural biologist and two membrane engineers, we discuss the following subjects: (i) Phenomenon of nonclassical protein release and its biological significance; (ii) Composition of the FGF1 multiprotein release complex (MRC); (iii) The relationship between FGF1 export and acidic phospholipid externalization; (iv) Interactions of FGF1 MRC components with acidic phospholipids; (v) Methods to study the transmembrane translocation of proteins; (vi) Membrane models to study nonclassical protein release. |
| Posted: 08 Feb 2013 12:00 AM PST We present an immunoassay for Interferon-γ (IFN-γ) with a limit of detection of 1.9 pM (30 pg/mL) and a linear concentration range spanning three orders of magnitude. The developed one-step assay takes only 12 min and can replace the time-consuming and labor-intensive enzyme-linked immunosorbent assay (ELISA). The solid-phase sandwich assay is performed on a new measurement system comprising single-use test tubes and a compact fluorescence reader. The polymer tubes contain an optical configuration for the detection of supercritical angle fluorescence, allowing for highly sensitive real-time binding measurements. |
| Posted: 08 Feb 2013 12:00 AM PST Neurodegenerative diseases represent a major public health problem, but beneficial clinical treatment with neurotrophic factors has not been established yet. The therapeutic use of neurotrophins has been restrained by their instability and rapid degradation in biological medium. A variety of strategies has been proposed for the administration of these leading therapeutic candidates, which are essential for the development, survival and function of human neurons. In this review, we describe the existing approaches for delivery of brain-derived neurotrophic factor (BDNF), which is the most abundant neurotrophin in the mammalian central nervous system (CNS). Biomimetic peptides of BDNF have emerged as a promising therapy against neurodegenerative disorders. Polymer-based carriers have provided sustained neurotrophin delivery, whereas lipid-based particles have contributed also to potentiation of the BDNF action. Nanotechnology offers new possibilities for the design of vehicles for neuroprotection and neuroregeneration. Recent developments in nanoscale carriers for encapsulation and transport of BDNF are highlighted. |
| Now there's 50 Shades of game play Posted: 08 Feb 2013 02:07 AM PST Game play: Clockwise from front left, Gen Whaites, Kelly Noble, Emma Shaw and Tom Williamson test out the game. |
| Axioms, Vol. 2, Pages 10-19: Generalized q-Stirling Numbers and Their Interpolation Functions Posted: 08 Feb 2013 12:00 AM PST In this paper, we define the generating functions for the generalized q-Stirling numbers of the second kind. By applying Mellin transform to these functions, we construct interpolation functions of these numbers at negative integers. We also derive some identities and relations related to q-Bernoulli numbers and polynomials and q-Stirling numbers of the second kind. |
| Posted: 08 Feb 2013 12:00 AM PST This paper presents an integration design and implementation of an air motor and a DC servo motor which utilizes a magnetic powder brake to integrate these two motors together. The dynamic model of the air/electric hybrid system will be derived and eventually leads to successful ECE-40 driving cycle tests with a FPGA-based speed controller. The testing results obtained by using the proposed experimental platform indicate that the total air consumption is about 256 L under air motor mode and the electric charge consumption is about 530 coulombs under DC servo motor mode. In a hybrid mode, the current reduction of the battery is about 18.5%, and then the service life of the battery can be improved. Furthermore, a prototype is built with a proportional-integral (PI) speed controller based on a field-programmable gate array (FPGA) in order to facilitate the entire analysis of the velocity switch experiment. Through the modular methodology of FPGA, the hybrid power platform can successfully operate under ECE-40 driving cycle with the PI speed controller. The experimental data shows that the chattering ranges of the air motor within ±1 km/h and ±0.2 km/h under DC servo motor drive. Therefore, the PI speed controller based on FPGA is successfully actualized. |
| Posted: 08 Feb 2013 12:00 AM PST Modeling of supermarket refrigeration systems for supervisory control in the smart grid is presented in this paper. A modular modeling approach is proposed in which each module is modeled and identified separately. The focus of the work is on estimating the power consumption of the system while estimating the cold reservoir temperatures as well. The models developed for each module as well as for the overall integrated system are validated by real data collected from a supermarket in Denmark. The results show that the model is able to estimate the actual electrical power consumption with a high fidelity. Moreover a simulation benchmark is introduced based on the produced model for demand-side management in smart grid. Finally, a potential application of the proposed benchmark in direct control of the power/energy consumption is presented by a simple simulation example. |
| Posted: 08 Feb 2013 12:00 AM PST Optimization of nutrient supplements i.e., yeast extract (1, 3 and 5 g·L−1), dried spent yeast (DSY: 4, 12 and 20 g·L−1) and osmoprotectant (glycine: 1, 3 and 5 g·L−1) to improve the efficiency of ethanol production from a synthetic medium under very high gravity (VHG) fermentation by Saccharomyces cerevisiae NP 01 was performed using a statistical method, an L9 (34) orthogonal array design. The synthetic medium contained 280 g·L−1 of sucrose as a sole carbon source. When the fermentation was carried out at 30 °C, the ethanol concentration (P), yield (Yp/s) and productivity (Qp) without supplementation were 95.3 g·L−1, 0.49 g·g−1 and 1.70 g·L−1·h−1, respectively. According to the orthogonal results, the order of influence on the P and Qp values were yeast extract > glycine > DSY, and the optimum nutrient concentrations were yeast extract, 3; DSY, 4 and glycine, 5 g·L−1, respectively. The verification experiment using these parameters found that the P, Yp/s and Qp values were 119.9 g·L−1, 0.49 g g−1 and 2.14 g·L−1·h−1, respectively. These values were not different from those of the synthetic medium supplemented with 9 g·L−1 of yeast extract, indicating that DSY could be used to replace some amount of yeast extract. When sweet sorghum juice cv. KKU40 containing 280 g·L−1 of total sugar supplemented with the three nutrients at the optimum concentrations was used as the ethanol production medium, the P value (120.0 g·L−1) was not changed, but the Qp value was increased to 2.50 g·L−1·h−1. |
| Posted: 08 Feb 2013 12:00 AM PST In their recent article [1], Chari et al. call attention to the important subject of setting National Ambient Air Quality Standards (NAAQS) to provide requisite protection for public health, including the health of sensitive groups, as specified under the Clean Air Act (73 FR 66965) [2]. The authors focus on consideration of susceptibility to inform policy choices, using lead (Pb)-related neurocognitive effects and children from low socioeconomic status (SES) families in the context of alternative Pb standard levels. Our comments focus on the authors’ analysis of the scientific evidence and not on policy. We agree with the authors that the health effects evidence for Pb indicates a role (or roles) for SES-related factors in influencing childhood Pb exposure and associated health effects. We disagree, however, with the authors’ interpretation of the literature on SES influence on the shape of the concentration-response (C-R) relationship between children’s blood Pb and IQ (e.g., steepness of the slope). We further address aspects of the scientific evidence that are important to the consideration of sensitive populations in the context of the Pb NAAQS, and how the U.S. Environmental Protection Agency (EPA) considered this evidence in setting the Pb NAAQS in 2008. |
| Posted: 08 Feb 2013 12:00 AM PST Condensed tannins (CT) from purple prairie clover (PPC; Dalea purpurea Vent.) and sainfoin (SF; Onobrychis viciifolia) were assessed for anti-Escherichia coli activity by comparing their ability to react with proteins and liposome, cause cell aggregation, and alter outer membrane (OM) morphology and permeability. The PPC CT had greater (P < 0.01) protein-precipitating capacity than SF CT using either bovine serum albumin or ribulose 1,5-disphosphate carboxylase as model proteins. Minimum inhibitory concentration of PPC CT for two strains of E. coli and five strains of E. coli O157:H7 was four to six times lower than that of SF CT. E. coli exposed to 10 µg/mL of both CT had higher (P < 0.05) OM permeability than controls and was greater (P < 0.05) for PPC than for SF CT. Addition of both CT at 50 and 200 µg/mL caused cell aggregation which was more evident (P < 0.05) for PPC than for SF CT. Transmission electron microscopy showed electron dense material on the cell surface when cells were exposed to 50 µg/mL of PPC CT. The greater anti-E. coli activity of PPC than SF CT was due to its enhanced ability to precipitate protein that increased OM permeability and promoted cell aggregation. |
| Posted: 08 Feb 2013 12:00 AM PST In this study, we developed a compact wireless Laplacian electrode module for electromyograms (EMGs). One of the advantages of the Laplacian electrode configuration is that EMGs obtained with it are expected to be sensitive to the firing of the muscle directly beneath the measurement site. The performance of the developed electrode module was investigated in two human interface applications: character-input interface and detection of finger movement during finger Braille typing. In the former application, the electrode module was combined with an EMG-mouse click converter circuit. In the latter, four electrode modules were used for detection of finger movements during finger Braille typing. Investigation on the character-input interface indicated that characters could be input stably by contraction of (a) the masseter, (b) trapezius, (c) anterior tibialis and (d) flexor carpi ulnaris muscles. This wide applicability is desirable when the interface is applied to persons with physical disabilities because the disability differs one to another. The investigation also demonstrated that the electrode module can work properly without any skin preparation. Finger movement detection experiments showed that each finger movement was more clearly detectable when comparing to EMGs recorded with conventional electrodes, suggesting that the Laplacian electrode module is more suitable for detecting the timing of finger movement during typing. This could be because the Laplacian configuration enables us to record EMGs just beneath the electrode. These results demonstrate the advantages of the Laplacian electrode module. |
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